V Tropepe

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival
    Nicole Forgione
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e41033. 2012
  2. pmc FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm
    Lan T H Dang
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Neural Dev 5:13. 2010
  3. pmc Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development
    Loksum Wong
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    BMC Dev Biol 10:100. 2010
  4. ncbi request reprint Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Dev Biol 208:166-88. 1999
  5. doi request reprint Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue
    Vincent Tropepe
    Department of Cell and Systems Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON M5S 3G5, Canada
    Stem Cells Dev 18:1533-42. 2009
  6. ncbi request reprint Kinship and descent: redefining the stem cell compartment in the adult hippocampus
    Vincent Tropepe
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
    Cell Stem Cell 1:481-3. 2007
  7. ncbi request reprint Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Toronto, Canada
    Neuron 30:65-78. 2001
  8. ncbi request reprint Separate proliferation kinetics of fibroblast growth factor-responsive and epidermal growth factor-responsive neural stem cells within the embryonic forebrain germinal zone
    D J Martens
    University of Toronto, Department of Anatomy and Cell Biology, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 20:1085-95. 2000
  9. ncbi request reprint Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    V Tropepe
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 17:7850-9. 1997
  10. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002

Collaborators

Detail Information

Publications14

  1. pmc Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival
    Nicole Forgione
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 7:e41033. 2012
    ..These data suggest that HDACs function to promote neuronal survival by activating a TLR and IL-6 dependent pathway...
  2. pmc FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm
    Lan T H Dang
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    Neural Dev 5:13. 2010
    ..Here we tested whether FGF and Wnt signaling pathways can regulate Zfhx1b expression to control early neural stem cell development...
  3. pmc Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development
    Loksum Wong
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    BMC Dev Biol 10:100. 2010
    ....
  4. ncbi request reprint Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, M5S 1A8, Canada
    Dev Biol 208:166-88. 1999
    ..These results support a model in which separate, lineage-related EGF- and FGF-responsive neural stem cells are present in the embryonic telencephalic germinal zone...
  5. doi request reprint Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue
    Vincent Tropepe
    Department of Cell and Systems Biology, Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, ON M5S 3G5, Canada
    Stem Cells Dev 18:1533-42. 2009
    ....
  6. ncbi request reprint Kinship and descent: redefining the stem cell compartment in the adult hippocampus
    Vincent Tropepe
    Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada
    Cell Stem Cell 1:481-3. 2007
  7. ncbi request reprint Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism
    V Tropepe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario M5S 1A8, Toronto, Canada
    Neuron 30:65-78. 2001
    ..These results are consistent with a default mechanism for neural fate specification and support a model whereby definitive neural stem cell formation is preceded by a primitive neural stem cell stage during neural lineage commitment...
  8. ncbi request reprint Separate proliferation kinetics of fibroblast growth factor-responsive and epidermal growth factor-responsive neural stem cells within the embryonic forebrain germinal zone
    D J Martens
    University of Toronto, Department of Anatomy and Cell Biology, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 20:1085-95. 2000
    ..The EGF-responsive stem cells arise after E11, and their population expands through symmetric divisions and through asymmetric divisions of FGF-responsive stem cells...
  9. ncbi request reprint Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    V Tropepe
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurosci 17:7850-9. 1997
    ..These results suggest that endogenous TGFalpha and the effects of senescence may regulate the proliferation of progenitor cells in the adult subependyma, but that the number of neural stem cells is maintained throughout life...
  10. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002
    ..These data are consistent with a role for Notch signaling in the maintenance of the neural stem cell, and inconsistent with a role in a neuronal/glial fate switch...
  11. ncbi request reprint A comparative framework for understanding the biological principles of adult neurogenesis
    Benjamin W Lindsey
    Department of Anatomy and Neurobiology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, NS, Canada
    Prog Neurobiol 80:281-307. 2006
    ....
  12. ncbi request reprint Neural induction and neural stem cell development
    Lan Dang
    Department of Cell and Systems Biology, University of Toronto, ON, Canada
    Regen Med 1:635-52. 2006
    ..A clearer understanding of the molecular and cellular mechanisms that govern mammalian neural cell fate determination will lead to improved ES technology applications in neural regeneration...
  13. ncbi request reprint Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1
    Vincent Tropepe
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Dev Biol 289:517-29. 2006
    ..These data suggest that interruption of BMP signaling facilitates neural determination via a complex mechanism, involving multiple regulatory factors that cooperate to control zic1 expression...
  14. ncbi request reprint Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 129:233-44. 2002
    ..Thus, neural stem cells and their progeny are regionally specified in the developing brain, but this regional identity can be altered by local inductive cues...