Research Topics
Species | Stephan F van EedenSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Interleukin 8 (IL-8) and the release of leukocytes from the bone marrowS F Van Eeden
Pulmonary Research Laboratory, University of British Columbia, St Pauls Hospital, Vancouver, Canada
Leuk Lymphoma 37:259-71. 2000..The mechanism for these effects of IL-8 is largely speculative. This report summarizes current ideas on the possible mechanisms how IL-8 influences cell trafficking in and from the bone marrow...- Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulationStephan F van Eeden
McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
J Toxicol Environ Health A 65:1597-613. 2002..We postulate that this systemic response to particulate air pollution augments lung inflammation and changes the phenotype of atherosclerotic plaques to make them more vulnerable to rupture... - Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary diseaseStephan F van Eeden
iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
Proc Am Thorac Soc 2:61-7. 2005..We speculate that this mechanism may contribute to the cardiovascular morbidity and mortality associated with COPD... - Chronic obstructive pulmonary disease: a chronic systemic inflammatory diseaseStephan F van Eeden
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
Respiration 75:224-38. 2008..This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects... - Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))S F Van Eeden
McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 164:826-30. 2001..We postulate that these cytokines induced a systemic response that has an important role in the pathogenesis of the cardiopulmonary adverse health effects associated with atmospheric pollution... 
Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitmentHiroshi Ishii
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
Respir Res 6:87. 2005....- Particulate matter air pollution stimulates monocyte release from the bone marrowYukinobu Goto
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
Am J Respir Crit Care Med 170:891-7. 2004..9 hours (p < 0.05), but supernatants of AM incubated with CC did not. We conclude that exposure to atmospheric PM(10) stimulates the production of mediators by AM, and these cytokines accelerate the monocyte release from the BM... - Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbitsYukinobu Goto
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, University of British Columbia, Vancouver, Canada
Am J Physiol Lung Cell Mol Physiol 287:L79-85. 2004..45, P <0.05). We conclude that atherosclerosis increases the release of monocytes from the BM, and PM(10) exposure accelerates this process in relation to the amount of particles phagocytosed by alveolar macrophages... - Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cellsNoriho Sakamoto
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
Toxicol Appl Pharmacol 225:134-41. 2007..The aim of the present study was to determine the nature and mechanism of calcium responses induced by PM(10) in HBECs and its relationship to cytokine synthesis... - Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaquesKazuhiro Yatera
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Saint Paul s Hospital, Vancouver, British Columbia, Canada
Am J Physiol Heart Circ Physiol 294:H944-53. 2008.... - Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)Hiroshi Ishii
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
Am J Physiol Lung Cell Mol Physiol 287:L176-83. 2004..We conclude that AM-derived TNF-alpha and IL-1 beta provide a major stimulus for the production of proinflammatory mediators by lung epithelial cells and that their relative importance may depend on the type of epithelial cell target... 
Diesel exhaust inhalation induces heat shock protein 70 expression in vivoTakashi Kido
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
Inhal Toxicol 23:593-601. 2011..Our results show that chronic inhalation of DE increases HSP70 expression in the lung and systemic circulation, and we postulate that HSP70 possibly contributes to air pollution induced vascular dysfunction and cardiovascular diseases...- Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrowTakeshi Fujii
McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, Canada
Am J Respir Cell Mol Biol 27:34-41. 2002..01). These results suggest that the interaction between AMs and HBECs during PM(10) exposure contributes to the production of mediators that induce a systemic inflammatory response... - Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulationEiji Tamagawa
Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, BC, Canada
Innate Immun 15:251-8. 2009..This murine model facilitates the estimation of cytokine translocation across the lungs and evaluation of compounds to modulate this gradient... - Particulate matter induces translocation of IL-6 from the lung to the systemic circulationTakashi Kido
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
Am J Respir Cell Mol Biol 44:197-204. 2011..These results support our hypothesis that exposure to PM(10) increases pulmonary inflammatory mediators that translocate to the circulation, contributing to systemic inflammation, with downstream effects such as vascular dysfunction... - Exposure to diesel exhaust upregulates COX-2 expression in ApoE knockout miceNi Bai
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
Inhal Toxicol 24:518-27. 2012..We hypothesize that exposure to DE upregulates cyclooxygenase (COX) expression and activity, which could play a role in DE-induced atherosclerosis... - Particulate matter exposure induces persistent lung inflammation and endothelial dysfunctionEiji Tamagawa
Division of Respiratory Medicine, University of British Columbia and James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
Am J Physiol Lung Cell Mol Physiol 295:L79-85. 2008..This suggests that PM-induced lung and systemic inflammatory responses contribute to the adverse vascular events associated with exposure to air pollution... - Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumoniaHisashi Suzuki
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Room 166, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada
Respir Res 9:25. 2008..Here we report the behavior of BM-derived lineage negative progenitor cells (Lin- PCs) during pneumococcal pneumonia using quantum dots (QDs), nanocrystal fluorescent probes as a cell-tracking technique... - Flow cytometric method for enumeration and characterization of newly released polymorphonuclear leukocytes from the bone marrow using 5'-bromo-2'-deoxyuridineChih-Horng Shih
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital-University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
Am J Physiol Cell Physiol 289:C757-65. 2005..We conclude that a flow cytometric approach for identifying BrdU-labeled leukocytes provides an objective and accurate method for studying leukocyte kinetics and behavior... - Novel properties of statins: suppression of the systemic and bone marrow responses induced by exposure to ambient particulate matter (PM(10)) air pollutionRyohei Miyata
UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, UK
Am J Physiol Lung Cell Mol Physiol 303:L492-9. 2012..01). We conclude that lovastatin downregulates the PM(10)-induced overactive bone marrow by attenuating PM(10)-induced systemic inflammatory responses... - Particulate air pollution induces progression of atherosclerosisTatsushi Suwa
McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada
J Am Coll Cardiol 39:935-42. 2002..CONCLUSIONS: Progression of atherosclerosis and increased vulnerability to plaque rupture may underlie the relationship between particulate air pollution and excess cardiovascular death... - Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cellsNoriho Sakamoto
University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
Int J Toxicol 28:17-23. 2009..It is concluded that statins can modulate the PM(10)-induced inflammatory response in the lung by reducing mediator production by AMs... - Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbitsErin M Tranfield
St Paul s Hospital, University of British Columbia, Vancouver
Can J Cardiol 26:e258-69. 2010..Epidemiological studies have established that cardiovascular events account for the greatest number of air pollution-related deaths. However, the underlying structural changes are still unknown... - Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary diseaseSean H Ling
James Hogg iCAPTURE Centre for Pulmonary and Cardiovascular Research and Heart and Lung Institute, University of British Columbia, Vancouver, British Columbia, Canada
Int J Chron Obstruct Pulmon Dis 4:233-43. 2009..This review focuses on the adverse effects of exposure to ambient PM air pollution on the exacerbation, progression, and development of COPD... - CCL23/myeloid progenitor inhibitory factor-1 inhibits production and release of polymorphonuclear leukocytes and monocytes from the bone marrowChih-Horng Shih
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada
Exp Hematol 33:1101-8. 2005..05). CONCLUSION: We conclude that CCL23 suppresses PMN and monocyte progenitors, decreases the pool size and slows their turnover in the bone marrow... - A novel method to quantify the turnover and release of monocytes from the bone marrow using the thymidine analog 5'-bromo-2'-deoxyuridineYukinobu Goto
McDonald Research Laboratory, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada V6Z1Y6
Am J Physiol Cell Physiol 285:C253-9. 2003..05). We conclude that this nonradioisotope method provides a novel way to monitor monocyte kinetics and confirmed previous reports that a focal pneumonia shortens monocyte marrow transit and increases their release into the circulation... - Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10Takeshi Fujii
McDonald Research Laboratory and iCAPTURE Center, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
Am J Physiol Lung Cell Mol Physiol 284:L290-7. 2003..We suggest that this amplified inflammatory response may contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease associated with exposure to particulate matter air pollution... - Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progressionSean H Ling
UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
Chest 140:1540-9. 2011..Particulate matter (PM) is present in lung tissues of smokers and urban dwellers. This study was designed to quantify the burden of PM in different lung tissues of subjects with COPD and determine its relationship to disease severity... - Monocyte recruitment into the lungs in pneumococcal pneumoniaYukinobu Goto
McDonald Research Laboratories and iCAPTURE Centre, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
Am J Respir Cell Mol Biol 30:620-6. 2004..9 +/- 0.5% versus 1.1 +/- 0.1%, P < 0.05). We conclude that immature monocytes released from the marrow by pneumonia sequester rapidly in lung microvessels but their migration in pneumonic airspaces is delayed... - The effect of interleukin-6 on L-selectin levels on polymorphonuclear leukocytesTatsushi Suwa
McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St. Paul's Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
Am J Physiol Heart Circ Physiol 283:H879-84. 2002..We postulate that this prolonged downregulation of L-selectin on circulating PMN could influence their recruitment into inflammatory sites... - Statins reduce ambient particulate matter-induced lung inflammation by promoting the clearance of particulate matter, < 10 μm from lung tissuesRyohei Miyata
UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, The University of British Columbia, Vancouver, BC
Chest 143:452-60. 2013..The aim of this study was to determine the effect of statins on PM(10) -induced lung inflammation in vivo... - The pharmacology of particulate matter air pollution-induced cardiovascular dysfunctionNi Bai
University of British Columbia, Department of Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Pharmacol Ther 113:16-29. 2007..This review summarizes current understanding of the mechanisms underlying the associations between PM(10) exposure and cardiovascular morbidity and mortality... - Neutrophil 'connectivity': key to neutrophil-mediated tissue injury?Salahaddin Mahmudi-Azer
Department of Medicine, University of British Columbia, U B C McDonald Research Laboratory and iCAPTURE Centre, St Paul s Hospital, Vancouver BC, Canada
Crit Care 7:285-7. 2003 - Ambient air particulates stimulate alveolar macrophages of smokers to promote differentiation of myeloid precursor cellsTatsushi Suwa
McDonald Research Laboratory, University of British Columbia, St Paul's Hospital, Vancouver, Canada
Exp Lung Res 28:1-18. 2002.... - The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matterRyohei Miyata
The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Toxicol Appl Pharmacol 257:209-26. 2011..PM drives AM towards a Th1 profile but secondary responses in a Th1- or Th-2 up-regulated milieu drive the response in favor of a Th2 profile... - Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout miceNi Bai
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
Toxicol Appl Pharmacol 255:184-92. 2011.... - Circulating white blood cells affect red cell pulmonary transit times in endurance athletes during intense exerciseGerald S Zavorsky
Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, BC, Canada
Med Sci Sports Exerc 34:954-9. 2002..5 min of exercise via a count-based ratio method from the MUGA technique...