Derek van der Kooy

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Why stem cells?
    D van der Kooy
    Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada
    Science 287:1439-41. 2000
  2. doi E-Cadherin regulates neural stem cell self-renewal
    Phillip Karpowicz
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 29:3885-96. 2009
  3. doi Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage
    Wado Akamatsu
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S3E1
    J Neurosci 29:2113-24. 2009
  4. pmc Maximizing functional photoreceptor differentiation from adult human retinal stem cells
    Tomoyuki Inoue
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 28:489-500. 2010
  5. doi Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward
    Andrew Heinmiller
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 123:145-55. 2009
  6. doi Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans
    David Tsui
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Learn Mem 15:844-55. 2008
  7. ncbi In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord
    David J Martens
    Department of Anatomy and Cell Biology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Eur J Neurosci 16:1045-57. 2002
  8. doi Don't look: growing clonal versus nonclonal neural stem cell colonies
    Brenda L K Coles-Takabe
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 26:2938-44. 2008
  9. ncbi Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 27:5437-47. 2007
  10. ncbi Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival
    Tamaki Wada
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:6803-12. 2006

Collaborators

Detail Information

Publications31

  1. ncbi Why stem cells?
    D van der Kooy
    Department of Anatomy and Cell Biology, University of Toronto Faculty of Medicine, Toronto, Ontario, M5S 1A8 Canada
    Science 287:1439-41. 2000
    ..Surprisingly, recent reports suggest that tissue-specific adult stem cells have the potential to contribute to replenishment of multiple adult tissues...
  2. doi E-Cadherin regulates neural stem cell self-renewal
    Phillip Karpowicz
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    J Neurosci 29:3885-96. 2009
    ..These data show the importance of E-Cadherin in the neural stem cell niche and suggest E-Cadherin regulates the number of these cells...
  3. doi Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage
    Wado Akamatsu
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada M5S3E1
    J Neurosci 29:2113-24. 2009
    ..Thus, the suppression of Oct4 by GCNF is important for the transition from primitive to definitive neural stem cells and restriction of the non-neural competency in the early neural stem cell lineage...
  4. pmc Maximizing functional photoreceptor differentiation from adult human retinal stem cells
    Tomoyuki Inoue
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 28:489-500. 2010
    ..This study suggests that gene modulation in human RSCs may provide a source of photoreceptor cells for the treatment of photoreceptor disease...
  5. doi Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward
    Andrew Heinmiller
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 123:145-55. 2009
    ..These results provide positive evidence for GABA-B and glutamate synapses in the TPP, which mediates systemic morphine reward and suggest that a serial pathway for morphine reward in the TPP is unlikely...
  6. doi Serotonin mediates a learned increase in attraction to high concentrations of benzaldehyde in aged C. elegans
    David Tsui
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
    Learn Mem 15:844-55. 2008
    ..We propose that associative learning may selectively modify pathways at or downstream from a low-affinity olfactory receptor...
  7. ncbi In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord
    David J Martens
    Department of Anatomy and Cell Biology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Eur J Neurosci 16:1045-57. 2002
    ....
  8. doi Don't look: growing clonal versus nonclonal neural stem cell colonies
    Brenda L K Coles-Takabe
    Departments of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 26:2938-44. 2008
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  9. ncbi Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 27:5437-47. 2007
    ..These adhesive differences suggest an evolving compartmentalization in multipotent NSCs during development and serve to illustrate the importance of cell-cell association for revealing cellular contribution...
  10. ncbi Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival
    Tamaki Wada
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:6803-12. 2006
    ..In conclusion, VEGF-A function through Flk1 mediates survival (and not proliferative or fate change) effects on NSCs, specifically...
  11. ncbi Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations
    Cindi M Morshead
    Department of Surgery, University of Toronto, Toronto, Ontario, Canada
    Nat Med 8:268-73. 2002
    ....
  12. doi Generation of neural stem cells from embryonic stem cells using the default mechanism: in vitro and in vivo characterization
    James W Rowland
    Division of Genetics and Development, Toronto Western Research Institute and Krembil Neuroscience Center, University Health Network, Toronto, Ontario, Canada
    Stem Cells Dev 20:1829-45. 2011
    ....
  13. ncbi Dopamine specifically inhibits forebrain neural stem cell proliferation, suggesting a novel effect of antipsychotic drugs
    Tod E Kippin
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Neurosci 25:5815-23. 2005
    ..These findings demonstrate a direct link between neural activity and NSC proliferation and implicate cell genesis in antipsychotic drug effects...
  14. doi β-Cell evolution: How the pancreas borrowed from the brain: The shared toolbox of genes expressed by neural and pancreatic endocrine cells may reflect their evolutionary relationship
    Margot E Arntfield
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Bioessays 33:582-7. 2011
  15. ncbi A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse
    Claudia M C Batista
    Neurobiology Research Group, Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:10452-60. 2006
    ..Our findings demonstrate that HD damage recruits precursor cells in two ways: expansion of neural stem cells and altered migration of progenitor cells...
  16. doi The adult mouse dentate gyrus contains populations of committed progenitor cells that are distinct from subependymal zone neural stem cells
    Laura Clarke
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 29:1448-58. 2011
    ..We propose that there are separate glial and neuronal clones in the adult hippocampus, with glial progenitors being the most proliferative in culture...
  17. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002
    ..These data are consistent with a role for Notch signaling in the maintenance of the neural stem cell, and inconsistent with a role in a neuronal/glial fate switch...
  18. pmc Embryonic stem cells assume a primitive neural stem cell fate in the absence of extrinsic influences
    Simon R Smukler
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    J Cell Biol 172:79-90. 2006
    ....
  19. doi The germline stem cells of Drosophila melanogaster partition DNA non-randomly
    Phillip Karpowicz
    Department of Medical Genetics and Microbiology, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1
    Eur J Cell Biol 88:397-408. 2009
    ..Our data suggest asymmetric chromatid segregation is coupled to mechanisms specifying cellular differentiation via asymmetric stem cell division...
  20. pmc Low oxygen enhances primitive and definitive neural stem cell colony formation by inhibiting distinct cell death pathways
    Laura Clarke
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
    Stem Cells 27:1879-86. 2009
    ..Low-oxygen concentrations may be involved in expansion of early NSC populations by inhibiting cell death through different pathways in these sequential pNSC and dNSC populations...
  21. pmc Dopamine D1 receptors are not critical for opiate reward but can mediate opiate memory retrieval in a state-dependent manner
    Ryan Ting-A-Kee
    Institute of Medical Science, University of Toronto, Terrence Donnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, M5S 3E1, Canada
    Behav Brain Res 247:174-7. 2013
    ....
  22. pmc Fetal alcohol exposure leads to abnormal olfactory bulb development and impaired odor discrimination in adult mice
    Katherine G Akers
    Neurosciences and Mental Health, Hospital for Sick Children, and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Mol Brain 4:29. 2011
    ..Here, we used a mouse model of fetal alcohol exposure to investigate relationships between brain abnormalities and specific behavioral alterations during adulthood...
  23. pmc Functional coordination of alternative splicing in the mammalian central nervous system
    Matthew Fagnani
    Banting and Best Department of Medical Research, Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario, Canada, M5S 3E1
    Genome Biol 8:R108. 2007
    ..However, the extent to which AS coordinates functions in a cell and tissue type specific manner is not known. Moreover, the sequence code that underlies cell and tissue type specific regulation of AS is poorly understood...
  24. ncbi GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state
    Steven R Laviolette
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario Canada M5S 1A8
    Eur J Neurosci 20:2179-87. 2004
    ..These findings suggest that GABAA receptors in the VTA can regulate differential reward signalling through separate neural systems during the transition from a drug-naive to a drug-dependent and withdrawn state...
  25. pmc Facile isolation and the characterization of human retinal stem cells
    Brenda L K Coles
    Departments of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:15772-7. 2004
    ..Their facile isolation, integration, and differentiation suggest that human RSCs eventually may be valuable in treating human retinal diseases...
  26. pmc Generation and clonal isolation of retinal stem cells from human embryonic stem cells
    Laura Clarke
    Institute of Medical Science, University of Toronto, 1 King s College Circle, Toronto, ON, Canada
    Eur J Neurosci 36:1951-9. 2012
    ..We show that RSCs emerge in an in vitro model of retinal development and are a potential source of human photoreceptors for use in transplantation...
  27. ncbi DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine
    Hai Ying M Cheng
    Departments of Medical Biophysics and Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Eur J Neurosci 19:3033-41. 2004
    ..Finally, whereas the absence of DREAM reduced the analgesic efficacy of THC, morphine analgesia was unaffected in dream(-/-) mice...
  28. pmc Subretinal gene delivery using helper-dependent adenoviral vectors
    Linda Wu
    Physiology and Experimental Medicine Program, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada
    Cell Biosci 1:15. 2011
    ..Since these vectors have a large cloning capacity, they have great potential to extend the success of gene therapy achieved using the adeno-associated viral vector...
  29. ncbi A genetic dissociation of learning and recall in Caenorhabditis elegans
    Karen Atkinson-Leadbeater
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 118:1206-13. 2004
    ..Therefore, the CB4856 strain does not have an acquisition deficit, but it suffers from a recall deficit specific to benzaldehyde...
  30. ncbi Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 129:233-44. 2002
    ..Thus, neural stem cells and their progeny are regionally specified in the developing brain, but this regional identity can be altered by local inductive cues...
  31. ncbi It is ethical to transplant human stem cells into nonhuman embryos
    Phillip Karpowicz
    Institute of Medical Science, Toronto, Ontario, Canada
    Nat Med 10:331-5. 2004