Laura E Targownick

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi Comparing resource utilization and gastrointestinal outcomes in patients treated with either standard-dose or high-dose proton pump inhibitors: a matched cohort study
    Laura E Targownik
    Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Dig Dis Sci 53:1519-26. 2008
  2. doi The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study [corrected] from the Canadian Multicentre Osteoporosis Study (CaMos)
    Laura E Targownik
    University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 107:1361-9. 2012
  3. doi The epidemiology of colectomy in ulcerative colitis: results from a population-based cohort
    Laura E Targownik
    Section of Gastroenterology, Department of Internal Medicine, University of Manitoba IBD Clinical and Research Centre, Winnipeg, Canada
    Am J Gastroenterol 107:1228-35. 2012
  4. pmc Comparing administrative and survey data for ascertaining cases of irritable bowel syndrome: a population-based investigation
    Lisa M Lix
    School of Public Health, University of Saskatchewan, Saskatoon, Canada
    BMC Health Serv Res 10:31. 2010
  5. pmc The role of rapid endoscopy for high-risk patients with acute nonvariceal upper gastrointestinal bleeding
    Laura E Targownik
    Section of Gastroenterology, Department of Internal Medicine, Universty of Manitoba, Winnipeg, Canada
    Can J Gastroenterol 21:425-9. 2007
  6. doi Underutilization of gastroprotective strategies in aspirin users at increased risk of upper gastrointestinal complications
    L E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Aliment Pharmacol Ther 28:88-96. 2008
  7. pmc Gastroprotective strategies among NSAID users: guidelines for appropriate use in chronic illness
    Laura E Targownik
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Can Fam Physician 52:1100-5. 2006
  8. doi Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, 804E 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:1475-82. 2009
  9. doi Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastroenterology 138:896-904. 2010
  10. ncbi Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba
    Clin Gastroenterol Hepatol 4:1459-1466. 2006

Detail Information

Publications27

  1. ncbi Comparing resource utilization and gastrointestinal outcomes in patients treated with either standard-dose or high-dose proton pump inhibitors: a matched cohort study
    Laura E Targownik
    Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Dig Dis Sci 53:1519-26. 2008
    ..Initial therapy with double-dose PPIs does not reduce GI-related resource utilization. Prescription of double-dose PPIs as initial therapy for upper gastrointestinal symptoms should be discouraged...
  2. doi The relationship between proton pump inhibitor use and longitudinal change in bone mineral density: a population-based study [corrected] from the Canadian Multicentre Osteoporosis Study (CaMos)
    Laura E Targownik
    University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 107:1361-9. 2012
    ..Demonstrating that PPIs are associated with accelerated bone mineral density (BMD) loss would provide supportive evidence for a mechanism through which PPIs could increase fracture risk...
  3. doi The epidemiology of colectomy in ulcerative colitis: results from a population-based cohort
    Laura E Targownik
    Section of Gastroenterology, Department of Internal Medicine, University of Manitoba IBD Clinical and Research Centre, Winnipeg, Canada
    Am J Gastroenterol 107:1228-35. 2012
    ..We sought to determine the incidence of colectomy in UC and identify risk factors associated with early colectomy (EC) and late colectomy (LC)...
  4. pmc Comparing administrative and survey data for ascertaining cases of irritable bowel syndrome: a population-based investigation
    Lisa M Lix
    School of Public Health, University of Saskatchewan, Saskatoon, Canada
    BMC Health Serv Res 10:31. 2010
    ....
  5. pmc The role of rapid endoscopy for high-risk patients with acute nonvariceal upper gastrointestinal bleeding
    Laura E Targownik
    Section of Gastroenterology, Department of Internal Medicine, Universty of Manitoba, Winnipeg, Canada
    Can J Gastroenterol 21:425-9. 2007
    ..It is unknown whether performing endoscopy early within this 24 h window is beneficial for clinically high-risk patients...
  6. doi Underutilization of gastroprotective strategies in aspirin users at increased risk of upper gastrointestinal complications
    L E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada
    Aliment Pharmacol Ther 28:88-96. 2008
    ..Proton pump inhibitors (PPIs) decrease the risk of UGICs among aspirin users. The distribution of risk factors for UGIC and PPI utilization among aspirin users remains uncharacterized...
  7. pmc Gastroprotective strategies among NSAID users: guidelines for appropriate use in chronic illness
    Laura E Targownik
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Can Fam Physician 52:1100-5. 2006
    ..To review proper use of gastroprotective strategies in family medicine for patients requiring chronic nonsteroidal anti-inflammatory drug (NSAID) therapy...
  8. doi Selective serotonin reuptake inhibitors are associated with a modest increase in the risk of upper gastrointestinal bleeding
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, 804E 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 104:1475-82. 2009
    ..The role for PPIs in chronic SSRI users without other risk factors remains uncharacterized...
  9. doi Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastroenterology 138:896-904. 2010
    ..The mechanism by which PPI use promotes the development of hip fracture is uncharacterized. Therefore, we sought to determine whether PPI use is associated with osteoporosis or accelerated bone mineral density (BMD) loss...
  10. ncbi Trends in management and outcomes of acute nonvariceal upper gastrointestinal bleeding: 1993-2003
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba
    Clin Gastroenterol Hepatol 4:1459-1466. 2006
    ..There have been numerous innovations in the prevention and management of ANVUGIB in recent years, although the effect of these innovations on ANVUGIB incidence and outcomes is unknown...
  11. ncbi The prevalence of risk factors for gastrointestinal complications and use of gastroprotection among persons hospitalized for cardiovascular disease
    L E Targownik
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Aliment Pharmacol Ther 23:743-9. 2006
    ..Proton pump inhibitors reduce the risk of gastrointestinal complications in aspirin users with a history of gastrointestinal complications...
  12. doi The relationship among proton pump inhibitors, bone disease and fracture
    Laura E Targownik
    University of Manitoba, Division of Internal Medicine, Section of Gastroenterology, McDermot Avenue, Winnipeg, Canada
    Expert Opin Drug Saf 10:901-12. 2011
    ..As PPIs are widely used in clinical practice, this association is of paramount clinical importance...
  13. doi The relative efficacies of gastroprotective strategies in chronic users of nonsteroidal anti-inflammatory drugs
    Laura E Targownik
    Section of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Gastroenterology 134:937-44. 2008
    ..The relative efficacy of the different strategies alone or in combination is uncertain...
  14. ncbi Pre-endoscopic proton pump inhibitor therapy reduces recurrent adverse gastrointestinal outcomes in patients with acute non-variceal upper gastrointestinal bleeding
    L Keyvani
    Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, 804E 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Aliment Pharmacol Ther 24:1247-55. 2006
    ..Many advocate the use of PPIs prior to endoscopy, although its incremental benefit is unproven...
  15. ncbi Physicians' approaches to the use of gastroprotective strategies in low-risk non-steroidal anti-inflammatory drug users
    S K Murthy
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Aliment Pharmacol Ther 23:1365-72. 2006
    ..Many doctors unnecessarily prescribe gastroprotective strategies to non-steroidal anti-inflammatory drugs users at low risk of non-steroidal anti-inflammatory drug-related gastrointestinal complications...
  16. ncbi Risk of developing colorectal cancer following a negative colonoscopy examination: evidence for a 10-year interval between colonoscopies
    Harminder Singh
    Department of Internal Medicine, Cancer Care Manitoba, University of Manitoba, Winnipeg
    JAMA 295:2366-73. 2006
    ..Limited evidence exists to guide the optimal frequency of repeat endoscopic examination for colorectal cancer screening after a negative colonoscopy...
  17. pmc An assessment of endoscopic and concomitant management of acute variceal bleeding at a tertiary care centre
    H Singh
    Section of Gastroenterology, University of Manitoba, 715 McDermot Avenue, Winnipeg, Manitoba, Canada
    Can J Gastroenterol 21:85-90. 2007
    ..Several therapies have been demonstrated to be beneficial in the management of acute variceal bleeding (AVB). The aim of the present study was to characterize the use of these therapies at a Canadian tertiary care centre...
  18. pmc Use of proton pump inhibitors and risk of osteoporosis-related fractures
    Laura E Targownik
    Department of Gastroenterology, Division of Internal Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 179:319-26. 2008
    ..The use of proton pump inhibitors has been associated with an increased risk of hip fracture. We sought to further explore the relation between duration of exposure to proton pump inhibitors and osteoporosis-related fractures...
  19. ncbi The prevalence of and the clinical and demographic characteristics associated with high-intensity proton pump inhibitor use
    Laura E Targownik
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 102:942-50. 2007
    ..We therefore sought to calculate the prevalence and predictors of high-intensity PPI use...
  20. doi Proton pump inhibitors, osteoporosis, and osteoporosis-related fractures
    Marc R Fournier
    Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Maturitas 64:9-13. 2009
    ....
  21. ncbi Intravenous versus high-dose oral proton pump inhibitor therapy after endoscopic hemostasis of high-risk lesions in patients with acute nonvariceal upper gastrointestinal bleeding
    Sanjay Murthy
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Dig Dis Sci 52:1685-90. 2007
    ..01 for developing an adverse outcome versus oral PPIs (95% CI: 0.44-2.33). We conclude that oral PPIs are probably equivalent to IV PPIs for preventing rebleeding in ANVUGIB patients...
  22. ncbi The cost-effectiveness of hepatic venous pressure gradient monitoring in the prevention of recurrent variceal hemorrhage
    Laura E Targownik
    Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 99:1306-15. 2004
    ..Combination of beta-blocker and nitrate therapy, guided by hepatic venous pressure gradient (HVPG) monitoring, is a novel alternative strategy. We sought to determine the cost-effectiveness of these competing strategies...
  23. pmc The cost-effectiveness of colonic stenting as a bridge to curative surgery in patients with acute left-sided malignant colonic obstruction: a Canadian perspective
    Harminder Singh
    Department of Internal Medicine, University of Manitoba, Winnipeg
    Can J Gastroenterol 20:779-85. 2006
    ..The aim of the present study was to determine the most cost-effective strategy in a Canadian setting. patients and..
  24. ncbi Colonoscopic screening for colorectal cancer
    Harminder Singh
    JAMA 296:2438; author reply 2438-9. 2006
  25. ncbi Management of acute nonvariceal upper gastrointestinal hemorrhage: comparison of an American and a Canadian medical centre
    Laura E Targownik
    Veterans Affairs Greater Los Angeles Health Care System, California, USA
    Can J Gastroenterol 17:489-95. 2003
    ..The aim of the present study was to compare the structure, process and outcomes of care between a Canadian and an American tertiary care medical centre in the management of acute nonvariceal UGIH...
  26. ncbi Colonic stent vs. emergency surgery for management of acute left-sided malignant colonic obstruction: a decision analysis
    Laura E Targownik
    Division of Digestive Diseases, School of Medicine, UCLA Center for the Health Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA
    Gastrointest Endosc 60:865-74. 2004
    ..This study sought to determine the cost-effectiveness of colonic stent vs. surgery for emergent management of acute malignant colonic obstruction...
  27. ncbi The quality of published health economic analyses in digestive diseases: a systematic review and quantitative appraisal
    Brennan M R Spiegel
    Division of Gastroenterology, Veteran s Affairs Greater Los Angeles Healthcare System, California, USA
    Gastroenterology 127:403-11. 2004
    ..We sought to appraise the quality of health economic analyses in digestive diseases, and to identify predictors of study quality...