Derek van der Kooy

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors
    Brian G Ballios
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Biol Open 1:237-46. 2012
  2. ncbi Why stem cells?
    D van der Kooy
    Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada
    Science 287:1439-41. 2000
  3. doi Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward
    Andrew Heinmiller
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 123:145-55. 2009
  4. pmc Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine
    Taryn E Grieder
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 35:943-54. 2010
  5. doi GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol
    Ryan Ting-A-Kee
    Institute of Medical Science, University of Toronto, ON, Canada
    Eur J Neurosci 29:1235-44. 2009
  6. pmc Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats
    Hector Vargas-Perez
    Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Science 324:1732-4. 2009
  7. ncbi Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche
    Tania O Alexson
    Neurobiology Research Group, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Dev Neurosci 28:34-48. 2006
  8. doi Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15
    Laurie Sellings
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 37:743-56. 2013
  9. doi Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons
    Schreiber Pereira
    Department of Molecular Genetics, Faculty of Medicine, and The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    J Neurosci 32:9035-44. 2012
  10. ncbi A test of the opponent-process theory of motivation using lesions that selectively block morphine reward
    Hector Vargas-Perez
    Department of Medical Genetics and Microbiology, University of Toronto, Canada
    Eur J Neurosci 25:3713-8. 2007

Detail Information

Publications70

  1. pmc The adult retinal stem cell is a rare cell in the ciliary epithelium whose progeny can differentiate into photoreceptors
    Brian G Ballios
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Biol Open 1:237-46. 2012
    ..These results demonstrate that the RSC, an adult stem cell, can be enriched and directed to produce photoreceptors as a first step toward a targeted cell replacement strategy to treat retinal degenerative disease...
  2. ncbi Why stem cells?
    D van der Kooy
    Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada
    Science 287:1439-41. 2000
    ..Surprisingly, recent reports suggest that tissue-specific adult stem cells have the potential to contribute to replenishment of multiple adult tissues...
  3. doi Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward
    Andrew Heinmiller
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 123:145-55. 2009
    ..These results provide positive evidence for GABA-B and glutamate synapses in the TPP, which mediates systemic morphine reward and suggest that a serial pathway for morphine reward in the TPP is unlikely...
  4. pmc Dopaminergic signaling mediates the motivational response underlying the opponent process to chronic but not acute nicotine
    Taryn E Grieder
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Neuropsychopharmacology 35:943-54. 2010
    ..We suggest that the alleviation of nicotine withdrawal primarily may be driving nicotine motivation in dependent animals...
  5. doi GABA(A) receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol
    Ryan Ting-A-Kee
    Institute of Medical Science, University of Toronto, ON, Canada
    Eur J Neurosci 29:1235-44. 2009
    ..The opposite effects of ethanol and opiates can be explained by their proposed actions through a common VTA GABA(A) receptor switching mechanism...
  6. pmc Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats
    Hector Vargas-Perez
    Department of Molecular Genetics, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Science 324:1732-4. 2009
    ..This shift involves a switch in the gamma-aminobutyric acid type A (GABAA) receptors of VTA GABAergic neurons, from inhibitory to excitatory signaling...
  7. ncbi Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche
    Tania O Alexson
    Neurobiology Research Group, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Dev Neurosci 28:34-48. 2006
    ..Regardless, these findings demonstrate that PS1, and presumably Notch signaling, is required to maintain all NSCs...
  8. doi Nicotine-motivated behavior in Caenorhabditis elegans requires the nicotinic acetylcholine receptor subunits acr-5 and acr-15
    Laurie Sellings
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 37:743-56. 2013
    ....
  9. doi Two forms of learning following training to a single odorant in Caenorhabditis elegans AWC neurons
    Schreiber Pereira
    Department of Molecular Genetics, Faculty of Medicine, and The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    J Neurosci 32:9035-44. 2012
    ....
  10. ncbi A test of the opponent-process theory of motivation using lesions that selectively block morphine reward
    Hector Vargas-Perez
    Department of Medical Genetics and Microbiology, University of Toronto, Canada
    Eur J Neurosci 25:3713-8. 2007
    ....
  11. pmc Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells
    Sandrine Willaime-Morawek
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Cell Biol 175:159-68. 2006
    ..This demonstrates the existence of a novel dorsal-to-ventral migration of neural stem cells in the perinatal forebrain...
  12. ncbi The adult mouse and human pancreas contain rare multipotent stem cells that express insulin
    Simon R Smukler
    Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada
    Cell Stem Cell 8:281-93. 2011
    ..These findings demonstrate that the adult mammalian pancreas contains a population of insulin(+) multipotent stem cells and suggest that these cells may provide a promising line of investigation toward potential therapeutic benefit...
  13. pmc Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner
    Ryan Ting-A-Kee
    Institute of Medical Science, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, M5S 3E1, Canada
    Behav Brain Res 247:174-7. 2013
    ....
  14. pmc Support for the immortal strand hypothesis: neural stem cells partition DNA asymmetrically in vitro
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Toronto, M5R 1A8, Canada
    J Cell Biol 170:721-32. 2005
    ..We demonstrate that NSCs are unique among precursor cells in the uneven partitioning of genetic material during cell divisions...
  15. doi E-Cadherin regulates neural stem cell self-renewal
    Phillip Karpowicz
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 29:3885-96. 2009
    ..These data show the importance of E-Cadherin in the neural stem cell niche and suggest E-Cadherin regulates the number of these cells...
  16. pmc p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
    Tod E Kippin
    Neurobiology Research Group, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 19:756-67. 2005
    ..Thus, p21 contributes to adult NSC relative quiescence, which we propose is necessary for the life-long maintenance of NSC self-renewal because NSCs may be limited to a finite number of divisions...
  17. doi Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage
    Wado Akamatsu
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S3E1
    J Neurosci 29:2113-24. 2009
    ..Thus, the suppression of Oct4 by GCNF is important for the transition from primitive to definitive neural stem cells and restriction of the non-neural competency in the early neural stem cell lineage...
  18. doi Neural stem cells are increased after loss of β-catenin, but neural progenitors undergo cell death
    Tamara Holowacz
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Canada
    Eur J Neurosci 33:1366-75. 2011
    ..These data reveal that β-catenin is not required for the maintenance or differentiation of NSCs, but is required for the adhesion and survival of neural progenitor cells...
  19. ncbi GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8
    Eur J Neurosci 20:2179-87. 2004
    ..These findings suggest that GABAA receptors in the VTA can regulate differential reward signalling through separate neural systems during the transition from a drug-naive to a drug-dependent and withdrawn state...
  20. pmc Generation and clonal isolation of retinal stem cells from human embryonic stem cells
    Laura Clarke
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
    Eur J Neurosci 36:1951-9. 2012
    ..We show that RSCs emerge in an in vitro model of retinal development and are a potential source of human photoreceptors for use in transplantation...
  21. pmc The proliferation and expansion of retinal stem cells require functional Pax6
    Shunbin Xu
    Department of Medical Genetics and Microbiology, University of Toronto, and Program in Developmental Biology and Genetics, Research Institute, Hospital for Sick Children, Canada
    Dev Biol 304:713-21. 2007
    ..In vitro clonal inactivation of Pax6 in adult RSCs results in a serious proliferation defect, suggesting that Pax6 is required for the proliferation and expansion of RSCs...
  22. pmc Maximizing functional photoreceptor differentiation from adult human retinal stem cells
    Tomoyuki Inoue
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 28:489-500. 2010
    ..This study suggests that gene modulation in human RSCs may provide a source of photoreceptor cells for the treatment of photoreceptor disease...
  23. pmc Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal
    Taryn E Grieder
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada M5S 3E1
    Proc Natl Acad Sci U S A 109:3101-6. 2012
    ....
  24. doi Infusion of brain-derived neurotrophic factor into the ventral tegmental area switches the substrates mediating ethanol motivation
    Ryan Ting-A-Kee
    Institute of Medical Science, University of Toronto, Toronto, ON, M5S 3E1, Canada
    Eur J Neurosci 37:996-1003. 2013
    ..The opposite switching of the mechanisms underlying morphine and ethanol motivation by BDNF in previously non-deprived animals is consistent with their proposed actions on VTA GABAA receptors...
  25. ncbi The ablation of glial fibrillary acidic protein-positive cells from the adult central nervous system results in the loss of forebrain neural stem cells but not retinal stem cells
    Cindi M Morshead
    Department of Surgery, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Eur J Neurosci 18:76-84. 2003
    ..Exposure to GCV in vitro has no effect on adult retinal stem cells hence, we conclude that adult forebrain NSCs comprise a subpopulation of the GFAP-positive cells within the subependyma...
  26. ncbi Loss of retinal progenitor cells leads to an increase in the retinal stem cell population in vivo
    Brenda L K Coles
    Department of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, M5S 1A8, Canada
    Eur J Neurosci 23:75-82. 2006
    ..These findings suggest that the mammalian retinal stem cell population may be capable of responding to genetically induced signals from the progenitor populations...
  27. pmc Adenosine A1 and A2A receptors are not upstream of caffeine's dopamine D2 receptor-dependent aversive effects and dopamine-independent rewarding effects
    Jessica E Sturgess
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Eur J Neurosci 32:143-54. 2010
    ....
  28. ncbi Intrinsic differences distinguish transiently neurogenic progenitors from neural stem cells in the early postnatal brain
    Raewyn M Seaberg
    Department of Medical Genetics and Microbiology, 1 King s College Circle, Rm 1105, Medical Sciences Building, University of Toronto, Toronto, Canada M5S 1A8
    Dev Biol 278:71-85. 2005
    ..These differences are evident in vitro and in vivo...
  29. ncbi Bone morphogenetic proteins and secreted frizzled related protein 2 maintain the quiescence of adult mammalian retinal stem cells
    Laurent Balenci
    Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research University of Toronto, Toronto, Ontario, Canada
    Stem Cells 31:2218-30. 2013
    ..As a similar induced quiescence was observed in vitro on both mouse and human RSCs, targeting these molecules in vivo may reactivate RSCs directly in situ in the eyes of the blind...
  30. ncbi Insulin signaling plays a dual role in Caenorhabditis elegans memory acquisition and memory retrieval
    Chia Hsun Anthony Lin
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 30:8001-11. 2010
    ....
  31. doi Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans
    David Tsui
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Learn Mem 15:844-55. 2008
    ..We propose that associative learning may selectively modify pathways at or downstream from a low-affinity olfactory receptor...
  32. pmc The asymmetric segregation of damaged proteins is stem cell-type dependent
    Mary Rose Bufalino
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    J Cell Biol 201:523-30. 2013
    ..Furthermore, we reveal a role for both niche-dependent and -independent mechanisms of asymmetric DP division...
  33. ncbi In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord
    David J Martens
    Department of Anatomy and Cell Biology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Eur J Neurosci 16:1045-57. 2002
    ....
  34. doi β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship
    Margot E Arntfield
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Bioessays 33:582-7. 2011
  35. ncbi The motivational valence of nicotine in the rat ventral tegmental area is switched from rewarding to aversive following blockade of the alpha7-subunit-containing nicotinic acetylcholine receptor
    Steven R Laviolette
    Department of Anatomy and Cell Biology, Neurobiology Research Group, University of Toronto, 1 King s College Circle, M5S 1A8, Toronto, Ontario, Canada
    Psychopharmacology (Berl) 166:306-13. 2003
    ..However, the specific neuronal nicotinic acetylcholine receptor (nAChR) subtypes responsible for these effects are not clearly understood...
  36. pmc Ventral tegmental area GABA neurons and opiate motivation
    Ryan Ting-A-Kee
    Institute of Medical Science, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada
    Psychopharmacology (Berl) 227:697-709. 2013
    ..Interestingly, a corresponding change is observed in ventral tegmental area (VTA) GABAA receptors, which change from mediating hyperpolarization of VTA GABA neurons to mediating depolarization...
  37. pmc The generation of definitive neural stem cells from PiggyBac transposon-induced pluripotent stem cells can be enhanced by induction of the NOTCH signaling pathway
    Ryan P Salewski
    Division of Genetics and Development, Toronto Western Research Institute, Toronto, Canada
    Stem Cells Dev 22:383-96. 2013
    ..This study suggests the intrinsic differences between ESCs and iPSCs in their ability to acquire a dNSC fate that can be overcome by inducing the NOTCH pathway...
  38. doi Clonal neural stem cells from human embryonic stem cell colonies
    Radha Chaddah
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    J Neurosci 32:7771-81. 2012
    ..This clonal culture method can be scaled up to produce NSCs for differentiation and use in cell therapies...
  39. ncbi Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival
    Tamaki Wada
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:6803-12. 2006
    ..In conclusion, VEGF-A function through Flk1 mediates survival (and not proliferative or fate change) effects on NSCs, specifically...
  40. ncbi DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine
    Hai Ying M Cheng
    Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur J Neurosci 19:3033-41. 2004
    ..Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice...
  41. doi Different neural systems mediate morphine reward and its spontaneous withdrawal aversion
    Hector Vargas-Perez
    Department of Molecular Genetics, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Eur J Neurosci 29:2029-34. 2009
    ..However, the TPP does not directly mediate the spontaneous withdrawal aversion (the opponent process), suggesting that a different system, triggered by the changes in the TPP after the primary drug response, produces the aversion itself...
  42. doi The adult mammalian pancreas contains separate precursors of pancreatic and neural crest developmental origins
    Margot Arntfield
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells Dev 22:2145-57. 2013
    ..This evidence suggests that there are at least two distinct types of precursors present in adult pancreatic islets, one of pancreatic origin and one of neural crest origin...
  43. ncbi A diacetyl-induced quiescence in young Caenorhabditis elegans
    Maria Christina Hoffmann
    Department of Molecular Genetics, University of Toronto, Toronto, M5S 3E1, Canada
    Behav Brain Res 214:12-7. 2010
    ..This quiescent behavior represents an alternative use of olfactory signaling pathways besides approach or avoidance, and is a novel model in which to characterize genes implicated in quiescence...
  44. doi Cortex- and striatum- derived neural stem cells produce distinct progeny in the olfactory bulb and striatum
    Sandrine Willaime-Morawek
    Department of Molecular Genetics, University of Toronto, CCBR, Toronto, ON, Canada
    Eur J Neurosci 27:2354-62. 2008
    ..Thus, history matters; cortex-derived neural stem cells in the subependyma give rise to progeny in the olfactory bulb and striatum but in different proportions than striatum-derived neural stem cells...
  45. ncbi Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 27:5437-47. 2007
    ..These adhesive differences suggest an evolving compartmentalization in multipotent NSCs during development and serve to illustrate the importance of cell-cell association for revealing cellular contribution...
  46. ncbi Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Canada
    Nat Neurosci 7:160-9. 2004
    ..After opiate exposure and subsequent withdrawal, the functional conductance properties of the rat VTA GABA(A) receptor switch from an inhibitory to an excitatory signaling mode...
  47. pmc Oct4 is required ~E7.5 for proliferation in the primitive streak
    Brian DeVeale
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 9:e1003957. 2013
    ..Impaired expansion of the primitive streak occurs coincident with Oct4 depletion ∼E7.5 and precedes deficient convergent extension which contributes to several aspects of the phenotype...
  48. doi Don't look: growing clonal versus nonclonal neural stem cell colonies
    Brenda L K Coles-Takabe
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 26:2938-44. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  49. ncbi Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs
    Tod E Kippin
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:5815-23. 2005
    ..These findings demonstrate a direct link between neural activity and NSC proliferation and implicate cell genesis in antipsychotic drug effects...
  50. ncbi Developing human-nonhuman chimeras in human stem cell research: ethical issues and boundaries
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Ontario, Canada
    Kennedy Inst Ethics J 15:107-34. 2005
    ..The article provides guidelines that set ethical boundaries for conducting such research that are consonant with the requirements of human dignity...
  51. ncbi A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse
    Claudia M C Batista
    Neurobiology Research Group, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:10452-60. 2006
    ..Our findings demonstrate that HD damage recruits precursor cells in two ways: expansion of neural stem cells and altered migration of progenitor cells...
  52. pmc Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences
    Simon R Smukler
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Cell Biol 172:79-90. 2006
    ....
  53. doi Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization
    James W Rowland
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Center, University Health Network, Toronto, Ontario, Canada
    Stem Cells Dev 20:1829-45. 2011
    ....
  54. doi Regulation of vertebrate nervous system alternative splicing and development by an SR-related protein
    John A Calarco
    Banting and Best Department of Medical Research, Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Cell 138:898-910. 2009
    ..Our results thus reveal a critical neural-specific alternative splicing regulator, the evolution of which has contributed to increased complexity in the vertebrate nervous system...
  55. pmc Facile isolation and the characterization of human retinal stem cells
    Brenda L K Coles
    Departments of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:15772-7. 2004
    ..Their facile isolation, integration, and differentiation suggest that human RSCs eventually may be valuable in treating human retinal diseases...
  56. ncbi Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations
    Cindi M Morshead
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Nat Med 8:268-73. 2002
    ....
  57. ncbi Contextual taste cues modulate olfactory learning in C. elegans by an occasion-setting mechanism
    Eric Law
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Curr Biol 14:1303-8. 2004
    ..We interpret these results as evidence for the occasion-setting mechanism in which context cues modulate primary Pavlovian association by functioning in a hierarchical manner to define the appropriate setting for memory recall...
  58. doi Surfaceome profiling reveals regulators of neural stem cell function
    Brian DeVeale
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 32:258-68. 2014
    ..This work elucidates several key mediators of NSC function whose relevance is confirmed on forebrain-derived populations and identifies a host of other candidates that may regulate NSCs...
  59. doi A hydrogel-based stem cell delivery system to treat retinal degenerative diseases
    Brian G Ballios
    Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Biomaterials 31:2555-64. 2010
    ....
  60. pmc Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice
    Katherine G Akers
    Neurosciences and Mental Health, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Mol Brain 4:29. 2011
    ..Here, we used a mouse model of fetal alcohol exposure to investigate relationships between brain abnormalities and specific behavioral alterations during adulthood...
  61. doi The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells
    Laura Clarke
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 29:1448-58. 2011
    ..We propose that there are separate glial and neuronal clones in the adult hippocampus, with glial progenitors being the most proliferative in culture...
  62. doi Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse
    Laura K K Pacey
    Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Canada
    Mol Cell Neurosci 46:563-72. 2011
    ..These findings suggest that tissue and cell-type specific differences in GPCR signaling and RGS function may contribute to the spectrum of phenotypic differences observed in FXS...
  63. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002
    ..These data are consistent with a role for Notch signaling in the maintenance of the neural stem cell, and inconsistent with a role in a neuronal/glial fate switch...
  64. pmc Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways
    Laura Clarke
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 27:1879-86. 2009
    ..Low-oxygen concentrations may be involved in expansion of early NSC populations by inhibiting cell death through different pathways in these sequential pNSC and dNSC populations...
  65. doi The germline stem cells of Drosophila melanogaster partition DNA non-randomly
    Phillip Karpowicz
    Department of Medical Genetics and Microbiology, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1
    Eur J Cell Biol 88:397-408. 2009
    ..Our data suggest asymmetric chromatid segregation is coupled to mechanisms specifying cellular differentiation via asymmetric stem cell division...
  66. pmc Functional coordination of alternative splicing in the mammalian central nervous system
    Matthew Fagnani
    Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada, M5S 3E1
    Genome Biol 8:R108. 2007
    ..However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood...
  67. pmc Subretinal gene delivery using helper-dependent adenoviral vectors
    Linda Wu
    Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada
    Cell Biosci 1:15. 2011
    ..Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector...
  68. ncbi Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 129:233-44. 2002
    ..Thus, neural stem cells and their progeny are regionally specified in the developing brain, but this regional identity can be altered by local inductive cues...
  69. ncbi It is ethical to transplant human stem cells into nonhuman embryos
    Phillip Karpowicz
    Institute of Medical Science, Toronto, Ontario, Canada
    Nat Med 10:331-5. 2004
  70. ncbi A genetic dissociation of learning and recall in Caenorhabditis elegans
    Karen Atkinson-Leadbeater
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 118:1206-13. 2004
    ..Therefore, the CB4856 strain does not have an acquisition deficit, but it suffers from a recall deficit specific to benzaldehyde...