Ruud A W Veldhuizen

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. doi request reprint Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation
    Cory Yamashita
    Department of Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L724-32. 2008
  2. ncbi request reprint Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant
    Ruud A W Veldhuizen
    Lawson Health Research Institute and Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 92:1169-75. 2002
  3. doi request reprint Surfactant protein-A reduces translocation of mediators from the lung into the circulation
    Emily A Truscott
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 36:431-9. 2010
  4. ncbi request reprint Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
    Erica L Martin
    Departments of Physiology and Pharmacology Lawson Health Research Inst H417, 268 Grosvenor St, London, ON, Canada, N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 289:L244-51. 2005
  5. pmc Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films, II: albumin-inhibited pulmonary surfactant films and the effect of SP-A
    Yi Y Zuo
    Department of Chemistry, University of Western Ontario, London, Ontario, Canada
    Biophys J 95:2779-91. 2008
  6. ncbi request reprint Lung mechanics in the TIMP3 null mouse and its response to mechanical ventilation
    Erica L Martin
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 33:99-113. 2007
  7. ncbi request reprint Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult
    Erica L Martin
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L779-89. 2007
  8. ncbi request reprint Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency
    Timothy C Bailey
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 4V2
    J Appl Physiol (1985) 96:1674-80. 2004
  9. doi request reprint Alterations to surfactant precede physiological deterioration during high tidal volume ventilation
    Adam A Maruscak
    Lawson Health Research Institute F4 117, 268 Grosvenor St, London, ON, Canada, N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 294:L974-83. 2008
  10. ncbi request reprint Elevated endogenous surfactant reduces inflammation in an acute lung injury model
    Melissa G Walker
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 35:591-604. 2009

Collaborators

Detail Information

Publications42

  1. doi request reprint Protective effects of elevated endogenous surfactant pools to injurious mechanical ventilation
    Cory Yamashita
    Department of Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 294:L724-32. 2008
    ..It is concluded that DMDP-liposome administration protects against ventilation-induced lung injury. This effect appears to be due to the presence of elevated endogenous surfactant pools...
  2. ncbi request reprint Mechanical ventilation of isolated rat lungs changes the structure and biophysical properties of surfactant
    Ruud A W Veldhuizen
    Lawson Health Research Institute and Department of Physiology, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 92:1169-75. 2002
    ..We conclude that the injurious mechanical ventilation impairs LA function and that this impairment is associated with significant morphological alterations...
  3. doi request reprint Surfactant protein-A reduces translocation of mediators from the lung into the circulation
    Emily A Truscott
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 36:431-9. 2010
    ..The authors conclude that LPS followed by MV resulted in lung inflammation and injury, and that SP-A significantly influenced inflammatory mediator release from these inflamed lungs into the perfusate...
  4. ncbi request reprint Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
    Erica L Martin
    Departments of Physiology and Pharmacology Lawson Health Research Inst H417, 268 Grosvenor St, London, ON, Canada, N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 289:L244-51. 2005
    ..In conclusion, this study provides insight into the role of TIMP-3 in response to various lung insults, specifically its importance in regulating MMPs to maintain compliance during a sepsis...
  5. pmc Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films, II: albumin-inhibited pulmonary surfactant films and the effect of SP-A
    Yi Y Zuo
    Department of Chemistry, University of Western Ontario, London, Ontario, Canada
    Biophys J 95:2779-91. 2008
    ..These experimental data indicate a new mechanism of surfactant inhibition by serum proteins, complementing the traditional competitive adsorption mechanism...
  6. ncbi request reprint Lung mechanics in the TIMP3 null mouse and its response to mechanical ventilation
    Erica L Martin
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 33:99-113. 2007
    ..In conclusion, TIMP3 null mice have significant alterations in lung mechanics; however, this does not affect their response to ventilation...
  7. ncbi request reprint Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult
    Erica L Martin
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L779-89. 2007
    ..This response may be mediated in part by MMP-7 activity but occurs independently of inflammatory cytokine and/or chemokine concentrations...
  8. ncbi request reprint Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency
    Timothy C Bailey
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada N6A 4V2
    J Appl Physiol (1985) 96:1674-80. 2004
    ..We conclude that instillation of an in vitro oxidized surfactant causes an inferior physiological response in a surfactant-deficient rat...
  9. doi request reprint Alterations to surfactant precede physiological deterioration during high tidal volume ventilation
    Adam A Maruscak
    Lawson Health Research Institute F4 117, 268 Grosvenor St, London, ON, Canada, N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 294:L974-83. 2008
    ..Together, these results suggest that alterations of surfactant are a consequence of the ventilation strategy that impair the biophysical activity of this material and thereby contribute directly to lung dysfunction over time...
  10. ncbi request reprint Elevated endogenous surfactant reduces inflammation in an acute lung injury model
    Melissa G Walker
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 35:591-604. 2009
    ..Elevated endogenous surfactant pools are protective against both LPS- and mechanical ventilation-induced inflammation, in addition to inflammation associated with the combination of these two insults...
  11. ncbi request reprint Physiological effects of oxidized exogenous surfactant in vivo: effects of high tidal volume and surfactant protein A
    Timothy C Bailey
    Lawson Health Research Institute, Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario N6A 4V2, Canada
    Am J Physiol Lung Cell Mol Physiol 291:L703-9. 2006
    ..Furthermore, the oxidative status of the surfactant does not appear to affect the alveolar metabolism of this material...
  12. doi request reprint The effects of long-term conventional mechanical ventilation on the lungs of adult rats
    Timothy C Bailey
    Department of Physiology and Pharmacology, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Crit Care Med 36:2381-7. 2008
    ..Whether these responses to ventilation occur with more clinically relevant ventilation strategies is not known...
  13. pmc A ToF-SIMS study of the lateral organization of lipids and proteins in pulmonary surfactant systems
    Eleonora Keating
    Lawson Health Research Institute, London, Ontario, Canada
    Biochim Biophys Acta 1808:614-21. 2011
    ..This may further our understanding of pulmonary surfactant function...
  14. ncbi request reprint The effects of hyperoxia exposure on lung function and pulmonary surfactant in a rat model of acute lung injury
    Patrick W Pace
    Department of Physiology and Pharmacology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 35:380-98. 2009
    ....
  15. doi request reprint A modified squeeze-out mechanism for generating high surface pressures with pulmonary surfactant
    Eleonora Keating
    Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Biochim Biophys Acta 1818:1225-34. 2012
    ..This allows the surface film to attain low surface tensions during compression and maintain values near equilibrium during expansion...
  16. ncbi request reprint Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
    Erica L Martin
    Department of Physiology, Lawson Health Research Institute, H417, 268 Grosvenor St, The University of Western Ontario, London, ON, Canada, N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 285:L1222-32. 2003
    ..In conclusion, exposing TIMP-3 null animals to sepsis rapidly enhances the phenotypic abnormalities of these mice, due to increased MMP activity induced by CLP...
  17. doi request reprint The effect of tidal volume on systemic inflammation in Acid-induced lung injury
    Melissa G Walker
    Lawson Health Research Institute, London, Ont, Canada
    Respiration 81:333-42. 2011
    ..Previous studies suggest that mechanical ventilation (MV) may be a key mediator of MOF through an upregulation of the systemic inflammatory response...
  18. doi request reprint The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury
    Valeria Puntorieri
    Department of Physiology and Pharmacology, Western University, London, Ontario, Canada
    BMC Pulm Med 13:67. 2013
    ..Since pulmonary surfactant has anti-inflammatory properties, the aim of the study was to investigate the effect of exogenous surfactant administration on ventilation-induced systemic inflammation...
  19. ncbi request reprint The biological effects of lung-derived mediators on the liver
    Nicole A Rocca
    Department of Physiology and Pharmacology and Lawson Health Research Institute, University of Western Ontario, London, Canada
    Exp Lung Res 37:419-26. 2011
    ..Therapies targeting these mediators may prevent multiorgan failure and death in patients with acute lung injury...
  20. ncbi request reprint Host response to intratracheally instilled bacteria in ventilated and nonventilated rats
    Angela M Brackenbury
    Department of Medicine, St Joseph s Health Care Centre, London, Ontario, Canada
    Crit Care Med 32:2502-7. 2004
    ..aeruginosa in the setting of noninjurious mechanical ventilation and compare this with normal, spontaneously breathing animals receiving bacteria...
  21. ncbi request reprint Protein inhibition of surfactant during mechanical ventilation of isolated rat lungs
    Keith Da Silva
    Lawson Health Research Institute and Department of Physiology, The University of Western Ontario, London, Ontario, Canada
    Exp Lung Res 31:745-58. 2005
    ..It is concluded that during mechanical ventilation, leakage of proteins results in surfactant inhibition and thereby contribute to decreased lung compliance...
  22. ncbi request reprint High oxygen concentrations predispose mouse lungs to the deleterious effects of high stretch ventilation
    Timothy C Bailey
    Departments of Physiology and Pharmacology, Obstetrics and Gynaecology, and Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Appl Physiol (1985) 94:975-82. 2003
    ..Our conclusion is that 48 h of >90% oxygen and high-stretch mechanical ventilation deleteriously affect lung function to a greater degree than stretch alone...
  23. doi request reprint Atomic force microscopy analysis of rat pulmonary surfactant films
    Xiujun Jiao
    Lawson Health Research Institute, University of Western Ontario, London, Canada
    Biophys Chem 158:119-25. 2011
    ..Overall, the data indicate that surfactant films demonstrate phase separation at low surface pressures and multilayer formation at higher pressure, features likely important for normal surfactant function...
  24. doi request reprint Recent advances in alveolar biology: some new looks at the alveolar interface
    Fred Possmayer
    University of Western Ontario, Departments of Obstetrics Gynaecology and Biochemistry, London, Ontario, Canada
    Respir Physiol Neurobiol 173:S55-64. 2010
    ..This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface...
  25. doi request reprint Current perspectives in pulmonary surfactant--inhibition, enhancement and evaluation
    Yi Y Zuo
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    Biochim Biophys Acta 1778:1947-77. 2008
    ....
  26. ncbi request reprint Early surfactant administration protects against lung dysfunction in a mouse model of ARDS
    Vijay P A Rasaiah
    Department of Physiology, Lawson Health Research Institute, University of Western Ontario, London, Ontario N6A 4V2, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L783-90. 2003
    ..We conclude that administration of exogenous surfactant at the time of a systemic insult can protect the lung from the damaging effects of MV 18 h later...
  27. doi request reprint Role of cholesterol in the biophysical dysfunction of surfactant in ventilator-induced lung injury
    Dan Vockeroth
    Lawson Health Research Institute E4 146, 268 Grosvenor St, London, ON, Canada N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 298:L117-25. 2010
    ..It is concluded that increased levels of cholesterol associated with endogenous surfactant represent a major contributor to the inhibition of surfactant function in ventilation-induced lung injury...
  28. doi request reprint High-frequency oscillation and surfactant treatment in an acid aspiration model
    Alexander J Aspros
    Lawson Health Research Institute, University of Western Ontario, 268 Grosvenor Street, London, ON N6A4V2, Canada
    Can J Physiol Pharmacol 88:14-20. 2010
    ..These data suggest an advantage of HFO over CMV when exogenous surfactant was not given, and that surfactant treatment combined with HFO was not superior to HFO ventilation alone...
  29. pmc Atomic force microscopy studies of functional and dysfunctional pulmonary surfactant films. I. Micro- and nanostructures of functional pulmonary surfactant films and the effect of SP-A
    Yi Y Zuo
    Department of Chemistry, University of Western Ontario, London, Ontario, Canada
    Biophys J 94:3549-64. 2008
    ..We conclude that the nanodomains play a predominant role in affecting the biophysical properties of PS monolayers and the monolayer-to-multilayer transition...
  30. ncbi request reprint Apolipoprotein E-deficient mice are susceptible to the development of acute lung injury
    Cory M Yamashita
    Lawson Health Research Institute, London, Ont, Canada
    Respiration 87:416-27. 2014
    ....
  31. pmc Human alveolar epithelial cells attenuate pulmonary microvascular endothelial cell permeability under septic conditions
    Lefeng Wang
    Centre for Critical Illness Research, Division of Respirology, Lawson Health Research Institute, London Health Sciences Center, London, Ontario, Canada
    PLoS ONE 8:e55311. 2013
    ..This study suggests a scientific and potential clinical therapeutic importance of epithelial-endothelial cross talk in maintaining alveolar integrity in ALI/ARDS...
  32. doi request reprint Systemic and cerebral inflammatory response to umbilical cord occlusions with worsening acidosis in the ovine fetus
    Andrew P Prout
    Department of Obstetrics and Gynecology, Lawson Health Research Institute, University of Western Ontario, London, Canada
    Am J Obstet Gynecol 202:82.e1-9. 2010
    ..We hypothesized that repetitive umbilical cord occlusions (UCOs) with worsening acidosis will lead to a fetal inflammatory response...
  33. ncbi request reprint Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A
    Jaret L Malloy
    Department of Physiology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Appl Physiol 92:809-16. 2002
    ..In addition, we did not detect a role for SP-A in regulating surfactant phospholipid pool sizes or pulmonary inflammation in septic mice...
  34. ncbi request reprint The future of surfactant therapy during ALI/ARDS
    James F Lewis
    St Joseph s Health Centre, University of Western Ontario, London, Ontario, Canada
    Semin Respir Crit Care Med 27:377-88. 2006
    ..This review discusses both the biophysical and host defense functions of surfactant in the context of novel therapeutic approaches for patients with ALI/ARDS...
  35. ncbi request reprint High-frequency oscillation and exogenous surfactant administration in lung-injured adult sheep
    Carolyn L Kerr
    Department of Physiology and Pharmacology, Lawson Health Research Institute, St Joseph s Health Centre, The University of Western Ontario, London, Canada
    Crit Care Med 31:2520-6. 2003
    ..To evaluate the effects of high-frequency oscillation on the response to exogenous surfactant in lung-injured adult sheep...
  36. ncbi request reprint Acute lung injury and lung transplantation influence in vitro subtype conversion of pulmonary surfactant
    Gayatri Maitra
    Medical Research Council Group in Fetal and Neonatal Health and Development, Department of Biochemistry and Obstetrics and Gynaecology, University of Western Ontario, London N6A 5A5, Ontario, Canada N6A 4V2
    Am J Physiol Lung Cell Mol Physiol 282:L67-74. 2002
    ..LA from all experimental groups had similar protein levels. These studies show acute lung injury, transplant, ischemia-reperfusion, and surfactant treatment have major effects on surfactant subtype integrity...
  37. doi request reprint IL-6 and TNFalpha across the umbilical circulation in term pregnancies: relationship with labour events
    Greg Duncombe
    Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, Canada
    Early Hum Dev 86:113-7. 2010
    ..We have determined venous and arterial cord blood levels for IL-6 and TNFalpha at the time of delivery to assess gestational tissue versus fetal sources in labouring and non-labouring patients at term, and the relationship to labour events...
  38. ncbi request reprint Effect of acute lung injury on structure and function of pulmonary surfactant films
    Amiya K Panda
    Department of Chemistry, Behala College, Kolkata, India
    Am J Respir Cell Mol Biol 30:641-50. 2004
    ....
  39. ncbi request reprint Pseudomonas aeruginosa protease IV degrades surfactant proteins and inhibits surfactant host defense and biophysical functions
    Jaret L Malloy
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 288:L409-18. 2005
    ..We speculate that protease IV may be an important contributing factor to the development and propagation of acute lung injury associated with P. aeruginosa via loss of surfactant function within the lung...
  40. ncbi request reprint Pre-emptive and continuous inhaled NO counteracts the cardiopulmonary consequences of extracorporeal circulation in a pig model
    Eric Troncy
    Unit of Anaesthesiology Pharmacology, Department of Veterinary Biomedicine, Faculty of Veterinary Medicine, Universite de Montreal, St Hyacinthe, Que, Canada
    Nitric Oxide 14:261-71. 2006
    ..We conclude from this study that the use of pre-emptive and continuous inhaled NO therapy has protective and safe effects against lung ischemia/reperfusion associated with CPB...
  41. ncbi request reprint Interleukin-6 has no effect on surfactant or lung function in different lung insults
    Tomoo Nakamura
    Department of Perinatal Medicine and Maternal Care, National Center for Children Health and Development, Tokyo, Japan
    Exp Lung Res 32:27-42. 2006
    ..These results suggest that IL-6 may have a limited role in the surfactant alterations observed in acute lung injury...
  42. ncbi request reprint Analyzing surfactant metabolism in humans: an important first step
    James F Lewis
    Am J Respir Crit Care Med 170:2-3. 2004