Bruce A Vallance

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 287:G865-74. 2004
  2. ncbi TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 289:G116-28. 2005
  3. ncbi IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, ACB, Rm K4 188, 4480 Oak St, Vancouver, BC, Canada V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 292:G385-94. 2007
  4. pmc Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-κB and p38 mitogen-activated protein kinase activation
    Ho Pan Sham
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
    Infect Immun 79:3552-62. 2011
  5. pmc CD4+ T cells drive goblet cell depletion during Citrobacter rodentium infection
    Justin M Chan
    Division of Gastroenterology, Department of Pediatrics, BC s Children s Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada
    Infect Immun 81:4649-58. 2013
  6. pmc A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis
    Ohad Gal-Mor
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Pathog 4:e1000036. 2008
  7. doi Nramp1 drives an accelerated inflammatory response during Salmonella-induced colitis in mice
    Yanet Valdez
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Cell Microbiol 11:351-62. 2009
  8. pmc Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice
    Mohammed A Khan
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia V6H 3V4, Canada
    Infect Immun 74:2522-36. 2006
  9. doi Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
    Guntram A Grassl
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 134:768-80. 2008
  10. pmc Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium
    Mohammed A Khan
    Division of Gastroenterology, BC Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:1410-22. 2008

Collaborators

Detail Information

Publications47

  1. ncbi Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 287:G865-74. 2004
    ..These results identify a protective role for both iNOS and eNOS during colitis, with eNOS deficiency resulting in impaired intestinal defense against lumenal bacteria and increased susceptibility to colitis...
  2. ncbi TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 289:G116-28. 2005
    ..Through adenoviral gene transfer technology, we describe a novel mouse model of colitis and implicate TGF-beta1 in the pathogenesis of obstructive intestinal fibrosis...
  3. ncbi IL-4 gene transfer to the small bowel serosa leads to intestinal inflammation and smooth muscle hyperresponsiveness
    Bruce A Vallance
    Division of Gastroenterology, British Columbia s Children s Hospital, ACB, Rm K4 188, 4480 Oak St, Vancouver, BC, Canada V6H 3V4
    Am J Physiol Gastrointest Liver Physiol 292:G385-94. 2007
    ..These results highlight an important causal role for IL-4 in the pathological regulation of enteric smooth muscle function and identify a novel strategy for gene transfer to the intestine...
  4. pmc Attaching and effacing bacterial effector NleC suppresses epithelial inflammatory responses by inhibiting NF-κB and p38 mitogen-activated protein kinase activation
    Ho Pan Sham
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia, Canada V6H 3V4
    Infect Immun 79:3552-62. 2011
    ..rodentium in a cecal loop model induced significantly greater chemokine responses than infection with wild-type bacteria. These studies thus advance our understanding of how A/E pathogens subvert host inflammatory responses...
  5. pmc CD4+ T cells drive goblet cell depletion during Citrobacter rodentium infection
    Justin M Chan
    Division of Gastroenterology, Department of Pediatrics, BC s Children s Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada
    Infect Immun 81:4649-58. 2013
    ..These results demonstrate that goblet cell depletion reflects host immunomodulation of IEC homeostasis and reflects a novel host defense mechanism against mucosal-adherent pathogens. ..
  6. pmc A novel secretion pathway of Salmonella enterica acts as an antivirulence modulator during salmonellosis
    Ohad Gal-Mor
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Pathog 4:e1000036. 2008
    ..Cumulatively, these results indicate that the ZirTS pathway plays a unique role as an antivirulence modulator during systemic disease and is involved in fine-tuning a host-pathogen balance during salmonellosis...
  7. doi Nramp1 drives an accelerated inflammatory response during Salmonella-induced colitis in mice
    Yanet Valdez
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Cell Microbiol 11:351-62. 2009
    ..These data show that an early and rapid inflammatory response results in protection against pathological effects of S. Typhimurium infection in Nramp1(+/+) mice...
  8. pmc Toll-like receptor 4 contributes to colitis development but not to host defense during Citrobacter rodentium infection in mice
    Mohammed A Khan
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia V6H 3V4, Canada
    Infect Immun 74:2522-36. 2006
    ....
  9. doi Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
    Guntram A Grassl
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 134:768-80. 2008
    ..Here, we present a novel murine model of severe and persistent intestinal fibrosis caused by chronic bacterial-induced colitis...
  10. pmc Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium
    Mohammed A Khan
    Division of Gastroenterology, BC Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:1410-22. 2008
    ....
  11. pmc Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG
    Philip R Hardwidge
    Michael Smith Laboratories, University of British Columbia, 301 2185 East Mall, Vancouver, BC V6T 1Z4, Canada
    Infect Immun 73:2586-94. 2005
    ....
  12. pmc The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells
    Mohammed A Khan
    Division of Pediatric Gastroenterology, BC Children s Hospital, Vancouver, British Columbia V6H 3V4, Canada
    J Immunol 184:2305-13. 2010
    ..Our findings show that Sigirr broadly regulates innate responses in differentiated human IECs; therefore, it may modulate epithelial involvement in infectious and inflammatory bowel diseases...
  13. pmc Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa
    Kirk S B Bergstrom
    Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada
    PLoS Pathog 6:e1000902. 2010
    ..Such actions limit tissue damage and translocation of pathogenic and commensal bacteria across the epithelium...
  14. pmc Nramp1 expression by dendritic cells modulates inflammatory responses during Salmonella Typhimurium infection
    Yanet Valdez
    Michael Smith Laboratories, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Cell Microbiol 10:1646-61. 2008
    ..Collectively, these findings reveal a new role for DCs and Nramp1 in modulating the host inflammatory response to S. Typhimurium...
  15. pmc Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine
    Nat F Brown
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Pathog 1:e32. 2005
    ..This induction of expression precedes any documented SPI-2-dependent phases of typhoid and may be involved in preparing Salmonella to successfully resist the antimicrobial environment encountered within macrophages...
  16. pmc Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen
    Kirk S B Bergstrom
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:796-811. 2008
    ....
  17. ncbi Citrobacter rodentium translocated intimin receptor (Tir) is an essential virulence factor needed for actin condensation, intestinal colonization and colonic hyperplasia in mice
    Wanyin Deng
    Biotechnology Laboratory, University of British Columbia, Room 237 Wesbrook Building, 6174 University Boulevard, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 48:95-115. 2003
    ..rodentium colonization of the mouse gut nor for inducing A/E lesions and colonic hyperplasia, thereby uncoupling colonization and disease from actin condensation for this A/E pathogen...
  18. pmc The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis
    Maryam Zarepour
    Department of Pediatrics, Division of Gastroenterology, Child and Family Research Institute, Vancouver, British Columbia, Canada
    Infect Immun 81:3672-83. 2013
    ..Our data suggest that the intestinal mucus layer (Muc2) and core 3 O-glycosylation play critical roles in controlling Salmonella intestinal burdens and intestinal epithelial barrier function, respectively. ..
  19. doi MyD88 signaling promotes both mucosal homeostatic and fibrotic responses during Salmonella-induced colitis
    Lisa E Månsson
    Division of Pediatric Gastroenterology, British Columbia s Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 303:G311-23. 2012
    ..In conclusion, MyD88 and Cox-2 signaling play roles in intestinal fibrosis during Salmonella-induced enterocolitis...
  20. ncbi Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis
    Deanna L Gibson
    Division of Gastroenterology, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Cell Microbiol 10:388-403. 2008
    ..These studies report for the first time that TLR2 plays a critical role in maintaining intestinal mucosal integrity during infection by a bacterial pathogen...
  21. ncbi Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map)
    Caixia Ma
    Division of Gastroenterology, BC s Children s Hospital, Vancouver, BC, Canada
    Cell Microbiol 8:1669-86. 2006
    ..rodentium...
  22. doi The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling
    Stephanie R Shames
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada
    Cell Microbiol 12:1322-39. 2010
    ..This study provides evidence that EspZ and CD98 promote host cell survival mechanisms involving FAK during A/E pathogen infection...
  23. ncbi Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes
    Leigh A Knodler
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada
    Mol Microbiol 49:685-704. 2003
    ..The enrichment of Salmonella effectors in DRMs on these intracellular membranes probably permits specific interactions with host cell molecules that are concentrated in these signalling platforms...
  24. doi Salmonella infection of gallbladder epithelial cells drives local inflammation and injury in a model of acute typhoid fever
    Alfredo Menendez
    Michael Smith Laboratories, Division of Anatomy and Cell Biology, Life Sciences Centre, University of British Columbia, Vancouver, Canada
    J Infect Dis 200:1703-13. 2009
    ....
  25. pmc SseK1 and SseK2 are novel translocated proteins of Salmonella enterica serovar typhimurium
    Sonya L Kujat Choy
    Biotechnology Laboratory, University of British Columbia, Room 237, Wesbrook Building, 6174 University Blvd, Vancouver, BC, Canada V6T 1Z3
    Infect Immun 72:5115-25. 2004
    ..In summary, this work demonstrates that SseK1 and SseK2 are novel translocated proteins of serovar Typhimurium...
  26. doi Interleukin-11 reduces TLR4-induced colitis in TLR2-deficient mice and restores intestinal STAT3 signaling
    Deanna L Gibson
    Division of Gastroenterology, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Gastroenterology 139:1277-88. 2010
    ..We investigated the roles of TLR2 and TLR4 and the cell types that express these receptors during infectious colitis...
  27. pmc Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis
    Bryan Coburn
    Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada
    Infect Immun 73:3219-27. 2005
    ..Collectively, these results indicate that SPI2 is needed for enterocolitis, as well as for systemic disease...
  28. pmc Dissecting virulence: systematic and functional analyses of a pathogenicity island
    Wanyin Deng
    Biotechnology Laboratory, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 101:3597-602. 2004
    ..Our findings provide significant insights into bacterial virulence mechanisms and disease...
  29. pmc Modulation of inducible nitric oxide synthase expression by the attaching and effacing bacterial pathogen citrobacter rodentium in infected mice
    Bruce A Vallance
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Infect Immun 70:6424-35. 2002
    ..rodentium infection. However, the selective expression of iNOS by uninfected but not infected cells suggests that this pathogen has developed mechanisms to locally limit its exposure to host-derived NO...
  30. ncbi SseA is required for translocation of Salmonella pathogenicity island-2 effectors into host cells
    Brian K Coombes
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, 237 6174 University Boulevard, University of British Columbia, BC, V6T 1Z3, Vancouver, Canada
    Microbes Infect 5:561-70. 2003
    ..These data demonstrate that SseA is essential for SPI2-mediated translocation of effector proteins...
  31. pmc SIGIRR, a negative regulator of TLR/IL-1R signalling promotes Microbiota dependent resistance to colonization by enteric bacterial pathogens
    Ho Pan Sham
    Division of Gastroenterology, BC s Children s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS Pathog 9:e1003539. 2013
    ..Thus, SIGIRR expression by IEC reflects a strategy that sacrifices maximal innate responsiveness by IEC in order to promote commensal microbe based colonization resistance against bacterial pathogens...
  32. pmc Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses
    Natasha R Ryz
    Department of Pediatrics, Division of Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Gastrointest Liver Physiol 303:G1299-311. 2012
    ..Taken together, these studies show that 1,25(OH)(2)D(3) suppresses Th17 T-cell responses in vivo and impairs mucosal host defense against an enteric bacterial pathogen...
  33. ncbi SopD2 is a novel type III secreted effector of Salmonella typhimurium that targets late endocytic compartments upon delivery into host cells
    John H Brumell
    Biotechnology Laboratory and Departments of Biochemistry and Molecular Biology, Microbiology and Immunology, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Traffic 4:36-48. 2003
    ..These findings demonstrate that the N-terminus of SopD2 is a bifunctional domain required for both type III secretion out of Salmonella as well as late endosome/lysosome targeting following translocation into host cells...
  34. doi Innate host responses to enteric bacterial pathogens: a balancing act between resistance and tolerance
    Kirk S Bergstrom
    Division of Gastroenterology, BC s Children s Hospital, the Child and Family Research Institute and the University of British Columbia, Vancouver, BC, Canada
    Cell Microbiol 14:475-84. 2012
    ..Further studies are needed to clarify the contribution of different pathogen recognition receptors to tolerance and resistance responses against bacterial pathogens, in the gut or in other host tissues...
  35. pmc Genetic profiling of dendritic cells exposed to live- or ultraviolet-irradiated Chlamydia muridarum reveals marked differences in CXC chemokine profiles
    Michelle L Zaharik
    University of British Columbia Centre for Disease Control, Vancouver, BC, Canada
    Immunology 120:160-72. 2007
    ..This has implications as to why early inactivated chlamydial vaccines were ineffective and suggests that new vaccine design efforts may benefit from in vitro DC screening for ELR chemokine expression profiles...
  36. ncbi Myenteric plexus injury and apoptosis in experimental colitis
    Lee Boyer
    British Columbia Research Institute, Vancouver, British Columbia, Canada V6H 3V4
    Auton Neurosci 117:41-53. 2005
    ..Taken together, these data suggest that acute colitis is associated with loss of myenteric plexus neurons that is partly mediated by neutrophil granulocyte infiltration and is accompanied by impairment of colonic motility...
  37. pmc Mice lacking T and B lymphocytes develop transient colitis and crypt hyperplasia yet suffer impaired bacterial clearance during Citrobacter rodentium infection
    Bruce A Vallance
    Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Infect Immun 70:2070-81. 2002
    ..While T and/or B lymphocytes are essential for host defense against C. rodentium, they also mediate much of the tissue pathology and disease symptoms that occur during infection...
  38. ncbi Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems
    Leigh A Knodler
    Biotechnology Laboratory, Room 237, 6174 University Blvd, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada
    Mol Microbiol 43:1089-103. 2002
    ..Thus, we demonstrate a functional and regulatory cross-talk between three chromosomal PAIs, SPI-1, SPI-2 and SPI-5, which has significant implications for the evolution and role of PAIs in bacterial pathogenesis...
  39. ncbi Current progress in enteropathogenic and enterohemorrhagic Escherichia coli vaccines
    Cathy Horne
    Biochemistry Labouratory, University of British Columbia, Vancouver, BC, Canada
    Expert Rev Vaccines 1:483-93. 2002
    ..Several lines of investigation indicate the feasibility of such strategies and justify further development of a vaccine targeting these significant intestinal pathogens...
  40. pmc Clearance of Citrobacter rodentium requires B cells but not secretory immunoglobulin A (IgA) or IgM antibodies
    Christian Maaser
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Infect Immun 72:3315-24. 2004
    ..These results indicate that host defense against C. rodentium depends on B cells and IgG antibodies but does not require production or transepithelial transport of IgA or secreted IgM...
  41. doi Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus
    Jean Eric Ghia
    Intestinal Diseases Research Programme, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G770-7. 2008
    ..These results indicate that M-CSF-dependent macrophages may play either a pro- or counterinflammatory role in acute experimental colitis, depending on the stimulus used to induce colitis...
  42. ncbi The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis
    Hui Xiao
    Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Immunity 26:461-75. 2007
    ..Taken together, our results indicate that epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora...
  43. pmc Cloning vectors and fluorescent proteins can significantly inhibit Salmonella enterica virulence in both epithelial cells and macrophages: implications for bacterial pathogenesis studies
    Leigh A Knodler
    Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, MT 59840, USA
    Infect Immun 73:7027-31. 2005
    ..Here we show that they can impair the ability of Salmonella enterica serovar Typhimurium to productively infect either cultured mammalian cells or mice. This has significant implications for studies that rely on these systems...
  44. pmc Host-pathogen interactions: Host resistance factor Nramp1 up-regulates the expression of Salmonella pathogenicity island-2 virulence genes
    Michelle L Zaharik
    Biotechnology Laboratory and Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 99:15705-10. 2002
    ..This study demonstrates the presence of a previously undescribed direct influence of a mammalian innate host resistance locus on a pathogen at the genetic level...
  45. pmc Host susceptibility to the attaching and effacing bacterial pathogen Citrobacter rodentium
    Bruce A Vallance
    Biotechnology Laboratory, University of British Columbia, Vancouver, Canada V6T 1Z3
    Infect Immun 71:3443-53. 2003
    ..rodentium infection of highly susceptible mouse strains. Determining the basis for these strains' susceptibility to intestinal colonization by an A/E pathogen will be the focus of future studies...
  46. ncbi Toll-like receptor 4 dependence of innate and adaptive immunity to Salmonella: importance of the Kupffer cell network
    Andres Vazquez-Torres
    Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 172:6202-8. 2004
    ..Alternative pattern-recognition receptors cannot completely compensate for the loss of TLR4, and compensation occurs at the expense of an increased microbial burden...
  47. ncbi Noradrenergic and cholinergic neural pathways mediate stress-induced reactivation of colitis in the rat
    Paul R Saunders
    Intestinal Disease Research Program, McMaster University, Hamilton, Ontario, Canada
    Auton Neurosci 124:56-68. 2006
    ..Moreover, this study demonstrates that noradrenergic and cholinergic neural pathways mediate the stress response critical for the relapse of colitis...