Helen Tremlett

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Gut microbiota composition and relapse risk in pediatric MS: A pilot study
    Helen Tremlett
    University of British Columbia, Vancouver, BC, Canada Electronic address
    J Neurol Sci 363:153-7. 2016
  2. doi request reprint Characteristics associated with drug-induced liver injury from interferon beta in multiple sclerosis patients
    Kaarina Kowalec
    University of British Columbia UBC, Neuroscience Program, Room S178, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada 1 604 822 0759
    Expert Opin Drug Saf 13:1305-17. 2014
  3. pmc Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance
    Ruth Ann Marrie
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    BMC Neurol 13:16. 2013
  4. ncbi request reprint Natural, innate improvements in multiple sclerosis disability
    Helen Tremlett
    Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada
    Mult Scler 18:1412-21. 2012
  5. pmc Birth hospitalization in mothers with multiple sclerosis and their newborns
    Ellen Lu
    Department of Medicine, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurology 80:447-52. 2013
  6. doi request reprint Factors associated with delay to medical recognition in two Canadian multiple sclerosis cohorts
    Elaine Kingwell
    Faculty of Medicine Neurology, Multiple Sclerosis Program, UBC Hospital, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada V6T 2B5
    J Neurol Sci 292:57-62. 2010
  7. doi request reprint Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis
    Afsaneh Shirani
    Division of Neurology and Brain Research Centre, Department of Medicine and Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, Canada
    JAMA 308:247-56. 2012
  8. doi request reprint Obstetrical epidural and spinal anesthesia in multiple sclerosis
    Ellen Lu
    Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Room S178, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    J Neurol 260:2620-8. 2013
  9. doi request reprint Monthly ambient sunlight, infections and relapse rates in multiple sclerosis
    Helen Tremlett
    Faculty of Medicine Neurology, University of British Columbia, Vancouver, B C, Canada
    Neuroepidemiology 31:271-9. 2008
  10. pmc Multiple sclerosis in older adults: the clinical profile and impact of interferon Beta treatment
    Afsaneh Shirani
    Department of Medicine, Division of Neurology and Brain Research Centre, UBC Hospital, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Biomed Res Int 2015:451912. 2015

Collaborators

Detail Information

Publications45

  1. doi request reprint Gut microbiota composition and relapse risk in pediatric MS: A pilot study
    Helen Tremlett
    University of British Columbia, Vancouver, BC, Canada Electronic address
    J Neurol Sci 363:153-7. 2016
    ..presence) of Fusobacteria was associated with relapse risk (hazard ratio=3.2 (95% CI: 1.2-9.0), p=0.024). Further investigation is warranted. Findings could offer new targets to alter the MS disease course. ..
  2. doi request reprint Characteristics associated with drug-induced liver injury from interferon beta in multiple sclerosis patients
    Kaarina Kowalec
    University of British Columbia UBC, Neuroscience Program, Room S178, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada 1 604 822 0759
    Expert Opin Drug Saf 13:1305-17. 2014
    ..To identify and characterize drug-induced liver injury (DILI) associated with IFN-β in multiple sclerosis (MS) using recommended criteria...
  3. pmc Mental comorbidity and multiple sclerosis: validating administrative data to support population-based surveillance
    Ruth Ann Marrie
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    BMC Neurol 13:16. 2013
    ..We validated and applied administrative case definitions for any mental comorbidities in MS...
  4. ncbi request reprint Natural, innate improvements in multiple sclerosis disability
    Helen Tremlett
    Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada
    Mult Scler 18:1412-21. 2012
    ..However, improvements have rarely been examined in natural history or IMD naive patients. We investigated annual and biennial improvements in Expanded Disability Status Scale (EDSS) scores in British Columbia, Canada...
  5. pmc Birth hospitalization in mothers with multiple sclerosis and their newborns
    Ellen Lu
    Department of Medicine, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurology 80:447-52. 2013
    ....
  6. doi request reprint Factors associated with delay to medical recognition in two Canadian multiple sclerosis cohorts
    Elaine Kingwell
    Faculty of Medicine Neurology, Multiple Sclerosis Program, UBC Hospital, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC, Canada V6T 2B5
    J Neurol Sci 292:57-62. 2010
    ..001). If early intervention at mild disability levels is warranted in MS, then the extended delays to medical recognition for young adult-onset and PPMS patients must be addressed...
  7. doi request reprint Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis
    Afsaneh Shirani
    Division of Neurology and Brain Research Centre, Department of Medicine and Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, Canada
    JAMA 308:247-56. 2012
    ..Interferon beta is widely prescribed to treat multiple sclerosis (MS); however, its relationship with disability progression has yet to be established...
  8. doi request reprint Obstetrical epidural and spinal anesthesia in multiple sclerosis
    Ellen Lu
    Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Room S178, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    J Neurol 260:2620-8. 2013
    ..1). Contrary to previous studies, epidural anesthesia use differed between women with MS and the general population and was influenced by parity and MS disease duration; these findings warrant further investigation...
  9. doi request reprint Monthly ambient sunlight, infections and relapse rates in multiple sclerosis
    Helen Tremlett
    Faculty of Medicine Neurology, University of British Columbia, Vancouver, B C, Canada
    Neuroepidemiology 31:271-9. 2008
    ..Monthly variation in multiple sclerosis (MS) relapses has been found. The relationship between seasonal environmental factors, infections, serum vitamin D [25(OH)D] and MS relapses is undetermined...
  10. pmc Multiple sclerosis in older adults: the clinical profile and impact of interferon Beta treatment
    Afsaneh Shirani
    Department of Medicine, Division of Neurology and Brain Research Centre, UBC Hospital, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5
    Biomed Res Int 2015:451912. 2015
    ....
  11. ncbi request reprint Hospital admissions and MS: temporal trends and patient characteristics
    Charity Evans
    Faculty of Medicine Neurology, University of British Columbia, Vancouver, Canada
    Am J Manag Care 18:735-42. 2012
    ..We examined hospital admission rates and patterns in a large Canadian MS cohort...
  12. doi request reprint Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance
    Ellen Lu
    Department of Medicine, Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
    Expert Rev Neurother 13:251-60; quiz 261. 2013
    ..Future pharmacovigilance studies should continue to pursue multicenter collaboration with an emphasis on appropriate study design...
  13. doi request reprint Natural history of secondary-progressive multiple sclerosis
    Helen Tremlett
    Department of Medicine Neurology, rm S159, 2211 Wesbrook Mall, University of British Columbia, Vancouver BC V6T 2B5, Canada
    Mult Scler 14:314-24. 2008
    ..To examine prognosis and risk factors for progression to and from secondary-progressive multiple sclerosis (SPMS)...
  14. doi request reprint Natural history comparisons of primary and secondary progressive multiple sclerosis reveals differences and similarities
    Helen Tremlett
    Dept of Medicine Neurology, rm S178, 2211 Wesbrook Mal, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    J Neurol 256:374-81. 2009
    ..We aimed to examine how this phenomenon impacts on demographic and clinical comparisons made between PP and SPMS...
  15. doi request reprint Birth outcomes in newborns fathered by men with multiple sclerosis exposed to disease-modifying drugs
    Ellen Lu
    Brain Research Centre and Department of Medicine Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    CNS Drugs 28:475-82. 2014
    ....
  16. doi request reprint Characterising aggressive multiple sclerosis
    Suresh Menon
    Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurol Neurosurg Psychiatry 84:1192-8. 2013
    ..To explore the occurrence and characteristics of aggressive multiple sclerosis (AMS) in adult-onset multiple sclerosis (MS) patients...
  17. doi request reprint Temporal trends of disability progression in multiple sclerosis: findings from British Columbia, Canada (1975-2009)
    Afsaneh Shirani
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Mult Scler 18:442-50. 2012
    ..Recent natural history studies suggest that multiple sclerosis (MS) is a more slowly progressing disease than previously thought. These observations are from studies separated by time, geography and methodological approach...
  18. doi request reprint The natural history of primary progressive multiple sclerosis
    Marcus Koch
    Faculty of Medicine, Division of Neurology, University of British Columbia, Vancouver, Canada
    Neurology 73:1996-2002. 2009
    ..Here, we extend previous analyses in an updated PPMS retrospective cohort study of prevalent cases...
  19. ncbi request reprint Is late-onset multiple sclerosis associated with a worse outcome?
    Helen Tremlett
    Department of Medicine Neurology, rm S159, 2211 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 2B5, Canada
    Neurology 67:954-9. 2006
    ..To describe the characteristics of late-onset multiple sclerosis (MS) (LOMS, 50+ years) vs adult-onset MS (AOMS, 16 to <50 years) and examine prognosis and associated risk factors...
  20. doi request reprint Characteristics of multiple sclerosis in aboriginals living in British Columbia, Canada
    Jameelah Saeedi
    Faculty of Medicine, Division of Neurology, Multiple Sclerosis Program, University of British Columbia, Vancouver, BC, Canada
    Mult Scler 18:1239-43. 2012
    ..The objectives of this study were to identify and describe the demographic and clinical characteristics of multiple sclerosis (MS) in aboriginals in British Columbia (BC), Canada and compare these findings with non-aboriginal MS patients...
  21. ncbi request reprint Longitudinal follow-up of "benign" multiple sclerosis at 20 years
    Ana Luiza Sayao
    Department of Medicine Neurology, University of British Columbia, Vancouver, BC, Canada
    Neurology 68:496-500. 2007
    ..To evaluate disease status after 20 years in a cohort defined as "benign multiple sclerosis (MS)" (Expanded Disability Status Scale [EDSS] score < or = 3) at 10 years from onset...
  22. ncbi request reprint Disability progression in multiple sclerosis is slower than previously reported
    Helen Tremlett
    Department of Medicine Neurology, University of British Columbia, Vancouver, Canada
    Neurology 66:172-7. 2006
    ..To investigate disease progression and risk factors in a large geographically based population with multiple sclerosis (MS), using two different inception points--clinical onset and date of birth...
  23. doi request reprint Assessment of cancer risk with β-interferon treatment for multiple sclerosis
    Elaine Kingwell
    Faculty of Medicine Division of Neurology, Multiple Sclerosis Program University of British Columbia, Vancouver, British Columbia, Canada
    J Neurol Neurosurg Psychiatry 85:1096-102. 2014
    ..We assessed whether IFNβ treatment for MS is associated with cancer risk or the risk of specific cancers in a population-based observational study...
  24. doi request reprint A review of safety-related pregnancy data surrounding the oral disease-modifying drugs for multiple sclerosis
    Ellen Lu
    Division of Neurology, Brain Research Centre and Department of Medicine, Faculty of Medicine, University of British Columbia, Room S178, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    CNS Drugs 28:89-94. 2014
    ....
  25. doi request reprint Oligoclonal bands and cerebrospinal fluid markers in multiple sclerosis: associations with disease course and progression
    Pedro Lourenco
    Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Mult Scler 19:577-84. 2013
    ..The use of oligoclonal bands (OCBs) and cerebrospinal fluid (CSF) parameters are established in the diagnosis of MS, but poorly as markers of disease...
  26. pmc Disease-modifying drugs for multiple sclerosis in pregnancy: a systematic review
    Ellen Lu
    Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurology 79:1130-5. 2012
    ..To systematically review the literature regarding safety of disease-modifying drug (DMD) use during pregnancy on perinatal and developmental outcomes in offspring of patients with multiple sclerosis (MS)...
  27. doi request reprint Cancer risk in multiple sclerosis: findings from British Columbia, Canada
    Elaine Kingwell
    Division of Neurology, Faculty of Medicine, Multiple Sclerosis Program, University of British Columbia, Vancouver, British Columbia, Canada
    Brain 135:2973-9. 2012
    ..The larger tumour sizes at cancer diagnosis suggested diagnostic neglect; this could have major implications for the health, well-being and longevity of people with multiple sclerosis...
  28. doi request reprint Long-term persistence with the immunomodulatory drugs for multiple sclerosis: a retrospective database study
    Charity Evans
    Faculty of Medicine Neurology, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Ther 34:341-50. 2012
    ..However, relatively little is known about the long-term persistence to these drugs...
  29. doi request reprint Differences in the burden of psychiatric comorbidity in MS vs the general population
    Ruth Ann Marrie
    From the Departments of Internal Medicine R A M and Community Health Sciences R A M, S L, University of Manitoba, Winnipeg Departments of Psychiatry and Medicine J D F, Dalhousie University, Halifax Department of Medicine Neurology H T, University of British Columbia, Vancouver Department of Epidemiology and Biostatistics and Occupational Health C W, McGill University, Montreal Faculty of Rehabilitation Medicine S W, University of Alberta, Edmonton and Department of Community Health Sciences S B P, University of Calgary, Canada
    Neurology 85:1972-9. 2015
    ..We aimed to compare the incidence and prevalence of psychiatric comorbidity in the multiple sclerosis (MS) population and in controls matched for age, sex, and geographic area...
  30. doi request reprint Five-minute Apgar score as a marker for developmental vulnerability at 5 years of age
    Neda Razaz
    School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Arch Dis Child Fetal Neonatal Ed 101:F114-20. 2016
    ..To assess the relationship between the 5 min Apgar score and developmental vulnerability at 5 years of age...
  31. doi request reprint Suspected autoimmune hepatitis and primary biliary cirrhosis unmasked by interferon-beta in a multiple sclerosis patient
    Kaarina Kowalec
    Neuroscience Program, University of British Columbia UBC, Vancouver, Canada Child and Family Research Institute, Vancouver, Canada Pharmaceutical Outcomes Programme, BC Children s Hospital, Vancouver, Canada
    Mult Scler Relat Disord 2:57-9. 2013
    ..This case highlights the importance of monitoring biochemical liver test results throughout interferon-beta treatment of multiple sclerosis. ..
  32. doi request reprint Health-related quality of life in patients with longstanding 'benign multiple sclerosis'
    Anna Marie Bueno
    Department of Medicine Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Mult Scler Relat Disord 4:31-8. 2015
    ..We explored health-related quality of life (HRQoL) and psychosocial aspects in a cohort of patients with a history of longstanding benign MS (BMS)...
  33. doi request reprint New perspectives in the natural history of multiple sclerosis
    Helen Tremlett
    Faculty of Medicine, Division of Neurology, Multiple Sclerosis Program, University of British Columbia, Vancouver, Canada
    Neurology 74:2004-15. 2010
    ....
  34. doi request reprint The psychosocial and cognitive impact of longstanding 'benign' multiple sclerosis
    Ana Luiza Sayao
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Mult Scler 17:1375-83. 2011
    ..We set out to examine important psychosocial and cognitive outcomes in patients with longstanding BMS compared with patients who had recently progressed to 'no longer benign' (NLB)...
  35. doi request reprint Adverse health behaviours are associated with depression and anxiety in multiple sclerosis: A prospective multisite study
    Kyla A McKay
    Department of Neurology, Faculty of Medicine, University of British Columbia, Canada
    Mult Scler 22:685-93. 2016
    ..Depression and anxiety are common among people with multiple sclerosis (MS), as are adverse health behaviours, but the associations between these factors are unclear...
  36. doi request reprint Impact of parental multiple sclerosis on early childhood development: A retrospective cohort study
    Neda Razaz
    School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Mult Scler 21:1172-83. 2015
    ..Exposure to parental chronic illness is associated with several adverse developmental outcomes...
  37. doi request reprint Retinal nerve fiber layer thickness in benign multiple sclerosis
    Alex P Lange
    Neuro Ophthalmology, Department of Ophthalmology, University of British Columbia, Canada
    Mult Scler 19:1275-81. 2013
    ..Retinal nerve fiber layer (RNFL) thickness has been linked to brain atrophy in multiple sclerosis (MS). However, little is known about retinal atrophy in 'benign' MS. We compared RNFL thickness in benign MS with healthy controls...
  38. ncbi request reprint The natural history of primary progressive MS in British Columbia, Canada
    Helen Tremlett
    Neurology, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Neurology 65:1919-23. 2005
    ..The authors examined patient characteristics, disease progression, and associated risk factors in the PP population of British Columbia, Canada...
  39. pmc Neonatal and delivery outcomes in women with multiple sclerosis
    Mia L van der Kop
    Division of Neurology, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 70:41-50. 2011
    ..To determine (1) whether the risk of adverse neonatal and delivery outcomes differs between mothers with and without multiple sclerosis (MS) and (2) whether risk is differentially associated with clinical factors of MS...
  40. doi request reprint Adherence to the immunomodulatory drugs for multiple sclerosis: contrasting factors affect stopping drug and missing doses
    Helen Tremlett
    Faculty of Medicine Neurology, University of British Columbia, Canada
    Pharmacoepidemiol Drug Saf 17:565-76. 2008
    ..We examined both levels of non-adherence-stopping IMD and missing doses...
  41. doi request reprint High incidence and increasing prevalence of multiple sclerosis in British Columbia, Canada: findings from over two decades (1991-2010)
    Elaine Kingwell
    Faculty of Medicine Neurology, UBC Hospital, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    J Neurol 262:2352-63. 2015
    ....
  42. doi request reprint Management of multiple sclerosis during pregnancy and the reproductive years: a systematic review
    Riley Bove
    Harvard Medical School and the Departments of Neurology and Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts the Departments of Medical Genetics and Neurology, University of British Columbia, Vancouver, British Columbia, The Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, and the Department of Neurology, University of Alberta, Edmonton, Alberta, Canada and St Joseph Hospital Neurology Clinic, Ruhr University, Bochum, Germany
    Obstet Gynecol 124:1157-68. 2014
    ..To examine the evidence guiding management of multiple sclerosis (MS) in reproductive-aged women...
  43. doi request reprint Serum proteomics in multiple sclerosis disease progression
    Helen Tremlett
    Faculty of Medicine, Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    J Proteomics 118:2-11. 2015
    ..Validated biomarkers may result in the development of a minimally-invasive tool to monitor MS progression and complement current clinical practices...
  44. pmc Children and adolescents adjustment to parental multiple sclerosis: a systematic review
    Neda Razaz
    School of Population and Public Health, Faculty of Medicine, University of British Columbia, 2206 East Mall, Vancouver, British Columbia, V6T 1Z3, Canada
    BMC Neurol 14:107. 2014
    ..Little is known about the child living with a parent who has Multiple Sclerosis (MS). We systematically reviewed the literature regarding possible effects of having a parent with MS on the child's or adolescent's psychosocial adjustment...
  45. ncbi request reprint Hepatic injury, liver monitoring and the beta-interferons for multiple sclerosis
    Helen Tremlett
    Department of Medicine Neurology rm S159, Vancouver Hospital and Health Sciences Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada
    J Neurol 251:1297-303. 2004
    ..However, testing will probably not prevent the Type B idiosyncratic reactions which can result in severe hepatic injury; hence patients need to be aware, and to report hepatic side effects promptly...