Mathilakath M Vijayan
Affiliation: University of Calgary
Gauthier P, Vijayan M. A rapid zebrafish embryo behavioral biosensor that is capable of detecting environmental β-blockers. Environ Pollut. 2019;250:493-502 pubmed publisher
..This systems level approach of rapid screening for BB effects provides the most promising evidence to date that behavioral neuromodulation can be potentially applied for environmental effects monitoring of pharmaceuticals. ..
Sandhu N, Liang L, McGeer J, Dores R, Vijayan M. Cadmium disrupts melanocortin 2 receptor signaling in rainbow trout. Aquat Toxicol. 2019;209:26-33 pubmed publisher
..Collectively, waterborne exposure to environmentally realistic concentration of cadmium compromises the stressor-induced cortisol response, and a mode of action involves the disruption of MC2R signaling in rainbow trout. ..
Faught E, Vijayan M. The mineralocorticoid receptor is essential for stress axis regulation in zebrafish larvae. Sci Rep. 2018;8:18081 pubmed publisher
..Overall, the results underscore a key physiological role for MR signalling in ray-finned fishes, and we propose that the regulation of the highly conserved stress axis as the original function of this receptor. ..
Birceanu O, Servos M, Vijayan M. Bisphenol A accumulation in eggs disrupts the endocrine regulation of growth in rainbow trout larvae. Aquat Toxicol. 2015;161:51-60 pubmed publisher
..Altogether, BPA accumulation in eggs, mimicking maternal transfer, affects larval growth and the mode of action involves disruption of genes involved in the GH/IGF and thyroid axes function in trout. ..
Das C, Thraya M, Vijayan M. Nongenomic cortisol signaling in fish. Gen Comp Endocrinol. 2018;265:121-127 pubmed publisher
..Emerging evidence suggests that cortisol activates multiple signaling pathways in cells to bring about rapid effects, but the underlying physiological implications on acute stress adaptation are far from clear. ..
Birceanu O, Mai T, Vijayan M. Maternal transfer of bisphenol A impacts the ontogeny of cortisol stress response in rainbow trout. Aquat Toxicol. 2015;168:11-8 pubmed publisher
Faught E, Vijayan M. Mechanisms of cortisol action in fish hepatocytes. Comp Biochem Physiol B Biochem Mol Biol. 2016;199:136-145 pubmed publisher
..The mode of actions and their physiological implications for stress coping awaits further study. ..
Gauthier P, Vijayan M. Nonlinear mixed-modelling discriminates the effect of chemicals and their mixtures on zebrafish behavior. Sci Rep. 2018;8:1999 pubmed publisher
..Overall, nonlinear mixed-modelling is a more comprehensive approach for screening the impact of chemicals and chemical mixtures on zebrafish behavior. ..
Faught E, Henrickson L, Vijayan M. Plasma exosomes are enriched in Hsp70 and modulated by stress and cortisol in rainbow trout. J Endocrinol. 2017;232:237-246 pubmed
..Overall, we propose a novel role for extracellular vesicular transport of Hsp70 in the organismal stress response. ..