Sheila J Thornton

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Stroke volume and cardiac output in juvenile elephant seals during forced dives
    Sheila J Thornton
    Department of Zoology, University of British Columbia, Vancouver, Canada
    J Exp Biol 208:3637-43. 2005
  2. ncbi request reprint Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections
    Kristina Sachs-Barrable
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Adv Drug Deliv Rev 60:692-701. 2008
  3. pmc Dietary supplementation with phytosterol and ascorbic acid reduces body mass accumulation and alters food transit time in a diet-induced obesity mouse model
    Sheila J Thornton
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Lipids Health Dis 10:107. 2011
  4. pmc Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism
    Sheila J Thornton
    University of British Columbia, Faculty of Pharmaceutical Sciences, 2146 University Blvd, Vancouver, British Columbia, V6T 1Z3, Canada
    Lipids Health Dis 7:21. 2008
  5. doi request reprint Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice
    Pavel Gershkovich
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    J Antimicrob Chemother 65:535-7. 2010
  6. doi request reprint The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis
    Sheila J Thornton
    Division of Pharmaceutics and Biopharmaceutics, The University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Expert Opin Drug Deliv 6:271-84. 2009
  7. doi request reprint Highly effective oral amphotericin B formulation against murine visceral leishmaniasis
    Kishor M Wasan
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    J Infect Dis 200:357-60. 2009
  8. ncbi request reprint Treatment with a cholesterol absorption inhibitor (FM-VP4) reduces body mass and adipose accumulation in developing and pre-obese mice
    Sheila J Thornton
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    Drug Dev Ind Pharm 33:1058-69. 2007
  9. doi request reprint Evaluation of the Contribution of the ATP Binding Cassette Transporter, P-glycoprotein, to in Vivo Cholesterol Homeostasis
    Stephen D Lee
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Mol Pharm 10:3203-12. 2013
  10. ncbi request reprint Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
    Kishor M Wasan
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada V6T 1Z3
    Nat Rev Drug Discov 7:84-99. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Stroke volume and cardiac output in juvenile elephant seals during forced dives
    Sheila J Thornton
    Department of Zoology, University of British Columbia, Vancouver, Canada
    J Exp Biol 208:3637-43. 2005
    ..In this study, the degree of bradycardia during diving was less than in previous pinniped studies, suggesting that the reduction in vagal input may contribute to the observed increase in Vs...
  2. ncbi request reprint Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections
    Kristina Sachs-Barrable
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Adv Drug Deliv Rev 60:692-701. 2008
    ....
  3. pmc Dietary supplementation with phytosterol and ascorbic acid reduces body mass accumulation and alters food transit time in a diet-induced obesity mouse model
    Sheila J Thornton
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Lipids Health Dis 10:107. 2011
    ....
  4. pmc Effect of dietary fat on hepatic liver X receptor expression in P-glycoprotein deficient mice: implications for cholesterol metabolism
    Sheila J Thornton
    University of British Columbia, Faculty of Pharmaceutical Sciences, 2146 University Blvd, Vancouver, British Columbia, V6T 1Z3, Canada
    Lipids Health Dis 7:21. 2008
    ..However, p-glycoprotein deficient mice (Mdr1a-/-/1b-/-) exhibit increased hepatic LXRalpha protein expression and an elevation in fecal cholesterol concentration when compared to controls...
  5. doi request reprint Visceral leishmaniasis affects liver and spleen concentrations of amphotericin B following administration to mice
    Pavel Gershkovich
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    J Antimicrob Chemother 65:535-7. 2010
    ..To assess the impact of visceral leishmaniasis (VL) on the concentration of amphotericin B (AmB) recovered in the liver and spleen following either intravenous (AmBisome) or oral (iCo-009) AmB administration to mice...
  6. doi request reprint The reformulation of amphotericin B for oral administration to treat systemic fungal infections and visceral leishmaniasis
    Sheila J Thornton
    Division of Pharmaceutics and Biopharmaceutics, The University of British Columbia, 2146 East Mall, Vancouver, BC, V6T 1Z3, Canada
    Expert Opin Drug Deliv 6:271-84. 2009
    ....
  7. doi request reprint Highly effective oral amphotericin B formulation against murine visceral leishmaniasis
    Kishor M Wasan
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    J Infect Dis 200:357-60. 2009
    ..This formulation has overcome amphotericin B's significant physicochemical barriers to absorption and holds promise for the development of a self-administered oral therapy for the treatment of visceral leishmaniasis...
  8. ncbi request reprint Treatment with a cholesterol absorption inhibitor (FM-VP4) reduces body mass and adipose accumulation in developing and pre-obese mice
    Sheila J Thornton
    Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    Drug Dev Ind Pharm 33:1058-69. 2007
    ..This study examined the FM-VP4 dose-dependent mass loss in mice and investigated some potential mechanisms by which decreased mass accumulation may have occurred. The effect of FM-VP4 administration on pre-obese mice was also tested...
  9. doi request reprint Evaluation of the Contribution of the ATP Binding Cassette Transporter, P-glycoprotein, to in Vivo Cholesterol Homeostasis
    Stephen D Lee
    Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Mol Pharm 10:3203-12. 2013
    ..Our finding that Pgp knockout mice were unable to maintain gallbladder bile composition when challenged with high dietary fat and/or cholesterol compliments recent reports that Pgp may be a secondary bile salt export pump. ..
  10. ncbi request reprint Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery
    Kishor M Wasan
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada V6T 1Z3
    Nat Rev Drug Discov 7:84-99. 2008
    ....
  11. doi request reprint Barriers to treatment for visceral leishmaniasis in hyperendemic areas: India, Bangladesh, Nepal, Brazil and Sudan
    Sheila J Thornton
    Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada
    Drug Dev Ind Pharm 36:1312-9. 2010
    ..Over 90% of reported cases occur in India, Bangladesh, Nepal, Sudan, and Brazil, affecting mainly impoverished individuals and creating a significant economic burden through direct and indirect costs of treatment...
  12. pmc The effects of experimentally induced hyperthyroidism on the diving physiology of harbor seals (Phoca vitulina)
    Gundula M Weingartner
    Department of Zoology, University of British Columbia Vancouver, BC, Canada
    Front Physiol 3:380. 2012
    ..Our results demonstrate the powerful role of thyroid hormones in metabolic regulation and support the hypothesis that thyroid hormones play a role in modulating the at-sea metabolism of phocid seals...
  13. doi request reprint The global access initiative at the University of British Columbia (UBC): Availability of UBC discoveries and technologies to the developing world
    Kishor M Wasan
    The University of British Columbia, Faculty of Pharmaceutical Sciences, Division of Pharmaceutics and Biopharmaceutics, 2146 East Mall, Vancouver, B C, Canada V6T 123
    J Pharm Sci 98:791-4. 2009
    ..This commentary will discuss these principles and provide examples of where they have been applied to several UBC technologies...