L U Thompson

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Variability in anticancer lignan levels in flaxseed
    L U Thompson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Nutr Cancer 27:26-30. 1997
  2. ncbi request reprint Dietary phytoestrogens, including isoflavones, lignans, and coumestrol, in nonvitamin, nonmineral supplements commonly consumed by women in Canada
    Lilian U Thompson
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Nutr Cancer 59:176-84. 2007
  3. ncbi request reprint Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan
    Lilian U Thompson
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Nutr Cancer 54:184-201. 2006
  4. ncbi request reprint Validation of a phytoestrogen food frequency questionnaire with urinary concentrations of isoflavones and lignan metabolites in premenopausal women
    Melissa R French
    Osteoporosis Research Program, Women s College Hospital, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada
    J Am Coll Nutr 26:76-82. 2007
  5. ncbi request reprint Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada)
    Michelle Cotterchio
    Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada
    Cancer Causes Control 19:259-72. 2008
  6. ncbi request reprint Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer?
    Krista A Power
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Mol Nutr Food Res 51:845-56. 2007
  7. ncbi request reprint Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy
    Jennifer D Brooks
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Am J Clin Nutr 79:318-25. 2004
  8. ncbi request reprint Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats
    W E Ward
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    J Toxicol Environ Health A 63:53-65. 2001
  9. ncbi request reprint Adolescent dietary phytoestrogen intake and breast cancer risk (Canada)
    Joanne Thanos
    Department of Public Health Sciences, University of Toronto, Toronto, Ont, Canada
    Cancer Causes Control 17:1253-61. 2006
  10. ncbi request reprint Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts
    Charlotta Dabrosin
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, ON, M5S 3E2, Toronto, Canada
    Cancer Lett 185:31-7. 2002

Research Grants

Collaborators

  • M Cotterchio
  • Wendy E Ward
  • N Saarinen
  • Young In Kim
  • G A Hawker
  • Paul Goss
  • Jacqueline E Lewis
  • Jianmin Chen
  • Krista A Power
  • Beatrice A Boucher
  • Jasdeep Kaur Saggar
  • Sandra M Sacco
  • Karen D Coulman
  • Zhen Liu
  • Jennifer D Brooks
  • Nancy Kreiger
  • Jian Min Chen
  • Linda Wang
  • Kah Poh Tan
  • Charlotta Dabrosin
  • Paul Corey
  • Karen K Y Sie
  • Winston Quan Hum
  • Malin Bergman Jungeström
  • John Michaelides
  • Melissa R French
  • Joanne Thanos
  • M Jenab
  • Ruth Croxford
  • Sandra Reza-Lopez
  • David W L Ma
  • Kyong Jin Sohn
  • Jessica M Y Jiang
  • Astor Cheng
  • Jaskaren Mann
  • Leslie Nickell
  • Evelyn Wong
  • John Hilditch

Detail Information

Publications37

  1. ncbi request reprint Variability in anticancer lignan levels in flaxseed
    L U Thompson
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Ontario, Canada
    Nutr Cancer 27:26-30. 1997
    ..Differences due to variety, harvest location, and harvest year of flaxseed should be taken into consideration when tumorigenesis studies are designed...
  2. ncbi request reprint Dietary phytoestrogens, including isoflavones, lignans, and coumestrol, in nonvitamin, nonmineral supplements commonly consumed by women in Canada
    Lilian U Thompson
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Nutr Cancer 59:176-84. 2007
    ..Hence, the intake of supplements should be taken into consideration in clinical or epidemiological studies for more accurate estimation of phytoestrogen intakes...
  3. ncbi request reprint Phytoestrogen content of foods consumed in Canada, including isoflavones, lignans, and coumestan
    Lilian U Thompson
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    Nutr Cancer 54:184-201. 2006
    ..The richest sources of specific phytoestrogens, including coumestrol, were identified. The database will improve phytoestrogen intake estimation in future epidemiological and clinical studies particularly in Western populations...
  4. ncbi request reprint Validation of a phytoestrogen food frequency questionnaire with urinary concentrations of isoflavones and lignan metabolites in premenopausal women
    Melissa R French
    Osteoporosis Research Program, Women s College Hospital, 76 Grenville Street, Toronto, Ontario M5S 1B2, Canada
    J Am Coll Nutr 26:76-82. 2007
    ..The purpose of this study was to examine the association between dietary intake of phytoestrogens estimated by a food frequency questionnaire (FFQ) with urinary metabolites...
  5. ncbi request reprint Dietary phytoestrogen intake--lignans and isoflavones--and breast cancer risk (Canada)
    Michelle Cotterchio
    Division of Preventive Oncology, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada
    Cancer Causes Control 19:259-72. 2008
    ..To evaluate whether phytoestrogen intake is associated with reduced breast cancer risk, using a novel phytoestrogen database...
  6. ncbi request reprint Can the combination of flaxseed and its lignans with soy and its isoflavones reduce the growth stimulatory effect of soy and its isoflavones on established breast cancer?
    Krista A Power
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Mol Nutr Food Res 51:845-56. 2007
    ..This may indicate that if soy is consumed with lignan-rich foods, it may continue to induce its other beneficial health effects, without inducing adverse effect on postmenopausal BC...
  7. ncbi request reprint Supplementation with flaxseed alters estrogen metabolism in postmenopausal women to a greater extent than does supplementation with an equal amount of soy
    Jennifer D Brooks
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Am J Clin Nutr 79:318-25. 2004
    ..Phytoestrogens, which are abundant in flaxseed and soy, have chemical structures resembling those of endogenous estrogens and have been shown to exert hormonal effects, thereby affecting chronic diseases...
  8. ncbi request reprint Exposure to flaxseed and its purified lignan reduces bone strength in young but not older male rats
    W E Ward
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    J Toxicol Environ Health A 63:53-65. 2001
    ....
  9. ncbi request reprint Adolescent dietary phytoestrogen intake and breast cancer risk (Canada)
    Joanne Thanos
    Department of Public Health Sciences, University of Toronto, Toronto, Ont, Canada
    Cancer Causes Control 17:1253-61. 2006
    ..This population-based case-control study evaluated the association between adolescent dietary phytoestrogen intake and adult breast cancer risk among women in Ontario, Canada...
  10. ncbi request reprint Flaxseed inhibits metastasis and decreases extracellular vascular endothelial growth factor in human breast cancer xenografts
    Charlotta Dabrosin
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, ON, M5S 3E2, Toronto, Canada
    Cancer Lett 185:31-7. 2002
    ..Moreover, flaxseed decreased extracellular levels of VEGF, which may be one mechanistic explanation to the decreased tumor growth and metastasis...
  11. ncbi request reprint Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells
    Jennifer D Brooks
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St, Toronto, Ont, Canada M5S 3E2
    J Steroid Biochem Mol Biol 94:461-7. 2005
    ..In conclusion, modulation of local E2 synthesis is one potential mechanism through which ED, EL and GEN may protect against breast cancer...
  12. ncbi request reprint Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats
    Zhen Liu
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, M5S 3E2, Canada
    J Nutr 136:906-12. 2006
    ..From intermediate metabolites of sesamin identified in rat urine by GC-MS, a tentative metabolic pathway of sesamin to mammalian lignans is suggested...
  13. ncbi request reprint Genistein alone and in combination with the mammalian lignans enterolactone and enterodiol induce estrogenic effects on bone and uterus in a postmenopausal breast cancer mouse model
    Krista A Power
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St Toronto, Ontario, Canada M5S 3E2
    Bone 39:117-24. 2006
    ..The lignans do not exert adverse effects on any tissue, however, when combined with GEN, they exert an adverse effect on the uterus...
  14. ncbi request reprint Whole sesame seed is as rich a source of mammalian lignan precursors as whole flaxseed
    Karen D Coulman
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Nutr Cancer 52:156-65. 2005
    ....
  15. ncbi request reprint Exposure to purified lignan from flaxseed (Linum usitatissimum) alters bone development in female rats
    W E Ward
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Br J Nutr 86:499-505. 2001
    ..Importantly, exposure to purified lignan does not have negative effects on bone strength...
  16. ncbi request reprint Exposure to flaxseed or its purified lignan during suckling only or continuously does not alter reproductive indices in male and female offspring
    W E Ward
    Department of Nutritional Sciences, University of Toronto, Ontario, Canada
    J Toxicol Environ Health A 64:567-77. 2001
    ....
  17. ncbi request reprint Purified and endogenous phytic acid in wheat bran affects early biomarkers of colon cancer risk
    M Jenab
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada M5S 3E2
    IARC Sci Publ 156:387-9. 2002
  18. doi request reprint Flaxseed combined with low-dose estrogen therapy preserves bone tissue in ovariectomized rats
    Sandra M Sacco
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Menopause 16:545-54. 2009
    ....
  19. doi request reprint Folic acid supplementation provided in utero and during lactation reduces the number of terminal end buds of the developing mammary glands in the offspring
    Karen K Y Sie
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Cancer Lett 280:72-7. 2009
    ..014). Our data suggest for the first time that folic acid supplementation provided in utero and during lactation may lower mammary tumor risk in the offspring...
  20. doi request reprint Fatty acids and lignans in unground whole flaxseed and sesame seed are bioavailable but have minimal antioxidant and lipid-lowering effects in postmenopausal women
    Karen D Coulman
    Department of Nutritional Sciences, University of Toronto, ON, Canada
    Mol Nutr Food Res 53:1366-75. 2009
    ....
  21. doi request reprint Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways
    Jasdeep Kaur Saggar
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Mol Nutr Food Res 54:415-25. 2010
    ..SDG and FO reduced the growth of TAM-treated tumors but FO was more effective. The mechanisms involve both the ER- and growth factor-signaling pathways...
  22. doi request reprint Prolonged administration of secoisolariciresinol diglycoside increases lignan excretion and alters lignan tissue distribution in adult male and female rats
    Niina M Saarinen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Toronto, ON, Canada M5S 3E2
    Br J Nutr 104:833-41. 2010
    ..These findings facilitate identification of target tissues for local lignan actions in vivo...
  23. ncbi request reprint Flaxseed and soy protein isolate, alone and in combination, differ in their effect on bone mass, biomechanical strength, and uterus in ovariectomized nude mice with MCF-7 human breast tumor xenografts
    Krista A Power
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Toxicol Environ Health A 70:1888-96. 2007
    ..Although the SPI + FS and SPI groups exerted stimulatory effects on uterus weight, other histological parameters need to be measured to determine the overall safety of these breast cancer treatments on the uterus...
  24. doi request reprint Lignans are accessible to human breast cancer xenografts in athymic mice
    Niina M Saarinen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Nutr Cancer 60:245-50. 2008
    ..5 g) tumors. Accessibility of lignans to tumor tissue suggests that part of the anticancer activity of lignans may be due to their direct local effects on the breast cancer tissues...
  25. ncbi request reprint Flaxseed alone or in combination with tamoxifen inhibits MCF-7 breast tumor growth in ovariectomized athymic mice with high circulating levels of estrogen
    Jianmin Chen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Toronto, ON, Canada M5S 3E2
    Exp Biol Med (Maywood) 232:1071-80. 2007
    ..Apoptosis was only associated with ERalpha. In conclusion, FS inhibited MCF-7 tumor growth in a dose-dependent manner and enhanced the inhibitory effect of TAM due to the modulation of ER and growth factor signal transduction pathways...
  26. ncbi request reprint Lignan-rich sesame seed negates the tumor-inhibitory effect of tamoxifen but maintains bone health in a postmenopausal athymic mouse model with estrogen-responsive breast tumors
    Sandra M Sacco
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Menopause 15:171-9. 2008
    ..This study determined the interactive effects of sesame seed and tamoxifen on established MCF-7 tumor growth and bone health in ovariectomized athymic mice simulating a postmenopausal condition...
  27. ncbi request reprint Lignans and tamoxifen, alone or in combination, reduce human breast cancer cell adhesion, invasion and migration in vitro
    Jianmin Chen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
    Breast Cancer Res Treat 80:163-70. 2003
    ..Although more investigations are required, the study also suggests that the intake of the lignan-rich flaxseed may not antagonize the effect of TAM in ER- breast cancer cells...
  28. ncbi request reprint Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis
    Jianmin Chen
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Exp Biol Med (Maywood) 228:951-8. 2003
    ....
  29. ncbi request reprint Mammary gland morphogenesis is enhanced by exposure to flaxseed or its major lignan during suckling in rats
    Kah Poh Tan
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto 150 College Street, Toronto, Ontario M5S 3E2, Canada
    Exp Biol Med (Maywood) 229:147-57. 2004
    ..The physiological outcomes of FS and SDG were similar, which suggests that SDG is partly responsible for the mammary gland differentiation effect...
  30. ncbi request reprint The inhibitory effect of flaxseed on the growth and metastasis of estrogen receptor negative human breast cancer xenograftsis attributed to both its lignan and oil components
    Linda Wang
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Int J Cancer 116:793-8. 2005
    ..In conclusion, FS reduced the growth and metastasis of established ER- human breast cancer in part due to its lignan and FO components, and not to lipid peroxidation...
  31. ncbi request reprint Dietary flaxseed alters tumor biological markers in postmenopausal breast cancer
    Lilian U Thompson
    Department of Nutritional Sciences, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 11:3828-35. 2005
    ..This study examined, in a randomized double-blind placebo-controlled clinical trial, the effects of dietary flaxseed on tumor biological markers and urinary lignan excretion in postmenopausal patients with newly diagnosed breast cancer...
  32. ncbi request reprint Mammalian lignans enterolactone and enterodiol, alone and in combination with the isoflavone genistein, do not promote the growth of MCF-7 xenografts in ovariectomized athymic nude mice
    Krista A Power
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Toronto, Ontario, Canada M5S 3E2
    Int J Cancer 118:1316-20. 2006
    ..When these phytoestrogens were given in combination, no tumor growth-promoting effects were observed. (c) 2005 Wiley-Liss, Inc...
  33. doi request reprint The effect of secoisolariciresinol diglucoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways
    Jasdeep Kaur Saggar
    University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Nutr Cancer 62:533-42. 2010
    ..SDG alone also lowered the ERalpha, ERbeta, EGFR, BCL2 mRNA, and PMAPK protein, indicating that its effect involves the modulation of the ER- and growth factor receptor-mediated signaling pathways...
  34. doi request reprint Hormone-related supplements and breast cancer risk: need for improved measurement of supplement use
    Beatrice A Boucher
    Int J Cancer 123:2465-6; author reply 2467-8. 2008
  35. ncbi request reprint Soy formula and breast cancer risk
    Beatrice A Boucher
    Epidemiology 19:165-6. 2008
  36. ncbi request reprint A randomized controlled trial of the effect of dietary soy and flaxseed muffins on quality of life and hot flashes during menopause
    Jacqueline E Lewis
    Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada
    Menopause 13:631-42. 2006
    ..To compare the effects of daily ingestion of soy flour (S), ground flaxseed (F), or wheat flour (W) muffins, on quality of life and hot flash frequency and severity in postmenopausal women...
  37. ncbi request reprint Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo
    Malin Bergman Jungeström
    Divison of Oncology, Faculty of Health Sciences, University Hospital, Linkoping, Sweden
    Clin Cancer Res 13:1061-7. 2007
    ..The main phytoestrogens in Western diet are lignans, and flaxseed is a rich source of the mammalian lignans enterodiol and enterolactone...

Research Grants1

  1. Interactive Effects of Flaxseed and Tamoxifen in Breast*
    Lilian Thompson; Fiscal Year: 2004
    ..abstract_text> ..