U Tepass

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint FERM proteins in animal morphogenesis
    Ulrich Tepass
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Genet Dev 19:357-67. 2009
  2. ncbi request reprint Epithelial differentiation in Drosophila
    U Tepass
    Department of Zoology, University of Toronto, Ontario, Canada
    Bioessays 19:673-82. 1997
  3. ncbi request reprint Epithelial cell polarity and cell junctions in Drosophila
    U Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S3G5, Canada
    Annu Rev Genet 35:747-84. 2001
  4. ncbi request reprint Cadherins in embryonic and neural morphogenesis
    U Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 1:91-100. 2000
  5. ncbi request reprint Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries
    Ulrich Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Ontario M5S 3G5, Toronto, Canada
    Curr Opin Genet Dev 12:572-82. 2002
  6. ncbi request reprint Adherens junctions: new insight into assembly, modulation and function
    Ulrich Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5
    Bioessays 24:690-5. 2002
  7. ncbi request reprint Genetic analysis of cadherin function in animal morphogenesis
    U Tepass
    Department of Zoology University of Toronto 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    Curr Opin Cell Biol 11:540-8. 1999
  8. ncbi request reprint Adherens junctions in Drosophila retinal morphogenesis
    Ulrich Tepass
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Trends Cell Biol 17:26-35. 2007
  9. pmc Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
    G Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Cell Biol 151:891-904. 2000
  10. pmc DE-Cadherin is required for intercellular motility during Drosophila oogenesis
    P Niewiadomska
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 144:533-47. 1999

Collaborators

Detail Information

Publications37

  1. doi request reprint FERM proteins in animal morphogenesis
    Ulrich Tepass
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Genet Dev 19:357-67. 2009
    ..1 as well as Yurt and its vertebrate homologs Mosaic Eyes and EPB41L5/YMO1/Limulus...
  2. ncbi request reprint Epithelial differentiation in Drosophila
    U Tepass
    Department of Zoology, University of Toronto, Ontario, Canada
    Bioessays 19:673-82. 1997
    ..The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes...
  3. ncbi request reprint Epithelial cell polarity and cell junctions in Drosophila
    U Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S3G5, Canada
    Annu Rev Genet 35:747-84. 2001
    ..Much remains to be learned of how these complexes assemble, establish their polarized distribution, and contribute to the asymmetric organization of epithelial cells...
  4. ncbi request reprint Cadherins in embryonic and neural morphogenesis
    U Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 1:91-100. 2000
    ..Cadherins may also contribute to neurite outgrowth and pathfinding, and to synaptic specificity and modulation in the central nervous system...
  5. ncbi request reprint Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries
    Ulrich Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Ontario M5S 3G5, Toronto, Canada
    Curr Opin Genet Dev 12:572-82. 2002
    ..Further, several examples demonstrate that cell sorting in vivo can be driven by Eph/ephrin signalling and by the differential expression of cadherins that modulate cell adhesion and motility...
  6. ncbi request reprint Adherens junctions: new insight into assembly, modulation and function
    Ulrich Tepass
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5
    Bioessays 24:690-5. 2002
    ..4 Finally, the asymmetric distribution of adherens junction material regulates spindle orientation during asymmetric cell division in the sensory organ lineage...
  7. ncbi request reprint Genetic analysis of cadherin function in animal morphogenesis
    U Tepass
    Department of Zoology University of Toronto 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    Curr Opin Cell Biol 11:540-8. 1999
    ..Fat-like cadherins are required for epithelial morphogenesis, proliferation control, and epithelial planar polarization...
  8. ncbi request reprint Adherens junctions in Drosophila retinal morphogenesis
    Ulrich Tepass
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Trends Cell Biol 17:26-35. 2007
    ..Adherens junctions are involved in the organization of simple cellular patterns, and more complex cell shape changes and cell movements that depend on the dynamic modulation of adherens junctions...
  9. pmc Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
    G Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Cell Biol 151:891-904. 2000
    ..Together with previous data showing that Crb is required for the formation of a zonula adherens, these findings indicate a mutual dependency of apical and lateral polarization mechanisms...
  10. pmc DE-Cadherin is required for intercellular motility during Drosophila oogenesis
    P Niewiadomska
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 144:533-47. 1999
    ..Finally, we show that the upregulation of DE-cadherin expression in border cells depends on the activity of the Drosophila C/EBP transcription factor that is essential for border cell migration...
  11. ncbi request reprint Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis
    Milena Pellikka
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nature 416:143-9. 2002
    ..Defects in such scaffolds may contribute to human CRB1-related retinal dystrophies...
  12. pmc Essential function of Drosophila Sec6 in apical exocytosis of epithelial photoreceptor cells
    Slobodan Beronja
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 169:635-46. 2005
    ..Furthermore, we show that Rab11 forms a complex with Sec5 and that Sec5 interacts with Sec6 suggesting that the exocyst is a Rab11 effector that facilitates protein transport to the apical rhabdomere in Drosophila PRCs...
  13. ncbi request reprint Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization
    Guy Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nat Cell Biol 5:46-52. 2003
    ....
  14. ncbi request reprint The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in Drosophila
    R Wilk
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Dev Biol 219:183-96. 2000
    ..These data suggest that HNT is a tissue-specific factor that regulates maintenance of the tracheal epithelium as well as differentiation of taenidia...
  15. pmc Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli
    Cecilia D'Alterio
    Department of Zoology, University of Toronto, Toronto, Ontario, Canada, M5S 3G5
    J Cell Biol 171:549-58. 2005
    ..This study reveals Cad99C as a critical regulator of microvillus length, the first example of a transmembrane protein that is involved in this process...
  16. ncbi request reprint Drosophila oocyte localization is mediated by differential cadherin-based adhesion
    D Godt
    Department of Zoology, University of Toronto, Ontario, Canada
    Nature 395:387-91. 1998
    ..This is, to our knowledge, the first in vivo example of a cell-sorting process that depends on differential adhesion mediated by a cadherin...
  17. pmc The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size
    Patrick Laprise
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Dev Cell 11:363-74. 2006
    ..We propose that Yurt is part of an evolutionary conserved negative-feedback mechanism that restricts Crb complex activity in promoting apical membrane formation...
  18. ncbi request reprint The agrin/perlecan-related protein eyes shut is essential for epithelial lumen formation in the Drosophila retina
    Nicole Husain
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Dev Cell 11:483-93. 2006
    ..Our findings show that the secretion of a proteoglycan into the apical matrix is critical for the formation of epithelial lumina in the fly retina...
  19. doi request reprint Adherens junctions: from molecules to morphogenesis
    Tony J C Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Nat Rev Mol Cell Biol 11:502-14. 2010
    ..As a result, we have gained important insights into the molecular mechanisms of tissue morphogenesis...
  20. pmc Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis
    Kathryn P Harris
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Cell Biol 183:1129-43. 2008
    ..This study reveals functional interactions between apical polarity proteins and endocytosis that are critical for stabilizing dynamic basolateral AJs...
  21. doi request reprint The germline stem cells of Drosophila melanogaster partition DNA non-randomly
    Phillip Karpowicz
    Department of Medical Genetics and Microbiology, University of Toronto, 160 College Street, Toronto, Ontario, Canada M5S 3E1
    Eur J Cell Biol 88:397-408. 2009
    ..Our data suggest asymmetric chromatid segregation is coupled to mechanisms specifying cellular differentiation via asymmetric stem cell division...
  22. doi request reprint Cdc42 and vesicle trafficking in polarized cells
    Kathryn P Harris
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    Traffic 11:1272-9. 2010
    ..The recent discovery that the Par polarity complex co-operates with Cdc42 in the regulation of endocytosis and recycling opens exciting possibilities for the integration of polarity protein function and endocytotic machinery...
  23. ncbi request reprint Organogenesis: keeping in touch with the germ cells
    Dorothea Godt
    Department of Zoology, University of Toronto, 25 Harbord Street, M5S 3G5, Toronto, Ontario, Canada
    Curr Biol 13:R683-5. 2003
    ..DE-cadherin and its novel regulator, the transmembrane protein Fear of Intimacy, have been found to control the adhesive interactions between germline and somatic cells that lead to gonad formation in Drosophila...
  24. ncbi request reprint Cellular morphogenesis: slow-as-molasses accelerates polarized membrane growth
    Slobodan Beronja
    Department of Zoology, University of Toronto, M5S 3G5, Toronto, Ontario, Canada
    Dev Cell 2:382-4. 2002
    ..The gene slow-as-molasses encodes a novel protein essential for the formation of a plasma membrane domain that initiates membrane growth during cellularization...
  25. ncbi request reprint Hand-me-downs. Transmitting anterior-posterior asymmetry from older to younger egg follicles
    Dorothea Godt
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Dev Cell 5:525-7. 2003
    ..A report in this issue of Developmental Cell shows that a developing follicle conveys its anterior-posterior asymmetry to the next younger follicle via a relay mechanism that involves the Notch/Delta and the JAK/STAT signaling pathways...
  26. doi request reprint Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins
    Patrick Laprise
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nature 459:1141-5. 2009
    ..We also find that the mammalian Yrt orthologue EPB41L5 (also known as YMO1 and Limulus) is required for lateral membrane formation, indicating a conserved function of Yrt proteins in epithelial polarity...
  27. pmc The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    Christian A Smith
    Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Mol Biol Cell 15:3698-708. 2004
    ..In addition, we present evidence that Numb has a novel function in endosomal recycling and intracellular trafficking of receptors...
  28. ncbi request reprint Function of Rho GTPases in embryonic blood cell migration in Drosophila
    Magda Paladi
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    J Cell Sci 117:6313-26. 2004
    ..We find eight deletions that cause defects in macrophage migration suggesting the existence of approximately ten zygotic genes essential for macrophage migration...
  29. doi request reprint Molecular evolution of SPARC: absence of the acidic module and expression in the endoderm of the starlet sea anemone, Nematostella vectensis
    Anne Koehler
    Laboratory of Tissue Repair and Regeneration, Matrix Dynamics Group, University of Toronto, 150 College Street, Toronto, ON, Canada
    Dev Genes Evol 219:509-21. 2009
    ..We propose that further Ca(2+)-dependent activities emerged with the acquisition of an acidic N-terminal module in triplobastic organisms...
  30. pmc Sinuous is a Drosophila claudin required for septate junction organization and epithelial tube size control
    Victoria M Wu
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Hogan Hall, Rm 2 100, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
    J Cell Biol 164:313-23. 2004
    ....
  31. ncbi request reprint Claudin complexities at the apical junctional complex
    Ulrich Tepass
    Nat Cell Biol 5:595-7. 2003
  32. pmc Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila
    Joost Schulte
    Dept of Zoology, University of British Columbia, Vancouver, Canada
    J Cell Biol 161:991-1000. 2003
    ..We propose a model, whereby Gli acts at tricellular junctions to bind, anchor, or compact SJ strands apically during SJ development...
  33. ncbi request reprint Talin's second persona
    Ulrich Tepass
    Nat Cell Biol 7:443-4. 2005
  34. ncbi request reprint Interaction between EGFR signaling and DE-cadherin during nervous system morphogenesis
    Karin Dumstrei
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, 90095, USA
    Development 129:3983-94. 2002
    ..Finally, EGFR can be co-immunoprecipitated with anti-DE-cadherin and anti-Armadillo antibodies from embryonic protein extracts. We propose that EGFR signaling plays a role in morphogenesis by modulating cell adhesion...
  35. ncbi request reprint Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components
    Sunil Q Mehta
    Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 46:219-32. 2005
    ..The data also show that functions of other exocyst components persist in the absence of sec15, suggesting that different exocyst components have separable functions...
  36. ncbi request reprint The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo
    Jeffrey D Lee
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Development 134:2007-16. 2007
    ..We propose that mouse Lulu (Epb4.1l5) helps anchor the actin-myosin contractile machinery to the membrane to allow the dynamic rearrangements of epithelia that mediate embryonic morphogenesis...
  37. ncbi request reprint CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina
    Adrienne K Mehalow
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Hum Mol Genet 12:2179-89. 2003
    ..The Crb1rd8 mouse model will facilitate the analysis of Crb1 function in the neural retina and the identification of interacting factors as candidate retinal disease genes...