Stephan F van Eeden

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Interleukin 8 (IL-8) and the release of leukocytes from the bone marrow
    S F Van Eeden
    Pulmonary Research Laboratory, University of British Columbia, St Pauls Hospital, Vancouver, Canada
    Leuk Lymphoma 37:259-71. 2000
  2. ncbi request reprint Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))
    S F Van Eeden
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:826-30. 2001
  3. ncbi request reprint Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease
    Stephan F van Eeden
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
    Respiration 75:224-38. 2008
  4. ncbi request reprint Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease
    Stephan F van Eeden
    iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Proc Am Thorac Soc 2:61-7. 2005
  5. ncbi request reprint Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation
    Stephan F van Eeden
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Toxicol Environ Health A 65:1597-613. 2002
  6. ncbi request reprint Particulate matter air pollution stimulates monocyte release from the bone marrow
    Yukinobu Goto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Am J Respir Crit Care Med 170:891-7. 2004
  7. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
  8. ncbi request reprint Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits
    Yukinobu Goto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L79-85. 2004
  9. ncbi request reprint Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
  10. ncbi request reprint Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L176-83. 2004

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Interleukin 8 (IL-8) and the release of leukocytes from the bone marrow
    S F Van Eeden
    Pulmonary Research Laboratory, University of British Columbia, St Pauls Hospital, Vancouver, Canada
    Leuk Lymphoma 37:259-71. 2000
    ..The mechanism for these effects of IL-8 is largely speculative. This report summarizes current ideas on the possible mechanisms how IL-8 influences cell trafficking in and from the bone marrow...
  2. ncbi request reprint Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))
    S F Van Eeden
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 164:826-30. 2001
    ..We postulate that these cytokines induced a systemic response that has an important role in the pathogenesis of the cardiopulmonary adverse health effects associated with atmospheric pollution...
  3. ncbi request reprint Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease
    Stephan F van Eeden
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
    Respiration 75:224-38. 2008
    ..This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects...
  4. ncbi request reprint Systemic response to ambient particulate matter: relevance to chronic obstructive pulmonary disease
    Stephan F van Eeden
    iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Proc Am Thorac Soc 2:61-7. 2005
    ..We speculate that this mechanism may contribute to the cardiovascular morbidity and mortality associated with COPD...
  5. ncbi request reprint Systemic inflammatory response induced by particulate matter air pollution: the importance of bone-marrow stimulation
    Stephan F van Eeden
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Toxicol Environ Health A 65:1597-613. 2002
    ..We postulate that this systemic response to particulate air pollution augments lung inflammation and changes the phenotype of atherosclerotic plaques to make them more vulnerable to rupture...
  6. ncbi request reprint Particulate matter air pollution stimulates monocyte release from the bone marrow
    Yukinobu Goto
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z1Y6 Canada
    Am J Respir Crit Care Med 170:891-7. 2004
    ..9 hours (p < 0.05), but supernatants of AM incubated with CC did not. We conclude that exposure to atmospheric PM(10) stimulates the production of mediators by AM, and these cytokines accelerate the monocyte release from the BM...
  7. pmc Alveolar macrophage-epithelial cell interaction following exposure to atmospheric particles induces the release of mediators involved in monocyte mobilization and recruitment
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    Respir Res 6:87. 2005
    ....
  8. ncbi request reprint Exposure to ambient particles accelerates monocyte release from bone marrow in atherosclerotic rabbits
    Yukinobu Goto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L79-85. 2004
    ..45, P <0.05). We conclude that atherosclerosis increases the release of monocytes from the BM, and PM(10) exposure accelerates this process in relation to the amount of particles phagocytosed by alveolar macrophages...
  9. ncbi request reprint Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells
    Noriho Sakamoto
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 225:134-41. 2007
    ..The aim of the present study was to determine the nature and mechanism of calcium responses induced by PM(10) in HBECs and its relationship to cytokine synthesis...
  10. ncbi request reprint Contribution of IL-1 beta and TNF-alpha to the initiation of the peripheral lung response to atmospheric particulates (PM10)
    Hiroshi Ishii
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L176-83. 2004
    ..We conclude that AM-derived TNF-alpha and IL-1 beta provide a major stimulus for the production of proinflammatory mediators by lung epithelial cells and that their relative importance may depend on the type of epithelial cell target...
  11. ncbi request reprint Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques
    Kazuhiro Yatera
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Saint Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Heart Circ Physiol 294:H944-53. 2008
    ....
  12. doi request reprint Diesel exhaust inhalation induces heat shock protein 70 expression in vivo
    Takashi Kido
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    Inhal Toxicol 23:593-601. 2011
    ..Our results show that chronic inhalation of DE increases HSP70 expression in the lung and systemic circulation, and we postulate that HSP70 possibly contributes to air pollution induced vascular dysfunction and cardiovascular diseases...
  13. ncbi request reprint Statins reduce ambient particulate matter-induced lung inflammation by promoting the clearance of particulate matter, < 10 μm from lung tissues
    Ryohei Miyata
    UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, The University of British Columbia, Vancouver, BC
    Chest 143:452-60. 2013
    ..The aim of this study was to determine the effect of statins on PM(10) -induced lung inflammation in vivo...
  14. ncbi request reprint Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 27:34-41. 2002
    ..01). These results suggest that the interaction between AMs and HBECs during PM(10) exposure contributes to the production of mediators that induce a systemic inflammatory response...
  15. doi request reprint Particulate matter induces translocation of IL-6 from the lung to the systemic circulation
    Takashi Kido
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 44:197-204. 2011
    ..These results support our hypothesis that exposure to PM(10) increases pulmonary inflammatory mediators that translocate to the circulation, contributing to systemic inflammation, with downstream effects such as vascular dysfunction...
  16. doi request reprint Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation
    Eiji Tamagawa
    Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, BC, Canada
    Innate Immun 15:251-8. 2009
    ..This murine model facilitates the estimation of cytokine translocation across the lungs and evaluation of compounds to modulate this gradient...
  17. doi request reprint Exposure to diesel exhaust upregulates COX-2 expression in ApoE knockout mice
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Inhal Toxicol 24:518-27. 2012
    ..We hypothesize that exposure to DE upregulates cyclooxygenase (COX) expression and activity, which could play a role in DE-induced atherosclerosis...
  18. pmc Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction
    Eiji Tamagawa
    Division of Respiratory Medicine, University of British Columbia and James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 295:L79-85. 2008
    ..This suggests that PM-induced lung and systemic inflammatory responses contribute to the adverse vascular events associated with exposure to air pollution...
  19. pmc Sequestration and homing of bone marrow-derived lineage negative progenitor cells in the lung during pneumococcal pneumonia
    Hisashi Suzuki
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St, Paul s Hospital, University of British Columbia, Room 166, 1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada
    Respir Res 9:25. 2008
    ..Here we report the behavior of BM-derived lineage negative progenitor cells (Lin- PCs) during pneumococcal pneumonia using quantum dots (QDs), nanocrystal fluorescent probes as a cell-tracking technique...
  20. ncbi request reprint Flow cytometric method for enumeration and characterization of newly released polymorphonuclear leukocytes from the bone marrow using 5'-bromo-2'-deoxyuridine
    Chih Horng Shih
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Cell Physiol 289:C757-65. 2005
    ..We conclude that a flow cytometric approach for identifying BrdU-labeled leukocytes provides an objective and accurate method for studying leukocyte kinetics and behavior...
  21. pmc Novel properties of statins: suppression of the systemic and bone marrow responses induced by exposure to ambient particulate matter (PM(10)) air pollution
    Ryohei Miyata
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, UK
    Am J Physiol Lung Cell Mol Physiol 303:L492-9. 2012
    ..01). We conclude that lovastatin downregulates the PM(10)-induced overactive bone marrow by attenuating PM(10)-induced systemic inflammatory responses...
  22. ncbi request reprint Particulate air pollution induces progression of atherosclerosis
    Tatsushi Suwa
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Am Coll Cardiol 39:935-42. 2002
    ..We sought to determine the effect of exposure to air pollution particulate matter <10 microm (PM(10)) on the progression of atherosclerosis in rabbits...
  23. pmc Particulate matter air pollution exposure: role in the development and exacerbation of chronic obstructive pulmonary disease
    Sean H Ling
    James Hogg iCAPTURE Centre for Pulmonary and Cardiovascular Research and Heart and Lung Institute, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Chron Obstruct Pulmon Dis 4:233-43. 2009
    ..This review focuses on the adverse effects of exposure to ambient PM air pollution on the exacerbation, progression, and development of COPD...
  24. pmc Ultrastructural changes in atherosclerotic plaques following the instillation of airborne particulate matter into the lungs of rabbits
    Erin M Tranfield
    St Paul s Hospital, University of British Columbia, Vancouver
    Can J Cardiol 26:e258-69. 2010
    ..Epidemiological studies have established that cardiovascular events account for the greatest number of air pollution-related deaths. However, the underlying structural changes are still unknown...
  25. doi request reprint Effect of atorvastatin on PM10-induced cytokine production by human alveolar macrophages and bronchial epithelial cells
    Noriho Sakamoto
    University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    Int J Toxicol 28:17-23. 2009
    ..It is concluded that statins can modulate the PM(10)-induced inflammatory response in the lung by reducing mediator production by AMs...
  26. ncbi request reprint CCL23/myeloid progenitor inhibitory factor-1 inhibits production and release of polymorphonuclear leukocytes and monocytes from the bone marrow
    Chih Horng Shih
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Exp Hematol 33:1101-8. 2005
    ..This study concerns in vivo inhibitory effect of CCL23 on production of polymorphonuclear leukocytes (PMNs) and monocytes in the bone marrow and their release into the circulation...
  27. ncbi request reprint Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10
    Takeshi Fujii
    McDonald Research Laboratory and iCAPTURE Center, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Physiol Lung Cell Mol Physiol 284:L290-7. 2003
    ..We suggest that this amplified inflammatory response may contribute to the pathogenesis of exacerbations of chronic obstructive pulmonary disease associated with exposure to particulate matter air pollution...
  28. ncbi request reprint A novel method to quantify the turnover and release of monocytes from the bone marrow using the thymidine analog 5'-bromo-2'-deoxyuridine
    Yukinobu Goto
    McDonald Research Laboratory, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada V6Z1Y6
    Am J Physiol Cell Physiol 285:C253-9. 2003
    ..05). We conclude that this nonradioisotope method provides a novel way to monitor monocyte kinetics and confirmed previous reports that a focal pneumonia shortens monocyte marrow transit and increases their release into the circulation...
  29. doi request reprint Patterns of retention of particulate matter in lung tissues of patients with COPD: potential role in disease progression
    Sean H Ling
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Chest 140:1540-9. 2011
    ..Particulate matter (PM) is present in lung tissues of smokers and urban dwellers. This study was designed to quantify the burden of PM in different lung tissues of subjects with COPD and determine its relationship to disease severity...
  30. ncbi request reprint Monocyte recruitment into the lungs in pneumococcal pneumonia
    Yukinobu Goto
    McDonald Research Laboratories and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 30:620-6. 2004
    ..9 +/- 0.5% versus 1.1 +/- 0.1%, P < 0.05). We conclude that immature monocytes released from the marrow by pneumonia sequester rapidly in lung microvessels but their migration in pneumonic airspaces is delayed...
  31. ncbi request reprint The effect of interleukin-6 on L-selectin levels on polymorphonuclear leukocytes
    Tatsushi Suwa
    McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada V6Z 1Y6
    Am J Physiol Heart Circ Physiol 283:H879-84. 2002
    ..We postulate that this prolonged downregulation of L-selectin on circulating PMN could influence their recruitment into inflammatory sites...
  32. ncbi request reprint The pharmacology of particulate matter air pollution-induced cardiovascular dysfunction
    Ni Bai
    University of British Columbia, Department of Pharmacology and Therapeutics, Faculty of Medicine, 2176 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
    Pharmacol Ther 113:16-29. 2007
    ..This review summarizes current understanding of the mechanisms underlying the associations between PM(10) exposure and cardiovascular morbidity and mortality...
  33. ncbi request reprint Ambient air particulates stimulate alveolar macrophages of smokers to promote differentiation of myeloid precursor cells
    Tatsushi Suwa
    McDonald Research Laboratory, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Exp Lung Res 28:1-18. 2002
    ....
  34. pmc Neutrophil 'connectivity': key to neutrophil-mediated tissue injury?
    Salahaddin Mahmudi-Azer
    Department of Medicine, University of British Columbia, U B C McDonald Research Laboratory and iCAPTURE Centre, St Paul s Hospital, Vancouver BC, Canada
    Crit Care 7:285-7. 2003
  35. doi request reprint The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter
    Ryohei Miyata
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 257:209-26. 2011
    ..PM drives AM towards a Th1 profile but secondary responses in a Th1- or Th-2 up-regulated milieu drive the response in favor of a Th2 profile...
  36. doi request reprint Exposure to diesel exhaust up-regulates iNOS expression in ApoE knockout mice
    Ni Bai
    Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada
    Toxicol Appl Pharmacol 255:184-92. 2011
    ....
  37. doi request reprint Circulating angiopoietin and Tie-2 levels in systemic sclerosis
    James V Dunne
    Department of Medicine, University of British Columbia, 700 West 57th Avenue, Vancouver, BC V6P 1S1, Canada
    Rheumatol Int 33:475-84. 2013
    ..The near doubling of the sAng-2/sTie-2 ratio in SSc cases compared to controls suggests a shift toward vascular regression and angiostasis perhaps caused by Ang-2 blocking the action of Tie-2...
  38. ncbi request reprint Circulating white blood cells affect red cell pulmonary transit times in endurance athletes during intense exercise
    Gerald S Zavorsky
    Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Vancouver, BC, Canada
    Med Sci Sports Exerc 34:954-9. 2002
    ..5 min of exercise via a count-based ratio method from the MUGA technique...