Roger J Thompson
Affiliation: University of Calgary
- Ischemia opens neuronal gap junction hemichannelsRoger J Thompson
Department of Psychiatry and Brain Research Centre, University of British Columbia, Vancouver, British Columbia V6T 2B5, Canada
Science 312:924-7. 2006..Both the current and dye flux were blocked by inhibitors of hemichannels. Therefore, hemichannel opening contributes to the profound ionic dysregulation during stroke and may be a ubiquitous component of ischemic neuronal death...
- Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampusRoger J Thompson
Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
Science 322:1555-9. 2008..We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity...
- Non-junction functions of pannexin-1 channelsBrian A MacVicar
Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Trends Neurosci 33:93-102. 2010..Novel functions for the pannexin channels are likely to be discovered as current understanding of how they are regulated in physiological and pathological situations improves...
- Connexin and pannexin hemichannels of neurons and astrocytesRoger J Thompson
Department of Psychiatry and the Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
Channels (Austin) 2:81-6. 2008..Additionally, pannexin-1 appears to play a role in neuronal death. Hemichannels form a novel and unique class of ion channels that likely have diverse physiological and pathophysiological roles in the nervous system...
- Tumor-suppressive effects of pannexin 1 in C6 glioma cellsCharles P K Lai
Departments of Cellular and Physiological Sciences and Psychiatry, The University of British Columbia, Vancouver, British Columbia, Canada
Cancer Res 67:1545-54. 2007..Altogether, we conclude that the loss of pannexin expression may participate in the development of C6 gliomas, whereas restoration of Panx1 plays a tumor-suppressive role...