P von Dadelszen

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc The effect of factor V Leiden carriage on maternal and fetal health
    Dena Bloomenthal
    Department of Obstetrics and Gynaecology, University of British Columbia, Children s and Women s Health Centre of British Columbia, Vancouver
    CMAJ 167:48-54. 2002
  2. ncbi request reprint Evidence-based management for preeclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia and British Columbia Reproductive Care Program, Provincial Health Services Authority, Vancouver, BC, Canada
    Front Biosci 12:2876-89. 2007
  3. ncbi request reprint An international benchmarking collaboration: measuring outcomes for the hypertensive disorders of pregnancy
    Charlene Thornton
    Royal Prince Alfred Hospital, Sydney, Australia
    J Obstet Gynaecol Can 29:794-800. 2007
  4. doi request reprint Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Lancet 377:219-27. 2011
  5. ncbi request reprint Pre-eclampsia: an update
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Rm V3 339, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada
    Curr Hypertens Rep 16:454. 2014
  6. ncbi request reprint Improving maternal and perinatal outcomes in the hypertensive disorders of pregnancy: a vision of a community-focused approach
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Int J Gynaecol Obstet 119:S30-4. 2012
  7. pmc Ethics review as a component of institutional approval for a multicentre continuous quality improvement project: the investigator's perspective
    Hanna Ezzat
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, V6 H 3N1, Canada
    BMC Health Serv Res 10:223. 2010
  8. doi request reprint Sildenafil citrate therapy for severe early-onset intrauterine growth restriction
    P von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    BJOG 118:624-8. 2011
  9. ncbi request reprint The active implementation of pregnancy hypertension guidelines in British Columbia
    Peter von Dadelszen
    Departments of Obstetrics and Gynaecology, Anesthesiology, Pharmacology and Therapeutics, and Medicine, School of Public and Population Health, Child and Family Research Institute, and Faculty of Medicine, University of British Columbia, and the BC Perinatal Health Program, Vancouver, British Columbia, Canada
    Obstet Gynecol 116:659-66. 2010
  10. ncbi request reprint The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes
    Peter von Dadelszen
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Twin Res 6:257-62. 2003

Collaborators

Detail Information

Publications68

  1. pmc The effect of factor V Leiden carriage on maternal and fetal health
    Dena Bloomenthal
    Department of Obstetrics and Gynaecology, University of British Columbia, Children s and Women s Health Centre of British Columbia, Vancouver
    CMAJ 167:48-54. 2002
    ..The role of antithrombotic therapy in the prevention of severe pregnancy complications remains unclear...
  2. ncbi request reprint Evidence-based management for preeclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia and British Columbia Reproductive Care Program, Provincial Health Services Authority, Vancouver, BC, Canada
    Front Biosci 12:2876-89. 2007
    ..11) Early-onset and/or severe preeclampsia predict later cardiovascular morbidity and mortality; it would seem prudent to offer such women screening and lipid lowering interventions...
  3. ncbi request reprint An international benchmarking collaboration: measuring outcomes for the hypertensive disorders of pregnancy
    Charlene Thornton
    Royal Prince Alfred Hospital, Sydney, Australia
    J Obstet Gynaecol Can 29:794-800. 2007
    ..To implement a set of clinical indicators to benchmark outcomes for women suffering from the hypertensive disorders of pregnancy...
  4. doi request reprint Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Lancet 377:219-27. 2011
    ..We developed and validated the fullPIERS model with the aim of identifying the risk of fatal or life-threatening complications in women with pre-eclampsia within 48 h of hospital admission for the disorder...
  5. ncbi request reprint Pre-eclampsia: an update
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Rm V3 339, 950 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada
    Curr Hypertens Rep 16:454. 2014
    ..Magnesium sulfate prevents and treats eclampsia; there is insufficient evidence to support alternative regimens. Pre-eclampsia predicts later cardiovascular disease; however, at this time we do not know what to do about it...
  6. ncbi request reprint Improving maternal and perinatal outcomes in the hypertensive disorders of pregnancy: a vision of a community-focused approach
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Int J Gynaecol Obstet 119:S30-4. 2012
    ....
  7. pmc Ethics review as a component of institutional approval for a multicentre continuous quality improvement project: the investigator's perspective
    Hanna Ezzat
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, V6 H 3N1, Canada
    BMC Health Serv Res 10:223. 2010
    ..We used our experience with ethical review of The Canadian Perinatal Network (CPN), to gain insight into the Canadian system...
  8. doi request reprint Sildenafil citrate therapy for severe early-onset intrauterine growth restriction
    P von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    BJOG 118:624-8. 2011
    ..3, 126; compared with institutional Sildenafil-naive early-onset IUGR controls]. Randomised controlled trial data are required to determine whether Sildenafil improves perinatal outcomes for early-onset IUGR-complicated pregnancies...
  9. ncbi request reprint The active implementation of pregnancy hypertension guidelines in British Columbia
    Peter von Dadelszen
    Departments of Obstetrics and Gynaecology, Anesthesiology, Pharmacology and Therapeutics, and Medicine, School of Public and Population Health, Child and Family Research Institute, and Faculty of Medicine, University of British Columbia, and the BC Perinatal Health Program, Vancouver, British Columbia, Canada
    Obstet Gynecol 116:659-66. 2010
    ..To reduce maternal and perinatal morbidity and mortality associated with the hypertensive disorders of pregnancy by using an active model of guideline implementation...
  10. ncbi request reprint The association between early membrane rupture, latency, clinical chorioamnionitis, neonatal infection, and adverse perinatal outcomes in twin pregnancies complicated by preterm prelabour rupture of membranes
    Peter von Dadelszen
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Twin Res 6:257-62. 2003
    ..Increased risk for neonatal sepsis at earlier delivery GA is consistent with gestation-dependent fetal immunocompetence. Early PPROM and long latencies were associated with increased adverse perinatal outcomes...
  11. ncbi request reprint The complications of hypertension in pregnancy
    P von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Minerva Med 96:287-302. 2005
    ....
  12. doi request reprint Predicting adverse outcomes in women with severe pre-eclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Semin Perinatol 33:152-7. 2009
    ....
  13. doi request reprint What matters in preeclampsia are the associated adverse outcomes: the view from Canada
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Opin Obstet Gynecol 20:110-5. 2008
  14. ncbi request reprint Antihypertensive medications in management of gestational hypertension-preeclampsia
    Peter von Dadelszen
    Centre for Healthcare Innovation and Improvement, and the Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Clin Obstet Gynecol 48:441-59. 2005
  15. ncbi request reprint Could an infectious trigger explain the differential maternal response to the shared placental pathology of preeclampsia and normotensive intrauterine growth restriction?
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Children s and Women s Health Centre of British Columbia and University of British Columbia, Vancouver, British Columbia, Canada
    Acta Obstet Gynecol Scand 81:642-8. 2002
    ..Also reviewed is the human and animal model evidence for an infectious trigger for preeclampsia. Perhaps preeclampsia truly is the 'toxemia' of pregnancy...
  16. ncbi request reprint Subclassification of preeclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine, University of British Columbia, Vancouver, Canada
    Hypertens Pregnancy 22:143-8. 2003
    ..We suggest that a first step would be to subdivide preeclampsia into early-onset disease (< 34 + 0 weeks') and late onset disease (> 34 + 0 weeks')...
  17. ncbi request reprint Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 30:1883-92. 2002
    ..To determine which patients would be offered rhAPC, the literature pertaining to fetal/neonatal outcomes for preeclampsia remote from term, transplacental transport of protein C, and pregnancy experience with the compound were reviewed...
  18. ncbi request reprint A survey of canadian practitioners regarding diagnosis and evaluation of the hypertensive disorders of pregnancy
    M Caetano
    Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada
    Hypertens Pregnancy 23:197-209. 2004
    ..How Canadian practitioners are diagnosing and managing the hypertensive disorders of pregnancy (HDP), particularly in relation to the 1997 recommendations published by the Canadian Hypertension Society (CHS), is not known...
  19. ncbi request reprint Women's views of their experiences in the CHIPS (Control of Hypertension in Pregnancy Study) Pilot Trial
    L A Magee
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Hypertens Pregnancy 26:371-87. 2007
    ..We sought to compare women's views about their care in a randomized trial of 'less tight' vs. 'tight' control of non-proteinuric pre-existing or gestational hypertension in pregnancy...
  20. ncbi request reprint The Control of Hypertension In Pregnancy Study pilot trial
    L A Magee
    Department of Medicine, University of British Columbia, Vancouver, Canada
    BJOG 114:770, e13-20. 2007
    ..To determine whether 'less tight' (versus 'tight') control of nonsevere hypertension results in a difference in diastolic blood pressure (dBP) between groups...
  21. doi request reprint Performance of the fullPIERS model in predicting adverse maternal outcomes in pre-eclampsia using patient data from the PIERS (Pre-eclampsia Integrated Estimate of RiSk) cohort, collected on admission
    B Payne
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
    BJOG 120:113-8. 2013
    ..8 (95% CI 9.1-24.1) or 17.5 (95% CI 11.7-26.3) based on 6- and 24-hour data, respectively, for the women identified to be at highest risk (predicted probability ≥ 30%)...
  22. pmc How to manage hypertension in pregnancy effectively
    Laura A Magee
    BC Women s Hospital and Heath Centre and University of British Columbia, 4500 Oak Street, Room D213, Vancouver, BC V6H 3N1, Canada
    Br J Clin Pharmacol 72:394-401. 2011
    ..Oral labetalol and methyldopa are used most commonly, but many different β-adrenoceptor blockers and calcium channel blockers have been studied in clinical trials...
  23. ncbi request reprint Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes
    J Menzies
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
    Hypertens Pregnancy 26:447-62. 2007
    ..To determine the association between adverse maternal/perinatal outcomes and Canadian and U.S. preeclampsia severity criteria...
  24. ncbi request reprint Control of hypertension in pregnancy
    Laura A Magee
    BC Women s Hospital and Health Centre and the Child and Family Research Institute, University of British Columbia, 4500 Oak Street, Room D213, Vancouver, BC V6H 3N1, Canada
    Curr Hypertens Rep 11:429-36. 2009
    ..The CHIPS Trial (Control of Hypertension In Pregnancy Study) is recruiting to answer this question...
  25. ncbi request reprint A survey of Canadian practitioners regarding the management of the hypertensive disorders of pregnancy
    M Caetano
    Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Canada
    Hypertens Pregnancy 23:61-74. 2004
    ..How Canadian practitioners are managing the hypertensive disorders of pregnancy (HDP) is not known, particularly in relation to the 1997 guidelines published by the Canadian Hypertension Society (CHS)...
  26. ncbi request reprint Do commonly used oral antihypertensives alter fetal or neonatal heart rate characteristics? A systematic review
    E J Waterman
    Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Hypertens Pregnancy 23:155-69. 2004
    ..To examine fetal (FHR) and neonatal heart rate patterns following use of common oral antihypertensives in pregnancy...
  27. doi request reprint Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia
    F Xie
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    BJOG 117:99-108. 2010
    ....
  28. ncbi request reprint Serious perinatal complications of non-proteinuric hypertension: an international, multicentre, retrospective cohort study
    L A Magee
    BC Women s Hospital and Health Centre, Vancouver, BC, Canada
    J Obstet Gynaecol Can 25:372-82. 2003
    ....
  29. ncbi request reprint Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: an updated metaregression analysis
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
    J Obstet Gynaecol Can 24:941-5. 2002
    ..To update our previous analysis of randomized controlled trials in pregnancy hypertension, which discerned that greater treatment-induced decreases in maternal mean arterial pressure (MAP) appear to adversely affect fetal growth...
  30. ncbi request reprint Expectant management of severe preeclampsia remote from term: a structured systematic review
    L A Magee
    Departments of Medicine, University of British Columbia, Vancouver, BC, V6H 3N1, Canada
    Hypertens Pregnancy 28:312-47. 2009
    ..To compare outcomes associated with expectant vs. interventionist care of severe preeclampsia in observational studies...
  31. ncbi request reprint Levels of antibodies against cytomegalovirus and Chlamydophila pneumoniae are increased in early onset pre-eclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Children s and Women s Health Centre of British Columbia, University of British Columbia, 2H30 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    BJOG 110:725-30. 2003
    ..Could reactivated chronic infection be both a trigger for these differential maternal responses to the same underlying pathology and a link between pre-eclampsia and its attendant lifelong risks of atherosclerosis?..
  32. ncbi request reprint What is SNOMED CT and why should the ISSHP care?
    K A Massey
    UBC, Obstetrics and Gynaecology, Vancouver, British Columbia, Canada
    Hypertens Pregnancy 28:119-21. 2009
    ..We believe that members of the ISSHP, and others interested in the HDP, should take a leadership role in this regard for a number of reasons...
  33. doi request reprint Optimal timing of delivery in pregnancies with pre-existing hypertension
    J A Hutcheon
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    BJOG 118:49-54. 2011
    ....
  34. doi request reprint mRNA induces RANTES production in trophoblast cells via TLR3 only when delivered intracellularly using lipid membrane encapsulation
    E Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
    Placenta 32:500-5. 2011
    ..Notably, inflammatory disorders of pregnancy are associated with increased circulating placenta-derived mRNA. Endogenous degraded, uncapped mRNA is recognized by TLR3 in other cell lines...
  35. doi request reprint The management of severe hypertension
    Laura A Magee
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Semin Perinatol 33:138-42. 2009
    ..Most commonly, severe hypertension is treated with parenteral labetalol or hydralazine, or oral nifedipine (capsules or PA tablet). Other options will depend on local availability. MgSO(4) should not be relied on as an antihypertensive...
  36. ncbi request reprint Canadian Pediatric Surgical Network: a population-based pediatric surgery network and database for analyzing surgical birth defects. The first 100 cases of gastroschisis
    Erik D Skarsgard
    Department of Surgery, British Columbia Children s Hospital, University of British Columbia, Vancouver, BC, Canada
    J Pediatr Surg 43:30-4; discussion 34. 2008
    ..The aim of this study is to create a national pediatric surgical network and database for gastroschisis (GS) that tracks cases from diagnosis to hospital discharge...
  37. pmc Hydralazine for treatment of severe hypertension in pregnancy: meta-analysis
    Laura A Magee
    University of British Columbia, BC Women s Hospital and Health Centre, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    BMJ 327:955-60. 2003
    ..To review outcomes in randomised controlled trials comparing hydralazine against other antihypertensives for severe hypertension in pregnancy...
  38. ncbi request reprint The prediction of adverse maternal outcomes in preeclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
    J Obstet Gynaecol Can 26:871-9. 2004
    ....
  39. ncbi request reprint Therapy with both magnesium sulfate and nifedipine does not increase the risk of serious magnesium-related maternal side effects in women with preeclampsia
    Laura A Magee
    Centre for Healthcare Innovation and Improvement, British Columbia Research Institute for Children s and Women s Health, Department of Specialized Women s Health, BC Women s Hospital and Health Centre, Canada
    Am J Obstet Gynecol 193:153-63. 2005
    ..Does the use of nifedipine and magnesium sulfate together increase serious magnesium-related effects?..
  40. ncbi request reprint Instituting surveillance guidelines and adverse outcomes in preeclampsia
    Jennifer Menzies
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
    Obstet Gynecol 110:121-7. 2007
    ..To assess the incidence of combined adverse maternal and perinatal outcomes in women with preeclampsia before and after introducing standardized assessment and surveillance...
  41. doi request reprint Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normotensive intrauterine growth restriction but not preeclampsia
    D K Bourque
    Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada
    Placenta 31:197-202. 2010
    ..The goal of the present study was to assess whether abnormal regulation of imprinted genes is associated with intrauterine growth restriction (IUGR) and/or preeclampsia (PET)...
  42. ncbi request reprint Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction
    D Goswami
    Department of Obstetrics and Gynaecology, University of British Columbia, 4500 Oak Street, Vancouver BC V6H 3N1, Canada
    Placenta 27:56-61. 2006
    ..Similar placental pathology occurs in some cases of normotensive intrauterine growth restriction (nIUGR), but in the absence of maternal disease...
  43. doi request reprint Decidual NK cell-derived conditioned medium enhances capillary tube and network organization in an extravillous cytotrophoblast cell line
    Y Hu
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Placenta 31:213-21. 2010
    ..Adhesion molecules, particularly ICAM-1, expressed on EVT may participate in the process. To our knowledge, this is the first report of a role for ICAM-1 in EVT angiogenesis, as previously reported for endothelial cells...
  44. doi request reprint Assessing the role of placental trisomy in preeclampsia and intrauterine growth restriction
    Wendy P Robinson
    Department of Medical Genetics, University of British Columbia, 950 W 28th Avenue, Vancouver, BC, Canada
    Prenat Diagn 30:1-8. 2010
    ..However, it is unclear how often this might underlie pregnancy complications. Our objective was to evaluate the frequency and distribution of trisomic cells in placentae ascertained for IUGR and/or preeclampsia...
  45. ncbi request reprint Nifedipine for severe hypertension in pregnancy: emotion or evidence?
    Laura A Magee
    Department of Specialized Women s Health, BC Women s Hospital and Health Centre, Vancouver, British Columbia, Canada
    J Obstet Gynaecol Can 27:260-2. 2005
    ..We must resist the temptation to throw out of our limited therapeutic armamentarium an effective oral preparation before adequately considering the evidence...
  46. ncbi request reprint An association between cytomegalovirus infection and pre-eclampsia: a case-control study and data synthesis
    Fang Xie
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, Canada
    Acta Obstet Gynecol Scand 89:1162-7. 2010
    ..Pre-eclampsia shares several similarities with atherosclerotic heart disease. We explored whether, like atherosclerosis, there is a potential link between cytomegalovirus (CMV) infection and pre-eclampsia...
  47. ncbi request reprint Identifying potentially eligible subjects for research: paper-based logs versus the hospital administrative database
    L A Magee
    Department of Medicine, Child and Family Research Institute, Vancouver, British Columbia, Canada
    Chronic Dis Inj Can 32:43-6. 2011
    ..Women with one or more conditions most commonly associated with very pre-term birth are included if admitted to a participating tertiary perinatal unit at 22 weeks and 0 days to 28 weeks and 6 days...
  48. doi request reprint Toll-like receptor-3 stimulation upregulates sFLT-1 production by trophoblast cells
    E Nakada
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver V6Z 1Y6, Canada
    Placenta 30:774-9. 2009
    ..Therefore, we tested the hypothesis that TLR stimulation of a trophoblast cell line induces inflammatory mediator production and, in particular, production of the preeclampsia-related anti-angiogenic factor sFLT-1...
  49. ncbi request reprint Activated protein C and the ovarian hyperstimulation syndrome: possible therapeutic implications
    Jason A Hitkari
    The Department of Obstetrics and Gynecology, University of British Columbia, British Columbia Women s Hospital, Vancouver, Canada
    Med Hypotheses 66:929-33. 2006
    ..Use of rhAPC in this group may attenuate the disease process and reduce the potential morbidity associated with this iatrogenic disorder...
  50. pmc Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes
    Ryan K C Yuen
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 4:e7389. 2009
    ..The identification of such "epipolymorphism" in other tissues and their use in association studies, should improve our understanding of interindividual phenotypic variability and complex disease susceptibility...
  51. ncbi request reprint Variations in early and intermediate neonatal outcomes for inborn infants admitted to a Canadian NICU and born of hypertensive pregnancies
    Megan A Hayter
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
    J Obstet Gynaecol Can 27:25-32. 2005
    ..To determine whether neonatal intensive care unit (NICU) outcomes vary by centre for inborn neonates of hypertensive pregnancies and, if so, whether that variation might be related to between-centre variations in obstetric practice...
  52. ncbi request reprint Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
    Akiko Fuchisawa
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada
    J Obstet Gynaecol Res 30:342-8. 2004
    ..To investigate the influence of maternal corticosteroid administration on neutrophil apoptosis in early onset preeclampsia...
  53. ncbi request reprint The association between preeclampsia and placental trisomy 16 mosaicism
    Paul J Yong
    Department of Medical Genetics, Vancouver, BC, Canada
    Prenat Diagn 26:956-61. 2006
    ..While maternal preeclampsia has also been reported in some cases, this has not been systematically evaluated...
  54. ncbi request reprint Maternal vitamin D status in pregnancy and adverse pregnancy outcomes in a group at high risk for pre-eclampsia
    A W Shand
    Department of Maternal Fetal Medicine, BC Women s Hospital, Vancouver, BC, Canada
    BJOG 117:1593-8. 2010
    ..To determine in a group of pregnant women if vitamin D status, based on serum 25-hydroxyvitamin D (25OHD) concentration, was associated with a subsequent risk of pre-eclampsia or adverse pregnancy outcomes...
  55. pmc DNA methylation profiling of human placentas reveals promoter hypomethylation of multiple genes in early-onset preeclampsia
    Ryan Kc Yuen
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Eur J Hum Genet 18:1006-12. 2010
    ..00001). Our results suggest that gene-specific hypomethylation may be a common phenomenon in EOPET placentas, and that TIMP3 could serve as a potential prenatal diagnostic marker for EOPET...
  56. ncbi request reprint Toll-like receptor signaling and pre-eclampsia
    Fang Xie
    Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada
    Am J Reprod Immunol 63:7-16. 2010
    ..Here, we review the rapid progress in this field, which has improved our understanding of the interplay between pathogen invasion, innate immune defense mechanisms, and pre-eclampsia...
  57. ncbi request reprint Caesarean section on maternal request: risks and benefits in healthy nulliparous women and their infants
    Leanne S Dahlgren
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC
    J Obstet Gynaecol Can 31:808-17. 2009
    ..To determine the risks and benefits of an elective Caesarean section (CS) at term in healthy nulliparous women...
  58. ncbi request reprint Placental pathology and clinical outcomes in a cohort of infants admitted to a neonatal intensive care unit
    Luc Beaudet
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC
    J Obstet Gynaecol Can 29:315-23. 2007
    ..Placental pathology predicts persistent neurological impairment, even in normally grown infants. However, few studies have linked placental pathology with neonatal outcomes in a large population...
  59. pmc Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women: systematic review
    Anne Marie Côté
    BC Women s Hospital and Health Centre, Vancouver, BC, Canada
    BMJ 336:1003-6. 2008
    ..To review the spot protein:creatinine ratio and albumin:creatinine ratio as diagnostic tests for significant proteinuria in hypertensive pregnant women...
  60. ncbi request reprint The role of decidual natural killer cells in normal placentation and in the pathogenesis of preeclampsia
    Genevieve Eastabrook
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC
    J Obstet Gynaecol Can 30:467-76. 2008
    ....
  61. ncbi request reprint Our patients do not need endocarditis prophylaxis for genitourinary tract procedures: insights from the 2007 American Heart Association guidelines
    Eliana Castillo
    Department of Medicine, University of British Columbia, Vancouver, BC
    J Obstet Gynaecol Can 30:796-9. 2008
    ..A short discussion on enterococcal infections associated to obstetric and gynaecological procedures and therapeutic implications is presented...
  62. ncbi request reprint A randomised controlled trial of biopsy forceps and cannula aspiration for transcervical chorionic villus sampling
    Peter von Dadelszen
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynaecology, University of Toronto, Toronto, Ontario, Canada
    BJOG 112:559-66. 2005
    ..This trial compared two instruments for transcervical chorionic villus sampling (CVS)...
  63. ncbi request reprint A current landscape of provincial perinatal data collection in Canada
    Kiran A Massey
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC Centre for Advanced Health Research and Evaluation, University of British Columbia, Vancouver BC BC Women s Hospital and Health Centre, Vancouver BC
    J Obstet Gynaecol Can 31:236-46. 2009
    ..The inaugural project of CPN is focused on interventions that optimize maternal and perinatal outcomes in women with threatened preterm birth at 22+0 to 28+6 weeks' gestation...
  64. ncbi request reprint Placental weight in pregnancies with trisomy confined to the placenta
    Paual J Yong
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver BC, Child and Family Research Institute, Vancouver, BC, Canada
    J Obstet Gynaecol Can 31:605-10. 2009
    ..The objective of this study was to assess placental weight and feto-placental weight ratio in pregnancies with trisomy confined to the placenta, and to correlate them with the level of trisomy in the three major placental lineages...
  65. ncbi request reprint Maternal hypertension and neonatal outcome among small for gestational age infants
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada
    Obstet Gynecol 106:335-9. 2005
    ..To determine whether maternal hypertension might improve perinatal outcome among small for gestational age (SGA) infants (< 10th percentile)...
  66. ncbi request reprint Chorioamnionitis with a fetal inflammatory response is associated with higher neonatal mortality, morbidity, and resource use than chorioamnionitis displaying a maternal inflammatory response only
    Jacqueline Lau
    Centre for Healthcare Innovation and Improvement, School of Medicine, Queen s University, Vancouver, British Columbia, Canada
    Am J Obstet Gynecol 193:708-13. 2005
    ..This study was undertaken to evaluate whether the proximity of infection of the chorion/amnion and fetal vessels affects neonatal outcomes...
  67. doi request reprint Gastroschisis closure--does method really matter?
    Robert L Weinsheimer
    Division of Pediatric General Surgery, IWK Health Centre, Dalhousie University, Halifax, Canada B3K 6R8
    J Pediatr Surg 43:874-8. 2008
    ..Management of gastroschisis varies. This study aims to determine which aspects of practice influence outcomes...
  68. ncbi request reprint Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment
    Peter von Dadelszen
    Obstet Gynecol 101:618. 2003