Douglas Wahlsten

Summary

Affiliation: University of Windsor
Country: Canada

Publications

  1. ncbi Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 103:16364-9. 2006
  2. ncbi Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, Alta, Canada T6G 2E9
    Behav Brain Res 165:36-51. 2005
  3. ncbi Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
  4. ncbi In search of a better mouse test
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Trends Neurosci 26:132-6. 2003
  5. ncbi Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alta, Canada T6G 2E9
    Brain Res 971:47-54. 2003
  6. ncbi Digit ratio (2Dratio4D) differences between 20 strains of inbred mice
    Reginia H Y Yan
    Department of Psychology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 4:e5801. 2009
  7. ncbi A robust, efficient and flexible method for staining myelinated axons in blocks of brain tissue
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada T6G 2E9
    J Neurosci Methods 123:207-14. 2003
  8. ncbi Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum
    P Melike Schalomon
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, Alberta, Canada
    Brain Res Bull 57:27-33. 2002
  9. ncbi Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA
    Behav Genet 36:536-52. 2006
  10. ncbi Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice
    Pamela Metten
    Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Appl Physiol 97:360-8. 2004

Research Grants

  1. REPLICABILITY OF DRUG AND GENETIC EFFECTS ON BEHAVIOR
    Douglas Wahlsten; Fiscal Year: 2002
  2. Ethanol effects on behavior: genes and environment
    Douglas Wahlsten; Fiscal Year: 2007

Detail Information

Publications18

  1. ncbi Stability of inbred mouse strain differences in behavior and brain size between laboratories and across decades
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, AB, Canada T6G 2E9
    Proc Natl Acad Sci U S A 103:16364-9. 2006
    ..Phenotypic drift over decades for most of the behaviors examined appears to be minimal...
  2. ncbi Different rankings of inbred mouse strains on the Morris maze and a refined 4-arm water escape task
    Douglas Wahlsten
    Department of Psychology, University of Alberta, Edmonton, Alta, Canada T6G 2E9
    Behav Brain Res 165:36-51. 2005
    ..We conclude that no single task can reveal the full richness of spatially guided behavior in a wide range of mouse genotypes...
  3. ncbi Different data from different labs: lessons from studies of gene-environment interaction
    Douglas Wahlsten
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, AB T6G 2E9, Canada
    J Neurobiol 54:283-311. 2003
    ..Implications for behavioral screening of targeted and induced mutations in mice are discussed...
  4. ncbi In search of a better mouse test
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Trends Neurosci 26:132-6. 2003
    ..The optimal apparatus configuration for certain genetic or pharmacological analyses might depend on the particular laboratory environment. Despite our best efforts, the mice will continue to win some innings...
  5. ncbi Survey of 21 inbred mouse strains in two laboratories reveals that BTBR T/+ tf/tf has severely reduced hippocampal commissure and absent corpus callosum
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, Alta, Canada T6G 2E9
    Brain Res 971:47-54. 2003
    ..Brain size varied greatly among strains but for any one strain was almost identical in mice housed for 5 weeks in the two laboratories. Sex differences in brain weight and forebrain commissure sizes were not statistically significant...
  6. ncbi Digit ratio (2Dratio4D) differences between 20 strains of inbred mice
    Reginia H Y Yan
    Department of Psychology, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 4:e5801. 2009
    ..We suggest that the inbred mice model presents an opportunity for researchers to investigate the genetic, and gene-environmental influence on the development of digit ratios...
  7. ncbi A robust, efficient and flexible method for staining myelinated axons in blocks of brain tissue
    Douglas Wahlsten
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada T6G 2E9
    J Neurosci Methods 123:207-14. 2003
    ..Useful data for morphometric analysis were obtained by scanning the surface of a gold chloride stained block of brain with an inexpensive flatbed scanner...
  8. ncbi Wheel running behavior is impaired by both surgical section and genetic absence of the mouse corpus callosum
    P Melike Schalomon
    Centre for Neuroscience and Department of Psychology, University of Alberta, Edmonton, Alberta, Canada
    Brain Res Bull 57:27-33. 2002
    ..The effect of absent CC is task dependent, but it is not obscured by developmental compensation in the recombinant mice...
  9. ncbi Effects of genetic and procedural variation on measurement of alcohol sensitivity in mouse inbred strains
    John C Crabbe
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, Portland, OR, 97239, USA
    Behav Genet 36:536-52. 2006
    ..In certain instances, substrain seems to matter little, while in others, substrains differed a great deal. These data are generally encouraging about the stability of genetic differences...
  10. ncbi Observer-rated ataxia: rating scales for assessment of genetic differences in ethanol-induced intoxication in mice
    Pamela Metten
    Department of Veterans Affairs Medical Center, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Appl Physiol 97:360-8. 2004
    ..Modest strain mean correlations among behaviors indicate that these behaviors are probably under control of largely different genes and that ataxia rating scales should rate separate behaviors on discrete scales...
  11. ncbi An analysis of the genetics of alcohol intoxication in inbred mice
    John C Crabbe
    Department of Behavioral Neuroscience, Portland Alcohol Research Center, Oregon Health and Science University, and VA Medical Center R and D 12, 3710 SW US Veterans Hospital Road, Portland, OR 97239, USA
    Neurosci Biobehav Rev 28:785-802. 2005
    ..This caveat likely extends to many behavioral domains (e.g. learning and memory, anxiety)...
  12. ncbi Assessment of genetic susceptibility to ethanol intoxication in mice
    Nathan R Rustay
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and Veterans Affairs Medical Center, 3710 Southwest U S Veterans Hospital Road R and D 12, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 100:2917-22. 2003
    ....
  13. ncbi Selective modification of short-term hippocampal synaptic plasticity and impaired memory extinction in mice with a congenitally reduced hippocampal commissure
    Lesley A Schimanski
    Department of Physiology, University of Alberta School of Medicine, Edmonton, Alberta T6G 2H7, Canada
    J Neurosci 22:8277-86. 2002
    ..Thus, the HC in mice is vital for particular aspects of memory function and for short-term synaptic modification in specific hippocampal circuits...
  14. ncbi Overview of mouse assays of ethanol intoxication
    John C Crabbe
    Portland VA Medical Center, Portland, Oregon, USA
    Curr Protoc Neurosci . 2008
    ..Whether or not a test is conducted in naïve mice or as part of a test battery can influence sensitivity, and do so in a strain-dependent manner. This unit reviews existing tests and recommends several...
  15. ncbi Impaired fear memory, altered object memory and modified hippocampal synaptic plasticity in split-brain mice
    Peter MacPherson
    University of Alberta School of Medicine, Department of Physiology, Edmonton, Alberta, Canada T6G 2H7
    Brain Res 1210:179-88. 2008
    ..Agenesis of the CC and HC may unmask some latent ability to encode, store or retrieve certain forms of recognition memory. We suggest that the increased susceptibility to DPT in BTBR may underlie the memory phenotype reported here...
  16. ncbi Genotypic differences in ethanol sensitivity in two tests of motor incoordination
    John C Crabbe
    VA Medical Center, R and D 12 3710 SW US Veterans Hospital Rd, Portland, OR 97239, USA
    J Appl Physiol 95:1338-51. 2003
    ..These results make clear that a single set of task parameters is insufficient to characterize genetic influences on behavior. Several other issues affect the interpretation of data using these tests...
  17. ncbi Of mice and their environments
    John C Crabbe
    Science 299:1313-4. 2003
  18. ncbi Influence of task parameters on rotarod performance and sensitivity to ethanol in mice
    Nathan R Rustay
    Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health and Science University, and VA Medical Center, Portland, OR 97239, USA
    Behav Brain Res 141:237-49. 2003
    ..These data also underscore the need to employ multiple behavioral assays in order to model a complex domain such as "ataxia" or "coordination."..

Research Grants9

  1. REPLICABILITY OF DRUG AND GENETIC EFFECTS ON BEHAVIOR
    Douglas Wahlsten; Fiscal Year: 2002
    ..The tests will be especially useful to investigators interested in screening chemically-induced and transgenic mutations for multiple behavioral effects. ..
  2. Ethanol effects on behavior: genes and environment
    Douglas Wahlsten; Fiscal Year: 2007
    ....