Research Topics
Genomes and Genes
| Derek van der KooySummaryAffiliation: University of Toronto Country: Canada Publications
| Collaborators
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Detail Information
Publications
Why stem cells?D van der Kooy
Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada
Science 287:1439-41. 2000..Surprisingly, recent reports suggest that tissue-specific adult stem cells have the potential to contribute to replenishment of multiple adult tissues...
E-Cadherin regulates neural stem cell self-renewalPhillip Karpowicz
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
J Neurosci 29:3885-96. 2009..These data show the importance of E-Cadherin in the neural stem cell niche and suggest E-Cadherin regulates the number of these cells...- Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineageWado Akamatsu
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S3E1
J Neurosci 29:2113-24. 2009..Thus, the suppression of Oct4 by GCNF is important for the transition from primitive to definitive neural stem cells and restriction of the non-neural competency in the early neural stem cell lineage... 
Maximizing functional photoreceptor differentiation from adult human retinal stem cellsTomoyuki Inoue
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Stem Cells 28:489-500. 2010..This study suggests that gene modulation in human RSCs may provide a source of photoreceptor cells for the treatment of photoreceptor disease...- Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine rewardAndrew Heinmiller
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Behav Neurosci 123:145-55. 2009..These results provide positive evidence for GABA-B and glutamate synapses in the TPP, which mediates systemic morphine reward and suggest that a serial pathway for morphine reward in the TPP is unlikely... - Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegansDavid Tsui
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
Learn Mem 15:844-55. 2008..We propose that associative learning may selectively modify pathways at or downstream from a low-affinity olfactory receptor... - Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterationsCindi M Morshead
Department of Surgery, University of Toronto, Toronto, Ontario, Canada
Nat Med 8:268-73. 2002.... - In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cordDavid J Martens
Department of Anatomy and Cell Biology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
Eur J Neurosci 16:1045-57. 2002.... - Don't look: growing clonal versus nonclonal neural stem cell coloniesBrenda L K Coles-Takabe
Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Stem Cells 26:2938-44. 2008..Disclosure of potential conflicts of interest is found at the end of this article... - Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotencyPhillip Karpowicz
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
J Neurosci 27:5437-47. 2007..These adhesive differences suggest an evolving compartmentalization in multipotent NSCs during development and serve to illustrate the importance of cell-cell association for revealing cellular contribution... - Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survivalTamaki Wada
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
J Neurosci 26:6803-12. 2006..In conclusion, VEGF-A function through Flk1 mediates survival (and not proliferative or fate change) effects on NSCs, specifically... - Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugsTod E Kippin
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
J Neurosci 25:5815-23. 2005..These findings demonstrate a direct link between neural activity and NSC proliferation and implicate cell genesis in antipsychotic drug effects... - Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterizationJames W Rowland
Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Center, University Health Network, Toronto, Ontario, Canada
Stem Cells Dev 20:1829-45. 2011.... - β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationshipMargot E Arntfield
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Bioessays 33:582-7. 2011 - The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cellsLaura Clarke
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Stem Cells 29:1448-58. 2011..We propose that there are separate glial and neuronal clones in the adult hippocampus, with glial progenitors being the most proliferative in culture... - A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouseClaudia M C Batista
Neurobiology Research Group, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
J Neurosci 26:10452-60. 2006..Our findings demonstrate that HD damage recruits precursor cells in two ways: expansion of neural stem cells and altered migration of progenitor cells... - Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cellsSeiji Hitoshi
Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Genes Dev 16:846-58. 2002..These data are consistent with a role for Notch signaling in the maintenance of the neural stem cell, and inconsistent with a role in a neuronal/glial fate switch... - Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathwaysLaura Clarke
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
Stem Cells 27:1879-86. 2009..Low-oxygen concentrations may be involved in expansion of early NSC populations by inhibiting cell death through different pathways in these sequential pNSC and dNSC populations... - The germline stem cells of Drosophila melanogaster partition DNA non-randomlyPhillip Karpowicz
Department of Medical Genetics and Microbiology, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1
Eur J Cell Biol 88:397-408. 2009..Our data suggest asymmetric chromatid segregation is coupled to mechanisms specifying cellular differentiation via asymmetric stem cell division... - Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influencesSimon R Smukler
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
J Cell Biol 172:79-90. 2006.... - Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult miceKatherine G Akers
Neurosciences and Mental Health, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Mol Brain 4:29. 2011..Here, we used a mouse model of fetal alcohol exposure to investigate relationships between brain abnormalities and specific behavioral alterations during adulthood... - Functional coordination of alternative splicing in the mammalian central nervous systemMatthew Fagnani
Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada, M5S 3E1
Genome Biol 8:R108. 2007..However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood... - Facile isolation and the characterization of human retinal stem cellsBrenda L K Coles
Departments of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8
Proc Natl Acad Sci U S A 101:15772-7. 2004..Their facile isolation, integration, and differentiation suggest that human RSCs eventually may be valuable in treating human retinal diseases... - GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate stateSteven R Laviolette
Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8
Eur J Neurosci 20:2179-87. 2004..These findings suggest that GABAA receptors in the VTA can regulate differential reward signalling through separate neural systems during the transition from a drug-naive to a drug-dependent and withdrawn state... - Generation and clonal isolation of retinal stem cells from human embryonic stem cellsLaura Clarke
Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
Eur J Neurosci 36:1951-9. 2012..We show that RSCs emerge in an in vitro model of retinal development and are a potential source of human photoreceptors for use in transplantation... - A genetic dissociation of learning and recall in Caenorhabditis elegansKaren Atkinson-Leadbeater
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
Behav Neurosci 118:1206-13. 2004..Therefore, the CB4856 strain does not have an acquisition deficit, but it suffers from a recall deficit specific to benzaldehyde... - DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphineHai Ying M Cheng
Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
Eur J Neurosci 19:3033-41. 2004..Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice... - Subretinal gene delivery using helper-dependent adenoviral vectorsLinda Wu
Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada
Cell Biosci 1:15. 2011..Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector... - It is ethical to transplant human stem cells into nonhuman embryosPhillip Karpowicz
Institute of Medical Science, Toronto, Ontario, Canada
Nat Med 10:331-5. 2004 - Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brainSeiji Hitoshi
Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
Development 129:233-44. 2002..Thus, neural stem cells and their progeny are regionally specified in the developing brain, but this regional identity can be altered by local inductive cues...