Miles D Thompson

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, London Health Sciences Centre, Toronto, Ontario, Canada
    Neuroreport 23:45-8. 2012
  2. ncbi request reprint A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha
    Miles D Thompson
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenetics 13:641-9. 2003
  3. doi request reprint G protein-coupled receptors disrupted in human genetic disease
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, Ontario, Canada
    Methods Mol Biol 448:109-37. 2008
  4. doi request reprint Phenotypic variability in hyperphosphatasia with seizures and neurologic deficit (Mabry syndrome)
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 158:553-8. 2012
  5. ncbi request reprint A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate
    Miles D Thompson
    Laboratory Medicine, Banting Institute, Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenet Genomics 17:539-49. 2007
  6. ncbi request reprint G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Department of Medical Genetics and Microbiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Diagn Ther 10:353-66. 2006
  7. ncbi request reprint Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
    Miles D Thompson
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 129:69-75. 2004
  8. ncbi request reprint The G protein-coupled receptors: pharmacogenetics and disease
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, ON, Canada
    Crit Rev Clin Lab Sci 42:311-92. 2005
  9. pmc Metabolic syndrome features and risk of neural tube defects
    Joel G Ray
    Department of Medicine, St, Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    BMC Pregnancy Childbirth 7:21. 2007
  10. doi request reprint Vitamin B-12 and neural tube defects: the Canadian experience
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, ON, Canada
    Am J Clin Nutr 89:697S-701S. 2009

Detail Information

Publications17

  1. doi request reprint Chromosome 1p36 in migraine with aura: association study of the 5HT(1D) locus
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, London Health Sciences Centre, Toronto, Ontario, Canada
    Neuroreport 23:45-8. 2012
    ..Further work using a genome-wide association study approach in familial typical migraine, consisting of those affected by MO or MA, will serve to further distinguish how and why MA differs from MO...
  2. ncbi request reprint A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha
    Miles D Thompson
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenetics 13:641-9. 2003
    ..0015). This represents the first association of a coding mutation in the CysLT2 receptor gene, located on chromosome 13q14, with the atopic phenotype found in the Tristan da Cunha population...
  3. doi request reprint G protein-coupled receptors disrupted in human genetic disease
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, Ontario, Canada
    Methods Mol Biol 448:109-37. 2008
    ..This review of the variety of GPCRs that are disrupted in monogenic disease provides the basis for examining the significance of common pharmacogenetic variants...
  4. doi request reprint Phenotypic variability in hyperphosphatasia with seizures and neurologic deficit (Mabry syndrome)
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 158:553-8. 2012
    ..2010] have PIGV mutations, we suggest that other genes critical to GPI anchor biosynthesis are likely to be disrupted in some patients...
  5. ncbi request reprint A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate
    Miles D Thompson
    Laboratory Medicine, Banting Institute, Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenet Genomics 17:539-49. 2007
    ..These in vitro analyses provide evidence that the 300S CysLT1 variant, found more commonly in atopics in the Tristan da Cunha population, encodes a functionally more sensitive variant...
  6. ncbi request reprint G-protein-coupled receptors and asthma endophenotypes: the cysteinyl leukotriene system in perspective
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, and Department of Medical Genetics and Microbiology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Mol Diagn Ther 10:353-66. 2006
    ..The genetic variant(s) of receptors that are associated with endophenotypes are discussed in the context of the extent to which they contribute to a disease phenotype or altered drug efficacy...
  7. ncbi request reprint Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity
    Miles D Thompson
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 129:69-75. 2004
    ..Further work is warranted to study the variability of the orexin/hypocretin system in a variety of disorders characterized by EDS...
  8. ncbi request reprint The G protein-coupled receptors: pharmacogenetics and disease
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, ON, Canada
    Crit Rev Clin Lab Sci 42:311-92. 2005
    ..These developments will be discussed with respect to strategies for drug discovery that take into account the potential for the development of drugs targeted at mutated and wild-type proteins...
  9. pmc Metabolic syndrome features and risk of neural tube defects
    Joel G Ray
    Department of Medicine, St, Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada
    BMC Pregnancy Childbirth 7:21. 2007
    ..Whether they, in combination with additional features of MetSyn, alter this risk is not known. We evaluated the risk of NTD in association with maternal features of the MetSyn...
  10. doi request reprint Vitamin B-12 and neural tube defects: the Canadian experience
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, ON, Canada
    Am J Clin Nutr 89:697S-701S. 2009
    ..A multicenter randomized controlled trial comparing periconceptional vitamin B-12 in combination with FA against FA alone is warranted...
  11. doi request reprint G protein-coupled receptor pharmacogenetics
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, Ontario, Canada
    Methods Mol Biol 448:139-85. 2008
    ..The continued effort by the basic science of pharmacogenetics may draw the attention of drug discovery projects and clinicians alike to the utility of personalized pharmacogenomics as a means to optimize novel GPCR drug targets...
  12. doi request reprint Pharmacogenomics of G protein-coupled receptor signaling: insights from health and disease
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, Banting Institute, University of Toronto, Toronto, Ontario, Canada
    Methods Mol Biol 448:77-107. 2008
    ..An understanding of the pharmacogenomics of GPCR signaling provides the basis for examining the GPCRs disrupted in monogenic disease and the pharmacogenetics of a given receptor system...
  13. ncbi request reprint Whole genome amplification of buccal cell DNA: genotyping concordance before and after multiple displacement amplification
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Chem Lab Med 43:157-62. 2005
    ..Genotyping DNA from MDA-based WGA is indistinguishable from routine polymerase chain reaction and offers a stable DNA source for genomic research and clinical diagnosis...
  14. doi request reprint Hyperphosphatasia with seizures, neurologic deficit, and characteristic facial features: Five new patients with Mabry syndrome
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Am J Med Genet A 152:1661-9. 2010
    ..This was confirmed in three of our patients, but the inclusions are not always observed and the intracellular storage material has not been identified...
  15. ncbi request reprint Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population
    Joel G Ray
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Epidemiology 18:362-6. 2007
    ..Prior studies used relatively insensitive measures of B(12), did not adjust for folate levels, and were conducted in countries without folic acid food fortification. In Canada, flour has been fortified with folic acid since mid-1997...
  16. ncbi request reprint Hyperphosphatasia with neurologic deficit: a pyridoxine-responsive seizure disorder?
    Miles D Thompson
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Pediatr Neurol 34:303-7. 2006
    ..Conversely, pyridoxine challenge should be considered in cases of hyperphosphatasia with seizures and neurologic deficit...
  17. ncbi request reprint Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends
    Valerie Capra
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Med Res Rev 27:469-527. 2007
    ....