Bruce Urch

Summary

Affiliation: Gage Occupational & Environmental Health Unit, University of Toronto & St. Michaels Hospital
Location: Toronto, Canada
Summary:
Air pollution research
Controlled Human Exposure Studies
Teaching
Grants:
Cardiovascular Effects of Urban and Rural Coarse Particulate Matter in Obese and Lean Adults, 2008-2012, Environmental Protection Agency, National Center for Environmental Research (EPA grant number: R833740).

Publications

  1. ncbi Occupational asthma induced by a carpet fungicide--tributyl tin oxide
    D Shelton
    Occupational Lung Disease Clinic, Toronto Hospital, Western Division, Ontario, Canada
    J Allergy Clin Immunol 90:274-5. 1992
  2. ncbi Interaction of ozone and cigarette smoke exposure
    R J Shephard
    Environ Res 31:125-37. 1983
  3. ncbi Effect of exposure to low levels of ozone on the response to inhaled allergen in allergic asthmatic patients
    N A Hanania
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Chest 114:752-6. 1998
  4. ncbi Induced sputum: comparison of postinfectious cough with allergic asthma in children
    B Zimmerman
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, and the Asthma Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Allergy Clin Immunol 105:495-9. 2000
  5. ncbi Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals
    N Alexis
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, 104 Mason Farm Rd, Chapel Hill, NC 27599 7310, USA
    Inhal Toxicol 12:1205-24. 2000
  6. ncbi Peanut allergy: children who lose the positive skin test response
    B Zimmerman
    J Allergy Clin Immunol 107:558-9. 2001
  7. ncbi The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers
    Gopal Sivagangabalan
    Division of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 57:198-206. 2011
  8. ncbi Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone
    Asghar A Fakhri
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1287-92. 2009
  9. ncbi Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
  10. ncbi Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma
    Michelle L North
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Respir Res 12:19. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Occupational asthma induced by a carpet fungicide--tributyl tin oxide
    D Shelton
    Occupational Lung Disease Clinic, Toronto Hospital, Western Division, Ontario, Canada
    J Allergy Clin Immunol 90:274-5. 1992
  2. ncbi Interaction of ozone and cigarette smoke exposure
    R J Shephard
    Environ Res 31:125-37. 1983
    ..It is concluded that over an acute 2-hr exposure, there is no appreciable interaction between cigarette smoking and responses to ozone...
  3. ncbi Effect of exposure to low levels of ozone on the response to inhaled allergen in allergic asthmatic patients
    N A Hanania
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Chest 114:752-6. 1998
    ..Other studies failed to confirm this effect. In the present study, using a similar design, we reexamined this effect using a larger group of asthmatics and a larger chamber allowing minimal fluctuations in ozone levels during exposures...
  4. ncbi Induced sputum: comparison of postinfectious cough with allergic asthma in children
    B Zimmerman
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, and the Asthma Centre, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    J Allergy Clin Immunol 105:495-9. 2000
    ..Cough persisting after a respiratory infection is common in children and is often managed as asthma. However, little is known about the pathophysiologic mechanisms of such cough and how it compares with asthma...
  5. ncbi Cyclooxygenase metabolites play a different role in ozone-induced pulmonary function decline in asthmatics compared to normals
    N Alexis
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, 104 Mason Farm Rd, Chapel Hill, NC 27599 7310, USA
    Inhal Toxicol 12:1205-24. 2000
    ..Specifically, COX metabolites contribute to restrictive-type changes in normals and obstructive-type changes in small airways in asthmatics...
  6. ncbi Peanut allergy: children who lose the positive skin test response
    B Zimmerman
    J Allergy Clin Immunol 107:558-9. 2001
  7. ncbi The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers
    Gopal Sivagangabalan
    Division of Cardiology, Toronto General Hospital, Toronto, Ontario, Canada
    J Am Coll Cardiol 57:198-206. 2011
    ..We tested the hypothesis that exposure to concentrated ambient particles (CAP) and/or ozone (O(3)) would increase dispersion of ventricular repolarization...
  8. ncbi Autonomic effects of controlled fine particulate exposure in young healthy adults: effect modification by ozone
    Asghar A Fakhri
    Cardiovascular Epidemiology Research Unit, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:1287-92. 2009
    ....
  9. ncbi Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans
    Robert D Brook
    University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106, USA
    Hypertension 54:659-67. 2009
    ..Our findings demonstrate credible mechanisms whereby fine particulate matter could trigger acute cardiovascular events and that aspects of exposure location may be an important determinant of the health consequences...
  10. ncbi Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma
    Michelle L North
    Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Respir Res 12:19. 2011
    ..Thus, we hypothesize that arginase contributes to the exacerbation of respiratory symptoms following exposure to air pollution, and that pharmacologic inhibition of arginase would abrogate the pollution-induced AHR...
  11. ncbi A novel application of capnography during controlled human exposure to air pollution
    Karl Z Lukic
    Gage Occupational and Environmental Health Unit, St Michael s Hospital and University of Toronto, Toronto, ON, Canada
    Biomed Eng Online 5:54. 2006
    ..The objective was to determine the repeatability and stability of capnography interfaced with human exposure facility...
  12. ncbi Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humans
    Bruce Urch
    Gage Occupational and Environmental Health Unit, St. Michael's Hospital, and Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Inhal Toxicol 16:345-52. 2004
    ..An understanding of the PM constituents most responsible for adverse health outcomes is critical for efforts to develop pollution abatement strategies that maximize benefits to public health...
  13. ncbi Baseline repeated measures from controlled human exposure studies: associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen
    Aaron M S Thompson
    Gage Occupational and Environmental Health Unit, University of Toronto, Ontario, Canada
    Environ Health Perspect 118:120-4. 2010
    ..Interleukin-6 (IL-6) and fibrinogen are biomarkers of systemic inflammation that are independent risk factors for cardio-vascular disease...
  14. ncbi Concentrated ambient fine particles and not ozone induce a systemic interleukin-6 response in humans
    Bruce Urch
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, Toronto, Ontario, Canada
    Inhal Toxicol 22:210-8. 2010
    ..The study demonstrated an acute IL-6 response to PM(2.5), providing evidence to support the epidemiological findings of associations between ambient levels of particles and cardiopulmonary morbidity and mortality...
  15. ncbi Acute blood pressure responses in healthy adults during controlled air pollution exposures
    Bruce Urch
    Gage Occupational and Environmental Health Unit, St Michael s Hospital, Toronto, Ontario, Canada
    Environ Health Perspect 113:1052-5. 2005
    ..5 carbon content. Exposure to vehicular traffic may provide a common link between our observations and previous studies in which traffic exposure was identified as a potential risk factor for cardiovascular disease...
  16. ncbi Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults
    Robert D Brook
    University of Michigan, Ann Arbor, USA
    Circulation 105:1534-6. 2002
    ..Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function...