M B Urowitz

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Prolonged remission in systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Rheumatol 32:1467-72. 2005
  2. pmc Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Arthritis Res Ther 12:R125. 2010
  3. ncbi request reprint Burden of autoantibodies and association with disease activity and damage in systemic lupus erythematosus
    Z Touma
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Canada
    Clin Exp Rheumatol 28:525-31. 2010
  4. pmc Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Arthritis Res Ther 13:R156. 2011
  5. doi request reprint Ability of non-fasting and fasting triglycerides to predict coronary artery disease in lupus patients
    Zahi Touma
    Toronto Western Hospital, Toronto, Canada
    Rheumatology (Oxford) 51:528-34. 2012
  6. pmc Modification of hypertension and hypercholesterolaemia in patients with systemic lupus erythematosus: a quality improvement study
    M B Urowitz
    Rheumatology Department, University Health Network, Toronto Western Hospital, Canada
    Ann Rheum Dis 65:115-7. 2006
  7. ncbi request reprint Contributions of observational cohort studies in systemic lupus erythematosus: the university of toronto lupus clinic experience
    Murray B Urowitz
    University of Toronto, Toronto, ON, Canada
    Rheum Dis Clin North Am 31:211-21, v. 2005
  8. ncbi request reprint Atherosclerotic vascular events in a single large lupus cohort: prevalence and risk factors
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 34:70-5. 2007
  9. doi request reprint Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort
    M B Urowitz
    Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 64:132-7. 2012
  10. ncbi request reprint Outcomes in patients with active lupus nephritis requiring immunosuppressives who never received cyclophosphamide
    Murray B Urowitz
    University of Toronto Lupus Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 34:1491-6. 2007

Detail Information

Publications72

  1. ncbi request reprint Prolonged remission in systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Ontario, Canada
    J Rheumatol 32:1467-72. 2005
    ..To also determine the frequency of remission utilizing less restrictive definitions, such as allowing shorter period of disease quiescence, persistence of serological activity, or treatment in the absence of clinical disease...
  2. pmc Variability over time and correlates of cholesterol and blood pressure in systemic lupus erythematosus: a longitudinal cohort study
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Arthritis Res Ther 12:R125. 2010
    ..The objective of this study was to describe and quantify variability over time of TC and BP among patients with SLE and to determine their correlates...
  3. ncbi request reprint Burden of autoantibodies and association with disease activity and damage in systemic lupus erythematosus
    Z Touma
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Canada
    Clin Exp Rheumatol 28:525-31. 2010
    ..To determine whether immunological burden of autoantibodies as reflected by the number of cumulative antibodies present at inception and after 3 and 5 years is associated with or predicts subsequent disease activity and damage in lupus...
  4. pmc Importance of cumulative exposure to elevated cholesterol and blood pressure in development of atherosclerotic coronary artery disease in systemic lupus erythematosus: a prospective proof-of-concept cohort study
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada
    Arthritis Res Ther 13:R156. 2011
    ....
  5. doi request reprint Ability of non-fasting and fasting triglycerides to predict coronary artery disease in lupus patients
    Zahi Touma
    Toronto Western Hospital, Toronto, Canada
    Rheumatology (Oxford) 51:528-34. 2012
    ..To test whether non-fasting and fasting triglyceride (TG) levels differ in individual patients and whether TG (non-fasting and fasting) levels predict coronary artery disease (CAD) in lupus patients...
  6. pmc Modification of hypertension and hypercholesterolaemia in patients with systemic lupus erythematosus: a quality improvement study
    M B Urowitz
    Rheumatology Department, University Health Network, Toronto Western Hospital, Canada
    Ann Rheum Dis 65:115-7. 2006
    ..Hypercholesterolaemia and hypertension are risk factors for coronary artery disease in patients with systemic lupus erythematosus (SLE)...
  7. ncbi request reprint Contributions of observational cohort studies in systemic lupus erythematosus: the university of toronto lupus clinic experience
    Murray B Urowitz
    University of Toronto, Toronto, ON, Canada
    Rheum Dis Clin North Am 31:211-21, v. 2005
    ..This article uses the University of Toronto Lupus Cohort to illustrate the benefits of observational cohort studies in generating important new knowledge in chronic disease such as systemic lupus erythematosus...
  8. ncbi request reprint Atherosclerotic vascular events in a single large lupus cohort: prevalence and risk factors
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 34:70-5. 2007
    ....
  9. doi request reprint Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort
    M B Urowitz
    Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 64:132-7. 2012
    ..We describe disease activity, damage, and the accrual of key autoantibodies in an inception systemic lupus erythematosus (SLE) cohort...
  10. ncbi request reprint Outcomes in patients with active lupus nephritis requiring immunosuppressives who never received cyclophosphamide
    Murray B Urowitz
    University of Toronto Lupus Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 34:1491-6. 2007
    ..To assess outcomes in patients with lupus nephritis treated with immunosuppressives compared to those treated with cyclophosphamide in a cohort study and in a matched cohort study...
  11. pmc Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus
    M B Urowitz
    Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Care Res (Hoboken) 62:881-7. 2010
    ..To describe vascular events during an 8-year followup in a multicenter systemic lupus erythematosus (SLE) inception cohort and their attribution to atherosclerosis...
  12. ncbi request reprint The effect of menopause on disease activity in systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic and Toronto Western Hospital, Edith Cavell Wing, 399 Bathurst Street, Toronto, Ontario, M5T 2S8, Canada
    J Rheumatol 33:2192-8. 2006
    ..To determine the effect of menopause on disease activity and course of systemic lupus erythematosus (SLE)...
  13. doi request reprint Neurocognitive abnormalities in offspring of mothers with systemic lupus erythematosus
    M B Urowitz
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University of Toronto Lupus Clinic, Toronto, Ontario, Canada
    Lupus 17:555-60. 2008
    ..The matched analyses of the neuropsychological domains revealed impairment in SLE children compared with matched controls in two of the nine domains: learning and memory and behaviour...
  14. ncbi request reprint The SLICC inception cohort for atherosclerosis
    Murray B Urowitz
    University of Toronto Lupus Clinic, Toronto Western Hospital, Room 1E 409, 399 Bathurst Street, Toronto, ON, Canada
    Curr Rheumatol Rep 10:281-5. 2008
    ..Additional studies using this cohort are ongoing...
  15. ncbi request reprint Changing patterns in mortality and disease outcomes for patients with systemic lupus erythematosus
    Murray B Urowitz
    Toronto Western Hospital, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Canada
    J Rheumatol 35:2152-8. 2008
    ..We examined changes in mortality and other outcomes over time in a large SLE cohort...
  16. ncbi request reprint Role of specialty care in the management of patients with systemic lupus erythematosus
    Murray B Urowitz
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:1207-10. 2002
    ..To determine the role of rheumatologists in the management of systemic lupus erythematosus (SLE)...
  17. doi request reprint Accumulation of coronary artery disease risk factors over three years: data from an international inception cohort
    M B Urowitz
    Centre for Prognosis Studies, Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 59:176-80. 2008
    ..To examine the accumulation of risk factors over 3 years in a multicenter, international inception cohort of patients with systemic lupus erythematosus (SLE)...
  18. ncbi request reprint Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort
    M B Urowitz
    SLICC Registry for Atherosclerosis Coordinating Centre, University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    Lupus 16:731-5. 2007
    ..4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE...
  19. doi request reprint Hormone replacement therapy in women with systemic lupus erythematosus and risk of cardiovascular disease
    J Hochman
    University of Toronto Lupus Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    Lupus 18:313-7. 2009
    ..0001, HR = 1.11, 95% CI = 1.05, 1.17) and SLEDAI-2K (P = 0.0001, HR = 1.10, 95% CI = 1.05, 1.16) were significantly associated with the risk of CAD. In this small group of patients with SLE, HRT alone did not appear to predispose to CAD...
  20. ncbi request reprint Outcomes of symptomatic osteonecrosis in 95 patients with systemic lupus erythematosus
    D D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 28:2226-9. 2001
    ....
  21. doi request reprint Vitamin D insufficiency in a large female SLE cohort
    S M A Toloza
    University of Toronto Lupus Clinic, Toronto Western Hospital, Toronto, ON, Canada M5T 2S8
    Lupus 19:13-9. 2010
    ..In conclusion, sub-optimal vitamin D status is common in women with systemic lupus erythematosus and is related to season, cumulative glucocorticoid dose, and serum creatinine...
  22. ncbi request reprint Ethnic variation in disease patterns and health outcomes in systemic lupus erythematosus
    Sindhu R Johnson
    Division of Rheumatology, Centre for Prognostic Studies in the Rheumatic Diseases, University of Toronto, Toronto, Ontario, Canada
    J Rheumatol 33:1990-5. 2006
    ..In a single-center multiethnic lupus cohort, to investigate the influence of ethnicity on the prevalence of cumulative renal and central nervous system (CNS) lupus disease and damage, overall end-organ damage, and mortality...
  23. doi request reprint Variability and correlates of high sensitivity C-reactive protein in systemic lupus erythematosus
    M Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Lupus 18:966-73. 2009
    ..The variability of hsCRP in SLE casts doubt over its usefulness as an independent predictor of CAD risk in this disease and potentially in other chronic inflammatory diseases...
  24. ncbi request reprint Early damage as measured by the SLICC/ACR damage index is a predictor of mortality in systemic lupus erythematosus
    P Rahman
    Centre for Prognosis Studies in the Rheumatic Diseases, The Toronto Western Hospital, University Health Network, Ontario, Canada
    Lupus 10:93-6. 2001
    ..013), and a trend toward more cardiovascular disease (P = 0.056), compared to patients who were alive. Early damage as reflected by the initial SLICC/ACR Damage Index is associated with a higher rate of mortality...
  25. ncbi request reprint Accurately describing changes in disease activity in Systemic Lupus Erythematosus
    D D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 27:377-9. 2000
    ..To determine whether Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores correlate with the clinician's impression of level of disease activity...
  26. ncbi request reprint Summarizing disease features over time: I. Adjusted mean SLEDAI derivation and application to an index of disease activity in lupus
    Dominique Ibanez
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1977-82. 2003
    ..To develop a measurement of lupus disease activity over time...
  27. ncbi request reprint Premature coronary heart disease in systemic lupus erythematosus: what risk factors do we understand?
    M Nikpour
    1University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Canada
    Lupus 22:1243-50. 2013
    ..An understanding of risk factors is fundamental to the prevention of CHD in SLE. In this review, we will discuss the role of risk factors for CHD in SLE and offer some strategies for their assessment and management. ..
  28. ncbi request reprint Association of a gene expression profile from whole blood with disease activity in systemic lupus erythaematosus
    M Nikpour
    University of Toronto Lupus Clinic and Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Ann Rheum Dis 67:1069-75. 2008
    ..To determine whether peripheral blood gene expression of patients with systemic lupus erythaematosus (SLE) correlates with disease activity measured using the SLE Disease Activity Index 2000 (SLEDAI-2K)...
  29. ncbi request reprint Monoclonal gammopathy in systemic lupus erythematosus
    Y M Ali
    Centre for Progrosis Studies, Toronto Hospital Western Division, Toronto, Ontario, Canada
    Lupus 16:426-9. 2007
    ..There were no differences in disease manifestations, treatment approaches, or malignancies between SLE patients with and those without monoclonal gammopathy...
  30. ncbi request reprint Predictive factors for symptomatic osteonecrosis in patients with systemic lupus erythematosus
    D D Gladman
    Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 28:761-5. 2001
    ..CONCLUSION: Glucocorticosteroid therapy, the presence of arthritis, and use of cytotoxic medication are independent risk factors for development of ON in patients with SLE...
  31. ncbi request reprint The nature and outcome of infection in systemic lupus erythematosus
    D D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Ontario, Canada
    Lupus 11:234-9. 2002
    ..Until new medications which will control disease activity without predisposing to infection are developed, careful titration of steroids and cytotoxic drugs to control disease activity will remain crucial...
  32. doi request reprint SLEDAI-2K 10 days versus SLEDAI-2K 30 days in a longitudinal evaluation
    Z Touma
    Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Lupus 20:67-70. 2011
    ..SLEDAI-2K 30 days was validated against SLEDAI-2K 10 days in a longitudinal evaluation over 1 year. We recommend the use of SLEDAI-2K 30 days in clinical studies and clinical trials...
  33. ncbi request reprint Pulmonary hypertension in systemic lupus
    S R Johnson
    University of Toronto Lupus Clinic, Centre for Prognostic Studies in the Rheumatic Diseases, Division of Rheumatology, University of Toronto, Toronto, Canada
    Lupus 13:506-9. 2004
    ..Disease activity, organ involvement and anticardiolipin antibodies were not associated with PAH. Further research is needed to identify the mechanism, response to immunosuppression and impact on quality of life in these patients...
  34. ncbi request reprint SLEDAI-2K Responder Index 50 captures 50% improvement in disease activity over 10 years
    Z Touma
    University of Toronto Lupus Clinic, Toronto Western Hospital, Toronto, Ontario, Canada
    Lupus 21:1305-11. 2012
    ....
  35. ncbi request reprint Osteoporosis in systemic lupus erythematosus: factors associated with referral for bone mineral density studies, prevalence of osteoporosis and factors associated with reduced bone density
    C A Pineau
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario
    Lupus 13:436-41. 2004
    ..Interestingly, disease activity and corticosteroid use were not associated with osteoporosis in this study which may suggest other potential causes such as decreased physical activity associated with damage...
  36. doi request reprint Systemic lupus erythematosus disease activity index 2000 responder index-50: a reliable index for measuring improvement in disease activity
    Zahi Touma
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada
    J Rheumatol 38:868-73. 2011
    ....
  37. ncbi request reprint Systemic lupus erythematosus disease activity index 2000
    Dafna D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:288-91. 2002
    ....
  38. ncbi request reprint Adjusted mean Systemic Lupus Erythematosus Disease Activity Index-2K is a predictor of outcome in SLE
    Dominique Ibanez
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 32:824-7. 2005
    ....
  39. doi request reprint Myocardial perfusion imaging in assessing risk of coronary events in patients with systemic lupus erythematosus
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 36:288-94. 2009
    ..In this prospective cohort study we investigated whether myocardial perfusion defects in SLE are predictive of CAD events, independently of traditional Framingham risk factors...
  40. doi request reprint Increased expression of B cell activation factor supports the abnormal expansion of transitional B cells in systemic lupus erythematosus
    Carolina Landolt-Marticorena
    Arthritis Centre of Excellence, Division of Genetics and Development, and the Division of Health Care and Outcomes Research, Toronto Western Hospital Research Institute, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 38:642-51. 2011
    ..To examine the relationship between interferon-α (IFN-α) and dysregulation of B cell activation factor (BAFF) and specific B cell phenotypes in systemic lupus erythematosus (SLE)...
  41. doi request reprint The effect of lupus nephritis on pregnancy outcome and fetal and maternal complications
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 37:754-8. 2010
    ..To evaluate the effect of lupus nephritis on pregnancy with respect to fetal outcome, maternal complications, and lupus activity...
  42. ncbi request reprint Clinically active serologically quiescent systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1960-2. 2003
    ..To identify the frequency and characteristics of clinical activity with serological quiescence (CASQ) in a large cohort of patients with systemic lupus erythematosus (SLE) followed prospectively at a single center...
  43. doi request reprint Lipid profiles in patients with rheumatoid arthritis: mechanisms and the impact of treatment
    George Steiner
    Department of Medicine, Division of Endocrinology, Toronto General Hospital and University of Toronto, Ontario, Canada
    Semin Arthritis Rheum 38:372-81. 2009
    ..To describe the impact of rheumatoid arthritis (RA), and its treatment, on lipoprotein levels with potential implications for atherosclerosis...
  44. doi request reprint Optimal frequency of visits for patients with systemic lupus erythematosus to measure disease activity over time
    Dominique Ibanez
    University of Toronto Lupus Clinic and Centre for Prognosis Studies in the Diseases, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 38:60-3. 2011
    ..adjusted mean Systemic Lupus Erythematosus Disease Activity Index (SLEDAI; AMS) measures lupus disease activity over time. Our aim was to determine optimal visit frequency for calculating AMS...
  45. doi request reprint Mycophenolate mofetil for induction treatment of lupus nephritis: a systematic review and metaanalysis
    Zahi Touma
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 38:69-78. 2011
    ..to systematically review the efficacy and safety of mycophenolic acid and mycophenolate mofetil (MMF) compared to cyclophosphamide (CYC) for the induction treatment of lupus nephritis (LN)...
  46. doi request reprint Frequency and determinants of flare and persistently active disease in systemic lupus erythematosus
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 61:1152-8. 2009
    ..We sought to elucidate the frequency and determinants of flare and PAD...
  47. ncbi request reprint Damage in lupus patients--what have we learned so far?
    L Eder
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Canada
    Lupus 22:1225-31. 2013
    ..However, medications administered to control disease activity, particularly corticosteroids, can also result in organ damage, emphasizing the need for adjustment of these agents as soon as disease is under control. ..
  48. ncbi request reprint Significance of isolated hematuria and isolated pyuria in systemic lupus erythematosus
    P Rahman
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, University of Toronto, Ontario, Canada
    Lupus 10:418-23. 2001
    ..Thus isolated hematuria and isolated sterile pyuria should be considered manifestations of active SLE...
  49. ncbi request reprint KIRs and autoimmune disease: studies in systemic lupus erythematosus and scleroderma
    F Pellett
    HLA Laboratory, Toronto Western Research Institute, Toronto, Ontario, Canada
    Tissue Antigens 69:106-8. 2007
    ..001). This suggests that KIR receptors play a role in susceptibility to both PSS and SLE...
  50. doi request reprint Relationship between cardiac symptoms, myocardial perfusion defects and coronary angiography findings in systemic lupus erythematosus
    M Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Lupus 20:299-304. 2011
    ..Overall there is poor agreement between the findings of coronary angiography and MPS in SLE, suggesting mechanisms of ischemia other than plaques...
  51. doi request reprint SLEDAI-2K for a 30-day window
    Z Touma
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, M5T 2S8, Canada
    Lupus 19:49-51. 2010
    ..Thus SLEDAI-2K 30 days is similar to SLEDAI-2K 10 days, both in patients in remission and with a spectrum of disease activity levels. SLEDAI-2K 30 days may now be used to describe disease activity over the previous 30 days...
  52. ncbi request reprint Accrual of organ damage over time in patients with systemic lupus erythematosus
    Dafna D Gladman
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, 399 Bathurst Street, EC 5 034, Toronto, Ontario, Canada M5T 2S8
    J Rheumatol 30:1955-9. 2003
    ....
  53. ncbi request reprint The effect of pregnancy on lupus nephritis
    Anu Tandon
    Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 50:3941-6. 2004
    ..To evaluate the effect of pregnancy on lupus nephritis with respect to renal activity and renal deterioration...
  54. ncbi request reprint Premature atherosclerosis in systemic lupus erythematosus
    Mandana Nikpour
    University of Toronto Lupus Clinic, Toronto Western Hospital, ON M5T 2S8, Canada
    Rheum Dis Clin North Am 31:329-54, vii-viii. 2005
    ..The article concludes with a discussion on the important questions that remain to be answered and future directions for research...
  55. doi request reprint Serum albumin as a marker for disease activity in patients with systemic lupus erythematosus
    Jonathan Yip
    Division of Health Care and Outcome Research, Toronto Western Research Institute, Toronto, Ontario, Canada
    J Rheumatol 37:1667-72. 2010
    ..There is currently no clinical "gold standard" in the assessment of disease activity in SLE...
  56. ncbi request reprint Single photon emission computed tomography dual isotope myocardial perfusion imaging in women with systemic lupus erythematosus. II. Predictive factors for perfusion abnormalities
    Ian N Bruce
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto, Ontario, Canada
    J Rheumatol 30:288-91. 2003
    ..Here we investigated risk factors for abnormal myocardial perfusion in a cohort of women with SLE without history of coronary artery disease...
  57. ncbi request reprint Epidemiology of atherosclerosis in systemic lupus erythematosus
    Mandana Nikpour
    University of Toronto Lupus Clinic and the Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    Curr Rheumatol Rep 11:248-54. 2009
    ..Elucidation of risk factors and preventive strategies for accelerated atherosclerosis in SLE is the subject of ongoing research...
  58. ncbi request reprint The impact of the 1997 update of the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus: what has been changed?
    Marie Feletar
    University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 48:2067-9. 2003
  59. ncbi request reprint Risk factors for coronary heart disease in women with systemic lupus erythematosus: the Toronto Risk Factor Study
    Ian N Bruce
    University of Toronto Lupus Clinic, and Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Toronto, Ontario, Canada
    Arthritis Rheum 48:3159-67. 2003
    ..Because women with systemic lupus erythematosus (SLE) are 5-8 times more likely to develop coronary heart disease (CHD) than are women in the general population, we assessed the prevalence of classic risk factors for CHD in women with SLE...
  60. doi request reprint Risk factors for development of coronary artery disease in women with systemic lupus erythematosus
    Robert J Goldberg
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Division of Rheumatology, University of Toronto, Toronto, Canada
    J Rheumatol 36:2454-61. 2009
    ..To ascertain coronary artery disease (CAD) outcomes and predictive factors in a prospective study of patients with systemic lupus erythematosus (SLE) and matched healthy controls...
  61. ncbi request reprint Fatigue in systemic lupus erythematosus: contributions of disordered sleep, sleepiness, and depression
    Andrea Iaboni
    University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 33:2453-7. 2006
    ..To clarify the role of sleep disorders, sleepiness, and depression in patients with systemic lupus erythematosus (SLE) who complain of disabling tiredness...
  62. doi request reprint Quality of life over time in patients with systemic lupus erythematosus
    Bindee Kuriya
    University of Toronto Lupus Clinic Toronto, Ontario, Canada
    Arthritis Rheum 59:181-5. 2008
    ..To determine whether quality of life in patients with systemic lupus erythematosus (SLE) measured by the Short Form 36 (SF-36) changes over time and which patient- and disease-related factors influence such change...
  63. doi request reprint Systemic Lupus Erythematosus Disease Activity Index 2000 Responder Index-50 enhances the ability of SLE Responder Index to identify responders in clinical trials
    Zahi Touma
    University of Toronto Lupus Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    J Rheumatol 38:2395-9. 2011
    ..Also, to determine whether the SRI-50 will enhance the ability of SRI in detecting responders...
  64. doi request reprint Is there an advantage over SF-36 with a quality of life measure that is specific to systemic lupus erythematosus?
    Zahi Touma
    Centre for Prognosis Studies in the Rheumatic Diseases, Room 1E 409, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    J Rheumatol 38:1898-905. 2011
    ....
  65. doi request reprint Development and initial validation of the systemic lupus erythematosus disease activity index 2000 responder index 50
    Zahi Touma
    Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Room 1E 409, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada
    J Rheumatol 38:275-84. 2011
    ..To describe the development and validation of the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) Responder Index 50 (SRI-50), an index to measure improvement in disease manifestations on followup visits...
  66. doi request reprint Altered expression of TNF-alpha signaling pathway proteins in systemic lupus erythematosus
    Lang jing Zhu
    Arthritis Centre of Excellence and Toronto Western Hospital Research Institute, Divisions of Genetics and Development and Population Health, Toronto Western Hospital, Toronto, Ontario, Canada
    J Rheumatol 37:1658-66. 2010
    ..To investigate the expression of tumor necrosis factor receptors (TNFR1 and TNFR2) and adapter proteins (TRADD, RIP, and TRAF2) in peripheral blood mononuclear cell (PBMC) subsets from patients with systemic lupus erythematosus (SLE)...
  67. ncbi request reprint Should all patients with systemic lupus erythematosus receive cardioprotection with statins?
    Sergio Toloza
    Centre for Prognosis Studies in the Rheumatic Diseases at Toronto Western Hospital, in Toronto, ON, Canada
    Nat Clin Pract Rheumatol 3:536-7. 2007
  68. ncbi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: comparison of agreement in rating renal response
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1789-95. 2008
    ..To assess the degree to which physicians agree with each other and with ratings obtained with 3 existing responder indices, in rating the response to treatment of lupus nephritis...
  69. ncbi request reprint Systemic lupus international collaborating clinics renal activity/response exercise: development of a renal activity score and renal response index
    Michelle Petri
    Department of Rheumatology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Arthritis Rheum 58:1784-8. 2008
    ..To develop a measure of renal activity in systemic lupus erythematosus and use it to develop a renal response index...
  70. ncbi request reprint Mortality studies in SLE: how far can we improve survival of patients with SLE
    Mahmoud Abu-Shakra
    Autoimmun Rev 3:418-20. 2004
  71. ncbi request reprint Item weightings for the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Disease Damage Index using Rasch analysis do not lead to an important improvement
    Hermine I Brunner
    William Rowe Division of Rheumatology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Rheumatol 30:292-7. 2003
    ....
  72. ncbi request reprint The apolipoprotein E2 isoform is associated with accelerated onset of coronary artery disease in systemic lupus erythematosus
    Antonio Orlacchio
    Laboratorio di Neurogenetica, CERC IRCCS Santa Lucia, Rome, Italy and Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Med Sci Monit 14:CR233-237. 2008
    ..It is hypothesized that apolipoprotein E (Apo E), which is involved in cholesterol metabolism, might play a role in this process...