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Genomes and Genes | P H WatsonSummaryAffiliation: University of Manitoba Country: Canada Publications
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Publications
Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancerGeorge P Skliris
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Canada
Breast Cancer Res Treat 104:75-85. 2007..These data support the hypothesis that psoriasin/S100A7 is specifically regulated by ERbeta activity and could be useful to guide future therapies targeting ERbeta in certain phenotypic subsets of breast cancers in-vivo...
Mammographic density is related to stroma and stromal proteoglycan expressionSalem Alowami
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Breast Cancer Res 5:R129-35. 2003..Although epithelial changes define the eventual pathway for breast cancer development, mammographic density might correspond more directly to alterations in stromal composition...- S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breastEthan D Emberley
Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
Breast Cancer Res 6:R308-15. 2004..Persistent S100A7 expression in invasive carcinoma is associated with a worse prognosis, and this effect may be mediated in part through interaction with the multifunctional cell signaling protein Jab1... - S100A7 and the progression of breast cancerEthan D Emberley
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
Breast Cancer Res 6:153-9. 2004..The present review outlines what is known about S100A7 in breast cancer and summarizes the need to better understand the importance of this protein in breast cancer... - Psoriasin (S100A7) expression is altered during skin tumorigenesisSalem Alowami
Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3E OW3
BMC Dermatol 3:1. 2003..Its expression profile for different stages of skin lesions is unknown. The aim of this study was to determine the relationship between psoriasin (S100A7) and tumor progression in skin... - RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancerEthan D Emberley
Department of Pathology, University of Manitoba, Winnipeg Manitoba, Canada, R3E OW3
BMC Cancer 2:28. 2002..However the protein is found in the nucleus, cytoplasm as well as extracellularly. In the present study we have sought to identify potential psoriasin-binding proteins and to describe their expression profile in breast tumors... - Expression analysis of the mouse S100A7/psoriasin gene in skin inflammation and mammary tumorigenesisMeghan Webb
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
BMC Cancer 5:17. 2005..In this study we have cloned the cDNA and characterized the expression of the potential murine ortholog of human S100A7/psoriasin in skin inflammation and mammary tumorigenesis... - Necrosis and hypoxia in invasive breast carcinomaLadislav Tomes
Faculty of Medicine, Department of Pathology, University of Manitoba, Winnipeg, MB, Canada
Breast Cancer Res Treat 81:61-9. 2003..We conclude that stromal and epithelial hypoxia may have different biological backgrounds and that stromal hypoxia may affect survival... 
Carbonic anhydrase XII is a marker of good prognosis in invasive breast carcinomaP H Watson
Department of Pathology, University of Manitoba, Winnipeg, Canada
Br J Cancer 88:1065-70. 2003....- Expression of lumican in human breast carcinomaE Leygue
Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
Cancer Res 58:1348-52. 1998.... - Mammaglobin, a potential marker of breast cancer nodal metastasisE Leygue
Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba R3E 0W3, Canada
J Pathol 189:28-33. 1999..0001). These results suggest that mammaglobin could be a marker of axillary lymph node breast metastases... - Expression of small breast epithelial mucin (SBEM) protein in tissue microarrays (TMAs) of primary invasive breast cancersG P Skliris
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Histopathology 52:355-69. 2008..The aim was to investigate for the first time SBEM protein expression in a large cohort (n = 300) of invasive breast cancers, its relationship to established clinical variables and its association with clinical outcome... - Altered expression of estrogen receptor coregulators during human breast tumorigenesisL C Murphy
Department of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
Cancer Res 60:6266-71. 2000..Although our study is small, these data are consistent with the above hypothesis and suggest that such alterations may have a role in the altered estrogen action occurring during breast tumorigenesis... - Relationship of coregulator and oestrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancerL C Murphy
Manitoba Institute of Cell Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3E OW3
Br J Cancer 87:1411-6. 2002..However, our data provide preliminary evidence that the expression of oestrogen receptor beta protein isoforms may differ in primary tumours of breast cancer patients who prove to have differential sensitivity to tamoxifen therapy... - Altered expression of estrogen receptor-alpha variant messenger RNAs between adjacent normal breast and breast tumor tissuesE Leygue
Department of Biochemistry and Molecular Biology, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada, R3EOW3
Breast Cancer Res 2:64-72. 2000..We suggest that these changes might be involved in the mechanisms that underlie breast carcinogenesis... - Oestrogen receptor-alpha variant mRNA expression in primary human breast tumours and matched lymph node metastasesE Leygue
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
Br J Cancer 79:978-83. 1999..Furthermore, the pattern of all deleted oestrogen receptor-alpha variant mRNAs appeared conserved between any primary and its matched secondary tumour... - Altered expression of exon 6 deleted progesterone receptor variant mRNA between normal human breast and breast tumour tissuesE Leygue
Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
Br J Cancer 80:379-82. 1999..Moreover, a trend to lower (P < 0.1) relative D6-PR expression was observed in high PR tumours, compared to low PR tumours. These data suggest that increased expression of D6-PR occurs during tumorigenesis... - Analysis of gene expression in ductal carcinoma in situ of the breastAdewale Adeyinka
Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
Clin Cancer Res 8:3788-95. 2002.... - Expression of estrogen receptor variant messenger RNAs and determination of estrogen receptor status in human breast cancerA Huang
Department of Pathology, University of Manitoba, Winnipeg, Canada
Am J Pathol 150:1827-33. 1997..05). These data suggest that ER variant mRNAs encoding truncated ER proteins may contribute to discrepancies in ER-IHA levels determined using amino- or carboxyl-terminal-targeted antibodies... - Psoriasin (S100A7) expression and invasive breast cancerS Al-Haddad
Department of Pathology University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
Am J Pathol 155:2057-66. 1999..0022). These results suggest that psoriasin may be a marker of aggressive behavior in invasive tumors and are consistent with a function as a chemotactic factor... - Oestrogen receptor variants and mutations in human breast cancerL C Murphy
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
Ann Med 29:221-34. 1997.... - Expression of estrogen receptor beta1, beta2, and beta5 messenger RNAs in human breast tissueE Leygue
Department of Biochemistry and Molecular Biology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
Cancer Res 59:1175-9. 1999..Our data suggest that changes in the relative expression of ER-beta1, -beta2, and -beta5 mRNAs occur during breast tumorigenesis and tumor progression... - Altered estrogen receptor alpha and beta messenger RNA expression during human breast tumorigenesisE Leygue
Department of Biochemistry, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
Cancer Res 58:3197-201. 1998..These results suggest that the role of ER-alpha- and ER-beta-driven pathways and/or their interaction change during breast tumorigenesis... - The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancerEthan D Emberley
Department of Biochemistry and Medical Genetics, University of Manitoba, Canada
Cancer Res 65:5696-702. 2005..We conclude that the S100A7-Jab1 pathway acts to enhance survival under conditions of cellular stress, such as anoikis, which may promote progression of breast cancer... - Intermittent hypoxia induces proteasome-dependent down-regulation of estrogen receptor alpha in human breast carcinomaCharlton Cooper
Manitoba Institute of Cell Biology and Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada
Clin Cancer Res 10:8720-7. 2004.... - The steroid receptor RNA activator is the first functional RNA encoding a proteinS Chooniedass-Kothari
Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, P309 Pathology Building, 770 Bannatyne Avenue, Winnipeg, MB, Canada R3E 0W3
FEBS Lett 566:43-7. 2004..Overall, our results suggest that SRA is the first example of a new class of functional RNAs also able to encode a protein... - Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumoursG P Skliris
Department of Biochemistry and Medical Genetics, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
Br J Cancer 95:616-26. 2006..Based on our in vivo observations, ERbeta may have the potential to become a therapeutic target in the specific subcohort of ERalpha-negative breast cancers... - Expression of the steroid receptor RNA activator in human breast tumorsE Leygue
Department of Biochemistry, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
Cancer Res 59:4190-3. 1999..53, n = 27, P = 0.004). These data suggest that changes in the expression of SRA-related molecules occur during breast tumor progression... - Psoriasin interacts with Jab1 and influences breast cancer progressionEthan D Emberley
Department of Pathology, University of Manitoba, Winnipeg, Manitoba R3E 0W3, Canada
Cancer Res 63:1954-61. 2003..We conclude that intracellular psoriasin influences breast cancer progression and that this may occur through stimulation of Jab1 activity... - Expression of estrogen receptor-beta in human breast tumorsH Dotzlaw
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
J Clin Endocrinol Metab 82:2371-4. 1997..However, some breast tumors and some cell lines coexpress ER-beta and ER-alpha mRNA. Our data support a possible role for ER-beta in human breast cancer... - The potential role for prolactin-inducible protein (PIP) as a marker of human breast cancer micrometastasisJ W Clark
Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
Br J Cancer 81:1002-8. 1999..However, the presence of PIP expression in skin creates a potential source of contamination in venepuncture samples that should be considered in its application as a marker for breast tumour micrometastases... - Estrogen receptor variants and mutationsL C Murphy
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
J Steroid Biochem Mol Biol 62:363-72. 1997.... - S100A7 (psoriasin) influences immune response genes in human breast cancerSoma Mandal
Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
Exp Cell Res 313:3016-25. 2007..042, n=149). These results are consistent with a role for S100A7 in modulating the immune response which may be a factor in early breast tumor progression... - Relationship between mammaglobin expression and estrogen receptor status in breast tumorsXiao-feng Guan
Departments of Biochemistry and Medical Genetics, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, Canada, R3EOW3
Endocrine 21:245-50. 2003..As estrogen and antiestrogen treatment of estrogen-positive breast cancer cell lines does not modify SCGB2A2 expression we suggest that SCGB2A2 may be a new independent breast cancer prognostic marker... - Influence of estrogen receptor variants on the determination of ER status in human breast cancerA Huang
Department of Pathology, University of Manitoba, Winnipeg, Canada
Breast Cancer Res Treat 58:219-25. 1999.... 
Estrogen receptor alpha negative breast cancer patients: estrogen receptor beta as a therapeutic targetGeorge P Skliris
Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada R3E OV9
J Steroid Biochem Mol Biol 109:1-10. 2008....- Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancerEthan D Emberley
Departments of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
Clin Cancer Res 9:2627-31. 2003.... - Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patientsYi Yan
Manitoba Institute of Cell Biology, 675 McDermot Avenue, R3E0V9, Winnipeg, Manitoba, Canada
Breast Cancer Res 11:R67. 2009..Our aim was to assess, in a large breast cancer cohort, whether levels of this protein could be associated with outcome or established clinical parameters... - The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivoLeigh C Murphy
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
J Steroid Biochem Mol Biol 114:90-5. 2009..Profiling of phosphorylated ERalpha may provide better biomarkers of endocrine therapy response over and above those currently available... - A phosphorylation code for oestrogen receptor-alpha predicts clinical outcome to endocrine therapy in breast cancerGeorgios P Skliris
Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada R3E 0V9
Endocr Relat Cancer 17:589-97. 2010.... - Clinical significance of estrogen receptor phosphorylationLeigh C Murphy
Department of Biochemistry and Medical Genetics, Faculty of Medicine Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, Canada
Endocr Relat Cancer 18:R1-14. 2011..This suggests the hypothesis that phospho-profiling of ERα in human breast tumors to establish an 'ERα phosphorylation code', may be a more accurate marker of prognosis and/or response to endocrine therapy in human breast cancer... - Estrogen receptor-alpha phosphorylated at Ser118 is present at the promoters of estrogen-regulated genes and is not altered due to HER-2 overexpressionGregory E Weitsman
Department of Biochemistry and Medical Genetics and Department of Pathology, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
Cancer Res 66:10162-70. 2006.... - Is oestrogen receptor-beta a predictor of endocrine therapy responsiveness in human breast cancer?Leigh C Murphy
Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, and Cancer Care Manitoba Winnipeg, Canada R3E 0V9
Endocr Relat Cancer 13:327-34. 2006.... - Claudins 1, 3, and 4 protein expression in ER negative breast cancer correlates with markers of the basal phenotypeAnne A Blanchard
Department of Pathology, University of Manitoba, 770 Bannatyne Avenue, Winnipeg, Manitoba, Canada R3E0W3
Virchows Arch 454:647-56. 2009..Our data also suggests that increased expression of claudins 1 and 4 was associated with the basal-like subtype of breast cancers, a subtype generally linked to poor outcome... - SR protein expression and CD44 splicing pattern in human breast tumoursMolly T Pind
Department of Pathology, Faculty of Medicine, University of Manitoba, Winnipeg, Man, Canada
Breast Cancer Res Treat 79:75-82. 2003..We conclude that while SR proteins may be important and necessary factors in mRNA splicing, other factors are also necessary to influence the regulation of alternatively spliced isoforms of CD44... - Identification of new human coding steroid receptor RNA activator isoformsEthan Emberley
Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3EOW3
Biochem Biophys Res Commun 301:509-15. 2003..Our results demonstrate that full-length SRA-RNAs likely to encode stable proteins are widely expressed in breast cancer cell lines... - Potential role of estrogen receptor alpha (ERalpha) phosphorylated at Serine118 in human breast cancer in vivoLeigh C Murphy
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Man R3E 0V9, Canada
J Steroid Biochem Mol Biol 102:139-46. 2006..However, the in vivo data are somewhat contradictory and limited by the small cohorts used and the lack of standard well-characterized reagents and protocols... - Assessment of multiple different estrogen receptor-beta antibodies for their ability to immunoprecipitate under chromatin immunoprecipitation conditionsGregory E Weitsman
Manitoba Institute of Cell Biology, Department of Biochemistry and Medical Genetics, University of Manitoba, 675 McDermot Avenue, R3E 0V9 Winnipeg, Manitoba, Canada
Breast Cancer Res Treat 100:23-31. 2006.... - Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancerSandra Troup
Department of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada
Clin Cancer Res 9:207-14. 2003.... - Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomasGeorge P Skliris
Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, MB, R3E 0V9, Canada
Breast Cancer Res Treat 118:443-53. 2009.... - The NCIC-Manitoba Breast Tumor Bank: a resource for applied cancer researchP H Watson
NCIC Manitoba Breast Tumor Bank, University of Manitoba, Winnipeg
CMAJ 155:281-3. 1996..In the first 3 years the tumour bank has accrued data and samples from over 1800 cases of breast cancer and has provided support for 20 research projects across Canada and the United States... - HLA-DRB alleles are differentially expressed by tumor cells in breast carcinomaSharon A Oldford
Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
Int J Cancer 112:399-406. 2004.... - Activated mitogen-activated protein kinase expression during human breast tumorigenesis and breast cancer progressionAdewale Adeyinka
Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, 675 McDermot Avenue, Winnipeg, Manitoba, R3E 0W3 Canada
Clin Cancer Res 8:1747-53. 2002..However, active MAPK is unlikely to be a marker of endocrine sensitivity or involved in de novo tamoxifen resistance... - S100 proteins and their influence on pro-survival pathways in cancerEthan D Emberley
Manitoba Institute of Cell Biology, Winnipeg, Canada
Biochem Cell Biol 82:508-15. 2004..Others suggest that, many S100s may also promote cancer progression through specific roles in cell survival and apoptosis pathways. This review summarizes these findings and their implications... - Estrogen receptor-beta mRNA variants in human and murine tissuesB Lu
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Canada
Mol Cell Endocrinol 138:199-203. 1998..Interestingly, no equivalent of the mouse inserted transcript was detected in any of the four human tissues analyzed... - Psoriasin (S100A7)P H Watson
Department of Pathology, University of Manitoba, Winnipeg, Canada
Int J Biochem Cell Biol 30:567-71. 1998.... - Tumor cell expression of HLA-DM associates with a Th1 profile and predicts improved survival in breast carcinoma patientsSharon A Oldford
Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John's, Newfoundland, Canada
Int Immunol 18:1591-602. 2006..We conclude that expression of determinants of the immune response by tumor cells may influence breast tumor progression and patient outcome... - Differential expression of claudin 1, 3, and 4 during normal mammary gland development in the mouseAnne A A Blanchard
Department of Pathology and Physiology, University of Manitoba, Winnipeg, Manitoba, Canada
DNA Cell Biol 25:79-86. 2006..In addition, cldn1 and cldn3 are detected in mammary tumors and the wide distribution of cldn3 in particular, suggest specific roles for these proteins in mammary tumorigenesis... - Breast tissue banking: collection, handling, storage, and release of tissue for breast cancer researchLinda Snell
Department of Pathology, University of Manitoba, Winnipeg, Canada
Methods Mol Med 120:3-24. 2006..This chapter describes the design, operating protocols, and methods for processing, storage, and release of the Manitoba Breast Tumor Bank... - Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomasKeisuke Kurose
Comprehensive Cancer Center, and the Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Nat Genet 32:355-7. 2002..Mutations in TP53 and PTEN are mutually exclusive in either compartment. In contrast, mutations in WFDC1 (16q24, encoding WAP four-disulfide core domain 1) occur with low frequency in the stroma... - Jab1 is a target of EGFR signaling in ERalpha-negative breast cancerJiaxu Wang
Deeley Research Center, BC Cancer Agency, Vancouver Island Center, Victoria, BC, Canada
Breast Cancer Res 10:R51. 2008.... - The hypoxia-regulated transcription factor DEC1 (Stra13, SHARP-2) and its expression in human tissues and tumoursHelen Turley
Cancer Research UK Molecular Oncology Laboratory, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
J Pathol 203:808-13. 2004..Its interrelationship with other hypoxically regulated molecules, such as the hypoxia-inducible factors or carbonic anhydrase IX, and differentiation of tumours now requires further investigation... - Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epitheliumRichard J Miksicek
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
Cancer Res 62:2736-40. 2002..The SBEM gene is predicted to code for a putative low molecular weight, secreted sialoglycoprotein, potentially useful for the diagnosis of metastatic breast cancer... - BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible geneRichard D Kennedy
Cancer Research Centre, Queen s University Belfast, Belfast City Hospital, Belfast, United Kingdom
Cancer Res 65:10265-72. 2005..Therefore, we identified a novel transcriptional mechanism that is likely to contribute to BRCA1-mediated resistance to etoposide...