P H Watson

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer
    George P Skliris
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res Treat 104:75-85. 2007
  2. pmc Mammographic density is related to stroma and stromal proteoglycan expression
    Salem Alowami
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Breast Cancer Res 5:R129-35. 2003
  3. pmc S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast
    Ethan D Emberley
    Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Breast Cancer Res 6:R308-15. 2004
  4. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
  5. pmc Psoriasin (S100A7) expression is altered during skin tumorigenesis
    Salem Alowami
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3E OW3
    BMC Dermatol 3:1. 2003
  6. pmc RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer
    Ethan D Emberley
    Department of Pathology, University of Manitoba, Winnipeg Manitoba, Canada, R3E OW3
    BMC Cancer 2:28. 2002
  7. pmc Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
    Meghan Webb
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    BMC Cancer 5:17. 2005
  8. ncbi request reprint Necrosis and hypoxia in invasive breast carcinoma
    Ladislav Tomes
    Faculty of Medicine, Department of Pathology, University of Manitoba, Winnipeg, MB, Canada
    Breast Cancer Res Treat 81:61-9. 2003
  9. pmc Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
    P H Watson
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Br J Cancer 88:1065-70. 2003
  10. ncbi request reprint Expression of lumican in human breast carcinoma
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Cancer Res 58:1348-52. 1998

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer
    George P Skliris
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res Treat 104:75-85. 2007
    ..These data support the hypothesis that psoriasin/S100A7 is specifically regulated by ERbeta activity and could be useful to guide future therapies targeting ERbeta in certain phenotypic subsets of breast cancers in-vivo...
  2. pmc Mammographic density is related to stroma and stromal proteoglycan expression
    Salem Alowami
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    Breast Cancer Res 5:R129-35. 2003
    ..In this study we have examined breast biopsies for a relationship between mammographic density and stromal alterations...
  3. pmc S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast
    Ethan D Emberley
    Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Breast Cancer Res 6:R308-15. 2004
    ..Persistent S100A7 expression in invasive carcinoma is associated with a worse prognosis, and this effect may be mediated in part through interaction with the multifunctional cell signaling protein Jab1...
  4. pmc S100A7 and the progression of breast cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res 6:153-9. 2004
    ..The present review outlines what is known about S100A7 in breast cancer and summarizes the need to better understand the importance of this protein in breast cancer...
  5. pmc Psoriasin (S100A7) expression is altered during skin tumorigenesis
    Salem Alowami
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3E OW3
    BMC Dermatol 3:1. 2003
    ..Its expression profile for different stages of skin lesions is unknown. The aim of this study was to determine the relationship between psoriasin (S100A7) and tumor progression in skin...
  6. pmc RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer
    Ethan D Emberley
    Department of Pathology, University of Manitoba, Winnipeg Manitoba, Canada, R3E OW3
    BMC Cancer 2:28. 2002
    ..However the protein is found in the nucleus, cytoplasm as well as extracellularly. In the present study we have sought to identify potential psoriasin-binding proteins and to describe their expression profile in breast tumors...
  7. pmc Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesis
    Meghan Webb
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    BMC Cancer 5:17. 2005
    ..In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis...
  8. ncbi request reprint Necrosis and hypoxia in invasive breast carcinoma
    Ladislav Tomes
    Faculty of Medicine, Department of Pathology, University of Manitoba, Winnipeg, MB, Canada
    Breast Cancer Res Treat 81:61-9. 2003
    ..We conclude that stromal and epithelial hypoxia may have different biological backgrounds and that stromal hypoxia may affect survival...
  9. pmc Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinoma
    P H Watson
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Br J Cancer 88:1065-70. 2003
    ....
  10. ncbi request reprint Expression of lumican in human breast carcinoma
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Cancer Res 58:1348-52. 1998
    ....
  11. pmc Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancers
    G P Skliris
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
    Histopathology 52:355-69. 2008
    ..The aim was to investigate for the first time SBEM protein expression in a large cohort (n = 300) of invasive breast cancers, its relationship to established clinical variables and its association with clinical outcome...
  12. ncbi request reprint Mammaglobin, a potential marker of breast cancer nodal metastasis
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba R3E 0W3, Canada
    J Pathol 189:28-33. 1999
    ..0001). These results suggest that mammaglobin could be a marker of axillary lymph node breast metastases...
  13. ncbi request reprint Altered expression of estrogen receptor coregulators during human breast tumorigenesis
    L C Murphy
    Department of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Cancer Res 60:6266-71. 2000
    ..Although our study is small, these data are consistent with the above hypothesis and suggest that such alterations may have a role in the altered estrogen action occurring during breast tumorigenesis...
  14. pmc Relationship of coregulator and oestrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancer
    L C Murphy
    Manitoba Institute of Cell Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3E OW3
    Br J Cancer 87:1411-6. 2002
    ..However, our data provide preliminary evidence that the expression of oestrogen receptor beta protein isoforms may differ in primary tumours of breast cancer patients who prove to have differential sensitivity to tamoxifen therapy...
  15. pmc Altered expression of estrogen receptor-alpha variant messenger RNAs between adjacent normal breast and breast tumor tissues
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada, R3EOW3
    Breast Cancer Res 2:64-72. 2000
    ..We suggest that these changes might be involved in the mechanisms that underlie breast carcinogenesis...
  16. pmc Oestrogen receptor-alpha variant mRNA expression in primary human breast tumours and matched lymph node metastases
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    Br J Cancer 79:978-83. 1999
    ..Furthermore, the pattern of all deleted oestrogen receptor-alpha variant mRNAs appeared conserved between any primary and its matched secondary tumour...
  17. pmc Altered expression of exon 6 deleted progesterone receptor variant mRNA between normal human breast and breast tumour tissues
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Br J Cancer 80:379-82. 1999
    ..Moreover, a trend to lower (P < 0.1) relative D6-PR expression was observed in high PR tumours, compared to low PR tumours. These data suggest that increased expression of D6-PR occurs during tumorigenesis...
  18. ncbi request reprint Analysis of gene expression in ductal carcinoma in situ of the breast
    Adewale Adeyinka
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
    Clin Cancer Res 8:3788-95. 2002
    ..Our purpose was to identify molecular alterations underlying progression of DCIS...
  19. pmc Expression of estrogen receptor variant messenger RNAs and determination of estrogen receptor status in human breast cancer
    A Huang
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Am J Pathol 150:1827-33. 1997
    ..05). These data suggest that ER variant mRNAs encoding truncated ER proteins may contribute to discrepancies in ER-IHA levels determined using amino- or carboxyl-terminal-targeted antibodies...
  20. pmc Psoriasin (S100A7) expression and invasive breast cancer
    S Al-Haddad
    Department of Pathology University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Am J Pathol 155:2057-66. 1999
    ..0022). These results suggest that psoriasin may be a marker of aggressive behavior in invasive tumors and are consistent with a function as a chemotactic factor...
  21. ncbi request reprint Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesis
    E Leygue
    Department of Biochemistry, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Cancer Res 58:3197-201. 1998
    ..These results suggest that the role of ER-alpha- and ER-beta-driven pathways and/or their interaction change during breast tumorigenesis...
  22. ncbi request reprint Oestrogen receptor variants and mutations in human breast cancer
    L C Murphy
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    Ann Med 29:221-34. 1997
    ....
  23. ncbi request reprint Expression of estrogen receptor beta1, beta2, and beta5 messenger RNAs in human breast tissue
    E Leygue
    Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Cancer Res 59:1175-9. 1999
    ..Our data suggest that changes in the relative expression of ER-beta1, -beta2, and -beta5 mRNAs occur during breast tumorigenesis and tumor progression...
  24. ncbi request reprint The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer
    Ethan D Emberley
    Department of Biochemistry and Medical Genetics, University of Manitoba, Canada
    Cancer Res 65:5696-702. 2005
    ..We conclude that the S100A7-Jab1 pathway acts to enhance survival under conditions of cellular stress, such as anoikis, which may promote progression of breast cancer...
  25. ncbi request reprint Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor alpha in human breast carcinoma
    Charlton Cooper
    Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
    Clin Cancer Res 10:8720-7. 2004
    ..However, the effect of intermittent hypoxia, which is likely more prevalent in breast cancers, remains to be determined...
  26. pmc Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours
    G P Skliris
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    Br J Cancer 95:616-26. 2006
    ..Based on our in vivo observations, ERbeta may have the potential to become a therapeutic target in the specific subcohort of ERalpha-negative breast cancers...
  27. ncbi request reprint Expression of the steroid receptor RNA activator in human breast tumors
    E Leygue
    Department of Biochemistry, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Cancer Res 59:4190-3. 1999
    ..53, n = 27, P = 0.004). These data suggest that changes in the expression of SRA-related molecules occur during breast tumor progression...
  28. ncbi request reprint The steroid receptor RNA activator is the first functional RNA encoding a protein
    S Chooniedass-Kothari
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, P309 Pathology Building, 770 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0W3
    FEBS Lett 566:43-7. 2004
    ..Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein...
  29. ncbi request reprint Psoriasin interacts with Jab1 and influences breast cancer progression
    Ethan D Emberley
    Department of Pathology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
    Cancer Res 63:1954-61. 2003
    ..We conclude that intracellular psoriasin influences breast cancer progression and that this may occur through stimulation of Jab1 activity...
  30. ncbi request reprint Expression of estrogen receptor-beta in human breast tumors
    H Dotzlaw
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    J Clin Endocrinol Metab 82:2371-4. 1997
    ..However, some breast tumors and some cell lines coexpress ER-beta and ER-alpha mRNA. Our data support a possible role for ER-beta in human breast cancer...
  31. ncbi request reprint Estrogen receptor variants and mutations
    L C Murphy
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    J Steroid Biochem Mol Biol 62:363-72. 1997
    ....
  32. pmc The potential role for prolactin-inducible protein (PIP) as a marker of human breast cancer micrometastasis
    J W Clark
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    Br J Cancer 81:1002-8. 1999
    ..However, the presence of PIP expression in skin creates a potential source of contamination in venepuncture samples that should be considered in its application as a marker for breast tumour micrometastases...
  33. ncbi request reprint S100A7 (psoriasin) influences immune response genes in human breast cancer
    Soma Mandal
    Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
    Exp Cell Res 313:3016-25. 2007
    ..042, n=149). These results are consistent with a role for S100A7 in modulating the immune response which may be a factor in early breast tumor progression...
  34. ncbi request reprint Relationship between mammaglobin expression and estrogen receptor status in breast tumors
    Xiao feng Guan
    Departments of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3EOW3
    Endocrine 21:245-50. 2003
    ..As estrogen and antiestrogen treatment of estrogen-positive breast cancer cell lines does not modify SCGB2A2 expression we suggest that SCGB2A2 may be a new independent breast cancer prognostic marker...
  35. ncbi request reprint Influence of estrogen receptor variants on the determination of ER status in human breast cancer
    A Huang
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Breast Cancer Res Treat 58:219-25. 1999
    ....
  36. doi request reprint Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic target
    George P Skliris
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
    J Steroid Biochem Mol Biol 109:1-10. 2008
    ....
  37. ncbi request reprint Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer
    Ethan D Emberley
    Departments of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
    Clin Cancer Res 9:2627-31. 2003
    ..This study explores the clinical significance of psoriasin in relation to patient survival in invasive breast cancer...
  38. ncbi request reprint Identification of new human coding steroid receptor RNA activator isoforms
    Ethan Emberley
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3EOW3
    Biochem Biophys Res Commun 301:509-15. 2003
    ..Our results demonstrate that full-length SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines...
  39. ncbi request reprint Estrogen receptor-alpha phosphorylated at Ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpression
    Gregory E Weitsman
    Department of Biochemistry and Medical Genetics and Department of Pathology, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Cancer Res 66:10162-70. 2006
    ....
  40. ncbi request reprint Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?
    Leigh C Murphy
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, and Cancer Care Manitoba Winnipeg, Canada R3E 0V9
    Endocr Relat Cancer 13:327-34. 2006
    ....
  41. doi request reprint The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo
    Leigh C Murphy
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    J Steroid Biochem Mol Biol 114:90-5. 2009
    ..Profiling of phosphorylated ERalpha may provide better biomarkers of endocrine therapy response over and above those currently available...
  42. doi request reprint Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotype
    Anne A Blanchard
    Department of Pathology, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E0W3
    Virchows Arch 454:647-56. 2009
    ..Our data also suggests that increased expression of claudins 1 and 4 was associated with the basal-like subtype of breast cancers, a subtype generally linked to poor outcome...
  43. ncbi request reprint SR protein expression and CD44 splicing pattern in human breast tumours
    Molly T Pind
    Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada
    Breast Cancer Res Treat 79:75-82. 2003
    ..We conclude that while SR proteins may be important and necessary factors in mRNA splicing, other factors are also necessary to influence the regulation of alternatively spliced isoforms of CD44...
  44. pmc Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients
    Yi Yan
    Manitoba Institute of Cell Biology, 675 McDermot Avenue, R3E0V9, Winnipeg, Manitoba, Canada
    Breast Cancer Res 11:R67. 2009
    ..Our aim was to assess, in a large breast cancer cohort, whether levels of this protein could be associated with outcome or established clinical parameters...
  45. doi request reprint A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancer
    Georgios P Skliris
    Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9
    Endocr Relat Cancer 17:589-97. 2010
    ....
  46. doi request reprint Clinical significance of estrogen receptor phosphorylation
    Leigh C Murphy
    Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
    Endocr Relat Cancer 18:R1-14. 2011
    ..This suggests the hypothesis that phospho-profiling of ERα in human breast tumors to establish an 'ERα phosphorylation code', may be a more accurate marker of prognosis and/or response to endocrine therapy in human breast cancer...
  47. ncbi request reprint Potential role of estrogen receptor alpha (ERalpha) phosphorylated at Serine118 in human breast cancer in vivo
    Leigh C Murphy
    Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Man R3E 0V9, Canada
    J Steroid Biochem Mol Biol 102:139-46. 2006
    ..However, the in vivo data are somewhat contradictory and limited by the small cohorts used and the lack of standard well-characterized reagents and protocols...
  48. ncbi request reprint Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditions
    Gregory E Weitsman
    Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 675 McDermot Avenue, R3E 0V9 Winnipeg, Manitoba, Canada
    Breast Cancer Res Treat 100:23-31. 2006
    ....
  49. ncbi request reprint Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer
    Sandra Troup
    Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
    Clin Cancer Res 9:207-14. 2003
    ..To examine the prognostic significance of lumican and decorin, two abundant small leucine-rich proteoglycans in breast tissue stroma...
  50. pmc Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas
    George P Skliris
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9, Canada
    Breast Cancer Res Treat 118:443-53. 2009
    ....
  51. doi request reprint Expression of both estrogen receptor-beta 1 (ER-β1) and its co-regulator steroid receptor RNA activator protein (SRAP) are predictive for benefit from tamoxifen therapy in patients with estrogen receptor-alpha (ER-α)-negative early breast cancer (EBC)
    Y Yan
    Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, CancerCare Manitoba, University of Manitoba, Winnipeg, Canada
    Ann Oncol 24:1986-93. 2013
    ..Previously, ER-β1 and SRAP expression were found positively correlated in breast cancer and, therefore, expression of these two molecules could characterize cancers with a distinct clinical outcome...
  52. pmc The NCIC-Manitoba Breast Tumor Bank: a resource for applied cancer research
    P H Watson
    NCIC Manitoba Breast Tumor Bank, University of Manitoba, Winnipeg
    CMAJ 155:281-3. 1996
    ..In the first 3 years the tumour bank has accrued data and samples from over 1800 cases of breast cancer and has provided support for 20 research projects across Canada and the United States...
  53. ncbi request reprint S100 proteins and their influence on pro-survival pathways in cancer
    Ethan D Emberley
    Manitoba Institute of Cell Biology, Winnipeg, Canada
    Biochem Cell Biol 82:508-15. 2004
    ..Others suggest that, many S100s may also promote cancer progression through specific roles in cell survival and apoptosis pathways. This review summarizes these findings and their implications...
  54. ncbi request reprint HLA-DRB alleles are differentially expressed by tumor cells in breast carcinoma
    Sharon A Oldford
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Int J Cancer 112:399-406. 2004
    ....
  55. ncbi request reprint Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progression
    Adewale Adeyinka
    Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, R3E 0W3 Canada
    Clin Cancer Res 8:1747-53. 2002
    ....
  56. ncbi request reprint Psoriasin (S100A7)
    P H Watson
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Int J Biochem Cell Biol 30:567-71. 1998
    ....
  57. ncbi request reprint Estrogen receptor-beta mRNA variants in human and murine tissues
    B Lu
    Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
    Mol Cell Endocrinol 138:199-203. 1998
    ..Interestingly, no equivalent of the mouse inserted transcript was detected in any of the four human tissues analyzed...
  58. ncbi request reprint Tumor cell expression of HLA-DM associates with a Th1 profile and predicts improved survival in breast carcinoma patients
    Sharon A Oldford
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Int Immunol 18:1591-602. 2006
    ..We conclude that expression of determinants of the immune response by tumor cells may influence breast tumor progression and patient outcome...
  59. ncbi request reprint Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouse
    Anne A A Blanchard
    Department of Pathology and Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
    DNA Cell Biol 25:79-86. 2006
    ..In addition, cldn1 and cldn3 are detected in mammary tumors and the wide distribution of cldn3 in particular, suggest specific roles for these proteins in mammary tumorigenesis...
  60. ncbi request reprint Breast tissue banking: collection, handling, storage, and release of tissue for breast cancer research
    Linda Snell
    Department of Pathology, University of Manitoba, Winnipeg, Canada
    Methods Mol Med 120:3-24. 2006
    ..This chapter describes the design, operating protocols, and methods for processing, storage, and release of the Manitoba Breast Tumor Bank...
  61. ncbi request reprint Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium
    Richard J Miksicek
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Cancer Res 62:2736-40. 2002
    ..The SBEM gene is predicted to code for a putative low molecular weight, secreted sialoglycoprotein, potentially useful for the diagnosis of metastatic breast cancer...
  62. ncbi request reprint BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene
    Richard D Kennedy
    Cancer Research Centre, Queen s University Belfast, Belfast City Hospital, Belfast, United Kingdom
    Cancer Res 65:10265-72. 2005
    ..Therefore, we identified a novel transcriptional mechanism that is likely to contribute to BRCA1-mediated resistance to etoposide...
  63. ncbi request reprint Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
    Keisuke Kurose
    Comprehensive Cancer Center, and the Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Nat Genet 32:355-7. 2002
    ..Mutations in TP53 and PTEN are mutually exclusive in either compartment. In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma...
  64. ncbi request reprint The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumours
    Helen Turley
    Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Pathol 203:808-13. 2004
    ..Its interrelationship with other hypoxically regulated molecules, such as the hypoxia-inducible factors or carbonic anhydrase IX, and differentiation of tumours now requires further investigation...
  65. pmc Jab1 is a target of EGFR signaling in ERalpha-negative breast cancer
    Jiaxu Wang
    Deeley Research Center, BC Cancer Agency, Vancouver Island Center, Victoria, BC, Canada
    Breast Cancer Res 10:R51. 2008
    ....