Kiril Trpkov

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint 'Insignificant' prostate cancer on prostatectomy and cystoprostatectomy: variation on a theme 'low-volume/low-grade' prostate cancer?
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, Calgary, Alberta, Canada
    BJU Int 106:304-15. 2010
  2. doi request reprint Prostate cancer with tertiary Gleason pattern 5 in prostate needle biopsy: clinicopathologic findings and disease progression
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Am J Surg Pathol 33:233-40. 2009
  3. doi request reprint Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada
    Histopathology 57:893-906. 2010
  4. doi request reprint How much tissue sampling is required when unsuspected minimal prostate carcinoma is identified on transurethral resection?
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Anatomical Pathology, Rockyview General Hospital, Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada
    Arch Pathol Lab Med 132:1313-6. 2008
  5. pmc Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Rockyview General Hospital, 7007 14 st, Calgary, T2V 1P9, Alberta, Canada
    Diagn Pathol 6:78. 2011
  6. doi request reprint Arias-Stella reaction as a diagnostic pitfall in a bladder biopsy with endometriosis: case report and review of the pseudoneoplastic bladder lesions
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Alberta, Canada
    Pathol Res Pract 205:653-6. 2009
  7. ncbi request reprint No residual cancer on radical prostatectomy after positive 10-core biopsy: incidence, biopsy findings, and DNA specimen identity analysis
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Anatomical Pathology, Rockyview General Hospital, University of Calgary, Calgary, Alberta, Canada
    Arch Pathol Lab Med 130:811-6. 2006
  8. doi request reprint A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer: quality of life outcomes
    John W Robinson
    Department of Oncology, University of Calgary and Tom Baker Cancer Center, Calgary, Alberta, Canada
    Cancer 115:4695-704. 2009
  9. doi request reprint ERG protein expression and gene rearrangements are present at lower rates in metastatic and locally advanced castration-resistant prostate cancer compared to localized disease
    Liang Hong Teng
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Urology 82:394-9. 2013
  10. doi request reprint The impact of the 2005 International Society of Urological Pathology (ISUP) consensus on Gleason grading in contemporary practice
    Piotr Zareba
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Canada
    Histopathology 55:384-91. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint 'Insignificant' prostate cancer on prostatectomy and cystoprostatectomy: variation on a theme 'low-volume/low-grade' prostate cancer?
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, Calgary, Alberta, Canada
    BJU Int 106:304-15. 2010
    ..We conclude that in most cases these low-volume/low-grade prostate cancers represent an early stage and clinically 'silent' disease, which are only detected in different clinical settings...
  2. doi request reprint Prostate cancer with tertiary Gleason pattern 5 in prostate needle biopsy: clinicopathologic findings and disease progression
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Calgary, Alberta, Canada
    Am J Surg Pathol 33:233-40. 2009
    ..04, 95% CI: 0.47-2.32, P=0.92), but had a marginally higher risk of cause-specific mortality than patients with tertiary pattern 5 (adjusted HR: 2.13, 95% CI: 0.75-6.10, P=0.16)...
  3. doi request reprint Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada
    Histopathology 57:893-906. 2010
    ..To evaluate problematic diagnostic features in renal oncocytoma...
  4. doi request reprint How much tissue sampling is required when unsuspected minimal prostate carcinoma is identified on transurethral resection?
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Anatomical Pathology, Rockyview General Hospital, Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada
    Arch Pathol Lab Med 132:1313-6. 2008
    ..When minimal prostate cancer is detected in the initial transurethral resection of the prostate (TURP) sample, it is uncertain how extensively the remaining tissue should be sampled for accurate grading and staging...
  5. pmc Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Rockyview General Hospital, 7007 14 st, Calgary, T2V 1P9, Alberta, Canada
    Diagn Pathol 6:78. 2011
    ..Documentation of these rare tumors will allow their distinction from true malignant mesotheliomas and will facilitate the development of specific treatment recommendations...
  6. doi request reprint Arias-Stella reaction as a diagnostic pitfall in a bladder biopsy with endometriosis: case report and review of the pseudoneoplastic bladder lesions
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Alberta, Canada
    Pathol Res Pract 205:653-6. 2009
    ..We also discuss endometriosis, endocervicosis, and müllerianosis of the bladder, which are benign glandular lesions that may mimic tumors within the bladder wall...
  7. ncbi request reprint No residual cancer on radical prostatectomy after positive 10-core biopsy: incidence, biopsy findings, and DNA specimen identity analysis
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, Anatomical Pathology, Rockyview General Hospital, University of Calgary, Calgary, Alberta, Canada
    Arch Pathol Lab Med 130:811-6. 2006
    ..It is uncertain whether extensive prostate-specific antigen (PSA) testing and extended biopsies currently performed will increase the incidence of no residual cancer on subsequent prostatectomy...
  8. doi request reprint A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer: quality of life outcomes
    John W Robinson
    Department of Oncology, University of Calgary and Tom Baker Cancer Center, Calgary, Alberta, Canada
    Cancer 115:4695-704. 2009
    ..We report on the quality of life (QOL) outcomes for this trial...
  9. doi request reprint ERG protein expression and gene rearrangements are present at lower rates in metastatic and locally advanced castration-resistant prostate cancer compared to localized disease
    Liang Hong Teng
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Urology 82:394-9. 2013
    ....
  10. doi request reprint The impact of the 2005 International Society of Urological Pathology (ISUP) consensus on Gleason grading in contemporary practice
    Piotr Zareba
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Canada
    Histopathology 55:384-91. 2009
    ..To investigate the impact of the 2005 International Society of Urological Pathology (ISUP) Gleason grading consensus in contemporary practice...
  11. doi request reprint Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium
    Wenjie Wang
    Department of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada
    J Immunol 190:1239-49. 2013
    ..Taken together, these data support a novel and direct role for NLRP3 in promoting TGF-β signaling and R-Smad activation in epithelial cells independent of the inflammasome...
  12. doi request reprint Use of immunohistochemistry in routine workup of prostate needle biopsies: a tertiary academic institution experience
    Kristalee Watson
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services and Rockyview General Hospital, Calgary, Alberta, Canada T2V 1P9
    Arch Pathol Lab Med 137:541-5. 2013
    ..Diagnostic use of immunohistochemistry has been extensively studied in prostate needle biopsy, but its use in routine practice and the quality assurance and associated cost have not been previously addressed...
  13. doi request reprint Testicular hilum and vascular invasion predict advanced clinical stage in nonseminomatous germ cell tumors
    Asli Yilmaz
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, Alberta, Canada
    Mod Pathol 26:579-86. 2013
    ....
  14. doi request reprint Interobserver agreement for Polyomavirus nephropathy grading in renal allografts using the working proposal from the 10th Banff Conference on Allograft Pathology
    Aylin Sar
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, T2V 1P9 Alberta, Canada
    Hum Pathol 42:2018-24. 2011
    ..The proposed grading schema can be applied in routine allograft biopsy practice for grading the Polyomavirus nephropathy stage and the viral load level...
  15. doi request reprint Handling and staging of renal cell carcinoma: the International Society of Urological Pathology Consensus (ISUP) conference recommendations
    Kiril Trpkov
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, AB Department of Laboratory Medicine, Credit Valley Hospital, Mississauga Department of Pathology and Molecular Medicine, McMaster University, Toronto, ON, Canada Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN Nephropath, Little Rock, AR Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA Department of Pathology, MD Anderson Cancer Center Houston, Houston, TX School of Medical Sciences, State University of Campinas UNICAMP, Campinas, Brazil Department of Pathology and Surgery, University of Cordoba Medical School, Cordoba, Spain Aquesta Pathology, University of Queensland, Brisbane, QLD, Australia Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand Department of Oncology and Pathology, Karolinska University Hospital, Solna, Stockholm, Sweden Section of Pathological Anatomy, Polytechnic University of Marche Region, United Hospitals Ancona, Ancona, Italy
    Am J Surg Pathol 37:1505-17. 2013
    ....
  16. doi request reprint Long term outcome of primary urothelial papilloma: a single institution cohort
    Samir Al Bashir
    1Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary 2Division of Urology, University of Calgary, Calgary, Alberta, Canada
    Pathology 46:37-40. 2014
    ..Primary UP does not progress to UC when diagnosed using strict criteria, when no previous or concurrent neoplasms are documented, and when complete initial resection is performed...
  17. ncbi request reprint Detection of ERG gene rearrangements and PTEN deletions in unsuspected prostate cancer of the transition zone
    ShuHong Liu
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Canada
    Cancer Biol Ther 11:562-6. 2011
    ..Additional studies implementing ERG and PTEN tissue-based FISH assays in tumors of the TZ are warranted to substantiate the potential clinical value of these biomarkers in the management of men with incidental PCA...
  18. doi request reprint A randomized trial of external beam radiotherapy versus cryoablation in patients with localized prostate cancer
    Bryan J Donnelly
    Department of Surgery, Tom Baker Cancer Center, Suite 212, 1011 Glenmore Trail SW, Calgary, Alberta T2V 4R6, Canada
    Cancer 116:323-30. 2010
    ..The authors of this report conducted a randomized, unblinded, noninferiority trial to compare cryoablation with external beam radiotherapy in these patients...
  19. doi request reprint Interobserver variability between expert urologic pathologists for extraprostatic extension and surgical margin status in radical prostatectomy specimens
    Andrew J Evans
    Department of Pathology and Laboratory Medicine, University Health Network, Toronto, Ontario, Canada
    Am J Surg Pathol 32:1503-12. 2008
    ..Interobserver variability for EPE and SM interpretation was principally related to the lack of a clearly definable prostatic capsule and crush/thermal artifact along the edge of the gland, respectively...
  20. ncbi request reprint Urinary bladder melanosis associated with urothelial dysplasia and invasive urothelial carcinoma: a report of two cases
    Premal Patel
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Anal Quant Cytol Histol 35:294-300. 2013
    ..Melanosis of the urinary bladder is typically considered a benign condition, but it has also been described in association with malignant melanoma and urothelial carcinoma...
  21. pmc Autoimmune pancreatitis associated with renal lesions mimicking metastatic tumours
    Lucas Rudmik
    Department of Surgery, University of Calgary, Calgary, Alta
    CMAJ 175:367-9. 2006
    ..We describe a novel case of IgG4-associated autoimmune pancreatitis presenting with tubulointerstitial nephritis as renal lesions mimicking metastatic tumours but with no change in renal function...
  22. ncbi request reprint Renal medullary carcinoma as an incidental finding in a horseshoe kidney: case report and literature review
    Gilles Molgat
    Department of Pathology and Laboratory Medicine, Calgary Laboratory Services, University of Calgary, Alberta, Canada
    Can J Urol 12:2837-40. 2005
    ..Due to the small size of the tumor and the limited metastatic spread only to the regional lymph nodes, the tumor was considered an incidental finding, and not the primary cause of patient's death...
  23. doi request reprint Usefulness of cytokeratin 5/6 and AMACR applied as double sequential immunostains for diagnostic assessment of problematic prostate specimens
    Kiril Trpkov
    Anatomical Pathology, Rockyview General Hospital, Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, 7007 14 Street SW, Calgary, Alberta T2V 1P9, Canada
    Am J Clin Pathol 132:211-20; quiz 307. 2009
    ..Double immunohistochemical staining for CK5/6 and AMACR is a simple assay to perform and may be used as an alternative to antibody cocktails for routine evaluation of problematic prostate specimens...
  24. doi request reprint Long-term clinical outcome of inverted urothelial papilloma including cases with focal papillary pattern: is continuous surveillance necessary?
    Premal Patel
    Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada
    Urology 82:857-60. 2013
    ..To investigate the necessity for continuous cystoscopic surveillance of inverted papilloma (IP), including tumors exhibiting mixed morphology (IP with focal papillary architecture)...
  25. pmc The NLRP3 inflammasome promotes renal inflammation and contributes to CKD
    Akosua Vilaysane
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Am Soc Nephrol 21:1732-44. 2010
    ..Taken together, these results strongly support a role for NLRP3 in renal injury and identify the inflammasome as a possible therapeutic target in the treatment of patients with progressive CKD...
  26. ncbi request reprint HPC2/ELAC2 gene variants associated with incident prostate cancer
    David Adler
    Southern Alberta Cancer Research Centre, Department of Oncology, University of Calgary, Room 300 Heritage Medical Research Building, 3330 Hospital Dr NW, Calgary, Alberta, T2 N 4N1, Canada
    J Hum Genet 48:634-8. 2003
    ..0 versus 34.6%) (OR 1.89, 95% CI 0.75-4.78). In summary, the HPC2 gene variants Leu217 and Thr541 were associated with an increased risk for prostate cancer and for PIN in males undergoing radical prostatectomies in the Calgary region...
  27. doi request reprint Oncolytic viral therapy for prostate cancer: efficacy of reovirus as a biological therapeutic
    Chandini M Thirukkumaran
    Departments of Oncology, University of Calgary, Calgary, Alberta, Canada
    Cancer Res 70:2435-44. 2010
    ..These findings suggest that reovirus therapy may provide a promising novel treatment for prostate cancer and also imply a possible role for viral immune targeting of tumor...
  28. ncbi request reprint Use of digital maps and sampling of radical prostatectomy specimens
    Kiril Trpkov
    Arch Pathol Lab Med 130:1751-2; author reply 1752. 2006
  29. ncbi request reprint Editorial comment on: systematic assessment of the ability of the number and percentage of positive biopsy cores to predict pathologic stage and biochemical recurrence after radical prostatectomy
    Kiril Trpkov
    Eur Urol 52:743-4. 2007
  30. ncbi request reprint A nomogram for predicting low-volume/low-grade prostate cancer: a tool in selecting patients for active surveillance
    Hiroyuki Nakanishi
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 110:2441-7. 2007
    ..On the basis of those findings, they developed a nomogram to predict the probability of low-volume/low-grade prostate cancer specifically for men with a single positive biopsy core...
  31. ncbi request reprint IBF as a formalin substitute fixative in prostate biopsy pathology
    Kiril Trpkov
    Arch Pathol Lab Med 130:13-4. 2006
  32. ncbi request reprint Reproducibility of the Banff schema in reporting protocol biopsies of stable renal allografts
    James Gough
    Department of Pathology, University of Manitoba Health Sciences Centre, Winnipeg, Manitoba, Canada
    Nephrol Dial Transplant 17:1081-4. 2002
    ..However, the reproducibility of such histological evaluation has not been tested in this setting. We tested the reproducibility of the Banff schema for this purpose...