Wyeth W Wasserman

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences
    Elodie Portales-Casamar
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    Nucleic Acids Res 37:D54-60. 2009
  2. pmc On the identification of potential regulatory variants within genome wide association candidate SNP sets
    Chih Yu Chen
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Med Genomics 7:34. 2014
  3. pmc Gene characterization index: assessing the depth of gene annotation
    Danielle Kemmer
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 3:e1440. 2008
  4. pmc oPOSSUM: integrated tools for analysis of regulatory motif over-representation
    Shannan J Ho Sui
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver BC, Canada
    Nucleic Acids Res 35:W245-52. 2007
  5. pmc Validation of skeletal muscle cis-regulatory module predictions reveals nucleotide composition bias in functional enhancers
    Andrew T Kwon
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Genetics Graduate Program, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Comput Biol 7:e1002256. 2011
  6. pmc Improving analysis of transcription factor binding sites within ChIP-Seq data based on topological motif enrichment
    Rebecca Worsley Hunt
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    BMC Genomics 15:472. 2014
  7. pmc oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes
    Shannan J Ho Sui
    Centre for Molecular Medicine and Therapeutics, University of British Columbia Vancouver, BC, Canada
    Nucleic Acids Res 33:3154-64. 2005
  8. pmc Identification of conserved regulatory elements by comparative genome analysis
    Boris Lenhard
    Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Biol 2:13. 2003
  9. pmc Understanding the language of gene regulation
    Wynand Alkema
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Genome Biol 4:327. 2003
  10. pmc MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model
    Antony Le Béchec
    Cytoskeleton and Cell Plasticity Lab, Life Sciences Research Unit FSCT, University of Luxembourg, L 1511 Luxembourg, Luxembourg
    BMC Bioinformatics 12:67. 2011

Detail Information

Publications53

  1. pmc The PAZAR database of gene regulatory information coupled to the ORCA toolkit for the study of regulatory sequences
    Elodie Portales-Casamar
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    Nucleic Acids Res 37:D54-60. 2009
    ..PAZAR is available at http://www.pazar.info. ORCAtk can be accessed through convenient buttons located in the PAZAR pages or via our website at http://www.cisreg.ca/ORCAtk...
  2. pmc On the identification of potential regulatory variants within genome wide association candidate SNP sets
    Chih Yu Chen
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Med Genomics 7:34. 2014
    ....
  3. pmc Gene characterization index: assessing the depth of gene annotation
    Danielle Kemmer
    Center for Genomics and Bioinformatics, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 3:e1440. 2008
    ....
  4. pmc oPOSSUM: integrated tools for analysis of regulatory motif over-representation
    Shannan J Ho Sui
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver BC, Canada
    Nucleic Acids Res 35:W245-52. 2007
    ..Analysis using user-defined background gene sets is now supported. The transcription factor binding site models have been updated to include new profiles from the JASPAR database. oPOSSUM is available at http://www.cisreg.ca/oPOSSUM/..
  5. pmc Validation of skeletal muscle cis-regulatory module predictions reveals nucleotide composition bias in functional enhancers
    Andrew T Kwon
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Genetics Graduate Program, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Comput Biol 7:e1002256. 2011
    ..Comparison with recent MyoD and histone modification ChIP-Seq data supports the validity of the functional regions...
  6. pmc Improving analysis of transcription factor binding sites within ChIP-Seq data based on topological motif enrichment
    Rebecca Worsley Hunt
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    BMC Genomics 15:472. 2014
    ..Analysis of the ChIP-Seq regions is now a central component in gene regulation studies. The need remains strong for methods to improve the interpretation of ChIP-Seq data and the study of specific TF binding sites (TFBS)...
  7. pmc oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes
    Shannan J Ho Sui
    Centre for Molecular Medicine and Therapeutics, University of British Columbia Vancouver, BC, Canada
    Nucleic Acids Res 33:3154-64. 2005
    ..Simulation studies indicate that oPOSSUM produces few false positives using empirically defined thresholds and can tolerate up to 50% noise in a set of co-expressed genes...
  8. pmc Identification of conserved regulatory elements by comparative genome analysis
    Boris Lenhard
    Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden
    J Biol 2:13. 2003
    ..Mutations are more likely to be disruptive if they appear in functional sites, resulting in a measurable difference in evolution rates between functional and non-functional genomic segments...
  9. pmc Understanding the language of gene regulation
    Wynand Alkema
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Genome Biol 4:327. 2003
  10. pmc MIR@NT@N: a framework integrating transcription factors, microRNAs and their targets to identify sub-network motifs in a meta-regulation network model
    Antony Le Béchec
    Cytoskeleton and Cell Plasticity Lab, Life Sciences Research Unit FSCT, University of Luxembourg, L 1511 Luxembourg, Luxembourg
    BMC Bioinformatics 12:67. 2011
    ..An integrative computational resource generating a comprehensive view of these regulatory molecular interactions at a genome-wide scale would be of great interest to biologists, but is not available to date...
  11. pmc Identification of cis-regulatory sequence variations in individual genome sequences
    Rebecca Worsley-Hunt
    Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Genome Med 3:65. 2011
    ..Here we explore the existing methods and software for prediction of functional variation situated in the cis-regulatory sequences governing gene transcription and RNA processing...
  12. ncbi request reprint In silico identification of metazoan transcriptional regulatory regions
    Wyeth W Wasserman
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada
    Naturwissenschaften 90:156-66. 2003
    ..We present here an overview of advances in the analysis of regulatory systems and the fundamental methods that underlie the recent developments...
  13. pmc JASPAR 2010: the greatly expanded open-access database of transcription factor binding profiles
    Elodie Portales-Casamar
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada
    Nucleic Acids Res 38:D105-10. 2010
    ..Additionally, three new special collections provide matrix profile data produced by recent alternative high-throughput approaches...
  14. pmc Identification of functional SNPs in the 5-prime flanking sequences of human genes
    Salim Mottagui-Tabar
    Center for Genomics and Bioinformatics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    BMC Genomics 6:18. 2005
    ..Robust methods for the identification of functional SNPs are therefore crucial. We report one such experimental approach...
  15. pmc In silico detection of sequence variations modifying transcriptional regulation
    Malin C Andersen
    Department of Gene Technology, School of Biotechnology, AlbaNova University Center, Royal Institute of Technology KTH, Stockholm, Sweden
    PLoS Comput Biol 4:e5. 2008
    ..The RAVEN system is available at http://www.cisreg.ca for all researchers interested in the detection and characterization of regulatory sequence variation...
  16. pmc JASPAR: an open-access database for eukaryotic transcription factor binding profiles
    Albin Sandelin
    Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vag 35, S 17177 Stockholm, Sweden
    Nucleic Acids Res 32:D91-4. 2004
    ..JASPAR is available at http://jaspar. cgb.ki.se...
  17. pmc ConSite: web-based prediction of regulatory elements using cross-species comparison
    Albin Sandelin
    Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius vag 35, S 17177 Stockholm, Sweden
    Nucleic Acids Res 32:W249-52. 2004
    ..Programming modules and biological databases that form the foundation of the ConSite service are freely available to the research community. ConSite is available at http:/www.phylofoot.org/consite...
  18. pmc The Gene Set Builder: collation, curation, and distribution of sets of genes
    Dimas Yusuf
    Centre for Molecular Medicine and Therapeutics CMMT, Child and Family Research Institute, Vancouver, Canada
    BMC Bioinformatics 6:305. 2005
    ..In this paper, we present a simple online tool which - with the help of the gene catalogs Ensembl and GeneLynx - can help researchers build and annotate sets of genes quickly and easily...
  19. pmc oPOSSUM-3: advanced analysis of regulatory motif over-representation across genes or ChIP-Seq datasets
    Andrew T Kwon
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada
    G3 (Bethesda) 2:987-1002. 2012
    ..oPOSSUM-3 is available at http://opossum.cisreg.ca...
  20. ncbi request reprint Prediction of nuclear hormone receptor response elements
    Albin Sandelin
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Mol Endocrinol 19:595-606. 2005
    ..The model is implemented in a web interface, freely available for academic researchers, available at http://mordor.cgb.ki.se/NHR-scan...
  21. pmc JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles
    Anthony Mathelier
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada, Department of Biology and Biotech Research and Innovation Centre, The Bioinformatics Centre, Copenhagen University, Ole Maaloes Vej 5, DK 2200, Denmark, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA, Laboratoire Physiologie Cellulaire and Végétale, Université Grenoble Alpes, CNRS, CEA, iRTSV, INRA, 38054 Grenoble, France, Computational Regulatory Genomics, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK, and Department of Informatics, University of Bergen, Thormøhlensgate 55, N 5008 Bergen, Norway
    Nucleic Acids Res 42:D142-7. 2014
    ..Finally, the new JASPAR release is accompanied by a new BioPython package, a new R tool package and a new R/Bioconductor data package to facilitate access for both manual and automated methods. ..
  22. pmc NovelFam3000--uncharacterized human protein domains conserved across model organisms
    Danielle Kemmer
    Centre for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    BMC Genomics 7:48. 2006
    ..Thus knowledge of a domain's function, or the protein within which it arises, can facilitate the analysis of an entire set of proteins...
  23. pmc A regulatory toolbox of MiniPromoters to drive selective expression in the brain
    Elodie Portales-Casamar
    Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z4H4
    Proc Natl Acad Sci U S A 107:16589-94. 2010
    ..The publicly available Pleiades MiniPromoter Project is a key resource to facilitate research on brain development and therapies...
  24. pmc Arrays of ultraconserved non-coding regions span the loci of key developmental genes in vertebrate genomes
    Albin Sandelin
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    BMC Genomics 5:99. 2004
    ..Here, we focus on UCRs that cluster around genes involved in early vertebrate development; genes conserved over 450 million years of vertebrate evolution...
  25. pmc PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation
    Elodie Portales-Casamar
    Centre for Molecular Medicine and Therapeutics, CFRI, University of British Columbia, Vancouver, BC, V5Z 4H4, Canada
    Genome Biol 8:R207. 2007
    ..The Pleiades Promoter Project collection of brain-linked regulatory sequences is introduced to demonstrate the depth of annotation possible within PAZAR. PAZAR, located at http://www.pazar.info, is open for business...
  26. ncbi request reprint Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis
    Jonathan M Coutinho
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Lipid Res 46:1113-23. 2005
    ..Our humanized ABCA1 mice can serve as a useful model system for functional analysis of the human ABCA1 gene in vivo and can be used for the generation of potential new therapeutics that target HDL metabolism...
  27. pmc Discovery and expansion of gene modules by seeking isolated groups in a random graph process
    Jochen Brumm
    Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 3:e3358. 2008
    ..As a result, there is a persistent need for practical, principled methods to infer the modular organization of genes from genome-scale data...
  28. ncbi request reprint TFBS: Computational framework for transcription factor binding site analysis
    Boris Lenhard
    Bioinformatics Unit, Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Bioinformatics 18:1135-6. 2002
    ..It implements objects representing specificity profile matrices, binding sites and sets thereof, pattern generators, and pattern database interfaces. The modules are interoperable with the BioPerl open source system...
  29. pmc The transcription factor encyclopedia
    Dimas Yusuf
    Department of Medical Genetics, Faculty of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 13:R24. 2012
    ..TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe...
  30. pmc MSCAN: identification of functional clusters of transcription factor binding sites
    Wynand B L Alkema
    Center for Genomics and Bioinformatics, Karolinska Institutet, SE 17177 Stockholm, Sweden
    Nucleic Acids Res 32:W195-8. 2004
    ..We have chosen the features in MSCAN such that sequence and matrix retrieval is highly facilitated, resulting in a web server that is intuitive to use. MSCAN is available at http://mscan.cgb.ki.se/cgi-bin/MSCAN...
  31. pmc Ulysses - an application for the projection of molecular interactions across species
    Danielle Kemmer
    Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Genome Biol 6:R106. 2005
    ..The relevance of projections was assessed and validated against published reference collections. All source code is freely available, and the Ulysses system can be accessed via a web interface http://www.cisreg.ca/ulysses...
  32. ncbi request reprint Integrated analysis of yeast regulatory sequences for biologically linked clusters of genes
    Albin Sandelin
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Funct Integr Genomics 3:125-34. 2003
    ..YRSA is available at http://yrsa.cgb.ki.se. [YRSA: ancient Scandinavian name meaning old she-bear (Latin Ursus arctos = brown bear/grizzly).]..
  33. ncbi request reprint Constrained binding site diversity within families of transcription factors enhances pattern discovery bioinformatics
    Albin Sandelin
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    J Mol Biol 338:207-15. 2004
    ..Biochemically motivated constraints upon sequence diversity of binding sites will complement the genetically motivated constraints imposed in "phylogenetic footprinting" algorithms...
  34. pmc Regulog analysis: detection of conserved regulatory networks across bacteria: application to Staphylococcus aureus
    Wynand B L Alkema
    Center for Genomics and Bioinformatics, Karolinska Institutet, Stockholm, Sweden
    Genome Res 14:1362-73. 2004
    ..A total of 125 regulogs were found in this organism, including both well-defined functional groups and a subset with unknown functions...
  35. pmc GeneLynx mouse: integrated portal to the mouse genome
    Boris Lenhard
    Center for Genomics and Bioinformatics, Karolinska Institutet, 17177 Stockholm, Sweden
    Genome Res 13:1501-4. 2003
    ..As a result of the integration of the human and mouse systems, GeneLynx now serves as a powerful comparative genomics data mining resource. GeneLynx Mouse can be freely accessed at http://mouse.genelynx.org...
  36. pmc Compensating for literature annotation bias when predicting novel drug-disease relationships through Medical Subject Heading Over-representation Profile (MeSHOP) similarity
    Warren A Cheung
    Centre for Molecular Medicine and Therapeutics at Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    BMC Med Genomics 6:S3. 2013
    ....
  37. ncbi request reprint Applied bioinformatics for the identification of regulatory elements
    Wyeth W Wasserman
    Centre for Molecular Medicine and Therapeutics and British Columbia Women s and Children s Hospitals, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    Nat Rev Genet 5:276-87. 2004
  38. doi request reprint Dynamics of the yeast transcriptome during wine fermentation reveals a novel fermentation stress response
    Virginia D Marks
    Wine Research Centre, University of British Columbia, Vancouver, Canada
    FEMS Yeast Res 8:35-52. 2008
    ..Ethanol, rather than nutrient depletion, seems to be responsible for entry of yeast cells into the stationary phase...
  39. doi request reprint Laboratory Animal Management Assistant (LAMA): a LIMS for active research colonies
    Marko Milisavljevic
    Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Mamm Genome 21:224-30. 2010
    ..LAMA is an open-access software tool, freely available to the research community at http://launchpad.net/mousedb ...
  40. pmc TFBSshape: a motif database for DNA shape features of transcription factor binding sites
    Lin Yang
    Molecular and Computational Biology Program, University of Southern California, Los Angeles, CA 90089, USA, Department of Biology, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Nucleic Acids Res 42:D148-55. 2014
    ....
  41. pmc Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice
    Jean Francois Schmouth
    Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    BMC Biol 11:106. 2013
    ..In this study, we build upon our HuGX ('high-throughput human genes on the X chromosome') strategy to expand our understanding of human gene regulation in vivo...
  42. pmc TFCat: the curated catalog of mouse and human transcription factors
    Debra L Fulton
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Genome Biol 10:R29. 2009
    ..All data and user-feedback mechanisms are available at the TFCat portal (http://www.tfcat.ca)...
  43. pmc The next generation of transcription factor binding site prediction
    Anthony Mathelier
    Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Comput Biol 9:e1003214. 2013
    ..These results demonstrate the capacity of TFFMs to accurately model DNA-protein interactions, while providing a single unified framework suitable for the next generation of TFBS prediction. ..
  44. pmc Towards resolving the transcription factor network controlling myelin gene expression
    Debra L Fulton
    Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, V5Z 4H4, Canada
    Nucleic Acids Res 39:7974-91. 2011
    ..Further, it links to numerous TFs with previously unsuspected roles in CNS myelination and suggests collaborative relationships amongst both known and novel TFs, thus providing deeper insight into the myelin gene transcriptional network...
  45. pmc Quantitative biomedical annotation using medical subject heading over-representation profiles (MeSHOPs)
    Warren A Cheung
    Centre for Molecular Medicine and Therapeutics at the Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    BMC Bioinformatics 13:249. 2012
    ..Distilling the essential biomedical themes for a topic of interest from the relevant literature is important to both understand the importance of related concepts and discover new relationships...
  46. pmc SAGE2Splice: unmapped SAGE tags reveal novel splice junctions
    Byron Yu Lin Kuo
    Genetics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Comput Biol 2:e34. 2006
    ..Thus, SAGE2Splice provides a new functionality for the identification of novel transcripts and exons. SAGE2Splice is available online at http://www.cisreg.ca...
  47. pmc Identification of a set of genes showing regionally enriched expression in the mouse brain
    Cletus A D'Souza
    Genome Sciences Centre, British Columbia Cancer Agency, 570 West 7th Ave Suite 100, Vancouver, BC, V5Z 4E6, Canada
    BMC Neurosci 9:66. 2008
    ....
  48. pmc The clonal and mutational evolution spectrum of primary triple-negative breast cancers
    Sohrab P Shah
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Nature 486:395-9. 2012
    ..Taken together, our results show that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes...
  49. ncbi request reprint Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer
    Arezoo Astanehe
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada
    J Cell Sci 121:664-74. 2008
    ....
  50. pmc Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood
    Clara D van Karnebeek
    Division of Biochemical Diseases, BC Children s Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada Department of Pediatrics, BC Children s Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada Treatable Intellectual Disability Endeavour in British Columbia, BC Children s Hospital, University of British Columbia, Vancouver, BC V5Z 4H4, Canada Center for Molecular Medicine and Therapeutics, Child and Family Research Institute, BC Children s Hospital, University of British Columbia, Vancouver, BC V5Z 4H4, Canada Electronic address
    Am J Hum Genet 94:453-61. 2014
    ..CA-VA deficiency should therefore be added to urea cycle defects, organic acidurias, and pyruvate carboxylase deficiency as a treatable condition in the differential diagnosis of hyperammonemia in the neonate and young child...
  51. pmc Utilizing social media to study information-seeking and ethical issues in gene therapy
    Julie M Robillard
    National Core for Neuroethics, Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    J Med Internet Res 15:e44. 2013
    ....

Research Grants1

  1. Computational Resources for the Compilation and Distribution of Transcription Fac
    Wyeth W Wasserman; Fiscal Year: 2010
    ..The PAZAR system captures and organizes data from laboratory research on transcription regulation, facilitating studies of gene regulation and genetic networks. ..