Mathilakath M Vijayan

Summary

Affiliation: University of Waterloo
Country: Canada

Publications

  1. ncbi request reprint Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome
    Adrienne N Boone
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1 Canada
    Am J Physiol Regul Integr Comp Physiol 283:R680-7. 2002
  2. ncbi request reprint Fasting augments PCB impact on liver metabolism in anadromous arctic char
    Mathilakath M Vijayan
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Toxicol Sci 91:431-9. 2006
  3. ncbi request reprint Salicylate impacts the physiological responses to an acute handling disturbance in rainbow trout
    Amélie Gravel
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Aquat Toxicol 85:87-95. 2007
  4. doi request reprint Non-steroidal anti-inflammatory drugs disturb the osmoregulatory, metabolic and cortisol responses associated with seawater exposure in rainbow trout
    Amélie Gravel
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 149:481-90. 2009
  5. doi request reprint Brain transcriptomics in response to beta-naphthoflavone treatment in rainbow trout: the role of aryl hydrocarbon receptor signaling
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, 200 University Avenue West, Ontario, Canada N2L 3G1
    Aquat Toxicol 87:1-12. 2008
  6. ncbi request reprint Resveratrol affects CYP1A expression in rainbow trout hepatocytes
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ont, Canada, N2L 3G1
    Aquat Toxicol 77:291-7. 2006
  7. doi request reprint Temporal changes in stress and tissue-specific metabolic responses to municipal wastewater effluent exposure in rainbow trout
    Jennifer S Ings
    Department of Biology, University of Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 156:67-74. 2012
  8. ncbi request reprint Ah Receptor-mediated impairment of interrenal steroidogenesis involves StAR protein and P450scc gene attenuation in rainbow trout
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Ontario, Canada N2L 3G1
    Toxicol Sci 84:260-9. 2005
  9. doi request reprint Exposure to municipal wastewater effluent impacts stress performance in rainbow trout
    Jennifer S Ings
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Aquat Toxicol 103:85-91. 2011
  10. doi request reprint Rapid cortisol signaling in response to acute stress involves changes in plasma membrane order in rainbow trout liver
    Laura Dindia
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Am J Physiol Endocrinol Metab 304:E1157-66. 2013

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Glucocorticoid-mediated attenuation of the hsp70 response in trout hepatocytes involves the proteasome
    Adrienne N Boone
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1 Canada
    Am J Physiol Regul Integr Comp Physiol 283:R680-7. 2002
    ..Taken together, our results suggest proteasome-mediated GR degradation as a mechanism for the attenuation of hsp70 response by cortisol in heat-shocked hepatocytes...
  2. ncbi request reprint Fasting augments PCB impact on liver metabolism in anadromous arctic char
    Mathilakath M Vijayan
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Toxicol Sci 91:431-9. 2006
    ....
  3. ncbi request reprint Salicylate impacts the physiological responses to an acute handling disturbance in rainbow trout
    Amélie Gravel
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Aquat Toxicol 85:87-95. 2007
    ..The mode of action of salicylate involves disruption of StAR and liver GR, two key proteins critical for cortisol production and target tissue responsiveness to this steroid, respectively...
  4. doi request reprint Non-steroidal anti-inflammatory drugs disturb the osmoregulatory, metabolic and cortisol responses associated with seawater exposure in rainbow trout
    Amélie Gravel
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 149:481-90. 2009
    ..Altogether, salicylate and ibuprofen exposures impaired the hyposmoregulatory capacity of rainbow trout in seawater, but the mode of action of the two drugs in bringing about these changes appears distinct in trout...
  5. doi request reprint Brain transcriptomics in response to beta-naphthoflavone treatment in rainbow trout: the role of aryl hydrocarbon receptor signaling
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, 200 University Avenue West, Ontario, Canada N2L 3G1
    Aquat Toxicol 87:1-12. 2008
    ....
  6. ncbi request reprint Resveratrol affects CYP1A expression in rainbow trout hepatocytes
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ont, Canada, N2L 3G1
    Aquat Toxicol 77:291-7. 2006
    ..Taken together, RVT is an effective AhR antagonist, but induces CYP1A expression at lower doses (<10(-8) M) in trout hepatocytes...
  7. doi request reprint Temporal changes in stress and tissue-specific metabolic responses to municipal wastewater effluent exposure in rainbow trout
    Jennifer S Ings
    Department of Biology, University of Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 156:67-74. 2012
    ..The tissue-specific temporal changes in the metabolic capacity suggest enhanced energy demand in fish exposed to MWWE, which may eventually lead to reduced fitness...
  8. ncbi request reprint Ah Receptor-mediated impairment of interrenal steroidogenesis involves StAR protein and P450scc gene attenuation in rainbow trout
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Ontario, Canada N2L 3G1
    Toxicol Sci 84:260-9. 2005
    ..Overall, endocrine disruption by xenobiotics acting via AhR includes impaired cortisol biosynthesis and abnormal cortisol target tissue GR responses in rainbow trout...
  9. doi request reprint Exposure to municipal wastewater effluent impacts stress performance in rainbow trout
    Jennifer S Ings
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Aquat Toxicol 103:85-91. 2011
    ..Our results reveal that the impact of tertiary-treated MWWE on stress performance in rainbow trout is abolished by 90% effluent dilution...
  10. doi request reprint Rapid cortisol signaling in response to acute stress involves changes in plasma membrane order in rainbow trout liver
    Laura Dindia
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Am J Physiol Endocrinol Metab 304:E1157-66. 2013
    ..Together, our results indicate that stressor-induced elevation of plasma cortisol level is associated with alterations in plasma membrane fluidity and rapid activation of stress-related signaling pathways in trout liver...
  11. doi request reprint Cortisol regulates Na+ uptake in zebrafish, Danio rerio, larvae via the glucocorticoid receptor
    Yusuke Kumai
    Department of Biology, University of Ottawa, Ottawa, ON, Canada
    Mol Cell Endocrinol 364:113-25. 2012
    ....
  12. doi request reprint Tissue-specific metabolic changes in response to an acute handling disturbance in juvenile rainbow trout exposed to municipal wastewater effluent
    Jennifer S Ings
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Aquat Toxicol 108:53-9. 2012
    ..Altogether, chronic exposure to MWWE impacts the metabolic performances to a secondary stressor challenge and this includes disruptions in tissue-specific gluconeogenic and glycolytic capacities in rainbow trout...
  13. ncbi request reprint Aryl hydrocarbon receptor activation impairs cortisol response to stress in rainbow trout by disrupting the rate-limiting steps in steroidogenesis
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Ontario, Canada
    Endocrinology 147:1895-903. 2006
    ..Altogether, xenobiotics activating Ah receptor signaling are steroidogenic disruptors, and the mode of action includes inhibition of StAR and P450scc, the rate-limiting steps in steroidogenesis...
  14. doi request reprint Embryo exposure to elevated cortisol level leads to cardiac performance dysfunction in zebrafish
    Dinushan Nesan
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Mol Cell Endocrinol 363:85-91. 2012
    ..Altogether, high cortisol content during embryogenesis, mimicking increased deposition due to maternal stress, decreases cardiac performance and may reduce zebrafish offspring survival...
  15. doi request reprint Aroclor 1254 disrupts liver glycogen metabolism and enhances acute stressor-mediated glycogenolysis in rainbow trout
    Steve Wiseman
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 154:254-60. 2011
    ..Collectively, this study demonstrates that short-term PCB exposure may impair the liver metabolic performance that is critical to cope with the enhanced energy demand associated with additional stressor exposure in rainbow trout...
  16. ncbi request reprint Tissue-specific modulation of glucocorticoid receptor expression in response to salinity acclimation in rainbow trout
    Thomas D Singer
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Comp Biochem Physiol B Biochem Mol Biol 146:271-8. 2007
    ..Collectively, salinity exposure modulates GR expression and glucocorticoid signaling in rainbow trout...
  17. ncbi request reprint PCB disruption of the hypothalamus-pituitary-interrenal axis involves brain glucocorticoid receptor downregulation in anadromous Arctic charr
    Neelakanteswar Aluru
    Dept of Biology, Univ of Waterloo, Waterloo, Ontario, Canada
    Am J Physiol Regul Integr Comp Physiol 287:R787-93. 2004
    ..Taken together, the hypothalamus-pituitary-interrenal axis is a target for PCB impact during winter emaciation in anadromous Arctic charr...
  18. ncbi request reprint Modulation of Ah receptor and CYP1A1 expression by alpha-naphthoflavone in rainbow trout hepatocytes
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1 Canada
    Comp Biochem Physiol C Toxicol Pharmacol 141:40-9. 2005
    ..Overall, ANF is not only a partial AhR agonist, but may also modify BNF-mediated AhR signaling in trout hepatocytes...
  19. doi request reprint Central and peripheral glucocorticoid receptors are involved in the plasma cortisol response to an acute stressor in rainbow trout
    Sarah L Alderman
    Department of Biology, University of Waterloo, Waterloo, ON, Canada
    Gen Comp Endocrinol 176:79-85. 2012
    ..Overall, our results underscore a critical role for central and peripheral GR signaling in the regulation of plasma cortisol levels during stress in fish...
  20. doi request reprint Hyperosmotic shock adaptation by cortisol involves upregulation of branchial osmotic stress transcription factor 1 gene expression in Mozambique Tilapia
    Alison McGuire
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Gen Comp Endocrinol 165:321-9. 2010
    ..Overall, cortisol adapts tilapia to a hyperosmotic shock associated with abrupt seawater exposure. This involves upregulation of OSTF1 gene expression and a concomitant suppression of branchial metabolism in tilapia...
  21. doi request reprint Hepatic transcriptomics and protein expression in rainbow trout exposed to municipal wastewater effluent
    Jennifer S Ings
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Environ Sci Technol 45:2368-76. 2011
    ..The disruption in multiple stress-related pathways suggests that tertiary-treated MWWEs exposure may reduce fish performance to subsequent stressors...
  22. ncbi request reprint beta-Naphthoflavone disrupts cortisol production and liver glucocorticoid responsiveness in rainbow trout
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ont, Canada N2L 3G1
    Aquat Toxicol 67:273-85. 2004
    ..Altogether, our results suggest that AhR activation disrupts interrenal corticosteroidogenesis and target tissue responsiveness to glucocorticoid stimulation in rainbow trout...
  23. doi request reprint Serum corticosteroid binding globulin expression is modulated by fasting in polar bears (Ursus maritimus)
    Brian A Chow
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L3G1, Canada
    Comp Biochem Physiol A Mol Integr Physiol 158:111-5. 2011
    ..Overall, our results suggest that elevated serum CBG expression may be an important adaptation to spare proteins by limiting cortisol bioavailability during extended fasting in polar bears...
  24. ncbi request reprint Hepatic transcriptome response to glucocorticoid receptor activation in rainbow trout
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Physiol Genomics 31:483-91. 2007
    ..Taken together, our results suggest a key role for genomic cortisol signaling in the liver molecular reprogramming that is critical for coping with stress in fish...
  25. ncbi request reprint Salicylate disrupts interrenal steroidogenesis and brain glucocorticoid receptor expression in rainbow trout
    Amélie Gravel
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Toxicol Sci 93:41-9. 2006
    ..Taken together, salicylate is a corticosteroid disruptor in trout and the targets include the key rate-limiting step in interrenal steroidogenesis and brain glucocorticoid signaling...
  26. doi request reprint 11β-Hydroxysteroid dehydrogenase type 2 in zebrafish brain: a functional role in hypothalamus-pituitary-interrenal axis regulation
    Sarah L Alderman
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    J Endocrinol 215:393-402. 2012
    ..Taken together, our results underscore an important role for brain Hsd11b2 involvement in the negative feedback regulation of cortisol poststress in zebrafish...
  27. ncbi request reprint Development of the corticosteroid stress axis and receptor expression in zebrafish
    Derek Alsop
    Department of Biology, University of Waterloo, Waterloo, ON, Canada N2L 3G1
    Am J Physiol Regul Integr Comp Physiol 294:R711-9. 2008
    ....
  28. doi request reprint Cadmium-mediated disruption of cortisol biosynthesis involves suppression of corticosteroidogenic genes in rainbow trout
    Navdeep Sandhu
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada
    Aquat Toxicol 103:92-100. 2011
    ..We propose that MC2R signaling, the primary step in ACTH-induced cortocosteroidogenesis, is a key target for cadmium-mediated disruption of cortisol production in trout...
  29. doi request reprint Role of glucocorticoid in developmental programming: evidence from zebrafish
    Dinushan Nesan
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Gen Comp Endocrinol 181:35-44. 2013
    ..Use of zebrafish as a model may lead to significant insights into the conserved role of glucocorticoids during early development with potential implications in biomedical research, including fetal stress syndromes in humans...
  30. pmc Novel nongenomic signaling by glucocorticoid may involve changes to liver membrane order in rainbow trout
    Laura Dindia
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    PLoS ONE 7:e46859. 2012
    ..Our results suggest that biophysical changes to plasma membrane properties, triggered by stressor-induced glucocorticoid elevation, act as a nonspecific stress response and may rapidly modulate acute stress-signaling pathways...
  31. doi request reprint Glucocorticoid receptor signaling is essential for mesoderm formation and muscle development in zebrafish
    Dinushan Nesan
    University of Waterloo, Department of Biology, 200 University Avenue West, Waterloo, Ontario, Canada
    Endocrinology 153:1288-300. 2012
    ..Our results for the first time indicate that GR signaling is essential for zebrafish muscle development, and we hypothesize a role for BMP morphogens in this process...
  32. doi request reprint Cortisol modulates the expression of cytokines and suppressors of cytokine signaling (SOCS) in rainbow trout hepatocytes
    Anju M Philip
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Dev Comp Immunol 38:360-7. 2012
    ..Altogether, cortisol modulates the molecular immune response in trout hepatocytes. The upregulation of SOCS-1 and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response...
  33. ncbi request reprint Non-steroidal anti-inflammatory drugs disrupt the heat shock response in rainbow trout
    Amélie Gravel
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Aquat Toxicol 81:197-206. 2007
    ..Overall, NSAIDs disrupt the heat shock response in rainbow trout, while the mode of action of salicylate and ibuprofen in impacting the cellular stress response appears distinct...
  34. pmc Adrenocorticotropic hormone suppresses gonadotropin-stimulated estradiol release from zebrafish ovarian follicles
    Derek Alsop
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    PLoS ONE 4:e6463. 2009
    ....
  35. pmc Molecular characterization, tissue-specific expression, and regulation of melanocortin 2 receptor in rainbow trout
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Endocrinology 149:4577-88. 2008
    ....
  36. doi request reprint Grizzly bear corticosteroid binding globulin: Cloning and serum protein expression
    Brian A Chow
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Gen Comp Endocrinol 167:317-25. 2010
    ..Overall, serum CBG levels may be a better marker of chronic stress, especially because this protein is not modulated by the stress of capture and restraint in grizzly bears...
  37. ncbi request reprint Aryl hydrocarbon receptor signaling in rainbow trout hepatocytes: role of hsp90 and the proteasome
    Steve B Wiseman
    Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 146:484-91. 2007
    ..Altogether our results suggest a betaNF-mediated autoregulation of AhR content in trout hepatocytes. We propose a key role for hsp90 and the proteasome in this ligand-mediated AhR regulation and Cyp1A response...
  38. pmc Bisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trout
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    PLoS ONE 5:e10741. 2010
    ..We tested the hypothesis that BPA in eggs, mimicking maternal transfer, impact development, growth and stress performance in juveniles of rainbow trout (Oncorhynchus mykiss)...
  39. doi request reprint Molecular programming of the corticosteroid stress axis during zebrafish development
    Derek Alsop
    Department of Biology, University of Waterloo, Waterloo, ON, Canada
    Comp Biochem Physiol A Mol Integr Physiol 153:49-54. 2009
    ..Overall, zebrafish appear to be an excellent model for elucidating the molecular mechanisms leading to the development of the corticoid stress axis in vertebrates...
  40. doi request reprint Stress transcriptomics in fish: a role for genomic cortisol signaling
    Neelakanteswar Aluru
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Gen Comp Endocrinol 164:142-50. 2009
    ....
  41. ncbi request reprint The role of Hsp70 and Hsp90 in TGF-beta-induced epithelial-to-mesenchymal transition in rat lens epithelial explants
    Alice Banh
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Mol Vis 13:2248-62. 2007
    ..This study investigates the effects of heat shock treatment and the role of Hsp70 and Hsp90 on tranforming growth factor beta 2 (TGF-beta2)-induced epithelial-to-mesenchymal transition (EMT) in rat lens epithelial explants...
  42. doi request reprint Modulation of hypothalamic-pituitary-interrenal axis function by social status in rainbow trout
    Jennifer D Jeffrey
    Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Gen Comp Endocrinol 176:201-10. 2012
    ....
  43. ncbi request reprint Autoregulation of glucocorticoid receptor by cortisol in rainbow trout hepatocytes
    Ramesh Sathiyaa
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Am J Physiol Cell Physiol 284:C1508-15. 2003
    ..The autoregulation of GR may be a crucial step in the physiological stress response process, especially in modulating energy-dependent processes that are glucocorticoid dependent, including gluconeogenesis...
  44. doi request reprint Exposure to environmental levels of waterborne cadmium impacts corticosteroidogenic and metabolic capacities, and compromises secondary stressor performance in rainbow trout
    Navdeep Sandhu
    Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada
    Aquat Toxicol 146:20-7. 2014
    ....
  45. pmc The transcriptomics of glucocorticoid receptor signaling in developing zebrafish
    Dinushan Nesan
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    PLoS ONE 8:e80726. 2013
    ..Together, this study underscores a critical role for glucocorticoid signaling in programming molecular events essential for zebrafish development. ..
  46. pmc Serum immune-related proteins are differentially expressed during hibernation in the American black bear
    Brian A Chow
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    PLoS ONE 8:e66119. 2013
    ..We propose that the observed serum protein changes contribute to the maintenance of the hibernation phenotype and health, including increased capacities for bone maintenance and wound healing during hibernation in bears. ..
  47. ncbi request reprint Cortisol treatment affects glucocorticoid receptor and glucocorticoid-responsive genes in the liver of rainbow trout
    Mathilakath M Vijayan
    Department of Biology, University of Waterloo, Waterloo, Ont, Canada N2L
    Gen Comp Endocrinol 132:256-63. 2003
    ....
  48. ncbi request reprint Copper impact on heat shock protein 70 expression and apoptosis in rainbow trout hepatocytes
    Qiang Feng
    Department of Biology, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada N2L 3G1
    Comp Biochem Physiol C Toxicol Pharmacol 135:345-55. 2003
    ..Together, these results suggest that hepatotoxicity of copper includes impairment of hsp70 response to subsequent stressors and/or signals, which is crucial for protecting cells from proteotoxicity...
  49. ncbi request reprint Hsp70 in bovine lenses during temperature stress
    Alice Banh
    School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Mol Vis 9:323-8. 2003
    ..To determine the effects of heat shock treatment on cold cataract formation in bovine lenses...
  50. ncbi request reprint Constitutive heat shock protein 70 (HSC70) expression in rainbow trout hepatocytes: effect of heat shock and heavy metal exposure
    Adrienne N Boone
    Department of Biology, University of Waterloo, Waterloo, Ont, Canada N2L 3G1
    Comp Biochem Physiol C Toxicol Pharmacol 132:223-33. 2002
    ..Taken together, we have for the first time generated polyclonal antibodies specific to rainbow trout hsc70 and this antibody will allow for the characterization of the role of hsc70 in the cellular stress response process in fish...
  51. ncbi request reprint Tissue contaminants and associated transcriptional response in trout liver from high elevation lakes of Washington
    Patrick W Moran
    U S Geological Survey, Washington Water Science Center, Tacoma, Washington 98402, USA
    Environ Sci Technol 41:6591-7. 2007
    ..Specifically, the gene expression pattern leads us to hypothesize a role for mercury in disrupting the metabolic and reproductive pathways in fish from high elevation lakes in western Washington...
  52. ncbi request reprint PCB impairs smoltification and seawater performance in anadromous Arctic charr (Salvelinus alpinus)
    Even H Jørgensen
    Norwegian College of Fishery Science, University of Tromsø, N 9037
    Comp Biochem Physiol C Toxicol Pharmacol 138:203-12. 2004
    ..Our findings suggest that PCB might compromise mechanisms important for fitness in a fish species living in an extreme environment...
  53. ncbi request reprint Toxicokinetics and effects of PCBs in Arctic fish: a review of studies on Arctic charr
    Even H Jørgensen
    Norwegian Institute of Nature Research, The Polar Environmental Center, Tromsø
    J Toxicol Environ Health A 69:37-52. 2006
    ..Pilot studies on Arctic charr from Bjørnøya Island revealed marked CYP1A biomarker responses and an upregulation of genes involved in cellular homeostatic mechanisms in charr from Lake Ellasjøen (high PCB levels)...
  54. ncbi request reprint Salinity acclimation affects the somatotropic axis in rainbow trout
    Brian S Shepherd
    National Center for Cool and Coldwater Aquaculture, ARS USDA, 11861 Leetown Rd, Kearneysville, WV 25430, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1385-95. 2005
    ..Considered together, the elevated plasma IGFBPs suggest a key role for these binding proteins in the regulation of IGF-I during salinity acclimation in salmonids...
  55. ncbi request reprint Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss)
    Brian S Shepherd
    USDA ARS, National Center for Cool and Coldwater Aquaculture, Kearneysville, WV 25430, USA
    Comp Biochem Physiol A Mol Integr Physiol 146:390-9. 2007
    ....
  56. ncbi request reprint Aroclor 1254 exposure reduces disease resistance and innate immune responses in fasted Arctic charr
    Alec G Maule
    US Geological Survey BRD, WFRC, Columbia River Research Laboratory, Cook, Washington 98605, USA
    Environ Toxicol Chem 24:117-24. 2005
    ..These results demonstrate the immunosuppressive effects of PCBs on Arctic charr, and they illustrate the importance of considering environmentally relevant nutritional status in ecotoxicological studies...
  57. ncbi request reprint Tissue-specific suppression of estrogen, androgen and glucocorticoid receptor gene expression in feral vitellogenic male Mozambique tilapia
    Chang Beom Park
    Marine and Environmental Research Institute, Cheju National University, Jeju 695 814, South Korea
    Chemosphere 69:32-40. 2007
    ..Overall, our results imply that xenoestrogen exposure and VTG synthesis may lead to disruption of liver responsiveness to sex steroids and glucocorticoid stimulation in feral male fish...