Research Topics
Genomes and GenesSpecies | V VuksanSummaryAffiliation: University of Toronto Country: Canada Publications
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Publications
The metabolic syndrome in healthy, multiethnic adolescents in Toronto, Ontario: the use of fasting blood glucose as a simple indicatorVladimir Vuksan
Clinical Nutrition and Risk Factor Modification Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario
Can J Cardiol 26:e128-32. 2010..Usually identified in middle age, the MetS has pediatric roots and there are variable incidence rates between ethnic groups. Due to the difficulty of diagnosis, it remains largely undetected in adolescents...
Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safetyVladimir Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada
Nutr Metab Cardiovasc Dis 18:46-56. 2008....
Viscosity rather than quantity of dietary fibre predicts cholesterol-lowering effect in healthy individualsVladimir Vuksan
Li Ka Shing Knowledge Institute, Clinical Nutrition and Risk Factor Modification Centre, Saint Michael s, Toronto, ON, Canada
Br J Nutr 106:1349-52. 2011..These data support the inclusion of high-viscosity fibre in the diet to reduce plasma lipids among apparently healthy individuals consuming a typical NA diet...- Herbal remedies in the management of diabetes: lessons learned from the study of ginsengVladimir Vuksan
Risk Factor Modification Centre, St Michael s Hospital, Toronto, Canada
Nutr Metab Cardiovasc Dis 15:149-60. 2005..In absence of such standardization, the use of herbs in diabetes must be approached cautiously... - Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trialVladimir Vuksan
Risk Factor Modification Centre, St Michael s Hospital, 70 Richmond St East, Toronto, Ontario, Canada, M5C 1N8
Diabetes Care 30:2804-10. 2007..a novel whole grain that is rich in fiber, alpha-linolenic acid (ALA), and minerals to conventional treatment is associated with improvement in major and emerging cardiovascular risk factors in individuals with type 2 diabetes... - Using cereal to increase dietary fiber intake to the recommended level and the effect of fiber on bowel function in healthy persons consuming North American dietsVladimir Vuksan
Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Canada
Am J Clin Nutr 88:1256-62. 2008..Dietary fiber intake remains low despite increasing evidence for its health benefits, including laxation... - Viscosity of fiber preloads affects food intake in adolescentsV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Nutr Metab Cardiovasc Dis 19:498-503. 2009.... - Fiber facts: benefits and recommendations for individuals with type 2 diabetesVladimir Vuksan
Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, 70 Richmond Street East, Suite 100, Toronto, ON, M5C 1N8, Canada
Curr Diab Rep 9:405-11. 2009..Increasing consumption of foods containing fiber or use of fiber supplements could play an important role in managing diabetes with positive outcomes on vascular complications and reduced cardio-vascular disease risk... - Reduction in postprandial glucose excursion and prolongation of satiety: possible explanation of the long-term effects of whole grain Salba (Salvia Hispanica L.)V Vuksan
Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Toronto, Ontario, Canada
Eur J Clin Nutr 64:436-8. 2010..05). Decrease in postprandial glycemia provides a potential explanation for improvements in blood pressure, coagulation and inflammatory markers previously observed after 12-week Salba supplementation in type II diabetes... - Konjac-Mannan and American ginsing: emerging alternative therapies for type 2 diabetes mellitusV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, and Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Ontario, Canada
J Am Coll Nutr 20:370S-380S; discussion 381S-383S. 2001..A determination of the active ingredients in AG, and the rheology-biology relationship of KJM are also warranted... - A novel source of wheat fiber and protein: effects on fecal bulk and serum lipidsV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, St Michael s Hospital, Ontario, Canada
Am J Clin Nutr 69:226-30. 1999..Wheat fiber is a laxative and wheat protein may affect blood lipids... - Konjac-mannan (glucomannan) improves glycemia and other associated risk factors for coronary heart disease in type 2 diabetes. A randomized controlled metabolic trialV Vuksan
Department of Nutritional Sciences, St Michael s Hospital, Faculty of Medicine, University of Toronto, Ontario, Canada
Diabetes Care 22:913-9. 1999..To examine whether Konjac-mannan (KJM) fiber improves metabolic control as measured by glycemia, lipidemia, and blood pressure in high-risk type 2 diabetic patients... - American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalationV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St Michael s Hospital, Ontario, Canada
J Am Coll Nutr 19:738-44. 2000..in nondiabetic individuals to achieve further improvements in glucose tolerance seen previously when 3 g of AG was taken 40 minutes before a 25 g glucose challenge... - Similar postprandial glycemic reductions with escalation of dose and administration time of American ginseng in type 2 diabetesV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
Diabetes Care 23:1221-6. 2000..We previously demonstrated that 3 g American ginseng (AG) reduced postprandial glycemia (PPG) in type 2 diabetic individuals. We investigated whether further reductions can be achieved with escalation of dose and time of AG administration... - Beneficial effects of viscous dietary fiber from Konjac-mannan in subjects with the insulin resistance syndrome: results of a controlled metabolic trialV Vuksan
Department of Nutritional Sciences, St Michael s Hospital, University of Toronto, Canada
Diabetes Care 23:9-14. 2000..To test this hypothesis, we investigated the effect of supplementing a high-carbohydrate diet with fiber from Konjac-mannan (KJM) on metabolic control in subjects with the insulin resistance syndrome... - American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitusV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, St Michael s Hospital, Ontario, Canada
Arch Intern Med 160:1009-13. 2000..We therefore undertook a preliminary short-term clinical study to assess whether American ginseng (Panax quinquefolius L) affects postprandial glycemia in humans... - American ginseng (Panax quinquefolius L.) attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individualsV Vuksan
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto
Am J Clin Nutr 73:753-8. 2001..Whether this effect can be replicated with doses <3 g and administration times closer to the oral glucose challenge is unclear... - Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic functionD J Jenkins
Clinical Nutrition and Risk Factor Modification Center, Department of Medicine, Division of Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Quebec, Canada
Metabolism 50:494-503. 2001..We conclude that very high-vegetable fiber intakes reduce risk factors for cardiovascular disease and possibly colon cancer. Vegetable and fruit fibers therefore warrant further detailed investigation... - Differences in risk factors, atherosclerosis, and cardiovascular disease between ethnic groups in Canada: the Study of Health Assessment and Risk in Ethnic groups (SHARE)S S Anand
Department of Medicine, McMaster University, Ontario, Canada
Lancet 356:279-84. 2000..To establish whether this variation can be explained by differences in disease risk factors and subclinical atherosclerosis, we undertook a population-based study of three ethnic groups in Canada: South Asians, Chinese, and Europeans... - Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemiaJ L Sievenpiper
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Eur J Clin Nutr 57:243-8. 2003..These data suggest that the ginsenoside profile of AG might play a role in its hypoglycemic effects. The involvement of other components cannot, however, be precluded... - Simple skinfold-thickness measurements complement conventional anthropometric assessments in predicting glucose toleranceJ L Sievenpiper
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and the Clinical Nutrition and Risk Factor Modification Centre, and the Division of Metabolism and Endocrinology, St Michael's Hospital, Toronto, ON, Canada
Am J Clin Nutr 73:567-73. 2001..59, P < 0.001) and the insulin sensitivity index (partial R(2) = 0.49, P < 0.001). CONCLUSION: Skinfold-thickness measurements may complement other established measurements for predicting abnormal glucose and insulin regulation... - Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart diseaseD J Jenkins
Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, and Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
Curr Opin Lipidol 11:49-56. 2000..In larger cohort studies, low glycaemic index foods or low glycaemic load diets have been associated with higher HDL-cholesterol levels and reduced incidence of diabetes and cardiovascular disease... - Depression of the glycemic index by high levels of beta-glucan fiber in two functional foods tested in type 2 diabetesA L Jenkins
Clinical Nutrition and Risk Factor Modification Centre, St Michael's Hospital, Toronto, ON, Canada
Eur J Clin Nutr 56:622-8. 2002..In a 50 g carbohydrate portion each gram of beta-glucan reduces the GI by 4 units, making it a useful functional food component for reducing postprandial glycemia. SPONSORSHIP: Nestec, Switzerland... - The glycaemic index values of foods containing fructose are affected by metabolic differences between subjectsT M S Wolever
Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
Eur J Clin Nutr 63:1106-14. 2009..We hypothesized that glycaemic index (GI) values are affected by the metabolic differences between subjects for foods containing fructose or fat, but not for starchy foods... - Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based studyF Razak
Population Health Research Institute, McMaster University, Hamilton General Hospital, Hamilton, ON, Canada
Int J Obes (Lond) 29:656-67. 2005..Existing action thresholds for these anthropometric indices do not apply to non-European ethnic groups and warrant revision... - High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal functionD J Jenkins
Clinical Nutrition and Risk Factor Modification Center and the Department of Medicine, The Division of Endocrinology and Metabolism, St Michael's Hospital, Toronto, Canada
Am J Clin Nutr 74:57-63. 2001..Further studies are required to assess the longer-term effects on renal function... - Korean red ginseng rootlets decrease acute postprandial glycemia: results from sequential preparation- and dose-finding studiesJohn L Sievenpiper
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Canada
J Am Coll Nutr 25:100-7. 2006..057). CONCLUSIONS: Together the studies indicate 2 g KRG-rootlets is sufficient to achieve reproducible reductions in postprandial glycemia. But the longterm sustainability of KRG selected using this approach remains to be tested... - Decreasing, null and increasing effects of eight popular types of ginseng on acute postprandial glycemic indices in healthy humans: the role of ginsenosidesJohn L Sievenpiper
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, ON, Canada
J Am Coll Nutr 23:248-58. 2004..04). CONCLUSIONS: Ginseng has variable glycemic effects, in which the PPD:PPT-ginsenoside ratio might be involved. But the low variance explained suggests the involvement of other unmeasured ginsenoside or non-ginsenoside components... - Beta-glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosityShirin Panahi
University of Toronto, Faculty of Medicine, Department of Nutritional Sciences, Toronto, ON, M5S 3E2, Canada
J Am Coll Nutr 26:639-44. 2007..enzymatic) in relation to the level of viscosity of beta-glucan and its effect on postprandial glycemia in healthy individuals... - Null and opposing effects of Asian ginseng (Panax ginseng C.A. Meyer) on acute glycemia: results of two acute dose escalation studiesJohn L Sievenpiper
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, 6 138-61 Queen Street East, Toronto, Ontario M5C 2T2, Canada
J Am Coll Nutr 22:524-32. 2003..This is in contrast to our findings with American ginseng. One explanation may be the marked ginsenoside differences. Practitioners and consumers should be aware of ginseng's variable effects... - Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trialDavid J A Jenkins
Clinical Nutrition and Risk Factor Modification Center, St Michael sHospital, Toronto
Am J Clin Nutr 75:834-9. 2002..The US Food and Drug Administration (FDA) approved health claims for 2 dietary fibers, beta-glucan (0.75 g/serving) and psyllium (1.78 g/serving), on the assumption that 4 servings/d would reduce cardiovascular disease risk... - Day-to-day variation in glycemic response elicited by white bread is not related to variation in satiety in humansThomas M S Wolever
Glycemic Index Laboratories, Inc, Toronto, Ontario, Canada
Appetite 52:654-8. 2009..4480+/-683 mm min, ns). The results were similar for males and females. These results do not support the hypothesis that glycemic responses per se influence feelings of satiety over the 2h period after eating... - Insulin resistance: concepts, controversies, and the role of nutritionJohn L Sievenpiper
Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, ON
Can J Diet Pract Res 63:20-32. 2002..Additional research is required to confirm the sustainability of this approach and sort out the determinants of insulin resistance so that more effective nutritional interventions will result... - Effects of Korean red ginseng (Panax ginseng C.A. Mayer) and its isolated ginsenosides and polysaccharides on arterial stiffness in healthy individualsElena Jovanovski
Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital, Toronto, Ontario, Canada
Am J Hypertens 23:469-72. 2010..Furthermore, in an attempt to elucidate which of the major components of KRG is responsible for these effects, the ginsenoside and polysaccharide fractions isolated from the same KRG root were also investigated... - Glycemic index in the treatment of diabetes: the debate continuesJohn L Sievenpiper
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto and Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, Toronto, Ontario, Canada
J Am Coll Nutr 23:1-4. 2004 - Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance testRavi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Obesity (Silver Spring) 16:1901-7. 2008..Based on these findings, the product of these two indices emerges as a potential OGTT-based measure of beta-cell function... - Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial glycemia in healthy individualsAnamaria Dascalu
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S3E2, Canada
Can J Physiol Pharmacol 85:856-64. 2007..05.) American ginseng decreased postprandial glycemia and insulinemia; however, 40% of the batches did not reduce glycemia with the anticipated magnitude, irrespective of their saponin composition... - Defining obesity cut points in a multiethnic populationFahad Razak
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
Circulation 115:2111-8. 2007..It is unknown whether these cut points are appropriate for non-European populations. We assessed the metabolic risk associated with BMI among South Asians, Chinese, Aboriginals, and Europeans... - Long-term intake of North American ginseng has no effect on 24-hour blood pressure and renal functionP Mark Stavro
Risk Factor Modification Centre, St Michael's Hospital, Toronto, Ontario, Canada
Hypertension 47:791-6. 2006..Ginseng did not affect serum cystatin C level. Overall, long-term ginseng use had no effect on 24-hour BP and renal function in hypertensive individuals... - High-complex carbohydrate or lente carbohydrate foods?David J A Jenkins
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Am J Med 113:30S-37S. 2002.... - When a placebo is not a 'placebo': a placebo effect on postprandial glycaemiaJohn L Sievenpiper
Risk Factor Modification Centre, St Michael s Hospital and Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Br J Clin Pharmacol 64:546-9. 2007..Placebo effects in clinical trials remain uncertain. To investigate a placebo effect on acute postprandial plasma glucose, we conducted a follow-up investigation on a previous study... - Replication of genetic associations with plasma lipoprotein traits in a multiethnic sampleMatthew B Lanktree
Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
J Lipid Res 50:1487-96. 2009..The findings indicate the potential utility of the Illumina CVD beadchip, but they underscore the need to consider meta-analysis of results from commonly studied clinical or epidemiological samples... - The relationship between dysglycemia and atherosclerosis in South Asian, Chinese, and European individuals in Canada: a randomly sampled cross-sectional studyHertzel C Gerstein
McMaster University and the Population Health Research Institute, Hamilton, Ontario, Canada
Diabetes Care 26:144-9. 2003..The relationship between dysglycemia and atherosclerosis (AS) in the general population and in different ethnic groups remains controversial... - North American ginseng exerts a neutral effect on blood pressure in individuals with hypertensionP Mark Stavro
Risk Factor Modification Centre, St. Michael's Hospital, 61 Queen St E, 6th Floor, Suite 138, Toronto, Ontario, M5C 2T2, Canada
Hypertension 46:406-11. 2005..The findings together suggested that North American ginseng exerts a neutral acute effect on blood pressure in hypertensive individuals... - Comparable postprandial glucose reductions with viscous fiber blend enriched biscuits in healthy subjects and patients with diabetes mellitus: acute randomized controlled clinical trialAlexandra L Jenkins
Clinical Nutrition and Risk Factor Modification Center, St Michael s Hospital and Li Ka Shing Knowledge Institute, 70 Richmond St E, Toronto, Ontario, Canada
Croat Med J 49:772-82. 2008..To compare the blood glucose-lowering effect of a highly viscous fiber blend (VFB) added to a starchy snack on postprandial glycemia between healthy participants and participants with diabetes mellitus... - A systematic quantitative analysis of the literature of the high variability in ginseng (Panax spp.): should ginseng be trusted in diabetes?John L Sievenpiper
Diabetes Care 27:839-40. 2004