Catherine H Trepanier
Affiliation: University of Toronto
- Group II metabotropic glutamate receptors modify N-methyl-D-aspartate receptors via Src kinaseCatherine Trepanier
Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
Sci Rep 3:926. 2013..This represents a potentially novel mechanism to correct the hypoglutamatergic state found in schizophrenia...
- Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy?Catherine H Trepanier
Department of Pharmacology, University of Toronto, Toronto, Canada
J Alzheimers Dis 21:1089-99. 2010..We also review recent anecdotal data with the TNF-α inhibitor, etanercept, and discuss possible explanations for the failure of preclinical data to translate into successful clinical trials...
- Fyn, a potential target for Alzheimer's diseaseKai Yang
Department of Physiology, University of Toronto, Toronto, ON, Canada
J Alzheimers Dis 27:243-52. 2011..Novel insights into the role of Fyn in AD may help identify alternative pharmacological approaches for the treatment of AD...
- Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmissionKai Yang
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Hippocampus 19:779-89. 2009..g., 100 nM) was mediated by PAC1-R as well as by Src kinase. Overall, these results show that VIP can regulate NMDA receptors through different receptors and signaling pathways...
- Regulation of NMDA receptors by the tyrosine kinase FynCatherine H Trepanier
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
FEBS J 279:12-9. 2012..In addition to its effects on NMDA receptor function, Fyn also modifies the threshold for synaptic plasticity at CA1 synapses, an effect that probably contributes to the effects of Fyn on spatial and contextual fear learning...