V L Trudeau


Affiliation: University of Ottawa
Country: Canada


  1. Trudeau V, Turque N, Le Mevel S, Alliot C, Gallant N, Coen L, et al. Assessment of estrogenic endocrine-disrupting chemical actions in the brain using in vivo somatic gene transfer. Environ Health Perspect. 2005;113:329-34 pubmed
    ..We provide a method adaptable to aquatic organisms to study the direct regulation of estrogen-responsive genes in vivo. ..
  2. Trudeau V, Martyniuk C, Zhao E, Hu H, Volkoff H, Decatur W, et al. Is secretoneurin a new hormone?. Gen Comp Endocrinol. 2012;175:10-8 pubmed publisher
    ..Intracerebroventricular injection of SN increases feeding and locomotory behaviors in goldfish. Given that SgII appeared early in vertebrate evolution, SN is an old peptide with emerging implications as a new multifunctional hormone. ..
  3. Vera Chang M, St Jacques A, Gagne R, Martyniuk C, Yauk C, Moon T, et al. Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio. Proc Natl Acad Sci U S A. 2018;115:E12435-E12442 pubmed publisher
    ..This may be a cause for concern given the high prescription rates of FLX to pregnant women and the potential long-term negative impacts on humans exposed to these therapeutic drugs. ..
  4. Salgado Costa C, Ronco A, Trudeau V, Marino D, Natale G. Tadpoles of the horned frog Ceratophrys ornata exhibit high sensitivity to chlorpyrifos for conventional ecotoxicological and novel bioacoustic variables. Environ Pollut. 2018;235:938-947 pubmed publisher
    ..Therefore, sound production may be a good biomarker since it anticipates other endpoints that are also affected by CPF. Ceratophrys ornata is a promising new model species in ecotoxicology. ..
  5. Pouso P, Quintana L, López G, Somoza G, Silva A, Trudeau V. The secretogranin-II derived peptide secretoneurin modulates electric behavior in the weakly pulse type electric fish, Brachyhypopomus gauderio. Gen Comp Endocrinol. 2015;222:158-66 pubmed publisher
    ..Taken together, our results suggest that SN may regulate electric behavior, and that its effect on EOD rate may be explained by direct action of SN at the PN level through either neuroendocrine and/or endocrine mechanisms. ..
  6. Trudeau V, Somoza G, Natale G, Pauli B, Wignall J, Jackman P, et al. Hormonal induction of spawning in 4 species of frogs by coinjection with a gonadotropin-releasing hormone agonist and a dopamine antagonist. Reprod Biol Endocrinol. 2010;8:36 pubmed publisher
    ..Our approach offers some advantages over other hormonally-based techniques. Both sexes are injected only once and at the same time, reducing handling stress. AMPHIPLEX is a new reproductive management tool for captive breeding in Anura. ..
  7. Xing L, Gutierrez Villagomez J, Da Fonte D, Venables M, Trudeau V. Dehydroabietic acid cytotoxicity in goldfish radial glial cells in vitro. Aquat Toxicol. 2016;180:78-83 pubmed publisher
    ..Due to the continuous presence of DHAA into water systems, results from this study provide indications as to the potential impacts of DHAA and demonstrate the importance of this class of chemicals on aquatic organisms. ..
  8. Venables M, Navarro Martín L, Basak A, Baum B, Zhang D, Trudeau V. Characterization of multiple nestin isoforms in the goldfish brain. Comp Biochem Physiol Part D Genomics Proteomics. 2016;19:8-17 pubmed publisher
    ..Studying the differential roles and regulation of these nestins could lead to a better understanding of cellular remodeling during neurogenesis and the unparalleled regenerative abilities after damage in the teleost CNS. ..
  9. Xing L, Venables M, Trudeau V. Role of aromatase and radial glial cells in neurotoxin-induced dopamine neuron degeneration and regeneration. Gen Comp Endocrinol. 2017;241:69-79 pubmed publisher
    ..Future studies focus on the molecular pathways for enhancing protective functions of estrogens and understanding global effects of estrogens in the central nervous system. ..

More Information


  1. Hamilton C, Navarro Martín L, Neufeld M, Basak A, Trudeau V. Early expression of aromatase and the membrane estrogen receptor GPER in neuromasts reveals a role for estrogens in the development of the frog lateral line system. Gen Comp Endocrinol. 2014;205:242-50 pubmed publisher
    ..Future study of this novel estrogen system in the amphibian lateral line may shed light on similar systems such as the mammalian inner ear. ..
  2. Vu M, Trudeau V. Neuroendocrine control of spawning in amphibians and its practical applications. Gen Comp Endocrinol. 2016;234:28-39 pubmed publisher
  3. Mikwar M, Navarro Martín L, Xing L, Volkoff H, Hu W, Trudeau V. Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish (Carassius auratus). Peptides. 2016;78:42-50 pubmed publisher
    ..01) at 2h and 5h post-injection, respectively. These data suggest interactions of SNa with stimulatory and inhibitory pathways of food intake control in fish. ..
  4. Gutierrez Villagomez J, Vázquez Martínez J, Ramírez Chávez E, Molina Torres J, Trudeau V. Analysis of naphthenic acid mixtures as pentafluorobenzyl derivatives by gas chromatography-electron impact mass spectrometry. Talanta. 2017;162:440-452 pubmed publisher
    ..This methodology will have wide applications in the elucidation of NA mixtures. ..
  5. Da Fonte D, Xing L, Mikwar M, Trudeau V. Secretoneurin-A inhibits aromatase B (cyp19a1b) expression in female goldfish (Carassius auratus) radial glial cells. Gen Comp Endocrinol. 2018;257:106-112 pubmed publisher
    ..By regulating neuroestrogen production in RGCs SNa may therefore be implicated in the control of major estrogen-dependent functions of the preoptic region such as reproductive behavior and osmoregulation. ..
  6. Trudeau V, Schueler F, Navarro Martín L, Hamilton C, Bulaeva E, Bennett A, et al. Efficient induction of spawning of northern leopard frogs (Lithobates pipiens) during and outside the natural breeding season. Reprod Biol Endocrinol. 2013;11:14 pubmed publisher
    ..We provide evidence for successful captive breeding of the leopard frog, L. pipiens. This simple protocol can be used to obtain large numbers of eggs in a predictable, timed manner. ..
  7. Xing L, Martyniuk C, Esau C, Da Fonte D, Trudeau V. Proteomic profiling reveals dopaminergic regulation of progenitor cell functions of goldfish radial glial cells in vitro. J Proteomics. 2016;144:123-32 pubmed publisher
    ..Lastly, this study begins to characterize signatures and biomarkers for specific neuroendocrine and neurogenesis disruptors. ..
  8. Vu M, Weiler B, Trudeau V. Time- and dose-related effects of a gonadotropin-releasing hormone agonist and dopamine antagonist on reproduction in the Northern leopard frog (Lithobates pipiens). Gen Comp Endocrinol. 2017;254:86-96 pubmed publisher
    ..The results from this study provide a fundamental framework for future time- and dose-response investigations to improve current spawning methods in amphibians. ..
  9. Da Fonte D, Martyniuk C, Xing L, Pelin A, Corradi N, Hu W, et al. Secretoneurin A regulates neurogenic and inflammatory transcriptional networks in goldfish (Carassius auratus) radial glia. Sci Rep. 2017;7:14930 pubmed publisher
    ..These data reveal an array of new functions that are proposed to be critical to neuronal-glial interactions through the mediator SNa. ..