Marcello Tonelli

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation
    John S Gill
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, Canada
    Kidney Int 68:2345-51. 2005
  2. ncbi request reprint Indigenous health: update on the impact of diabetes and chronic kidney disease
    Karen Yeates
    Department of Medicine, Queens University, Kingston, Ontario, Canada
    Curr Opin Nephrol Hypertens 15:588-92. 2006
  3. pmc Similar outcomes among black and white renal allograft recipients
    Karen Yeates
    Department of Medicine, Queen s University, 94 Stuart Street, Kingston, Ontario, Canada
    J Am Soc Nephrol 20:172-9. 2009
  4. doi request reprint Prevention of dialysis catheter malfunction with recombinant tissue plasminogen activator
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta
    N Engl J Med 364:303-12. 2011
  5. pmc A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes
    Natasha Wiebe
    Department of Medicine, 13 103 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada
    BMC Med 9:123. 2011
  6. doi request reprint The roads less traveled? Diverging research and clinical priorities for dialysis patients and those with less severe CKD
    Marcello Tonelli
    Alberta Kidney Disease Network, University of Alberta, Edmonton, Alberta, Canada Electronic address
    Am J Kidney Dis 63:124-32. 2014
  7. pmc Hypoglycemia associated with hospitalization and adverse events in older people: population-based cohort study
    Sumit R Majumdar
    Corresponding author Marcello Tonelli
    Diabetes Care 36:3585-90. 2013
  8. pmc Association between LDL-C and risk of myocardial infarction in CKD
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 24:979-86. 2013
  9. doi request reprint Spatial analysis to locate new clinics for diabetic kidney patients in the underserved communities in Alberta
    Labib Imran Faruque
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Nephrol Dial Transplant 27:4102-9. 2012
  10. doi request reprint Use of administrative databases for health-care planning in CKD
    Aminu Bello
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Nephrol Dial Transplant 27:iii12-8. 2012

Detail Information

Publications137 found, 100 shown here

  1. ncbi request reprint The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation
    John S Gill
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, Canada
    Kidney Int 68:2345-51. 2005
    ..Longer waiting times may limit the survival benefit of kidney transplantation in older patients or those with a high burden of comorbid disease...
  2. ncbi request reprint Indigenous health: update on the impact of diabetes and chronic kidney disease
    Karen Yeates
    Department of Medicine, Queens University, Kingston, Ontario, Canada
    Curr Opin Nephrol Hypertens 15:588-92. 2006
    ..The purpose of this review is to highlight recent epidemiologic and intervention studies that have occurred in the areas of diabetes and renal disease among indigenous populations...
  3. pmc Similar outcomes among black and white renal allograft recipients
    Karen Yeates
    Department of Medicine, Queen s University, 94 Stuart Street, Kingston, Ontario, Canada
    J Am Soc Nephrol 20:172-9. 2009
    ..Because this differs from the experience reported from the United States, further direct comparisons between the two populations is warranted...
  4. doi request reprint Prevention of dialysis catheter malfunction with recombinant tissue plasminogen activator
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta
    N Engl J Med 364:303-12. 2011
    ....
  5. pmc A systematic review on the effect of sweeteners on glycemic response and clinically relevant outcomes
    Natasha Wiebe
    Department of Medicine, 13 103 Clinical Sciences Building, University of Alberta, Edmonton, Alberta, T6G 2G3 Canada
    BMC Med 9:123. 2011
    ..The major metabolic complications of obesity and type 2 diabetes may be prevented and managed with dietary modification. The use of sweeteners that provide little or no calories may help to achieve this objective...
  6. doi request reprint The roads less traveled? Diverging research and clinical priorities for dialysis patients and those with less severe CKD
    Marcello Tonelli
    Alberta Kidney Disease Network, University of Alberta, Edmonton, Alberta, Canada Electronic address
    Am J Kidney Dis 63:124-32. 2014
    ..This article describes how this divergence of priorities could be approached. ..
  7. pmc Hypoglycemia associated with hospitalization and adverse events in older people: population-based cohort study
    Sumit R Majumdar
    Corresponding author Marcello Tonelli
    Diabetes Care 36:3585-90. 2013
    ..We hypothesized that hospitalized hypoglycemia would be associated with increased long-term morbidity and mortality, irrespective of diabetes status...
  8. pmc Association between LDL-C and risk of myocardial infarction in CKD
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 24:979-86. 2013
    ..Increased LDL-C may be less useful as a marker of coronary risk among people with CKD than the general population...
  9. doi request reprint Spatial analysis to locate new clinics for diabetic kidney patients in the underserved communities in Alberta
    Labib Imran Faruque
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Nephrol Dial Transplant 27:4102-9. 2012
    ..Canadians with chronic diseases often live far away from healthcare facilities, which may compromise their level of care. We used a new method for selecting optimal locations for new healthcare facilities in remote regions...
  10. doi request reprint Use of administrative databases for health-care planning in CKD
    Aminu Bello
    Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Nephrol Dial Transplant 27:iii12-8. 2012
    ..In this article, we use the example of the Alberta Kidney Disease Network to describe how researchers and policy makers can collaborate, using administrative data sources to guide health policy for the care of CKD patients...
  11. doi request reprint Risk of coronary events in people with chronic kidney disease compared with those with diabetes: a population-level cohort study
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Lancet 380:807-14. 2012
    ..We assessed whether chronic kidney disease should be regarded as a coronary heart disease risk equivalent...
  12. doi request reprint Access to kidney transplantation among remote- and rural-dwelling patients with kidney failure in the United States
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, AB T6B 2B7, Canada
    JAMA 301:1681-90. 2009
    ..US residents with end-stage renal disease (ESRD) may live far away from the closest transplant center, which could compromise their access to kidney transplantation...
  13. pmc Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton
    CMAJ 180:E62-71. 2009
    ..However, their safety and effectiveness is controversial. We did a systematic review of the clinical efficacy and harms of these agents in adults with anemia related to cancer or chemotherapy...
  14. doi request reprint Relation between alkaline phosphatase, serum phosphate, and all-cause or cardiovascular mortality
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 120:1784-92. 2009
    ..Higher levels of serum alkaline phosphatase (AlkP) are associated with excess mortality in dialysis patients, but whether AlkP is associated with adverse outcomes among people without kidney failure is unknown...
  15. pmc Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 183:E1189-202. 2011
    ..We did a systematic review of randomized trials to assess the efficacy and harms of statins in these individuals...
  16. pmc Trace elements in hemodialysis patients: a systematic review and meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Med 7:25. 2009
    ..We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients...
  17. pmc Association between proximity to the attending nephrologist and mortality among patients receiving hemodialysis
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 177:1039-44. 2007
    ..We investigated whether patients receiving hemodialysis who live farther from their attending nephrologist are more likely to die than those who live closer...
  18. doi request reprint Higher estimated glomerular filtration rates may be associated with increased risk of adverse outcomes, especially with concomitant proteinuria
    Marcello Tonelli
    Department of Public Health Sciences, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 80:1306-14. 2011
    ..We do not know, however, whether the finding at higher eGFR could be due to inadequacies of the eGFR formula at low serum creatinine levels...
  19. doi request reprint Reporting of the estimated glomerular filtration rate was associated with increased use of angiotensin-converting enzyme inhibitors and angiotensin-II receptor blockers in CKD
    Arsh K Jain
    London Kidney Chemical Research Unit, Division of Nephrology, Department of Medicine, London Health Science Center, University of Western Ontario, London, Canada
    Kidney Int 81:1248-53. 2012
    ..Thus, eGFR reporting contributes to improved, guideline-appropriate care of older patients with CKD...
  20. pmc A cluster randomized trial of an enhanced eGFR prompt in chronic kidney disease
    Braden Manns
    Department of Medicine, University of Calgary, Alberta, Canada
    Clin J Am Soc Nephrol 7:565-72. 2012
    ..This study sought to determine the effect of an enhanced eGFR laboratory prompt containing specific management recommendations, compared with standard eGFR reporting in CKD...
  21. doi request reprint Clinical decision support to improve blood pressure control in hemodialysis patients: a nonrandomized controlled trial
    Stephanie Thompson
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Nephrol 25:944-53. 2012
    ..Computer-based clinical decision support aims to improve the quality of patient care. The utility of decision support for improving blood pressure control in hemodialysis patients is unknown...
  22. ncbi request reprint Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease
    Marcello Tonelli
    Division of Nephrology and Division of Critical Care Medicine, University of Alberta, and Institute of Health Economics, Edmonton, Alberta, Canada
    Circulation 112:171-8. 2005
    ..We performed this analysis to determine whether pravastatin reduced the rate of kidney function loss over approximately 5 years in people with or at high risk for coronary disease...
  23. pmc Associations among estimated glomerular filtration rate, proteinuria, and adverse cardiovascular outcomes
    Aminu K Bello
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 6:1418-26. 2011
    ..Most studies of chronic kidney disease (CKD) and outcomes focus on mortality and ESRD, with limited data on other adverse outcomes. This study examined the associations among proteinuria, eGFR, and adverse cardiovascular (CV) events...
  24. doi request reprint Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    ..Although proteinuria is also associated with adverse outcomes, it is not used to refine risk estimates of adverse events in this current system...
  25. doi request reprint Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, Canada
    Circulation 123:409-16. 2011
    ..Acute kidney injury (AKI) is associated with early mortality after percutaneous coronary revascularization procedures, but its prognostic relevance to long-term clinical outcomes remains controversial...
  26. doi request reprint Impact of remote location on quality care delivery and relationships to adverse health outcomes in patients with diabetes and chronic kidney disease
    Aminu K Bello
    Department of Medicine and Public Health Sciences, University of Alberta, Edmonton, AB, Canada
    Nephrol Dial Transplant 27:3849-55. 2012
    ..To investigate the relation of residence location, markers of good quality healthcare and adverse clinical outcomes in patients with diabetes and chronic kidney disease (CKD)...
  27. doi request reprint Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Lancet 376:2096-103. 2010
    ..We aimed to investigate how eGFR and proteinuria jointly modified the risks of acute kidney injury and subsequent adverse clinical outcomes...
  28. doi request reprint Change in the estimated glomerular filtration rate over time and risk of all-cause mortality
    Tanvir C Turin
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 83:684-91. 2013
    ..Thus, both declining and increasing eGFR were independently associated with mortality and underscore the importance of identifying change in eGFR over time to improve mortality risk prediction...
  29. doi request reprint Quality of care and mortality are worse in chronic kidney disease patients living in remote areas
    Diana Rucker
    Department of Medicine, University of Alberta, Alberta, Canada
    Kidney Int 79:210-7. 2011
    ....
  30. doi request reprint Association between glycemic control and adverse outcomes in people with diabetes mellitus and chronic kidney disease: a population-based cohort study
    Sabin Shurraw
    Divisions of Nephrology, University of Alberta, Edmonton, Canada
    Arch Intern Med 171:1920-7. 2011
    ..Whether a lower HbA(1c) level improves outcomes in people with DM and chronic kidney disease (CKD) is unknown...
  31. ncbi request reprint Use and outcomes of peritoneal dialysis among Aboriginal people in Canada
    Marcello Tonelli
    Division of Nephrology, University of Alberta, 7 129 Clinical Science Building 8440, 112 Street, Edmonton, Alberta T6G 2G3 Canada
    J Am Soc Nephrol 16:482-8. 2005
    ..Future studies should address barriers to the initiation and maintenance of PD in the Aboriginal population, especially those who reside in rural locations...
  32. ncbi request reprint The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease
    Justin Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada T6G 2R7
    J Am Coll Cardiol 44:1587-92. 2004
    ..This study was designed to examine the use of cardiovascular medications and outcomes in patients with heart failure (HF) and renal dysfunction...
  33. doi request reprint An economic evaluation of erythropoiesis-stimulating agents in CKD
    Fiona M Clement
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Am J Kidney Dis 56:1050-61. 2010
    ..9 g/dL), intermediate (11-12 g/dL), or high (> 12 g/dL) hemoglobin level target compared with a strategy of managing anemia without ESAs...
  34. ncbi request reprint Wait-listing for kidney transplantation among Aboriginal hemodialysis patients
    Marcello Tonelli
    Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Kidney Dis 46:1117-23. 2005
    ..We investigated barriers to kidney transplantation for Aboriginal patients treated with hemodialysis for ESRD in Canada...
  35. ncbi request reprint NSAID use and progression of chronic kidney disease
    Katherine Gooch
    Institute of Health Economics, Edmonton, Alberta, Canada
    Am J Med 120:280.e1-7. 2007
    ..Due to the high prevalence of both CKD and NSAID use in older adults, we sought to determine the association between NSAID use and the progression of CKD in an elderly community-based cohort...
  36. pmc Quality of care for First Nations and non-First Nations People with diabetes
    Vinay Deved
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 8:1188-94. 2013
    ..This study examined First Nations and non-First Nations People with diabetes for differences in quality indicators and their association with kidney failure and death...
  37. ncbi request reprint Effect of pravastatin on cardiovascular events in people with chronic kidney disease
    Marcello Tonelli
    Division of Nephrology, University of Alberta, 7 129 Clinical Science Building, 8440 112 St, Edmonton, Alberta T6G 2G3, Canada
    Circulation 110:1557-63. 2004
    ..The objective of this analysis was to determine whether pravastatin reduced the incidence of cardiovascular events in people with or at high risk for coronary disease and with concomitant moderate CKD...
  38. doi request reprint Validating a case definition for chronic kidney disease using administrative data
    Paul E Ronksley
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Nephrol Dial Transplant 27:1826-31. 2012
    ..The purpose of this study was to determine the validity of an algorithm derived from administrative data for identifying chronic kidney disease (CKD) compared to the reference standard of estimated glomerular filtration rate (eGFR)...
  39. ncbi request reprint Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian, and white ESRD patients in Canada
    Brenda R Hemmelgarn
    Department of Medicine, Division of Nephrology, University of Calgary, Canada
    Am J Kidney Dis 48:964-71. 2006
    ..Racial differences in health outcomes in general are well documented; however, few studies examined the impact of East Asian and Indo Asian race on choice of dialytic modality and survival among patients with end-stage renal disease (ESRD)...
  40. pmc Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis
    Jaspreet Khangura
    Department of Medicine, University of British Columbia, Vancouver, Canada
    BMC Nephrol 11:13. 2010
    ..We sought to determine agreement between various blood pressure measurement methods, as well as identify which method was the strongest correlate of LV hypertrophy among patients on hemodialysis...
  41. ncbi request reprint Effect of pravastatin in people with diabetes and chronic kidney disease
    Marcello Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 16:3748-54. 2005
    ..Additional studies are needed to determine whether these benefits apply to patients with more severe CKD, and recruitment to such studies should be given high priority...
  42. doi request reprint The effects of nocturnal compared with conventional hemodialysis on mineral metabolism: A randomized-controlled trial
    Michael Walsh
    Department of Medicine, University of Calgary, Alberta, Canada
    Hemodial Int 14:174-81. 2010
    ..The effects of NHD on PTH are variable. The impact of these changes on long-term cardiovascular and bone-related outcomes requires further investigation...
  43. doi request reprint Nephrology visits and health care resource use before and after reporting estimated glomerular filtration rate
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:1151-8. 2010
    ..Laboratory reporting of estimated glomerular filtration rate (GFR) has been widely implemented, with limited evaluation...
  44. doi request reprint The effect of nocturnal and conventional hemodialysis on markers of nutritional status: results from a randomized trial
    Melissa Schorr
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Ren Nutr 21:271-6. 2011
    ..More frequent dialysis may improve nutrition and remove dietary restrictions in hemodialysis (HD) patients. We present results from a trial comparing nutritional parameters between nocturnal hemodialysis (NHD) and conventional HD patients...
  45. pmc Cost-effectiveness of the use of low- and high-potency statins in people at low cardiovascular risk
    Jon Conly
    Alberta Kidney Disease Network, Calgary, Alta
    CMAJ 183:E1180-8. 2011
    ....
  46. doi request reprint Short-term change in kidney function and risk of end-stage renal disease
    Tanvir Chowdhury Turin
    Foothills Medical Centre, Calgary, Alberta, Canada
    Nephrol Dial Transplant 27:3835-43. 2012
    ..It is unclear what degree of change in the eGFR over a 1-year period indicates clinically significant progression, and whether this change adds additional information beyond that obtained by a single eGFR measure alone...
  47. doi request reprint Rates of treated and untreated kidney failure in older vs younger adults
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 307:2507-15. 2012
    ..Studies of kidney failure in older adults have focused on receipt of dialysis, which may underestimate the burden of disease if older people are less likely to receive treatment...
  48. doi request reprint Economic evaluation of erythropoiesis-stimulating agents for anemia related to cancer
    Scott Klarenbach
    Department of Medicine, University of Alberta Edmonton, Alberta, Canada
    Cancer 116:3224-32. 2010
    ..Concerns about toxicity have led to more restrictive recommendations for ESA use; however, the incremental costs and benefits of such a strategy are unknown...
  49. doi request reprint Using proteinuria and estimated glomerular filtration rate to classify risk in patients with chronic kidney disease: a cohort study
    Marcello Tonelli
    University of Alberta, Edmonton, Canada
    Ann Intern Med 154:12-21. 2011
    ..The staging system for chronic kidney disease relies almost exclusively on estimated glomerular filtration rate (eGFR), although proteinuria is also associated with adverse outcomes...
  50. pmc Residence location and likelihood of kidney transplantation
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 175:478-82. 2006
    ..Within each region we also determined whether distance from the closest transplant centre was associated with the likelihood of transplantation...
  51. ncbi request reprint Prevalence of chronic kidney disease and survival among aboriginal people
    Song Gao
    Department of Medicine, Division of Nephrology, University of Calgary, Calgary, Alberta, Canada
    J Am Soc Nephrol 18:2953-9. 2007
    ....
  52. doi request reprint CKD and risk of hospitalization and death with pneumonia
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Am J Kidney Dis 54:24-32. 2009
    ..The objective of this study is to determine the associations between estimated glomerular filtration rate (eGFR) and hospitalization or death with pneumonia...
  53. doi request reprint Contrast-induced acute kidney injury and risk of adverse clinical outcomes after coronary angiography: a systematic review and meta-analysis
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Circ Cardiovasc Interv 6:37-43. 2013
    ..We performed a systematic review and meta-analysis to characterize the associations between CI-AKI and subsequent clinical outcomes...
  54. pmc Lifetime risk of ESRD
    Tanvir Chowdhury Turin
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Am Soc Nephrol 23:1569-78. 2012
    ..These population-based estimates may assist individuals who make decisions regarding public health policy...
  55. ncbi request reprint Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:2627-33. 2005
    ..Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes...
  56. pmc Nocturnal hypoxia and loss of kidney function
    Sofia B Ahmed
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 6:e19029. 2011
    ..Although obstructive sleep apnea (OSA) is more common in patients with kidney disease, whether nocturnal hypoxia affects kidney function is unknown...
  57. pmc Cardiovascular effects of angiotensin converting enzyme inhibition or angiotensin receptor blockade in hemodialysis: a meta-analysis
    Davina J Tai
    Division of Nephrology, Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta, Canada, T2N 2T9
    Clin J Am Soc Nephrol 5:623-30. 2010
    ..This meta-analysis was performed to determine whether angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) reduce fatal and nonfatal CV events and left ventricular (LV) mass in patients receiving HD...
  58. pmc Modeling survival of arteriovenous accesses for hemodialysis: semiparametric versus parametric methods
    Pietro Ravani
    Department of Medicine, Division of Nephrology, University of Calgary, Foothills Medical Centre, 1403 29th St NW, Calgary, AB, T2N2T9, Canada
    Clin J Am Soc Nephrol 5:1243-8. 2010
    ..Comparing outcomes of arteriovenous grafts and fistulas is challenging because the pathophysiology of access dysfunction and failure rate profiles differ by access type. Studying how risks vary over time may be important...
  59. pmc Association of enrolment in primary care networks with diabetes care and outcomes among First Nations and low-income Albertans
    David J T Campbell
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Open Med 6:e155-65. 2012
    ..However, it is unknown whether First Nations individuals and those in lower SES groups experience these benefits...
  60. doi request reprint Serum testosterone levels and clinical outcomes in male hemodialysis patients
    Aminu K Bello
    University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 63:268-75. 2014
    ..We investigated the role of testosterone in adverse outcomes and quality of life in an incident cohort of male Canadian hemodialysis patients...
  61. pmc Association between chronic conditions and perceived unmet health care needs
    Paul E Ronksley
    Department of Community Health Sciences at the University of Calgary, Calgary, Alberta, Canada
    Open Med 6:e48-58. 2012
    ..The objective of this study was therefore to determine the association between chronic conditions and perceived unmet health care needs...
  62. doi request reprint Quality-of-care indicators among remote-dwelling hemodialysis patients: a cohort study
    Stephanie Thompson
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 62:295-303. 2013
    ..We hypothesized that the higher mortality for hemodialysis patients who live farther from the closest attending nephrologist compared with patients living closer might be due to lower quality of care...
  63. doi request reprint One-year change in kidney function is associated with an increased mortality risk
    Tanvir Chowdhury Turin
    Department of Medicine, University of Calgary, AB, Canada
    Am J Nephrol 36:41-9. 2012
    ..Long-term cohort studies report that death is a likelier outcome than progression to kidney failure. However, it is unclear how short-term changes in estimated GFR (eGFR) over a 1-year period relate to subsequent mortality risk...
  64. pmc Kidney stones and kidney function loss: a cohort study
    R Todd Alexander
    7 129 Clinical Science Building, University of Alberta, 8440 112 Street, Edmonton, Alberta T6B 2G3, Canada
    BMJ 345:e5287. 2012
    ..To investigate whether the presence of kidney stones increase the risk of end stage renal disease (ESRD) or other adverse renal outcomes...
  65. ncbi request reprint Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial
    Bruce F Culleton
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 298:1291-9. 2007
    ..Morbidity and mortality rates in hemodialysis patients remain excessive. Alterations in the delivery of dialysis may lead to improved patient outcomes...
  66. pmc A novel technique to optimize facility locations of new nephrology services for remote areas
    Bharati Ayyalasomayajula
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 6:2157-64. 2011
    ....
  67. pmc Overview of the Alberta Kidney Disease Network
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 10:30. 2009
    ..The Alberta Kidney Disease Network is a collaborative nephrology research organization based on a central repository of laboratory and administrative data from the Canadian province of Alberta...
  68. doi request reprint Acute kidney injury following coronary angiography is associated with a long-term decline in kidney function
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 78:803-9. 2010
    ..8 ml/min following moderate to severe acute kidney injury. Thus, acute kidney injury following coronary angiography is associated with a sustained loss and a larger rate of future decline in kidney function...
  69. ncbi request reprint Factors associated with access blood flow in native vessel arteriovenous fistulae
    Marcello Tonelli
    Department of Medcine, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
    Nephrol Dial Transplant 19:2559-63. 2004
    ..Such factors could be used in conjunction with Qa to improve the diagnostic performance of screening. We examined the relationship between Qa and certain clinical characteristics in a large group of patients with AVF...
  70. pmc Proteinuria, impaired kidney function, and adverse outcomes in people with coronary disease: analysis of a previously conducted randomised trial
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G2C3
    BMJ 332:1426. 2006
    ..To determine whether data on proteinuria are useful for refining estimates of risk based on kidney function alone, and whether the results of kidney function tests can be a useful adjunct to data on proteinuria...
  71. ncbi request reprint Effect of pravastatin on loss of renal function in people with moderate chronic renal insufficiency and cardiovascular disease
    Marcello Tonelli
    University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 14:1605-13. 2003
    ..These findings require confirmation by a large randomized trial conducted specifically in people with chronic renal insufficiency...
  72. ncbi request reprint Association between multidisciplinary care and survival for elderly patients with chronic kidney disease
    Brenda R Hemmelgarn
    Department of Medicine, Community Health Schiences, University of Calgary, Calgary, Canada
    J Am Soc Nephrol 18:993-9. 2007
    ..The benefits of MDC and an assessment of their economic impact should be tested in a randomized, controlled trial...
  73. pmc Adding specialized clinics for remote-dwellers with chronic kidney disease: a cost-utility analysis
    Natasha Wiebe
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Clin J Am Soc Nephrol 7:24-34. 2012
    ..This study aimed to determine whether opening a new clinic in a remote region would be a cost-effective means of improving care for remote-dwellers with CKD...
  74. ncbi request reprint Economic evaluation of sevelamer in patients with end-stage renal disease
    Braden Manns
    Department of Community Health Sciences, University of Alberta, Edmonton, Alberta T6B 2b7 Canada
    Nephrol Dial Transplant 22:2867-78. 2007
    ..To account for uncertainty, we considered four separate modelling strategies, obtaining data on the relative effectiveness of sevelamer from the recent Dialysis Clinical Outcomes Revisited study...
  75. doi request reprint Risk of bloodstream infection in patients with chronic kidney disease not treated with dialysis
    Matthew T James
    Department of Medicine, University of Calgary, Foothills Medical Center, 1403 29th St NW, Calgary, AB T2N 2T9, Canada
    Arch Intern Med 168:2333-9. 2008
    ..Whether patients with chronic kidney disease who are not receiving dialysis are also at increased risk of bloodstream infection is less clear...
  76. doi request reprint Phosphate removal with several thrice-weekly dialysis methods in overweight hemodialysis patients
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Kidney Dis 54:1108-15. 2009
    ..Whether modifying dialysis prescription to intensify small-solute clearance also leads to better phosphate clearance is unknown...
  77. pmc Death and renal transplantation among Aboriginal people undergoing dialysis
    Marcello Tonelli
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alta
    CMAJ 171:577-82. 2004
    ..We evaluated differences in survival and rate of renal transplantation among Aboriginal and white patients after initiation of dialysis...
  78. pmc Validation of a case definition to define chronic dialysis using outpatient administrative data
    Fiona M Clement
    Department of Medicine, University of Calgary, 2500 University Dr NW, Calgary, Alberta, T2N 1N4, Canada
    BMC Med Res Methodol 11:25. 2011
    ..The objective of this study is to determine the validity of outpatient physician billing derived algorithms for defining chronic dialysis compared to a reference standard ESRD registry...
  79. pmc Population based screening for chronic kidney disease: cost effectiveness study
    Braden Manns
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMJ 341:c5869. 2010
    ..To determine the cost effectiveness of one-off population based screening for chronic kidney disease based on estimated glomerular filtration rate...
  80. doi request reprint Higher mortality among remote compared to rural or urban dwelling hemodialysis patients in the United States
    Stephanie Thompson
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 82:352-9. 2012
    ..02 and 1.01, respectively. Thus, remote but not rural residence was associated with increased mortality among patients initiating chronic hemodialysis treatment in the United States...
  81. pmc The new FDA labeling for ESA--implications for patients and providers
    Braden J Manns
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Clin J Am Soc Nephrol 7:348-53. 2012
    ..Although the US Food and Drug Administration labeling changes are based on the results of recent large randomized trials testing ESAs targeting near-normal hemoglobin levels, more specific guidance to clinicians would have been helpful...
  82. doi request reprint Multiple versus single and other estimates of baseline proteinuria status as predictors of adverse outcomes in the general population
    Aminu Bello
    Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Kidney Dis 59:364-71. 2012
    ..The optimal method of classifying proteinuria status for study participants in whom it is measured multiple times is unknown, especially when the frequency of measurement varies between participants...
  83. doi request reprint Association between GFR, proteinuria, and adverse outcomes among White, Chinese, and South Asian individuals in Canada
    Joslyn Conley
    Department of Medicine, University of Calgary, Alberta, Canada
    Am J Kidney Dis 59:390-9. 2012
    ..We investigated the association between proteinuria, estimated glomerular filtration rate (eGFR), and risk of mortality and kidney failure in white, Chinese, and South Asian populations...
  84. ncbi request reprint Biomarkers of inflammation and progression of chronic kidney disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 68:237-45. 2005
    ..We examined the association between pravastatin use, levels of C-reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFrii), and the rate of kidney function loss...
  85. ncbi request reprint Effect of gemfibrozil on change in renal function in men with moderate chronic renal insufficiency and coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 44:832-9. 2004
    ..We conducted this study to determine whether gemfibrozil reduced rates of renal function loss in people with moderate CRI...
  86. doi request reprint Ascorbic acid for anemia management in hemodialysis patients: a systematic review and meta-analysis
    Vinay Deved
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Am J Kidney Dis 54:1089-97. 2009
    ..Ascorbic acid is believed to improve anemia in patients with end-stage renal disease, but its overall effectiveness is unclear...
  87. pmc The safety of combining angiotensin-converting-enzyme inhibitors with angiotensin-receptor blockers in elderly patients: a population-based longitudinal analysis
    Finlay A McAlister
    Division of General Internal Medicine and Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alta
    CMAJ 183:655-62. 2011
    ..This study was designed to determine the safety of combination therapy with these two drugs in clinical practice...
  88. doi request reprint The impact of selecting a high hemoglobin target level on health-related quality of life for patients with chronic kidney disease: a systematic review and meta-analysis
    Fiona M Clement
    Departments of Community Health Sciences and Medicine, Centre for Health and Policy Studies, University of Calgary, Calgary, Alberta, Canada
    Arch Intern Med 169:1104-12. 2009
    ..0-12.0 g/dL) and high hemoglobin target levels (>12.0 g/dL) and performed a meta-analysis of all available 36-item short-form (SF-36) RCT data...
  89. pmc Enrolment in primary care networks: impact on outcomes and processes of care for patients with diabetes
    Braden J Manns
    Department of Medicine, University of Calgary, Calgary, Alta
    CMAJ 184:E144-52. 2012
    ..We sought to determine the association between enrolment in primary care networks and the care and outcomes of patients with diabetes...
  90. ncbi request reprint The effect of statins on preservation of kidney function in patients with coronary artery disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Curr Opin Cardiol 21:608-12. 2006
    ..This paper outlines evidence for the putative renal benefits of statins in people with vascular disease...
  91. doi request reprint Early recognition and prevention of chronic kidney disease
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Lancet 375:1296-309. 2010
    ..Novel clinical methods to better identify patients at risk of progression to later stages of chronic kidney disease, including kidney failure, are needed to target management to high-risk subgroups...
  92. ncbi request reprint Dialysate potassium and risk of death in chronic hemodialysis patients
    Ghassan Al-Ghamdi
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Nephrol 23:33-40. 2010
    ..Few data guide the prescription of dialysate potassium (dK) in hemodialysis, which is usually prescribed empirically on the basis of predialysis serum potassium levels...
  93. doi request reprint Economic evaluation of continuous renal replacement therapy in acute renal failure
    Scott Klarenbach
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Int J Technol Assess Health Care 25:331-8. 2009
    ..Controversy exists regarding the optimal method of providing dialysis in critically ill patients with acute renal failure. We sought to determine the cost-effectiveness of treatment strategies...
  94. doi request reprint The effect of increasing dialysis dose in overweight hemodialysis patients on quality of life: a 6-week randomized crossover trial
    Wenjie Wang
    Department of Medicine, Division of Nephrology, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada
    Am J Kidney Dis 51:796-803. 2008
    ..Whether increasing dialysis adequacy in large patients not achieving KDOQI targets improves HRQL is unknown...
  95. ncbi request reprint Access flow in arteriovenous accesses by optodilutional and ultrasound dilution methods
    Marcello Tonelli
    Department of Medicine, University of Alberta, Alberta, Canada
    Am J Kidney Dis 46:933-7. 2005
    ..There has been little exploration of how the use of other devices might affect the feasibility or performance of screening in AV accesses...
  96. ncbi request reprint A systematic review of the effect of nocturnal hemodialysis on blood pressure, left ventricular hypertrophy, anemia, mineral metabolism, and health-related quality of life
    Michael Walsh
    Department of Medicine, University of Calgary, Alberta, Canada
    Kidney Int 67:1500-8. 2005
    ..A systematic review of the current available literature was undertaken to examine the effect of nocturnal hemodialysis on key health outcomes...
  97. pmc The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: rationale and study design of a randomized controlled pilot study
    Michael Walsh
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Nephrol 7:2. 2006
    ..We have undertaken a multi-center RCT in hemodialysis patients comparing the effect of NHD to CvHD on left ventricular (LV) mass, as measured by cardiac magnetic resonance imaging (cMR)...
  98. pmc Relation between access blood flow and mortality in chronic hemodialysis patients
    Mohammed Al-Ghonaim
    Department of Medicine, University of Alberta, Edmonton, Canada
    Clin J Am Soc Nephrol 3:387-91. 2008
    ..Patients were followed from the date of Qa measurement until death; follow-up was discontinued at loss to follow-up, kidney transplantation, or end of study...
  99. doi request reprint Ultrasound monitoring to detect access stenosis in hemodialysis patients: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 51:630-40. 2008
    ..Observational studies indicate that routine measurements of access blood flow and use of Doppler ultrasound improve vascular access outcomes in hemodialysis patients, but randomized trials reached conflicting conclusions...
  100. ncbi request reprint Best threshold for diagnosis of stenosis or thrombosis within six months of access flow measurement in arteriovenous fistulae
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 14:3264-9. 2003
    ..It is recommended that clinicians arrange angiography when Qa is <500 ml/min in AVF...
  101. doi request reprint Nocturnal hemodialysis does not improve overall measures of quality of life compared to conventional hemodialysis
    Braden J Manns
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 75:542-9. 2009
    ....