Roger J Thompson

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi Ischemia opens neuronal gap junction hemichannels
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Science 312:924-7. 2006
  2. ncbi Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 322:1555-9. 2008
  3. ncbi Non-junction functions of pannexin-1 channels
    Brian A MacVicar
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Trends Neurosci 33:93-102. 2010
  4. ncbi Connexin and pannexin hemichannels of neurons and astrocytes
    Roger J Thompson
    Department of Psychiatry and the Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
    Channels (Austin) 2:81-6. 2008
  5. ncbi Tumor-suppressive effects of pannexin 1 in C6 glioma cells
    Charles P K Lai
    Departments of Cellular and Physiological Sciences and Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 67:1545-54. 2007

Collaborators

Detail Information

Publications5

  1. ncbi Ischemia opens neuronal gap junction hemichannels
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
    Science 312:924-7. 2006
    ..Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischemic neuronal death...
  2. ncbi Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 322:1555-9. 2008
    ..We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity...
  3. ncbi Non-junction functions of pannexin-1 channels
    Brian A MacVicar
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Trends Neurosci 33:93-102. 2010
    ..Novel functions for the pannexin channels are likely to be discovered as current understanding of how they are regulated in physiological and pathological situations improves...
  4. ncbi Connexin and pannexin hemichannels of neurons and astrocytes
    Roger J Thompson
    Department of Psychiatry and the Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
    Channels (Austin) 2:81-6. 2008
    ..Additionally, pannexin-1 appears to play a role in neuronal death. Hemichannels form a novel and unique class of ion channels that likely have diverse physiological and pathophysiological roles in the nervous system...
  5. ncbi Tumor-suppressive effects of pannexin 1 in C6 glioma cells
    Charles P K Lai
    Departments of Cellular and Physiological Sciences and Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 67:1545-54. 2007
    ..Altogether, we conclude that the loss of pannexin expression may participate in the development of C6 gliomas, whereas restoration of Panx1 plays a tumor-suppressive role...