James E Thomas

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. pmc In silico genomic analyses reveal three distinct lineages of Escherichia coli O157:H7, one of which is associated with hyper-virulence
    Chad R Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB, Canada
    BMC Genomics 10:287. 2009
  2. pmc Pan-genome sequence analysis using Panseq: an online tool for the rapid analysis of core and accessory genomic regions
    Chad Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB, Canada
    BMC Bioinformatics 11:461. 2010
  3. doi request reprint Biochemical monitoring in fenugreek to develop functional food and medicinal plant variants
    James E Thomas
    Dept of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    N Biotechnol 28:110-7. 2011
  4. ncbi request reprint Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 8:1935-9. 2009
  5. pmc Rapid determination of Escherichia coli O157:H7 lineage types and molecular subtypes by using comparative genomic fingerprinting
    Chad Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, Alberta, Canada
    Appl Environ Microbiol 74:6606-15. 2008
  6. pmc Escherichia coli O157:H7 strain origin, lineage, and Shiga toxin 2 expression affect colonization of cattle
    Ross M S Lowe
    Lethbridge Research Centre, Alberta, Canada
    Appl Environ Microbiol 75:5074-81. 2009
  7. pmc Lineage and host source are both correlated with levels of Shiga toxin 2 production by Escherichia coli O157:H7 strains
    Yongxiang Zhang
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB T1J 3Z4, Canada
    Appl Environ Microbiol 76:474-82. 2010

Collaborators

  • Olga Kovalchuk
  • Mohamed A Karmali
  • Ranjana Sharma
  • Yongxiang Zhang
  • Chad Laing
  • Victor P J Gannon
  • Eduardo N Taboada
  • Cody Buchanan
  • Kim Ziebell
  • Chad R Laing
  • Igor Koturbash
  • Ross M S Lowe
  • Andrew M Kropinski
  • Jennyka Hallewell
  • Andre Villegas
  • Roger P Johnson
  • Andrew Kropinski
  • Chunping You
  • Zhengzhong Zhang
  • Tim A McAllister
  • Danica Baines
  • Igor Kovalchuk
  • Victor Pj Gannon
  • L Brent Selinger
  • Marina Steele
  • Davis Yawney
  • Roger Johnson
  • Crystal Pegg

Detail Information

Publications7

  1. pmc In silico genomic analyses reveal three distinct lineages of Escherichia coli O157:H7, one of which is associated with hyper-virulence
    Chad R Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB, Canada
    BMC Genomics 10:287. 2009
    ..coli genome sequences from 17 O157:H7 strains and single O145:NM and K12 MG1655 strains to provide an overall picture of diversity of the E. coli O157:H7 population, and to compare genotyping methods for O157:H7 strains...
  2. pmc Pan-genome sequence analysis using Panseq: an online tool for the rapid analysis of core and accessory genomic regions
    Chad Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB, Canada
    BMC Bioinformatics 11:461. 2010
    ..In this study, we describe a new online pan-genome sequence analysis program, Panseq...
  3. doi request reprint Biochemical monitoring in fenugreek to develop functional food and medicinal plant variants
    James E Thomas
    Dept of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    N Biotechnol 28:110-7. 2011
    ..This research indicates that comprehensive biochemical analysis of plant products would facilitate the development of more reliable produce for use by the functional food/medicinal plant industry...
  4. ncbi request reprint Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues
    Igor Koturbash
    Department of Biological Sciences, University of Lethbridge, Lethbridge, AB, Canada
    Cell Cycle 8:1935-9. 2009
    ..Even though bacteria were non-pathogenic and unable to cause infection, their remnants still caused a profound effect on exposed animals...
  5. pmc Rapid determination of Escherichia coli O157:H7 lineage types and molecular subtypes by using comparative genomic fingerprinting
    Chad Laing
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, Alberta, Canada
    Appl Environ Microbiol 74:6606-15. 2008
    ..coli O157:H7 lineages and PT. As a comparative genomics typing method that is amenable for use in high-throughput platforms, CGF may be a valuable tool in outbreak investigations and strain characterization...
  6. pmc Escherichia coli O157:H7 strain origin, lineage, and Shiga toxin 2 expression affect colonization of cattle
    Ross M S Lowe
    Lethbridge Research Centre, Alberta, Canada
    Appl Environ Microbiol 75:5074-81. 2009
    ..The present study supports a role for strain origin, lineage type, cytotoxin activity, and stx(2) expression in modulating the amount of E. coli O157:H7 colonization of cattle...
  7. pmc Lineage and host source are both correlated with levels of Shiga toxin 2 production by Escherichia coli O157:H7 strains
    Yongxiang Zhang
    Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, Lethbridge, AB T1J 3Z4, Canada
    Appl Environ Microbiol 76:474-82. 2010
    ..However, the level of Stx2 production alone may also play an important role in the within-lineage association of E. coli O157:H7 strains with human clinical disease...