Ameer Y Taha

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    Metabolism 54:1127-32. 2005
  2. ncbi request reprint Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Ont M5S 1A8, Canada
    Epilepsy Res 71:40-6. 2006
  3. ncbi request reprint Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Lipids 41:933-5. 2006
  4. ncbi request reprint Commentary on the effects of a ketogenic diet enriched with omega-3 polyunsaturated fatty acids on plasma phospholipid fatty acid profile in children with drug-resistant epilepsy
    Ameer Y Taha
    Department of Pharmacology, University of Toronto Epilepsy Research Program, Medical Sciences Building, University of Toronto, 1 King s College Circle, Rm 4309, Toronto, ON M5S 1A8, Canada
    Epilepsy Res 76:148-9; discussion 150-1. 2007
  5. ncbi request reprint Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Neurochem 105:380-8. 2008
  6. doi request reprint Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo
    Ameer Y Taha
    Division of Fundamental Neurobiology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8 Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8 University of Toronto Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8 Electronic address
    Brain Res 1537:9-17. 2013
  7. doi request reprint A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures
    Ameer Y Taha
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Epilepsy Behav 27:49-58. 2013
  8. doi request reprint Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada
    Epilepsia 50:72-82. 2009
  9. doi request reprint Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Epilepsy Behav 14:27-31. 2009
  10. doi request reprint Dietary enrichment with medium chain triglycerides (AC-1203) elevates polyunsaturated fatty acids in the parietal cortex of aged dogs: implications for treating age-related cognitive decline
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, ON, Canada
    Neurochem Res 34:1619-25. 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Canada M5S 3E2
    Metabolism 54:1127-32. 2005
    ..In the absence of sustained ketosis, changes in fatty acid metabolism resulting in an increase in brain polyunsaturates, particularly docosahexaenoic acid may, nevertheless, contribute to the seizure protection by the ketogenic diet...
  2. ncbi request reprint Lack of benefit of linoleic and alpha-linolenic polyunsaturated fatty acids on seizure latency, duration, severity or incidence in rats
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Ont M5S 1A8, Canada
    Epilepsy Res 71:40-6. 2006
    ..Polyunsaturated fatty acids have been reported to increase seizure threshold and to reduce seizure duration and severity in rats...
  3. ncbi request reprint Markedly raised intake of saturated and monounsaturated fatty acids in rats on a high-fat ketogenic diet does not inhibit carbon recycling of 13C-alpha-linolenate
    Ameer Y Taha
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Lipids 41:933-5. 2006
    ..05). We conclude that carbon recycling into saturated and monounsaturated fatty acids persists when the main end products of ALA recycling are provided in excess, using a ketogenic diet...
  4. ncbi request reprint Commentary on the effects of a ketogenic diet enriched with omega-3 polyunsaturated fatty acids on plasma phospholipid fatty acid profile in children with drug-resistant epilepsy
    Ameer Y Taha
    Department of Pharmacology, University of Toronto Epilepsy Research Program, Medical Sciences Building, University of Toronto, 1 King s College Circle, Rm 4309, Toronto, ON M5S 1A8, Canada
    Epilepsy Res 76:148-9; discussion 150-1. 2007
  5. ncbi request reprint Seizure resistance in fat-1 transgenic mice endogenously synthesizing high levels of omega-3 polyunsaturated fatty acids
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Neurochem 105:380-8. 2008
    ..05). These findings demonstrate that n-3 PUFA have anticonvulsant properties and suggest the possibility of a novel, non-drug dietary approach for the treatment of epilepsy...
  6. doi request reprint Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo
    Ameer Y Taha
    Division of Fundamental Neurobiology, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8 Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8 University of Toronto Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8 Electronic address
    Brain Res 1537:9-17. 2013
    ..This reduction may be mediated by DHA in its unesterified form, and is likely related to a modulatory effect of DHA on GABAergic activity. ..
  7. doi request reprint A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures
    Ameer Y Taha
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada M5S 1A8
    Epilepsy Behav 27:49-58. 2013
    ..These observations suggest that chronic dietary fish oil supplementation can raise focal amygdaloid seizure thresholds and that this effect is likely mediated by DHA rather than by EPA...
  8. doi request reprint Dose-dependent anticonvulsant effects of linoleic and alpha-linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats
    Ameer Y Taha
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Canada
    Epilepsia 50:72-82. 2009
    ..The goal of the present study was to assess the dose-dependent anticonvulsant effects of a fatty acid mixture containing linoleic and alpha-linolenic acids in a 4 to 1 ratio (the "SR-3" compound)...
  9. doi request reprint Assessing the link between omega-3 fatty acids, cardiac arrest, and sudden unexpected death in epilepsy
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Epilepsy Behav 14:27-31. 2009
    ..We also discuss recent claims on the use of omega-3 polyunsaturated fatty acids to reduce the incidence of SUDEP because of their cardioprotective and anticonvulsant effects...
  10. doi request reprint Dietary enrichment with medium chain triglycerides (AC-1203) elevates polyunsaturated fatty acids in the parietal cortex of aged dogs: implications for treating age-related cognitive decline
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Medical Sciences Building, Toronto, ON, Canada
    Neurochem Res 34:1619-25. 2009
    ..05). Brain cholesterol concentrations did not differ significantly between the groups (P > 0.05). These results indicate that dietary enrichment with MCT, raises n-3 PUFA concentrations in the parietal cortex of aged dogs...
  11. doi request reprint Acute administration of docosahexaenoic acid increases resistance to pentylenetetrazol-induced seizures in rats
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
    Epilepsy Behav 17:336-43. 2010
    ..Sedation was measured to monitor for the potential toxicity of DHA...
  12. doi request reprint Assessing the metabolic and toxic effects of anticonvulsant doses of polyunsaturated fatty acids on the liver in rats
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Canada
    J Toxicol Environ Health A 72:1191-200. 2009
    ..These findings suggest that PUFA, given for 3 wk at anticonvulsant doses, result in significant changes in liver lipid metabolism, but do not alter measured genetic markers of liver toxicity...
  13. doi request reprint The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations
    Tupur Rahman
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Fitzgerald Building, 150 College Street, Room 306, Toronto, ON, Canada
    Prostaglandins Leukot Essent Fatty Acids 82:141-5. 2010
    ..These findings demonstrate that the VLDLr is not necessary for maintaining brain PUFA concentrations and suggest that other mechanisms to transport PUFA into the brain must exist...
  14. doi request reprint Increases in seizure latencies induced by subcutaneous docosahexaenoic acid are lost at higher doses
    Marc Olivier Trépanier
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Epilepsy Res 99:225-32. 2012
    ..c., but these properties are lost at higher doses. The anticonvulsant effects of DHA are accompanied by increased levels of unesterified DHA in the serum, but not in increased DHA release from brain phospholipids...
  15. doi request reprint High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet
    Sandra A Reza-López
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    Metabolism 58:722-30. 2009
    ..These observations demonstrate that high vitamin intake during pregnancy has short- and long-term effects on tissue FA concentration in the offspring...
  16. doi request reprint Intraperitoneal administration of docosahexaenoic acid for 14days increases serum unesterified DHA and seizure latency in the maximal pentylenetetrazol model
    Marc Olivier Trépanier
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada University of Toronto Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
    Epilepsy Behav 33:138-43. 2014
    ..An increase in serum unesterified DHA concentration reflecting increased flux of DHA to the brain appears to explain changes in seizure threshold, independent of changes in brain DHA concentrations. ..
  17. doi request reprint High multivitamin intake by Wistar rats during pregnancy results in increased food intake and components of the metabolic syndrome in male offspring
    Ignatius M Y Szeto
    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College St, Rm 322, Toronto, ON, Canada M5S 3E2
    Am J Physiol Regul Integr Comp Physiol 295:R575-82. 2008
    ..05). In conclusion, high multivitamin intake during pregnancy programmed the male offspring for the development of the components of metabolic syndrome in adulthood, possibly by its effects on central mechanisms of food intake control...
  18. doi request reprint Polyunsaturated fatty acids and epilepsy
    Ameer Y Taha
    Department of Pharmacology and Toxicology and the University of Toronto Epilepsy Research Program, Faculty of Medicine, University of Toronto, Toronto, Canada
    Epilepsia 51:1348-58. 2010
    ..Future clinical trials involving the n-3 PUFAs should involve higher doses and longer periods of administration in order to definitively assess their possible antiseizure effects...
  19. doi request reprint Microwave Energy Increases Fatty Acid Methyl Ester Yield in Human Whole Blood Due to Increased Sphingomyelin Transesterification
    Adam H Metherel
    Department of Kinesiology, University of Waterloo, 200 University Avenue, Waterloo, ON, N2L 3G1, Canada
    Lipids 50:895-905. 2015
    ..In conclusion, microwave-assisted direct transesterification of DBS achieved in as little as 1-min, and 5-min reaction times increase total fatty acids primarily by significantly improving sphingomyelin-derived fatty acid yield...
  20. doi request reprint The application of ultrasound energy to increase lipid extraction throughput of solid matrix samples (flaxseed)
    Adam H Metherel
    Laboratory of Nutritional and Nutraceutical Research, Department of Kinesiology, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada, N2L 3G1
    Prostaglandins Leukot Essent Fatty Acids 81:417-23. 2009
    ..Comprehensive testing on a variety of sample matrices and food products is required, but lipid extraction by ultrasound has potential to reduce sample processing time...
  21. doi request reprint Brainstem concentrations of cholesterol are not influenced by genetic ablation of the low-density lipoprotein receptor
    Ameer Y Taha
    Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada
    Neurochem Res 34:311-5. 2009
    ..Cholesterol concentrations were also measured in the cortex, which served as a reference point, due to the lower expression of the LDLr, as compared to the brainstem...