W C Tan
Affiliation: University of British Columbia
- Marijuana and chronic obstructive lung disease: a population-based studyWan C Tan
iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and the University of British Columbia, Vancouver, Canada
CMAJ 180:814-20. 2009..Our aim was to determine the combined and independent effects of tobacco and marijuana smoking on respiratory symptoms and chronic obstructive pulmonary disease (COPD) in the general population...
- Effectiveness of early budesonide intervention in Caucasian versus Asian patients with asthma: 3-year results of the START studyWan C Tan
iCAPTURE Centre, UBC, St Paul s Hospital, Vancouver, and Department of Medicine, McMaster University, Hamilton, ON, Canada
Respirology 11:767-75. 2006..The present analysis compared the efficacy of early intervention with inhaled budesonide in Caucasian and Asian patients over the first 3 years of the inhaled Steroid Treatment As Regular Therapy in early asthma study...
- Asthma management in the developing world: achievements and challengesWan C Tan
University of British Columbia, iCapture Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Expert Rev Respir Med 2:323-8. 2008..This article reviews the challenges and current status of asthma management and highlights the new global initiatives for bringing optimal asthma care to asthma sufferers in resource-poor countries...
- Trends in COPD mortality and hospitalizations in countries and regions of Asia-PacificWan C Tan
UBC James Hogg iCapture Centre, St Paul s Hospital, Vancouver, Canada
Respirology 14:90-7. 2009..This study estimated and compared COPD mortality and hospital morbidity rates and trends in these rates over time across countries and regions of Asia-Pacific...
- COPD in Asia: where East meets WestWan C Tan
iCapture Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada
Chest 133:517-27. 2008....
- Insights into early treatment of mild asthma: do inhaled corticosteroids make a difference?Wan C Tan
University of British Columbia, iCapture Centre for Cardiovascular and Respiratory Diseases, St Paul s Hospital, Vancouver, British Columbia, Canada
Paediatr Drugs 9:219-26. 2007....
- Dissemination and implementation of guidelines for the treatment of asthmaW C Tan
iCapture Centre for Pulmonary Research, University of British Columbia, St Paul s Hospital, Rm 166, Burrard Building, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Int J Tuberc Lung Dis 10:710-6. 2006..This state of the art article reviews the challenges and current status of and strategies for asthma dissemination and implementation globally, and highlights the specific strategies for such improvement in developing countries...
- The effects of inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthmaPaul M O'Byrne
Department of Medicine, McMaster University, Hamilton, ON, Canada
Chest 136:1514-20. 2009..The objective of this post hoc study was to study the effects of low-dose inhaled budesonide on lung function in smokers and nonsmokers with mild persistent asthma...
- Can age and sex explain the variation in COPD rates across large urban cities? A population study in CanadaW C Tan
University of British Columbia James Hogg Research Laboratories, Providence Heart and Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Int J Tuberc Lung Dis 15:1691-8. 2011..To measure the prevalence of chronic obstructive pulmonary disease (COPD) and determine the effect of age and sex on the variation in prevalence across major cities within the same country and health care system...
- Effects of early intervention with inhaled budesonide on lung function in newly diagnosed asthmaPaul M O'Byrne
Department of Medicine, McMaster University Medical Center, 1200 Main St West, Hamilton, ON, Canada
Chest 129:1478-85. 2006..Asthmatic patients lose lung function faster than normal subjects. The effectiveness of early intervention with inhaled corticosteroids on this decline in lung function is not established in recent-onset disease...
- Cytokines involved in the systemic inflammatory response induced by exposure to particulate matter air pollutants (PM(10))S F Van Eeden
McDonald Research Laboratory and iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 164:826-30. 2001..We postulate that these cytokines induced a systemic response that has an important role in the pathogenesis of the cardiopulmonary adverse health effects associated with atmospheric pollution...
- Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathologyJames C Hogg
University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:454-9. 2007..COPD is associated with reduced life expectancy...
- Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trialRomain A Pauwels
Department of Respiratory Diseases, Ghent University Hospital, Ghent, Belgium
Lancet 361:1071-6. 2003..Although inhaled glucocorticosteroids are recommended for persistent asthma, their long-term effect on recent onset, mild, persistent asthma has yet to be established...
- The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow-up: effectiveness of early intervention with budesonide in mild persistent asthmaWilliam W Busse
Department of Medicine, University of Wisconsin School of Medicine and Public Health, J5 219 CSC, Box 2454, 600 Highland Ave, Madison, WI 53792, USA
J Allergy Clin Immunol 121:1167-74. 2008....
- Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary diseaseWan C Tan
Department of Medicine, National University of Singapore, Singapore
Am J Med 115:272-7. 2003....
- Breaking down the "Great Wall" of COPD care in ChinaDon D Sin
Am J Respir Crit Care Med 176:732-3. 2007
- Validation of the English version of the Asthma Quality of Life Questionnaire in a multi-ethnic Asian populationWan C Tan
Department of Medicine, Faculty of Medicine, National University of Singapore, Singapore
Qual Life Res 13:551-6. 2004..001). The results of this study showed that the English version of the AQLQ-S is a sensitive and valid instrument for measuring health-related quality of life in asthmatic subjects from a multi-ethnic Asian population...
- Factors associated with outcomes of acute exacerbations of chronic obstructive pulmonary diseaseWan C Tan
Department of Medicine, National University of Singapore, Singapore, Singapore
COPD 1:225-47. 2004..The optimal strategy for the reduction of hospitalization in COPD remains unclear. Long-term interventional studies are needed to provide clearer information for the prevention of exacerbations and hospitalizations in COPD...
- Risk factors associated with habitual snoring and sleep-disordered breathing in a multi-ethnic Asian population: a population-based studySee M Khoo
Department of Medicine, Division of Respiratory Medicine, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
Respir Med 98:557-66. 2004..Differential risks underscore the importance of ethnicity in determining the burden of SDB...
- IL-4 receptor genetic polymorphisms and asthma in Asian populationsWeidong Zhang
Guangzhou Institute of Respiratory Diseases, Respiratory Medicine, 151, Guangzhou, China
Respir Med 101:186-90. 2007..IL-4 receptor alpha chain is crucial for the binding and signaling of IL-4, which mediates isotype switching and IgE production. The gene of IL-4 receptor alpha chain is a candidate gene for asthma and atopy...
- Viruses in asthma exacerbationsWan C Tan
Department of Medicine, National University Hospital, Singapore
Curr Opin Pulm Med 11:21-6. 2005..This article reviews publications since October 2002 for an update of the role of viruses in exacerbations of asthma...
- Trends and ethnic differences in asthma hospitalization rates in Singapore, 1991 to 1998Tze Pin Ng
Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore
Ann Allergy Asthma Immunol 90:51-5. 2003..A few reports have indicated that asthma hospitalization rates in several countries have stopped rising or started falling in the 1990s...
- The global initiative for chronic obstructive lung disease: Gold standards and the Asia-Pacific perspectiveWan C Tan
Respirology 7:1-2. 2002
- Comparison of three methods for respiratory virus detection between induced sputum and nasopharyngeal aspirate specimens in acute asthmaXueyu Xiang
Department of Medicine, Respiratory Division, National University of Singapore, 119260, Singapore, Singapore
J Virol Methods 101:127-33. 2002..It is concluded that induced sputum specimens are feasible for detection of viral respiratory tract infections by RT-PCR during acute exacerbations of asthma...