Marcello Tonelli,

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Statins for improving renal outcomes: a meta-analysis
    Sabrina Sandhu
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2006-16. 2006
  2. ncbi request reprint The effect of statins on preservation of kidney function in patients with coronary artery disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Curr Opin Cardiol 21:608-12. 2006
  3. ncbi request reprint Effect of pravastatin on blood pressure in people with cardiovascular disease
    M Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Hum Hypertens 20:560-5. 2006
  4. pmc Evaluating the impact of a novel restricted reimbursement policy for quinolone antibiotics: a time series analysis
    Braden Manns
    Department of Medicine, Calgary, Alberta, Canada
    BMC Health Serv Res 12:290. 2012
  5. pmc Design and implementation of the Canadian Kidney Disease Cohort Study (CKDCS): A prospective observational study of incident hemodialysis patients
    Aminu K Bello
    Department of Medicine, University of Alberta, Edmonton, Canada
    BMC Nephrol 12:10. 2011
  6. pmc The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: rationale and study design of a randomized controlled pilot study
    Michael Walsh
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Nephrol 7:2. 2006
  7. pmc Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis
    Jaspreet Khangura
    Department of Medicine, University of British Columbia, Vancouver, Canada
    BMC Nephrol 11:13. 2010
  8. pmc Overview of the Alberta Kidney Disease Network
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 10:30. 2009
  9. pmc Overview of the Canadian pediatric end-stage renal disease database
    Susan M Samuel
    Division of Pediatric Nephrology, Department of Pediatrics, Alberta Children s Hospital, 2888 Shaganappi Trail NW, Calgary T3B 6A8, Canada
    BMC Nephrol 11:21. 2010
  10. pmc Validation of a case definition to define chronic dialysis using outpatient administrative data
    Fiona M Clement
    Department of Medicine, University of Calgary, 2500 University Dr NW, Calgary, Alberta, T2N 1N4, Canada
    BMC Med Res Methodol 11:25. 2011

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Statins for improving renal outcomes: a meta-analysis
    Sabrina Sandhu
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2006-16. 2006
    ..17 to 0.98). Statin therapy seems to reduce proteinuria modestly and results in a small reduction in the rate of kidney function loss, especially in populations with cardiovascular disease...
  2. ncbi request reprint The effect of statins on preservation of kidney function in patients with coronary artery disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Curr Opin Cardiol 21:608-12. 2006
    ..This paper outlines evidence for the putative renal benefits of statins in people with vascular disease...
  3. ncbi request reprint Effect of pravastatin on blood pressure in people with cardiovascular disease
    M Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Hum Hypertens 20:560-5. 2006
    ..99, 95% CI 0.80-1.23), or incident diastolic hypertension (odds ratio 0.97, 95% CI 0.73-1.27). In summary, pravastatin 40 mg daily did not reduce blood pressure in survivors of myocardial infarction without overt hypercholesterolaemia...
  4. pmc Evaluating the impact of a novel restricted reimbursement policy for quinolone antibiotics: a time series analysis
    Braden Manns
    Department of Medicine, Calgary, Alberta, Canada
    BMC Health Serv Res 12:290. 2012
    ..We conducted an observational study to determine the impact of this new formulary restriction policy on antimicrobial prescription rates as well as any clinical consequences...
  5. pmc Design and implementation of the Canadian Kidney Disease Cohort Study (CKDCS): A prospective observational study of incident hemodialysis patients
    Aminu K Bello
    Department of Medicine, University of Alberta, Edmonton, Canada
    BMC Nephrol 12:10. 2011
    ..This study focuses on delineating potentially reversible determinants of adverse outcomes that occur in patients receiving dialysis for end-stage renal disease (ESRD)...
  6. pmc The effects of nocturnal hemodialysis compared to conventional hemodialysis on change in left ventricular mass: rationale and study design of a randomized controlled pilot study
    Michael Walsh
    Department of Medicine, University of Calgary, Calgary, Canada
    BMC Nephrol 7:2. 2006
    ..We have undertaken a multi-center RCT in hemodialysis patients comparing the effect of NHD to CvHD on left ventricular (LV) mass, as measured by cardiac magnetic resonance imaging (cMR)...
  7. pmc Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis
    Jaspreet Khangura
    Department of Medicine, University of British Columbia, Vancouver, Canada
    BMC Nephrol 11:13. 2010
    ..We sought to determine agreement between various blood pressure measurement methods, as well as identify which method was the strongest correlate of LV hypertrophy among patients on hemodialysis...
  8. pmc Overview of the Alberta Kidney Disease Network
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMC Nephrol 10:30. 2009
    ..The Alberta Kidney Disease Network is a collaborative nephrology research organization based on a central repository of laboratory and administrative data from the Canadian province of Alberta...
  9. pmc Overview of the Canadian pediatric end-stage renal disease database
    Susan M Samuel
    Division of Pediatric Nephrology, Department of Pediatrics, Alberta Children s Hospital, 2888 Shaganappi Trail NW, Calgary T3B 6A8, Canada
    BMC Nephrol 11:21. 2010
    ....
  10. pmc Validation of a case definition to define chronic dialysis using outpatient administrative data
    Fiona M Clement
    Department of Medicine, University of Calgary, 2500 University Dr NW, Calgary, Alberta, T2N 1N4, Canada
    BMC Med Res Methodol 11:25. 2011
    ..The objective of this study is to determine the validity of outpatient physician billing derived algorithms for defining chronic dialysis compared to a reference standard ESRD registry...
  11. ncbi request reprint Use and outcomes of peritoneal dialysis among Aboriginal people in Canada
    Marcello Tonelli
    Division of Nephrology, University of Alberta, 7 129 Clinical Science Building 8440, 112 Street, Edmonton, Alberta T6G 2G3 Canada
    J Am Soc Nephrol 16:482-8. 2005
    ..Future studies should address barriers to the initiation and maintenance of PD in the Aboriginal population, especially those who reside in rural locations...
  12. ncbi request reprint Effect of gemfibrozil on change in renal function in men with moderate chronic renal insufficiency and coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 44:832-9. 2004
    ..We conducted this study to determine whether gemfibrozil reduced rates of renal function loss in people with moderate CRI...
  13. ncbi request reprint Extended reuse of polysulfone hemodialysis membranes using citric acid and heat
    Marcello Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    ASAIO J 50:98-101. 2004
    ..Increasing the maximum number of uses to 20 may permit cost savings compared with current practice without additional risk...
  14. ncbi request reprint Monitoring and maintenance of arteriovenous fistulae and graft function in haemodialysis patients
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Curr Opin Nephrol Hypertens 13:655-60. 2004
    ..Although observational studies show a significant benefit of such strategies, data from randomized trials are limited. This review describes recently published information that has helped to advance this field during the past year...
  15. ncbi request reprint Biomarkers of inflammation and progression of chronic kidney disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 68:237-45. 2005
    ..We examined the association between pravastatin use, levels of C-reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFrii), and the rate of kidney function loss...
  16. ncbi request reprint Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease
    Marcello Tonelli
    Division of Nephrology and Division of Critical Care Medicine, University of Alberta, and Institute of Health Economics, Edmonton, Alberta, Canada
    Circulation 112:171-8. 2005
    ..We performed this analysis to determine whether pravastatin reduced the rate of kidney function loss over approximately 5 years in people with or at high risk for coronary disease...
  17. ncbi request reprint Wait-listing for kidney transplantation among Aboriginal hemodialysis patients
    Marcello Tonelli
    Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Kidney Dis 46:1117-23. 2005
    ..We investigated barriers to kidney transplantation for Aboriginal patients treated with hemodialysis for ESRD in Canada...
  18. ncbi request reprint Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:2627-33. 2005
    ..Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes...
  19. ncbi request reprint Effect of pravastatin in people with diabetes and chronic kidney disease
    Marcello Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 16:3748-54. 2005
    ..Additional studies are needed to determine whether these benefits apply to patients with more severe CKD, and recruitment to such studies should be given high priority...
  20. ncbi request reprint Association between residence location and likelihood of kidney transplantation in Aboriginal patients treated with dialysis in Canada
    M Tonelli
    Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Alberta, and Division of Nephrology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Kidney Int 70:924-30. 2006
    ..In conclusion, remote location of residence does not explain the lower rate of kidney transplantation among Aboriginal people treated for ESRD in Canada...
  21. pmc Residence location and likelihood of kidney transplantation
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 175:478-82. 2006
    ..Within each region we also determined whether distance from the closest transplant centre was associated with the likelihood of transplantation...
  22. pmc Death and renal transplantation among Aboriginal people undergoing dialysis
    Marcello Tonelli
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alta
    CMAJ 171:577-82. 2004
    ..We evaluated differences in survival and rate of renal transplantation among Aboriginal and white patients after initiation of dialysis...
  23. ncbi request reprint Acute renal failure in the intensive care unit: a systematic review of the impact of dialytic modality on mortality and renal recovery
    Marcello Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 40:875-85. 2002
    ....
  24. ncbi request reprint Effect of pravastatin on loss of renal function in people with moderate chronic renal insufficiency and cardiovascular disease
    Marcello Tonelli
    University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 14:1605-13. 2003
    ..These findings require confirmation by a large randomized trial conducted specifically in people with chronic renal insufficiency...
  25. doi request reprint Ultrasound monitoring to detect access stenosis in hemodialysis patients: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Kidney Dis 51:630-40. 2008
    ..Observational studies indicate that routine measurements of access blood flow and use of Doppler ultrasound improve vascular access outcomes in hemodialysis patients, but randomized trials reached conflicting conclusions...
  26. ncbi request reprint Best threshold for diagnosis of stenosis or thrombosis within six months of access flow measurement in arteriovenous fistulae
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    J Am Soc Nephrol 14:3264-9. 2003
    ..It is recommended that clinicians arrange angiography when Qa is <500 ml/min in AVF...
  27. ncbi request reprint Access flow in arteriovenous accesses by optodilutional and ultrasound dilution methods
    Marcello Tonelli
    Department of Medicine, University of Alberta, Alberta, Canada
    Am J Kidney Dis 46:933-7. 2005
    ..There has been little exploration of how the use of other devices might affect the feasibility or performance of screening in AV accesses...
  28. ncbi request reprint Patient and allograft survival of Indo Asian and East Asian dialysis patients treated in Canada
    M Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 72:499-504. 2007
    ..These findings warrant further study, especially given the good graft outcomes in these individuals...
  29. ncbi request reprint Factors associated with access blood flow in native vessel arteriovenous fistulae
    Marcello Tonelli
    Department of Medcine, University of Alberta, Edmonton, Alberta T6G 2G3, Canada
    Nephrol Dial Transplant 19:2559-63. 2004
    ..Such factors could be used in conjunction with Qa to improve the diagnostic performance of screening. We examined the relationship between Qa and certain clinical characteristics in a large group of patients with AVF...
  30. ncbi request reprint Gemfibrozil for secondary prevention of cardiovascular events in mild to moderate chronic renal insufficiency
    Marcello Tonelli
    Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 66:1123-30. 2004
    ....
  31. ncbi request reprint Effect of pravastatin on cardiovascular events in people with chronic kidney disease
    Marcello Tonelli
    Division of Nephrology, University of Alberta, 7 129 Clinical Science Building, 8440 112 St, Edmonton, Alberta T6G 2G3, Canada
    Circulation 110:1557-63. 2004
    ..The objective of this analysis was to determine whether pravastatin reduced the incidence of cardiovascular events in people with or at high risk for coronary disease and with concomitant moderate CKD...
  32. ncbi request reprint The association among renal insufficiency, pharmacotherapy, and outcomes in 6,427 patients with heart failure and coronary artery disease
    Justin Ezekowitz
    Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada T6G 2R7
    J Am Coll Cardiol 44:1587-92. 2004
    ..This study was designed to examine the use of cardiovascular medications and outcomes in patients with heart failure (HF) and renal dysfunction...
  33. ncbi request reprint Mortality of Canadians treated by peritoneal dialysis in remote locations
    M Tonelli
    Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 72:1023-8. 2007
    ..Further study into the quality of care delivered to remote-dwelling patients on peritoneal dialysis is needed...
  34. ncbi request reprint Screening for subclinical stenosis in native vessel arteriovenous fistulae
    M Tonelli
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Soc Nephrol 12:1729-33. 2001
    ..Access failure after negative UDT was unusual. Measuring AR increases the time required to perform UDT but does not improve utility. Serial measurements of Q(a) alone may be the best strategy for screening AVF...
  35. ncbi request reprint Progression of kidney dysfunction in the community-dwelling elderly
    B R Hemmelgarn
    Department of Medicine, Division of Nephrology, University of Calgary, Calgary, Alberta, Canada
    Kidney Int 69:2155-61. 2006
    ..Strategies aimed at slowing progression of kidney disease should consider underlying risk factors for progression and the negligible loss of kidney function that occurs in the majority of older adults...
  36. doi request reprint An economic evaluation of erythropoiesis-stimulating agents in CKD
    Fiona M Clement
    Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
    Am J Kidney Dis 56:1050-61. 2010
    ..9 g/dL), intermediate (11-12 g/dL), or high (> 12 g/dL) hemoglobin level target compared with a strategy of managing anemia without ESAs...
  37. ncbi request reprint Prevalence of chronic kidney disease and survival among aboriginal people
    Song Gao
    Department of Medicine, Division of Nephrology, University of Calgary, Calgary, Alberta, Canada
    J Am Soc Nephrol 18:2953-9. 2007
    ....
  38. pmc Access to health care among status Aboriginal people with chronic kidney disease
    Song Gao
    Department of Medicine, Division of Nephrology, University of Calgary, Calgary, AB
    CMAJ 179:1007-12. 2008
    ..We determined whether access to care differed between status Aboriginal people (Aboriginal people registered under the federal Indian Act) and non-Aboriginal people with chronic kidney disease...
  39. doi request reprint Relation between kidney function, proteinuria, and adverse outcomes
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:423-9. 2010
    ..Although proteinuria is also associated with adverse outcomes, it is not used to refine risk estimates of adverse events in this current system...
  40. ncbi request reprint NSAID use and progression of chronic kidney disease
    Katherine Gooch
    Institute of Health Economics, Edmonton, Alberta, Canada
    Am J Med 120:280.e1-7. 2007
    ..Due to the high prevalence of both CKD and NSAID use in older adults, we sought to determine the association between NSAID use and the progression of CKD in an elderly community-based cohort...
  41. ncbi request reprint Why do preemptive kidney transplant recipients have an allograft survival advantage?
    John S Gill
    Division of Nephrology, St Paul s Hospital Vancouver, BC, Canada
    Transplantation 78:873-9. 2004
    ....
  42. ncbi request reprint The importance of transitions between dialysis and transplantation in the care of end-stage renal disease patients
    J S Gill
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    Kidney Int 71:442-7. 2007
    ....
  43. ncbi request reprint Economic implications of screening strategies in arteriovenous fistulae
    M Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Kidney Int 69:2219-26. 2006
    ..If screening is adopted, our findings suggest that angiography should be performed when Qa is <500 rather than <750 ml/min, especially when access to angiography is limited...
  44. ncbi request reprint Pravastatin for secondary prevention of cardiovascular events in persons with mild chronic renal insufficiency
    Marcello Tonelli
    Division of Nephrology and Immunology, University of Alberta, Clinical Sciences Building, Suite 11 108C, 8440 112 Street, Edmonton, Alberta T6B 2B7, Canada
    Ann Intern Med 138:98-104. 2003
    ....
  45. ncbi request reprint The impact of waiting time and comorbid conditions on the survival benefit of kidney transplantation
    John S Gill
    Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, Canada
    Kidney Int 68:2345-51. 2005
    ..Longer waiting times may limit the survival benefit of kidney transplantation in older patients or those with a high burden of comorbid disease...
  46. pmc Modeling survival of arteriovenous accesses for hemodialysis: semiparametric versus parametric methods
    Pietro Ravani
    Department of Medicine, Division of Nephrology, University of Calgary, Foothills Medical Centre, 1403 29th St NW, Calgary, AB, T2N2T9, Canada
    Clin J Am Soc Nephrol 5:1243-8. 2010
    ..Comparing outcomes of arteriovenous grafts and fistulas is challenging because the pathophysiology of access dysfunction and failure rate profiles differ by access type. Studying how risks vary over time may be important...
  47. doi request reprint CKD and risk of hospitalization and death with pneumonia
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Am J Kidney Dis 54:24-32. 2009
    ..The objective of this study is to determine the associations between estimated glomerular filtration rate (eGFR) and hospitalization or death with pneumonia...
  48. pmc Cardiovascular effects of angiotensin converting enzyme inhibition or angiotensin receptor blockade in hemodialysis: a meta-analysis
    Davina J Tai
    Division of Nephrology, Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta, Canada, T2N 2T9
    Clin J Am Soc Nephrol 5:623-30. 2010
    ..This meta-analysis was performed to determine whether angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) reduce fatal and nonfatal CV events and left ventricular (LV) mass in patients receiving HD...
  49. pmc Proteinuria, impaired kidney function, and adverse outcomes in people with coronary disease: analysis of a previously conducted randomised trial
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, AB, Canada T6G2C3
    BMJ 332:1426. 2006
    ..To determine whether data on proteinuria are useful for refining estimates of risk based on kidney function alone, and whether the results of kidney function tests can be a useful adjunct to data on proteinuria...
  50. doi request reprint Chronic kidney disease and postoperative mortality: a systematic review and meta-analysis
    A Mathew
    Division of Nephrology, Department of Medicine, University of Western Ontario, London, Ontario, Canada
    Kidney Int 73:1069-81. 2008
    ..Our review identifies chronic kidney disease as an independent risk factor for postoperative death and cardiovascular events after elective, noncardiac surgery...
  51. doi request reprint Bariatric surgery: a systematic review and network meta-analysis of randomized trials
    R Padwal
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Obes Rev 12:602-21. 2011
    ..Compared with Roux-en-Y gastric bypass, adjustable gastric banding has lower weight loss efficacy, but also leads to fewer serious adverse effects...
  52. doi request reprint The impact of selecting a high hemoglobin target level on health-related quality of life for patients with chronic kidney disease: a systematic review and meta-analysis
    Fiona M Clement
    Departments of Community Health Sciences and Medicine, Centre for Health and Policy Studies, University of Calgary, Calgary, Alberta, Canada
    Arch Intern Med 169:1104-12. 2009
    ..0-12.0 g/dL) and high hemoglobin target levels (>12.0 g/dL) and performed a meta-analysis of all available 36-item short-form (SF-36) RCT data...
  53. ncbi request reprint Access to kidney transplantation among patients insured by the United States Department of Veterans Affairs
    John S Gill
    Division of Nephrology, University of British Columbia, Vancouver, British Columbia, Canada
    J Am Soc Nephrol 18:2592-9. 2007
    ..We conclude that VA-insured patients are less likely to receive transplants than privately insured patients, and that further studies are needed to identify the reasons for this disparity...
  54. pmc Comorbidities do not influence primary fistula success in incident hemodialysis patients: a prospective study
    Wenjie Wang
    Division of Nephrology, University of Calgary, Foothills Medical Center, Calgary, Canada
    Clin J Am Soc Nephrol 3:78-84. 2008
    ..Concern about primary fistula failure may contribute to the underuse of arteriovenous fistula. The objective of this study was to investigate the baseline clinical parameters associated with primary fistula success...
  55. ncbi request reprint Barriers to blood pressure control and angiotensin enzyme inhibitor use in Canadian patients with chronic renal insufficiency
    Marcello Tonelli
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nephrol Dial Transplant 17:1426-33. 2002
    ..We designed this study to describe the use of these therapeutic strategies, and to investigate barriers to their implementation...
  56. doi request reprint Early recognition and prevention of chronic kidney disease
    Matthew T James
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Lancet 375:1296-309. 2010
    ..Novel clinical methods to better identify patients at risk of progression to later stages of chronic kidney disease, including kidney failure, are needed to target management to high-risk subgroups...
  57. ncbi request reprint Indigenous health: update on the impact of diabetes and chronic kidney disease
    Karen Yeates
    Department of Medicine, Queens University, Kingston, Ontario, Canada
    Curr Opin Nephrol Hypertens 15:588-92. 2006
    ..The purpose of this review is to highlight recent epidemiologic and intervention studies that have occurred in the areas of diabetes and renal disease among indigenous populations...
  58. ncbi request reprint Differences in use of peritoneal dialysis and survival among East Asian, Indo Asian, and white ESRD patients in Canada
    Brenda R Hemmelgarn
    Department of Medicine, Division of Nephrology, University of Calgary, Canada
    Am J Kidney Dis 48:964-71. 2006
    ..Racial differences in health outcomes in general are well documented; however, few studies examined the impact of East Asian and Indo Asian race on choice of dialytic modality and survival among patients with end-stage renal disease (ESRD)...
  59. doi request reprint The pregnancy rate and live birth rate in kidney transplant recipients
    J S Gill
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Am J Transplant 9:1541-9. 2009
    ..The live birth rate was substantially lower than reported in voluntary registries of transplant recipients, and the proportion of pregnancies resulting in unexpected fetal loss increased over time...
  60. doi request reprint Access to kidney transplantation among remote- and rural-dwelling patients with kidney failure in the United States
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, AB T6B 2B7, Canada
    JAMA 301:1681-90. 2009
    ..US residents with end-stage renal disease (ESRD) may live far away from the closest transplant center, which could compromise their access to kidney transplantation...
  61. pmc Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton
    CMAJ 180:E62-71. 2009
    ..However, their safety and effectiveness is controversial. We did a systematic review of the clinical efficacy and harms of these agents in adults with anemia related to cancer or chemotherapy...
  62. ncbi request reprint Development of diabetes mellitus following kidney transplantation: a Canadian experience
    Sita Gourishankar
    Division of Nephrology and Transplantation Immunology, 11 108E Clinical Sciences Building, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 4:1876-82. 2004
    ..This study demonstrates that in a Canadian kidney transplant population that there is a significant risk of PTDM following kidney transplantation, and it is therefore advisable to minimize this risk...
  63. ncbi request reprint Prophylaxis strategies for contrast-induced nephropathy
    Neesh Pannu
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton
    JAMA 295:2765-79. 2006
    ..Contrast-induced nephropathy is associated with significant economic and clinical consequences, including prolonged hospitalization, the requirement for dialysis, and an increased risk of death...
  64. doi request reprint Economic evaluation of continuous renal replacement therapy in acute renal failure
    Scott Klarenbach
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Int J Technol Assess Health Care 25:331-8. 2009
    ..Controversy exists regarding the optimal method of providing dialysis in critically ill patients with acute renal failure. We sought to determine the cost-effectiveness of treatment strategies...
  65. doi request reprint Economic evaluation of erythropoiesis-stimulating agents for anemia related to cancer
    Scott Klarenbach
    Department of Medicine, University of Alberta Edmonton, Alberta, Canada
    Cancer 116:3224-32. 2010
    ..Concerns about toxicity have led to more restrictive recommendations for ESA use; however, the incremental costs and benefits of such a strategy are unknown...
  66. doi request reprint Relation between alkaline phosphatase, serum phosphate, and all-cause or cardiovascular mortality
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 120:1784-92. 2009
    ..Higher levels of serum alkaline phosphatase (AlkP) are associated with excess mortality in dialysis patients, but whether AlkP is associated with adverse outcomes among people without kidney failure is unknown...
  67. ncbi request reprint Strategies to reduce the risk of contrast nephropathy: an evidence-based approach
    Neesh Pannu
    Department of Medicine, Division of Nephrology, Alberta, Canada
    Curr Opin Nephrol Hypertens 15:285-90. 2006
    ..Recent clinical trials of prophylactic strategies have reported contradictory results. This review presents recent insights into the pathophysiology of contrast nephropathy and reviews trial results in this context...
  68. doi request reprint Nephrology visits and health care resource use before and after reporting estimated glomerular filtration rate
    Brenda R Hemmelgarn
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 303:1151-8. 2010
    ..Laboratory reporting of estimated glomerular filtration rate (GFR) has been widely implemented, with limited evaluation...
  69. ncbi request reprint Optimizing dialysis delivery in tunneled dialysis catheters
    Neesh Pannu
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    ASAIO J 52:157-62. 2006
    ..This suggests that QB in CVC should be set as high as circuit pressure limits will allow, regardless of the potential for AR, and that reversal of line position confers no benefit with respect to solute clearance...
  70. ncbi request reprint A systematic review of the effect of nocturnal hemodialysis on blood pressure, left ventricular hypertrophy, anemia, mineral metabolism, and health-related quality of life
    Michael Walsh
    Department of Medicine, University of Calgary, Alberta, Canada
    Kidney Int 67:1500-8. 2005
    ..A systematic review of the current available literature was undertaken to examine the effect of nocturnal hemodialysis on key health outcomes...
  71. pmc Similar outcomes among black and white renal allograft recipients
    Karen Yeates
    Department of Medicine, Queen s University, 94 Stuart Street, Kingston, Ontario, Canada
    J Am Soc Nephrol 20:172-9. 2009
    ..Because this differs from the experience reported from the United States, further direct comparisons between the two populations is warranted...
  72. pmc Population based screening for chronic kidney disease: cost effectiveness study
    Braden Manns
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    BMJ 341:c5869. 2010
    ..To determine the cost effectiveness of one-off population based screening for chronic kidney disease based on estimated glomerular filtration rate...
  73. pmc Association between proximity to the attending nephrologist and mortality among patients receiving hemodialysis
    Marcello Tonelli
    Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, Alta
    CMAJ 177:1039-44. 2007
    ..We investigated whether patients receiving hemodialysis who live farther from their attending nephrologist are more likely to die than those who live closer...
  74. ncbi request reprint Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta, Edmonton, Canada
    Circulation 109:1004-9. 2004
    ..The prevalence, prognostic import, and impact of renal insufficiency on the benefits of ACE inhibitors and beta-blockers in community-dwelling patients with heart failure are uncertain...
  75. ncbi request reprint Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial
    Bruce F Culleton
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    JAMA 298:1291-9. 2007
    ..Morbidity and mortality rates in hemodialysis patients remain excessive. Alterations in the delivery of dialysis may lead to improved patient outcomes...
  76. ncbi request reprint The effect of maintenance immunosuppression medication on the change in kidney allograft function
    John S Gill
    Division of Nephrology, St Paul s Hospital, Vancouver, British Columbia, Canada
    Kidney Int 65:692-9. 2004
    ..In this study we determined the effect of maintenance immunosuppression medications on the rate of kidney allograft function loss defined by the annualized change in glomerular filtration rate (GFR)...
  77. ncbi request reprint The change in allograft function among long-term kidney transplant recipients
    John S Gill
    Division of Nephrology, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Am Soc Nephrol 14:1636-42. 2003
    ..Strategies to improve long-term kidney allograft survival that increase baseline allograft function may be more effective than strategies to slow the decline in GFR...
  78. doi request reprint The effect of increasing dialysis dose in overweight hemodialysis patients on quality of life: a 6-week randomized crossover trial
    Wenjie Wang
    Department of Medicine, Division of Nephrology, University of Calgary, Foothills Medical Center, Calgary, Alberta, Canada
    Am J Kidney Dis 51:796-803. 2008
    ..Whether increasing dialysis adequacy in large patients not achieving KDOQI targets improves HRQL is unknown...
  79. doi request reprint Phosphate removal with several thrice-weekly dialysis methods in overweight hemodialysis patients
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Canada
    Am J Kidney Dis 54:1108-15. 2009
    ..Whether modifying dialysis prescription to intensify small-solute clearance also leads to better phosphate clearance is unknown...
  80. pmc Trace elements in hemodialysis patients: a systematic review and meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Med 7:25. 2009
    ..We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients...
  81. ncbi request reprint Chronic kidney disease among Aboriginal people living in Canada
    K Yeates
    Department of Medicine, Queen s University, Kingston, Ontario, Canada
    Clin Nephrol 74:S57-60. 2010
    ..This paper will describe access to, quality of, and outcomes associated with the renal care of Aboriginal people living in Canada...
  82. doi request reprint Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes
    M Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Am J Transplant 11:2093-109. 2011
    ..These findings validate current attempts to increase the number of people worldwide that benefit from kidney transplantation...
  83. ncbi request reprint Dose-reducing H2 receptor antagonists in the presence of low glomerular filtration rate: a systematic review of the evidence
    J Manlucu
    Division of Nephrology, University of Western Ontario, London, Ontario, Canada
    Nephrol Dial Transplant 20:2376-84. 2005
    ..While it is recommended that H2 receptor antagonists (H2RAs) be dose reduced in the presence of low glomerular filtration rate (GFR), in practice such adjustments often do not occur. We reviewed the evidence for this recommendation...
  84. doi request reprint Practice pattern variation in oral glucocorticoid therapy after the induction of response in proliferative lupus nephritis
    M Walsh
    Department of Medicine, University of Calgary, Calgary, AB, Canada
    Lupus 19:628-33. 2010
    ..This variability likely represents clinical equipoise. A randomized trial evaluating the effect of glucocorticoid use after induction of response is warranted...
  85. ncbi request reprint Establishment and maintenance of vascular access in incident hemodialysis patients: a prospective cost analysis
    Braden Manns
    Department of Medicine, University of Calgary, Alberta, Canada
    J Am Soc Nephrol 16:201-9. 2005
    ..01). Vascular access care is responsible for a significant proportion of health care costs in the first year of hemodialysis. These results support clinical practice guidelines that recommend preferential placement of a native fistula...
  86. ncbi request reprint Do statins protect the kidney by reducing proteinuria?
    Marcello Tonelli
    Ann Intern Med 145:147-9. 2006
  87. ncbi request reprint Impact of anemia on hospitalization and mortality in older adults
    Bruce F Culleton
    Department of Medicine, University of Calgary, Foothills Hospital, Rm C210, 1403 29th St NW, Calgary, AB, Canada T2N 2T9
    Blood 107:3841-6. 2006
    ..Consideration should be given to redefine "normal" hemoglobin values in the elderly. Clinical trials are also necessary to determine whether anemia correction improves quality or quantity of life in this population...
  88. ncbi request reprint Patients with Fabry disease on dialysis in the United States
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 61:249-55. 2002
    ..Little is known about the characteristics of patients with Fabry disease that initiate dialysis in the United States, although data from Europe suggests these individuals have a poor survival...
  89. pmc Slowing the progression of chronic renal insufficiency
    Marcello Tonelli
    Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 166:906-7. 2002
  90. ncbi request reprint Design of the fish oil inhibition of stenosis in hemodialysis grafts (FISH) study
    Charmaine E Lok
    Nephrology, University Health Network Toronto General Hospital, Toronto, Ontario, Canada
    Clin Trials 4:357-67. 2007
    ..The fish oil inhibition of stenosis in hemodialysis grafts (FISH) study evaluates the efficacy of fish oil in improving HD graft patency...
  91. ncbi request reprint Cost of acute renal failure requiring dialysis in the intensive care unit: clinical and resource implications of renal recovery
    Braden Manns
    Department of Medicine, University of Calgary, Alberta, Canada
    Crit Care Med 31:449-55. 2003
    ..As such, the objective of this study was to estimate the cost of CRRT and intermittent hemodialysis in the intensive care unit and to explore the impact of renal recovery on subsequent clinical outcomes and costs among survivors...
  92. ncbi request reprint Hemodialysis clinical practice guidelines for the Canadian Society of Nephrology
    Kailash Jindal
    J Am Soc Nephrol 17:S1-27. 2006
  93. pmc Relation between access blood flow and mortality in chronic hemodialysis patients
    Mohammed Al-Ghonaim
    Department of Medicine, University of Alberta, Edmonton, Canada
    Clin J Am Soc Nephrol 3:387-91. 2008
    ..Patients were followed from the date of Qa measurement until death; follow-up was discontinued at loss to follow-up, kidney transplantation, or end of study...
  94. ncbi request reprint Access flow monitoring of patients with native vessel arteriovenous fistulae and previous angioplasty
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Am Soc Nephrol 13:2969-73. 2002
    ..Continued screening after correction of first stenoses appears reasonable, because of both the frequency of recurrent stenosis and the success of repeat intervention...
  95. ncbi request reprint Renal function and outcomes in acute coronary syndrome: impact of clopidogrel
    Matyas Keltai
    Gottsegen Gyorgy Hungarian Institute of Cardiology, Department of Cardiology, Semmelweis University, Budapest, Hungary
    Eur J Cardiovasc Prev Rehabil 14:312-8. 2007
    ..The aim of the study was to assess the impact of clopidogrel on safety and efficacy in patients with renal dysfunction in non-ST elevation acute coronary syndromes...
  96. ncbi request reprint Survival among patients with kidney failure in Jalisco, Mexico
    Guillermo Garcia-Garcia
    Hospital Civil de Guadalajara, Hospital 278, 44280 Guadalajara, Jalisco, Mexico
    J Am Soc Nephrol 18:1922-7. 2007
    ..Our findings demonstrate a tremendous opportunity to reduce morbidity and mortality from kidney disease in Jalisco and perhaps other regions of Mexico...
  97. ncbi request reprint Systematic review of the impact of N-acetylcysteine on contrast nephropathy
    Neesh Pannu
    Department of Medicine, Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 65:1366-74. 2004
    ..We performed a systematic review and meta-analysis to assess the efficacy of NAC for preventing contrast nephropathy after administration of intravenous contrast media...
  98. ncbi request reprint Systematic review of the clinical efficacy and safety of sevelamer in dialysis patients
    Marcello Tonelli
    Foothills Medical Centre, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada
    Nephrol Dial Transplant 22:2856-66. 2007
    ..The relative effectiveness and safety of sevelamer for treatment of hyperphosphataemia in dialysis patients is uncertain, as compared with calcium-based phosphate binders...
  99. ncbi request reprint Chronic kidney disease and mortality risk: a systematic review
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta T6B 2B7, Canada
    J Am Soc Nephrol 17:2034-47. 2006
    ..0 in 71% of cohorts. This review supports current guidelines that identify individuals with CKD as being at high risk for cardiovascular mortality. Determining which interventions best offset this risk remains a health priority...
  100. doi request reprint Statins for slowing kidney disease progression: an as yet unproven indication
    Marcello Tonelli
    Am J Kidney Dis 52:391-4. 2008