Research Topics
| Laura E TargownickSummaryAffiliation: University of Manitoba Country: Canada Publications
| Collaborators
|
Detail Information
Publications
Comparing resource utilization and gastrointestinal outcomes in patients treated with either standard-dose or high-dose proton pump inhibitors: a matched cohort studyLaura E Targownik
Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
Dig Dis Sci 53:1519-26. 2008..Initial therapy with double-dose PPIs does not reduce GI-related resource utilization. Prescription of double-dose PPIs as initial therapy for upper gastrointestinal symptoms should be discouraged...
The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study [corrected] from the Canadian Multicentre Osteoporosis Study (CaMos)Laura E Targownik
University of Manitoba, Winnipeg, Manitoba, Canada
Am J Gastroenterol 107:1361-9. 2012..Demonstrating that PPIs are associated with accelerated bone mineral density (BMD) loss would provide supportive evidence for a mechanism through which PPIs could increase fracture risk...- The epidemiology of colectomy in ulcerative colitis: results from a population-based cohortLaura E Targownik
Section of Gastroenterology, Department of Internal Medicine, University of Manitoba IBD Clinical and Research Centre, Winnipeg, Canada
Am J Gastroenterol 107:1228-35. 2012..We sought to determine the incidence of colectomy in UC and identify risk factors associated with early colectomy (EC) and late colectomy (LC)... 
Comparing administrative and survey data for ascertaining cases of irritable bowel syndrome: a population-based investigationLisa M Lix
School of Public Health, University of Saskatchewan, Saskatoon, Canada
BMC Health Serv Res 10:31. 2010....- The role of rapid endoscopy for high-risk patients with acute nonvariceal upper gastrointestinal bleedingLaura E Targownik
Section of Gastroenterology, Department of Internal Medicine, Universty of Manitoba, Winnipeg, Canada
Can J Gastroenterol 21:425-9. 2007..It is unknown whether performing endoscopy early within this 24 h window is beneficial for clinically high-risk patients... - Underutilization of gastroprotective strategies in aspirin users at increased risk of upper gastrointestinal complicationsL E Targownik
Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
Aliment Pharmacol Ther 28:88-96. 2008..Proton pump inhibitors (PPIs) decrease the risk of UGICs among aspirin users. The distribution of risk factors for UGIC and PPI utilization among aspirin users remains uncharacterized... - Gastroprotective strategies among NSAID users: guidelines for appropriate use in chronic illnessLaura E Targownik
Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
Can Fam Physician 52:1100-5. 2006..To review proper use of gastroprotective strategies in family medicine for patients requiring chronic nonsteroidal anti-inflammatory drug (NSAID) therapy... - Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleedingLaura E Targownik
Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, 804E 715 McDermot Avenue, Winnipeg, Manitoba, Canada
Am J Gastroenterol 104:1475-82. 2009..The role for PPIs in chronic SSRI users without other risk factors remains uncharacterized... - Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density lossLaura E Targownik
Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Gastroenterology 138:896-904. 2010..The mechanism by which PPI use promotes the development of hip fracture is uncharacterized. Therefore, we sought to determine whether PPI use is associated with osteoporosis or accelerated bone mineral density (BMD) loss... - Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003Laura E Targownik
Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba
Clin Gastroenterol Hepatol 4:1459-1466. 2006..There have been numerous innovations in the prevention and management of ANVUGIB in recent years, although the effect of these innovations on ANVUGIB incidence and outcomes is unknown... - The prevalence of risk factors for gastrointestinal complications and use of gastroprotection among persons hospitalized for cardiovascular diseaseL E Targownik
Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
Aliment Pharmacol Ther 23:743-9. 2006..Proton pump inhibitors reduce the risk of gastrointestinal complications in aspirin users with a history of gastrointestinal complications... - The relationship among proton pump inhibitors, bone disease and fractureLaura E Targownik
University of Manitoba, Division of Internal Medicine, Section of Gastroenterology, McDermot Avenue, Winnipeg, Canada
Expert Opin Drug Saf 10:901-12. 2011..However, clinicians should still endeavor to avoid using PPIs in situations where benefits are minimal or clinical indications are lacking... - The relative efficacies of gastroprotective strategies in chronic users of nonsteroidal anti-inflammatory drugsLaura E Targownik
Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Gastroenterology 134:937-44. 2008..The relative efficacy of the different strategies alone or in combination is uncertain... - Pre-endoscopic proton pump inhibitor therapy reduces recurrent adverse gastrointestinal outcomes in patients with acute non-variceal upper gastrointestinal bleedingL Keyvani
Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, 804E-715 McDermot Avenue, Winnipeg, Manitoba, Canada
Aliment Pharmacol Ther 24:1247-55. 2006..Future studies are required to better characterize this relationship... - Physicians' approaches to the use of gastroprotective strategies in low-risk non-steroidal anti-inflammatory drug usersS K Murthy
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Aliment Pharmacol Ther 23:1365-72. 2006..Improving doctors' awareness of non-steroidal anti-inflammatory drug-associated gastrointestinal risks may lead to a decrease in inappropriate utilization of gastroprotective strategies in low-risk patients... - Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopiesHarminder Singh
Department of Internal Medicine, Cancer Care Manitoba, University of Manitoba, Winnipeg
JAMA 295:2366-73. 2006..Limited evidence exists to guide the optimal frequency of repeat endoscopic examination for colorectal cancer screening after a negative colonoscopy... - An assessment of endoscopic and concomitant management of acute variceal bleeding at a tertiary care centreH Singh
Section of Gastroenterology, University of Manitoba, 715 McDermot Avenue, Winnipeg, Manitoba, Canada
Can J Gastroenterol 21:85-90. 2007..Several therapies have been demonstrated to be beneficial in the management of acute variceal bleeding (AVB). The aim of the present study was to characterize the use of these therapies at a Canadian tertiary care centre... - Use of proton pump inhibitors and risk of osteoporosis-related fracturesLaura E Targownik
Department of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Man
CMAJ 179:319-26. 2008..The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between duration of exposure to proton pump inhibitors and osteoporosis-related fractures... - The prevalence of and the clinical and demographic characteristics associated with high-intensity proton pump inhibitor useLaura E Targownik
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Gastroenterol 102:942-50. 2007..We therefore sought to calculate the prevalence and predictors of high-intensity PPI use... - Proton pump inhibitors, osteoporosis, and osteoporosis-related fracturesMarc R Fournier
Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Maturitas 64:9-13. 2009.... - Intravenous versus high-dose oral proton pump inhibitor therapy after endoscopic hemostasis of high-risk lesions in patients with acute nonvariceal upper gastrointestinal bleedingSanjay Murthy
Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Dig Dis Sci 52:1685-90. 2007..01 for developing an adverse outcome versus oral PPIs (95% CI: 0.44-2.33). We conclude that oral PPIs are probably equivalent to IV PPIs for preventing rebleeding in ANVUGIB patients... - The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhageLaura E Targownik
Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Gastroenterol 99:1306-15. 2004..CONCLUSIONS: Compared to EBL for the secondary prophylaxis of variceal rebleeding, combination medical therapy guided by HVPG monitoring is more effective and only marginally more expensive... - The cost-effectiveness of colonic stenting as a bridge to curative surgery in patients with acute left-sided malignant colonic obstruction: a Canadian perspectiveHarminder Singh
Department of Internal Medicine, University of Manitoba, Winnipeg
Can J Gastroenterol 20:779-85. 2006..Colonic stenting should be offered as the initial therapeutic modality for Canadian colorectal cancer patients presenting with acute obstruction as a bridge to definitive RS... - Colonoscopic screening for colorectal cancerHarminder Singh
JAMA 296:2438; author reply 2438-9. 2006 - Management of acute nonvariceal upper gastrointestinal hemorrhage: comparison of an American and a Canadian medical centreLaura E Targownik
Veterans Affairs Greater Los Angeles Health Care System, California, USA
Can J Gastroenterol 17:489-95. 2003..The aim of the present study was to compare the structure, process and outcomes of care between a Canadian and an American tertiary care medical centre in the management of acute nonvariceal UGIH... - Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysisLaura E Targownik
Division of Digestive Diseases, School of Medicine, UCLA Center for the Health Sciences, University of California-Los Angeles, Los Angeles, CA 90095, USA
Gastrointest Endosc 60:865-74. 2004..Our findings suggest that colonic stent insertion should be offered, whenever feasible, as a bridge to elective surgery in patients presenting with malignant colonic obstruction... - The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisalBrennan M R Spiegel
Division of Gastroenterology, Veteran s Affairs Greater Los Angeles Healthcare System, California, USA
Gastroenterology 127:403-11. 2004..We sought to appraise the quality of health economic analyses in digestive diseases, and to identify predictors of study quality...