D A Underhill

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation
    Leanna W K Tsang
    Department of Medical Genetics, School of Human Development, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e14447. 2010
  2. ncbi request reprint PAX proteins and fables of their reconstruction
    Darrell Alan Underhill
    Department of Oncology, School of Cancer, Engineering and Imaging Sciences, Faculty of Medicine and Dentistry, University of Alberta, 2328 Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada
    Crit Rev Eukaryot Gene Expr 22:161-77. 2012
  3. ncbi request reprint Identification of a novel, alternatively spliced isoform and single nucleotide polymorphisms in the murine Pea-15 gene
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mamm Genome 12:172-4. 2001
  4. ncbi request reprint Genetic and biochemical diversity in the Pax gene family
    D A Underhill
    Department of Medical Genetics, University of Alberta, Edmonton, Canada
    Biochem Cell Biol 78:629-38. 2000
  5. ncbi request reprint Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Mamm Genome 11:633-8. 2000
  6. ncbi request reprint Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail
    Z Kibar
    Department of Biochemistry, McGill University, Montreal, Canada
    Nat Genet 28:251-5. 2001
  7. pmc An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity
    K J Vogan
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 16:6677-86. 1996
  8. pmc Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, PQ, Canada
    Proc Natl Acad Sci U S A 92:3692-6. 1995
  9. ncbi request reprint Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping
    Z Kibar
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 72:331-7. 2001
  10. ncbi request reprint The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Biochemistry 38:14746-51. 1999

Collaborators

Detail Information

Publications13

  1. pmc Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation
    Leanna W K Tsang
    Department of Medical Genetics, School of Human Development, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 5:e14447. 2010
    ..At the same time, we characterized a second isoform of SUV420H1 (designated SUV420H1_i2) and compared the activity of all three SUV420H proteins with regard to localization and H4K20 methylation...
  2. ncbi request reprint PAX proteins and fables of their reconstruction
    Darrell Alan Underhill
    Department of Oncology, School of Cancer, Engineering and Imaging Sciences, Faculty of Medicine and Dentistry, University of Alberta, 2328 Cross Cancer Institute, 11560 University Avenue, Edmonton, Alberta, Canada
    Crit Rev Eukaryot Gene Expr 22:161-77. 2012
    ..When combined with alternative splicing and posttranslational modifications, this model confers an extraordinary degree of functional diversity to even highly related PAX proteins...
  3. ncbi request reprint Identification of a novel, alternatively spliced isoform and single nucleotide polymorphisms in the murine Pea-15 gene
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mamm Genome 12:172-4. 2001
  4. ncbi request reprint Genetic and biochemical diversity in the Pax gene family
    D A Underhill
    Department of Medical Genetics, University of Alberta, Edmonton, Canada
    Biochem Cell Biol 78:629-38. 2000
    ..This review focuses on both genetic and biochemical aspects of the Pax family, and emphasizes important differences in the activity of individual Pax genes and their protein products...
  5. ncbi request reprint Transcription mapping and expression analysis of candidate genes in the vicinity of the mouse Loop-tail mutation
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Mamm Genome 11:633-8. 2000
    ..Consequently, analysis of the Lp interval may provide important tools to understand how the corresponding region of human Chr 1 contributes to disease, in addition to defining a key gene product required for neurulation...
  6. ncbi request reprint Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail
    Z Kibar
    Department of Biochemistry, McGill University, Montreal, Canada
    Nat Genet 28:251-5. 2001
    ..Ltap is expressed broadly in the neuroectoderm throughout early neurogenesis and is altered in two independent Lp alleles, identifying this gene as a strong candidate for Lp...
  7. pmc An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity
    K J Vogan
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 16:6677-86. 1996
    ....
  8. pmc Analysis of the mouse Splotch-delayed mutation indicates that the Pax-3 paired domain can influence homeodomain DNA-binding activity
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, PQ, Canada
    Proc Natl Acad Sci U S A 92:3692-6. 1995
    ..Furthermore, it is apparent that the paired domain and homeodomain of Pax-3 do not function as independent domains, since a mutation in the former impairs the DNA-binding activity of the latter...
  9. ncbi request reprint Identification of a new chemically induced allele (Lp(m1Jus)) at the loop-tail locus: morphology, histology, and genetic mapping
    Z Kibar
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 72:331-7. 2001
    ..Based on these phenotypic and genetic data, Lp(m1Jus) is most likely allelic to Lp, thereby representing a valuable additional tool for the positional cloning of the Lp gene and its subsequent molecular characterization...
  10. ncbi request reprint The Na,K-ATPase alpha4 gene (Atp1a4) encodes a ouabain-resistant alpha subunit and is tightly linked to the alpha2 gene (Atp1a2) on mouse chromosome 1
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Biochemistry 38:14746-51. 1999
    ..Together, our studies indicate that the alpha4 subunit represents a functional Na,K-ATPase alpha subunit isoform...
  11. ncbi request reprint Physical delineation of a 700-kb region overlapping the Looptail mutation on mouse chromosome 1
    D A Underhill
    Department of Biochemistry, McGill University, Montreal, Quebec, H3G 1Y6, Canada
    Genomics 55:185-93. 1999
    ....
  12. ncbi request reprint Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region
    D A Underhill
    Department of Obstetrics and Gynecology, University of Western Ontario, Victoria Hospital, London, Canada
    Mol Endocrinol 3:1448-54. 1989
    ..It would therefore appear that these proteins are derived from a common ancestral gene, and this supports the concept that they may be functionally related...
  13. ncbi request reprint The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs
    G L Hammond
    Department of Obstetrics and Gynecology, University of Western Ontario, Victoria Hospital, London, Canada
    Mol Endocrinol 3:1869-76. 1989
    ..Although the relative abundance of the various SHBG-related mRNAs in the testis has not been established, Northern blot analysis indicates that they are similar in size (1.6 kb) to that of hepatic SHBG mRNA...