Research Topics
Species | Anna TaddioSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Knowledge translation of the HELPinKIDS clinical practice guideline for managing childhood vaccination pain: usability and knowledge uptake of educational materials directed to new parentsAnna Taddio
Clinical Social and Administrative Pharmacy, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario M5S 3M2, Canada
BMC Pediatr 13:23. 2013..The objectives of this study were to evaluate usability and effectiveness in terms of knowledge acquisition from the pamphlet and video in parents of newly born infants...
Survey of the prevalence of immunization non-compliance due to needle fears in children and adultsAnna Taddio
Clinical, Social and Administrative Pharmacy, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Vaccine 30:4807-12. 2012....- Addressing parental concerns about pain during childhood vaccination: is there enough time to include pain management in the ambulatory setting?Anna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, Canada
Clin J Pain 28:238-42. 2012.... - Ginkgo biloba for the treatment of vitilgo vulgaris: an open label pilot clinical trialOrest Szczurko
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, 130 Dundas St East, Suite 305, Mississauga, ON L5A 3V8, Canada
BMC Complement Altern Med 11:21. 2011..Vitiligo is a common hypopigmentation disorder with significant psychological impact if occurring before adulthood. A pilot clinical trial to determine the feasibility of an RCT was conducted and is reported here... - Evaluation of the reliability, validity and practicality of 3 measures of acute pain in infants undergoing immunization injectionsAnna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Vaccine 29:1390-4. 2011..The majority of raters (4 out of 5) preferred the MBPS. Together, these results provide preliminary support for the MBPS as the primary outcome of pain during vaccine injections in infants... - Effectiveness of sucrose analgesia in newborns undergoing painful medical proceduresAnna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
CMAJ 179:37-43. 2008..Our objectives were to evaluate the effectiveness and safety of sucrose in newborns undergoing various medical procedures within 2 days of birth... - Reduced infant response to a routine care procedure after sucrose analgesiaAnna Taddio
University of Toronto, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada
Pediatrics 123:e425-9. 2009..Our objective was to determine the effect of sucrose analgesia for procedural pain on infant pain responses during a subsequent caregiving procedure... - Influence of repeated painful procedures and sucrose analgesia on the development of hyperalgesia in newborn infantsAnna Taddio
Pharmacy Practice Division, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
Pain 144:43-8. 2009..In conclusion, sucrose analgesia for repeated painful procedures in the first day of life does not prevent development of remote hyperalgesia in newborns... - Variability in clinical practice guidelines for sweetening agents in newborn infants undergoing painful proceduresAnna Taddio
Department of Pharmacy Practice, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Clin J Pain 25:153-5. 2009..The objective of this study was to investigate unit-specific protocols for the use of sweetening agents... - Safety of morphine in nonintubated infants in the neonatal intensive care unitAnna Taddio
Pharmacy Practice Division, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
Clin J Pain 25:418-22. 2009..To determine the safety of morphine for procedural pain management in nonintubated infants in the neonatal intensive care unit... - Reliability and validity of observer ratings of pain using the visual analog scale (VAS) in infants undergoing immunization injectionsAnna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, and Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ont, Canada
Pain 147:141-6. 2009..However, different conclusions may be reached about the effectiveness of analgesic interventions depending on the rater. Sources of variability include use of multiple raters, rater focus (procedure vs. child) and experience level... - Physical interventions and injection techniques for reducing injection pain during routine childhood immunizations: systematic review of randomized controlled trials and quasi-randomized controlled trialsAnna Taddio
Division of Pharmacy Practice, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Clin Ther 31:S48-76. 2009..Their effectiveness, however, has not previously been studied using a systematic approach... - Canadian neonatologist practices regarding opioid use in ventilated and spontaneously breathing infants undergoing medical proceduresAnna Taddio
Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
Clin J Pain 26:422-8. 2010..Opioids are indicated for the management of procedural pain in neonates. There are limited data describing factors influencing patterns of use... - A randomized controlled trial of analgesia during vaccination in adultsAnna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, Canada
Vaccine 28:5365-9. 2010..This information can be incorporated in immunization programs... - Effect of liposomal lidocaine and sucrose alone and in combination for venipuncture pain in newbornsAnna Taddio
Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College St, Toronto, Ontario, Canada M5S 3M2
Pediatrics 127:e940-7. 2011..To determine the relative effectiveness of liposomal lidocaine, sucrose, and their combination for reducing pain in term newborns... - Inadequate pain management during routine childhood immunizations: the nerve of itAnna Taddio
Division of Pharmacy Practice, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Clin Ther 31:S152-67. 2009..Immunization is regarded as one of the most significant medical achievements of all time. Recently, increasing attention has been paid to the pain resulting from routine childhood immunizations... - Effectiveness and tolerability of pharmacologic and combined interventions for reducing injection pain during routine childhood immunizations: systematic review and meta-analysesVibhuti Shah
Department of Paediatrics, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
Clin Ther 31:S104-51. 2009..To date, no systematic review has been published on the effectiveness of pharmacologic and combined interventions for reducing injection pain... 
Routine immunization practices: use of topical anesthetics and oral analgesicsAnna Taddio
Department of Pharmacy, Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
Pediatrics 120:e637-43. 2007..Our objective was to evaluate analgesic use during childhood immunization...- Topical amethocaine gel 4% for intramuscular injection in term neonates: a double-blind, placebo-controlled, randomized trialVibhuti S Shah
Department of Paediatrics, Mount Sinai Hospital, Toronto, Ontario, Canada
Clin Ther 30:166-74. 2008..They have been found to attenuate pain from various procedures, including intramuscular (i.m.) injection of vaccines. Published data on their effectiveness for i.m. injection of vitamin K in neonates were not identified... - Tobramycin pharmacokinetics in children with febrile neutropenia undergoing stem cell transplantation: once-daily versus thrice-daily administrationL Lee Dupuis
Department of Pharmacy, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Pharmacotherapy 24:564-73. 2004.... - Intravenous morphine and topical tetracaine for treatment of pain in [corrected] neonates undergoing central line placementAnna Taddio
Department of Pharmacy, The Hospital for Sick Children, Faculty of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario
JAMA 295:793-800. 2006..There is limited evidence of the analgesic effectiveness of opioid analgesia or topical anesthesia during central line placement in neonates, and there are no previous studies of their relative effectiveness... - Order of vaccine injection and infant pain responseMoshe Ipp
Department of Paediatrics, Paediatric Outcomes Research Team, Division of Paediatric Medicine, The Hospital for Sick Children Research Institute, University of Toronto, 555 University Ave, Toronto, ON M5G 1X8, Canada
Arch Pediatr Adolesc Med 163:469-72. 2009.... - Topical 4% amethocaine gel reduces the pain of subcutaneous measles-mumps-rubella vaccinationAnna Taddio
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatrics 114:e720-4. 2004..Because of its relatively short application time (30 minutes), 4% amethocaine may be suitable for busy clinics and emergency departments... - Contact dermatitis and bradycardia in a preterm infant given tetracaine 4% gelAnna Taddio
Department of Pharmacy and Population Health Sciences, The Hospital for Sick Children, Toronto, Canada
Ther Drug Monit 28:291-4. 2006..This is the first report of a serious skin reaction in a neonate treated with tetracaine. Based on these findings, tetracaine gel can continue to be used to treat pain in neonates with careful evaluation of the skin... - Comparison of pain during two methods of urine collection in preterm infantsWalid El-Naggar
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada
Pediatrics 125:1224-9. 2010..Suprapubic aspiration (SPA) and urine catheterization (UC) are performed frequently in preterm neonates to rule out urinary tract infection; however, a comparison of the pain caused by both procedures has not been made previously... - Effects of age, gender and holding on pain response during infant immunizationMoshe Ipp
Department of Paediatrics, The Hospital for Sick Children, Toronto, Canada
Can J Clin Pharmacol 11:e2-7. 2004..Similarly gender did not affect pain response. In contrast, 2-month-old infants displayed more pain during immunization than did 4 or 6-month-old infants... - Hair cortisol as a potential biologic marker of chronic stress in hospitalized neonatesJanet Yamada
Faculties of Nursing and Medicine, University of Toronto, Toronto, Ont, Canada
Neonatology 92:42-9. 2007..As preterm and term infants in the neonatal intensive care unit (NICU) undergo multiple stressful/painful procedures, research is required that addresses chronic stress... - Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children: a randomized controlled trialAnna Taddio
The Department of Pharmacy and the Research Institute, The Hospital for Sick Children, Toronto, Ont
CMAJ 172:1691-5. 2005..Its routine use for painful cutaneous procedures should be considered whenever feasible... - Conditioning and hyperalgesia in newborns exposed to repeated heel lancesAnna Taddio
Department of Pharmacy, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, Canada M5G 1X8
JAMA 288:857-61. 2002..Hospitalized infants undergo repeated invasive procedures. It is unknown whether cumulative experiences with pain lead to anticipatory pain behaviors and hyperalgesia... - A systematic review of measures for reducing injection pain during adult immunizationMary Ellen Hogan
Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, Toronto, Ontario, Canada
Vaccine 28:1514-21. 2010..To evaluate the effectiveness of different pain-relieving interventions to reduce pain from immunization in adults... - A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric painAnna Taddio
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada
Paediatr Drugs 7:41-54. 2005.... - Evaluation of a new lancet device (BD QuikHeel) on pain response and success of procedure in term neonatesVibhuti Shah
Department of Paediatrics and Nursing, Mount Sinai Hospital, Toronto, Ontario, Canada
Arch Pediatr Adolesc Med 157:1075-8. 2003..To evaluate 2 heel lancet devices in terms of pain response and success of the procedure in neonates undergoing the newborn screening test... - CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot studySondra vanderVaart
Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
Ther Drug Monit 33:425-32. 2011..In contrast, poor metabolizers (PMs), individuals who have no active CYP2D6 genes, convert almost no codeine into morphine and as a result may take multiple doses of codeine without attaining analgesia... - Vaccine-related pain: randomised controlled trial of two injection techniquesMoshe Ipp
Division of Pediatric Medicine and Pediatric Outcomes Research Team PORT, Department of Pediatrics, Faculty of Medicine, University of Toronto, Canada
Arch Dis Child 92:1105-8. 2007..To compare acute pain response during immunisation in infants using a slow standard of care injection technique versus a rapid pragmatic technique... - Beta-endorphin concentration after administration of sucrose in preterm infantsAnna Taddio
Department of Pharmacy and Population Health Sciences, Research Institute, The Hospital for Sick Children, and Graduate Faculty of Pharmaceutical Sciences, University of Toronto, Canada
Arch Pediatr Adolesc Med 157:1071-4. 2003..Sucrose is an effective analgesic for procedural pain in preterm infants. It has been hypothesized that its analgesic effects are mediated by the release of endogenous opioid neurotransmitters such as beta-endorphin... - Lidocaine-prilocaine cream versus tetracaine gel for procedural pain in childrenAnna Taddio
Department of Pharmacy, The Hospital for Sick Children, Toronto, Ontario, Canada
Ann Pharmacother 36:687-92. 2002..Tetracaine is more efficacious than lidocaine-prilocaine when both anesthetics are applied for the same amount of time... - Epidemiology and management of painful procedures in children in Canadian hospitalsBonnie J Stevens
The Hospital for Sick Children, Toronto, Ont
CMAJ 183:E403-10. 2011.... - The premature infant pain profile: evaluation 13 years after developmentBonnie Stevens
Lawrence S Bloomberg Faculty of Nursing and Faculty of Medicine, University of Toronto, Toronto, ON, Canada
Clin J Pain 26:813-30. 2010..To review the (1) reliability, validation, feasibility, and clinical utility and (2) the use of the Premature Infant Pain Profile (PIPP) from 1996 to 2009 to determine the effectiveness of pain management strategies... - The effect of distant reiki on pain in women after elective Caesarean section: a double-blinded randomised controlled trialSondra vanderVaart
Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
BMJ Open 1:e000021. 2011..4±9.7 mm Hg vs 111.9±11.0 mm Hg, p=0.02) post surgery. Conclusion Distant reiki had no significant effect on pain following an elective C-section. Clinical Trial Registration Number ISRCTN79265996... - The effectiveness of Proctofoam-HC for treatment of hemorrhoids in late pregnancySabina Vohra
The Motherisk Program, Hospital for Sick Children, Toronto, ON, Canada
J Obstet Gynaecol Can 31:654-9. 2009..Currently no topical anti-hemorrhoidal agents have been studied for effectiveness in pregnancy. This study evaluated the effectiveness of Proctofoam-HC used during the last trimester of pregnancy... - The effects of early pain experience in neonates on pain responses in infancy and childhoodAnna Taddio
Department of Pharmacy and Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Paediatr Drugs 7:245-57. 2005..The precise determinants of these changes, their extent, and their permanence are not known but they appear to involve noxious stimulus-induced peripheral and central sensitization, as well as classical conditioning... - Systematic review and meta-analysis of the effect of warming local anesthetics on injection painMary Ellen Hogan
Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
Ann Emerg Med 58:86-98.e1. 2011..We determine the effectiveness of warming local anesthetics to reduce pain in adults and children undergoing local anesthetic infiltration into intradermal or subcutaneous tissue... - Caregivers' responses to pain in their children in the emergency departmentRyan W Smith
Graduate Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Ontario, Canada
Arch Pediatr Adolesc Med 161:578-82. 2007..To explore physiological and anxiety responses of caregivers who witness a venipuncture being performed on their child and the effects of caregivers' responses on child pain and distress... - Pain, opioid tolerance and sensitisation to nociception in the neonateAnna Taddio
Department of Population Health Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Best Pract Res Clin Anaesthesiol 18:291-302. 2004..Recent studies have demonstrated that untreated pain can have long-term effects on infant pain behaviours months beyond the events, thus, opioid analgesics may have a beneficial role that extends beyond the immediate painful event(s)... - A randomized control trial comparing immunogenicity, safety, and preference for self- versus nurse-administered intradermal influenza vaccineBrenda L Coleman
Mount Sinai Hospital, Department of Microbiology, Toronto, Canada
Vaccine 30:6287-93. 2012..Intradermally administered influenza vaccine is as immunogenic as intramuscular vaccine at a lower unit dose. New microinjection systems could allow self-administration of vaccine, potentially reducing the cost and inconvenience... - Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unitEugene Ng
Aubrey andMarla Dan ProgramforHigh RiskMothers and Babies, SunnybrookHealth Sciences Centre, Toronto, Canada
Cochrane Database Syst Rev 6:CD002052. 2012..Midazolam is a short-acting benzodiazepine that is increasingly used in neonatal intensive care units (NICU). However, its effectiveness as a sedative in neonates has not been systematically evaluated... - Effect of iron content on the tolerability of prenatal multivitamins in pregnancyPatricia Nguyen
Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada
BMC Pregnancy Childbirth 8:17. 2008.... - Safety and efficacy of ketorolac in children after cardiac surgeryMiho Inoue
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
Intensive Care Med 35:1584-92. 2009..To evaluate the nephrotoxic and opioid-sparing effects of ketorolac in children after cardiac surgery... - Opioid analgesia for infants in the neonatal intensive care unitAnna Taddio
Neonatal Intensive Care Unit, Research Institute, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Clin Perinatol 29:493-509. 2002..Further research is needed to determine how to optimize their effects. Data on the long-term effects of neonatal opioid exposure are warranted... - Cyclosporine excretion into breast milkMyla E Moretti
The Motherisk Program, The Hospital for Sick Children, Toronto, Ontario, Canada
Transplantation 75:2144-6. 2003..We show a wide range of infant exposures to the drug in milk, noting that one of the infants had therapeutic blood concentrations of cyclosporine despite relatively low concentrations of the drug in milk... - Prevalence of depression during pregnancy: systematic reviewHeather A Bennett
Faculty of Pharmacy and Department of Medicine, University of Toronto, Ontario, Canada
Obstet Gynecol 103:698-709. 2004.... - Benchmarking pain outcomes for children with sickle cell disease hospitalized in a tertiary referral pediatric hospitalAbi Vijenthira
Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada
Pain Res Manag 17:291-6. 2012..Painful vaso-occlusive crisis (VOC) is the most common reason for hospitalization in children with sickle cell disease... - Practices and perceptions regarding pain and pain management during routine childhood immunizations: Findings from a focus-group study with nurses working at Toronto Public Health, OntarioAndrew Kikuta
Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto
Can J Infect Dis Med Microbiol 22:43-8. 2011..Nurses in public health administer a substantial number of injections; however, their attitudes and practices surrounding acute pain during vaccine injections have not been previously explored... - Mothers' beliefs about analgesia during childhood immunizationElena Parvez
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario
Paediatr Child Health 15:289-93. 2010.... - Acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunizationJennifer Manley
Graduate Department of Pharmaceutical Sciences, University of Toronto, Ontario, Canada
Ann Pharmacother 41:1227-32. 2007..To evaluate the literature examining prophylactic use of acetaminophen and ibuprofen for prevention of adverse reactions associated with childhood immunization... - Pharmacology of milrinone in neonates with persistent pulmonary hypertension of the newborn and suboptimal response to inhaled nitric oxidePatrick J McNamara
Departments of Pediatrics, University of Toronto, Toronto, Canada
Pediatr Crit Care Med 14:74-84. 2013..The primary objective was to investigate the pharmacological profile of milrinone in persistent pulmonary hypertension of the newborn. Secondary objectives were to delineate short-term outcomes and safety profile... - Gabapentin improves postcesarean delivery pain management: a randomized, placebo-controlled trialALBERT MOORE
Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
Anesth Analg 112:167-73. 2011..Gabapentin is effective for preventing and treating acute and chronic postoperative pain; however, it has not been described for use in cesarean delivery. We hypothesized that preoperative gabapentin would reduce postcesarean delivery pain... - Development and validation of the pediatric nausea assessment tool for use in children receiving antineoplastic agentsL Lee Dupuis
Department of Pharmacy, Divisions of Haematology Oncology, Population Health Sciences, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Pharmacotherapy 26:1221-31. 2006..To develop and validate an instrument to assess nausea intensity in children aged 4-18 years... - Safety of benzodiazepines in newbornsEugene Ng
Department of Newborn and Developmental Paediatrics, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Ann Pharmacother 36:1150-5. 2002..Benzodiazepines are being used in neonatal intensive care units for sedation and control of seizures. However, anecdotal reports suggest that their use in infants may be associated with serious adverse effects (AEs)... - Randomized controlled trial of once- versus thrice-daily tobramycin in febrile neutropenic children undergoing stem cell transplantationLillian Sung
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
J Natl Cancer Inst 95:1869-77. 2003..In particular, the relative nephrotoxicity and efficacy of tobramycin administered as a single daily dose or as three daily doses among this patient population is not known... - Summary proceedings from the neonatal pain-control groupKanwaljeet J S Anand
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Pediatrics 117:S9-S22. 2006..Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005)... - Analgesia and anesthesia for neonates: study design and ethical issuesK J S Anand
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA
Clin Ther 27:814-43. 2005.... - Analgesia and local anesthesia during invasive procedures in the neonateK J S Anand
Department of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, USA
Clin Ther 27:844-76. 2005.... - Topical anesthesia in neonates: clinical practices and practical considerationsVictoria Tutag Lehr
Department of Pharmacy Practice, The Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Division of Clinical Pharmacology and Toxicology, Children s Hospital of Michigan, Detroit, MI, USA
Semin Perinatol 31:323-9. 2007..This review seeks to expand the options for topical anesthesia in neonates...