M G Swain

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc Fatigue in liver disease: pathophysiology and clinical management
    Mark G Swain
    University of Calgary, Liver Unit, Health Sciences Centre, Alberta
    Can J Gastroenterol 20:181-8. 2006
  2. ncbi request reprint I. Stress and hepatic inflammation
    M G Swain
    Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 279:G1135-8. 2000
  3. doi request reprint Role of methotrexate in the treatment of chronic cholestatic disorders
    Kerri Novak
    Division of Gastroenterology, Liver Unit, University of Calgary, 3330 Hospital Dr, NW, Health Sciences Center, Calgary, Alberta, Canada T2N 4N1
    Clin Liver Dis 12:81-96, viii. 2008
  4. doi request reprint Hepatic NKT cells: friend or foe?
    Mark G Swain
    Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Clin Sci (Lond) 114:457-66. 2008
  5. ncbi request reprint Fatigue in chronic disease
    M G Swain
    Liver Unit, Gastroenterlogy Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Clin Sci (Lond) 99:1-8. 2000
  6. doi request reprint Natural killer T cells within the liver: conductors of the hepatic immune orchestra
    Mark G Swain
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Dig Dis 28:7-13. 2010
  7. doi request reprint A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin
    Mark G Swain
    Health Research Innovation Center, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 139:1593-601. 2010
  8. ncbi request reprint Downregulated hypothalamic 5-HT3 receptor expression and enhanced 5-HT3 receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic rats
    H Nguyen
    Gastrointestinal Research Group, University of Calgary, Calgary, AB, Canada
    Neurogastroenterol Motil 20:228-35. 2008
  9. ncbi request reprint A case of coexisting primary biliary cirrhosis and primary sclerosing cholangitis: a new overlap of autoimmune liver diseases
    K W Burak
    Liver Unit, University of Calgary, Alberta, Canada
    Dig Dis Sci 46:2043-7. 2001
  10. ncbi request reprint Augmented interleukin-1beta-induced depression of locomotor activity in cholestatic rats
    M G Swain
    Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada
    Hepatology 28:1561-5. 1998

Collaborators

Detail Information

Publications35

  1. pmc Fatigue in liver disease: pathophysiology and clinical management
    Mark G Swain
    University of Calgary, Liver Unit, Health Sciences Centre, Alberta
    Can J Gastroenterol 20:181-8. 2006
    ..In conclusion, a reasonable approach to help guide in the management of the fatigued patient with liver disease is presented...
  2. ncbi request reprint I. Stress and hepatic inflammation
    M G Swain
    Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 279:G1135-8. 2000
    ....
  3. doi request reprint Role of methotrexate in the treatment of chronic cholestatic disorders
    Kerri Novak
    Division of Gastroenterology, Liver Unit, University of Calgary, 3330 Hospital Dr, NW, Health Sciences Center, Calgary, Alberta, Canada T2N 4N1
    Clin Liver Dis 12:81-96, viii. 2008
    ..In contrast, PSC continues to be an immensely challenging disease to effectively treat, and the role of MTX for treating PSC patients remains dubious...
  4. doi request reprint Hepatic NKT cells: friend or foe?
    Mark G Swain
    Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Clin Sci (Lond) 114:457-66. 2008
    ....
  5. ncbi request reprint Fatigue in chronic disease
    M G Swain
    Liver Unit, Gastroenterlogy Research Group, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Clin Sci (Lond) 99:1-8. 2000
    ..Hopefully, a broader understanding of this distressing symptom will lead to the development of specific therapies for treating fatigue in these patients...
  6. doi request reprint Natural killer T cells within the liver: conductors of the hepatic immune orchestra
    Mark G Swain
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Dig Dis 28:7-13. 2010
    ..This paper highlights the diverse roles played by iNKT cells as master regulators of immune-mediated liver injury...
  7. doi request reprint A sustained virologic response is durable in patients with chronic hepatitis C treated with peginterferon alfa-2a and ribavirin
    Mark G Swain
    Health Research Innovation Center, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 139:1593-601. 2010
    ..Although small studies have reported that the SVR is durable and lasts for long periods, it has not been conclusively shown...
  8. ncbi request reprint Downregulated hypothalamic 5-HT3 receptor expression and enhanced 5-HT3 receptor antagonist-mediated improvement in fatigue-like behaviour in cholestatic rats
    H Nguyen
    Gastrointestinal Research Group, University of Calgary, Calgary, AB, Canada
    Neurogastroenterol Motil 20:228-35. 2008
    ....
  9. ncbi request reprint A case of coexisting primary biliary cirrhosis and primary sclerosing cholangitis: a new overlap of autoimmune liver diseases
    K W Burak
    Liver Unit, University of Calgary, Alberta, Canada
    Dig Dis Sci 46:2043-7. 2001
    ..This case suggests that PBC, PSC, AIH, and autoimmune cholangitis are part of a spectrum of chronic autoimmune liver disease that develop in response to some yet unidentified antigen...
  10. ncbi request reprint Augmented interleukin-1beta-induced depression of locomotor activity in cholestatic rats
    M G Swain
    Liver Unit, Gastroenterology Research Group, University of Calgary, Calgary, Alberta, Canada
    Hepatology 28:1561-5. 1998
    ..These findings may explain, at least in part, the high incidence of symptoms such as fatigue, malaise, and lethargy that occur in cholestatic patients and may open novel future avenues for their treatment...
  11. ncbi request reprint Decreased orexigenic response to neuropeptide Y in rats with obstructive cholestasis
    K P Rioux
    Liver Unit, Gastrointestinal Research Group, University of Calgary, Health Sciences Centre, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 280:G449-56. 2001
    ....
  12. doi request reprint Epidemiology and natural history of primary biliary cirrhosis in a Canadian health region: a population-based study
    Robert P Myers
    Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Hepatology 50:1884-92. 2009
    ..87; 95% CI 1.89-4.17); male sex (hazard ratio [HR] 3.80; 95% CI 1.85-7.82) and an older age at diagnosis (HR per additional year, 1.06; 95% CI 1.03-1.10) were independent predictors of mortality...
  13. pmc Validation of coding algorithms for the identification of patients with primary biliary cirrhosis using administrative data
    Robert P Myers
    Liver Unit, Division of Gastroenterology, Department of Medicine, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta
    Can J Gastroenterol 24:175-82. 2010
    ..Large-scale epidemiological studies of primary biliary cirrhosis (PBC) have been hindered by difficulties in case ascertainment...
  14. ncbi request reprint Chemokines as novel therapeutic targets in inflammatory diseases
    Maureen N Ajuebor
    Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
    Biochem Pharmacol 63:1191-6. 2002
    ....
  15. doi request reprint Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factoralpha signaling during peripheral organ inflammation
    Charlotte D'Mello
    Immunology Research Group, Department of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Neurosci 29:2089-102. 2009
    ....
  16. pmc CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis
    Maureen N Ajuebor
    Department of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Am J Pathol 170:1975-88. 2007
    ..These results highlight the potential profound impact of altered chemokine receptor expression on the innate immune response in the setting of T cell-mediated hepatitis...
  17. ncbi request reprint A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients
    Vincent G Bain
    University of Alberta, Liver Unit, Zeidler Ledcor Center, 130 University Campus, Edmonton, Alberta, Canada, T6G 2X8
    J Hepatol 44:671-8. 2006
    ..Recombinant human albumin-interferon alfa (alb-IFN) is a novel 85.7-kD recombinant protein consisting of interferon alfa-2b genetically fused to human serum albumin...
  18. ncbi request reprint Reactivation of hepatitis B e antigen-negative chronic hepatitis B in a bone marrow transplant recipient following lamivudine withdrawal
    R P Myers
    Department of Pathology, University of Calgary Medical Clinical, Calgary, Alberta, Canada
    Can J Gastroenterol 15:599-603. 2001
    ..Clinicians should consider the risk of inducing serious flares of hepatic inflammation due to abrupt nucleoside analogue withdrawal in these patients...
  19. ncbi request reprint Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat
    J B Meddings
    Gastrointestinal Research Group, University of Calgary, Alberta, Canada
    Gastroenterology 119:1019-28. 2000
    ..We hypothesized that environmental stress increases gastrointestinal permeability...
  20. ncbi request reprint Profound suppression of chronic hepatitis C following superinfection with hepatitis B virus
    Carla S Coffin
    Liver Unit, Division of Gastroenterology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Liver Int 27:722-6. 2007
    ..Hepatitis B virus (HBV) and hepatitis C virus (HCV) share similar transmission routes; thus, coinfection is frequent. The consequences of acute HBV infection in patients with chronic hepatitis C are unknown...
  21. ncbi request reprint Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1
    Claudine S Bonder
    Immunology Research Group, Department Physiology and Biophysics, University of Calgary, Alberta, Canada
    Immunity 23:153-63. 2005
    ..While this may still be true for neutrophils, Th1 and Th2 cells use alpha(4)-integrin and VAP-1, respectively, to adhere within the liver sinusoids...
  22. pmc Role of chemokines and chemokine receptors in the gastrointestinal tract
    Maureen N Ajuebor
    Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Immunology 105:137-43. 2002
    ..This short review examines the role of chemokines and their receptors in the gastrointestinal tract with an emphasis on their involvement in the regulation of intestinal and hepatic inflammation...
  23. ncbi request reprint C-C chemokine ligand 2/monocyte chemoattractant protein-1 directly inhibits NKT cell IL-4 production and is hepatoprotective in T cell-mediated hepatitis in the mouse
    Maureen N Ajuebor
    Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 170:5252-9. 2003
    ..1(+) T cell-derived IL-4 production through direct stimulation of its specific receptor CCR2. These findings may have direct clinical relevance to T cell-mediated hepatitis...
  24. ncbi request reprint Methotrexate therapy for the symptomatic treatment of primary biliary cirrhosis patients, who are biochemical incomplete responders to ursodeoxycholic acid therapy
    M A Babatin
    Liver Unit, University of Calgary, AB, Canada
    Aliment Pharmacol Ther 24:813-20. 2006
    ..Although it has been shown to improve biochemical markers and delay disease progression, its effect upon fatigue and pruritus, is at best uncertain...
  25. pmc Glucocorticoid receptors are downregulated in hepatic T lymphocytes in rats with experimental cholangitis
    K Tjandra
    Gastrointestinal Research Group, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    Gut 52:1363-70. 2003
    ....
  26. ncbi request reprint CCL3/MIP-1alpha is pro-inflammatory in murine T cell-mediated hepatitis by recruiting CCR1-expressing CD4(+) T cells to the liver
    Maureen N Ajuebor
    Liver Unit, Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Eur J Immunol 34:2907-18. 2004
    ..These findings demonstrate that blockade of the CCL3/MIP-1alpha-CCR1 pathway may represent a novel therapeutic target for treating T cell-mediated liver diseases...
  27. ncbi request reprint CD154-CD40 interactions drive hepatocyte apoptosis in murine fulminant hepatitis
    Feng Zhou
    Liver Unit, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Hepatology 42:372-80. 2005
    ..Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html)...
  28. ncbi request reprint Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells
    Maureen N Ajuebor
    Gastrointestinal Research Group, Diabetes and Endocrine Research Group, and Department of Histopathology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 174:8027-37. 2005
    ....
  29. doi request reprint Natural killer T cells regulate the homing of chemokine CXC receptor 3-positive regulatory T cells to the liver in mice
    Tania Santodomingo-Garzon
    From the Immunology Research Group, University of Calgary, Calgary, Alberta, Canada
    Hepatology 49:1267-76. 2009
    ..In addition, prevention of CXCR3+ Treg recruitment into the liver enhanced inflammatory effector cell recruitment into the liver after alphaGal-C18-Cer treatment...
  30. doi request reprint Liver-brain inflammation axis
    Charlotte D'Mello
    Snyder Institute of Infection, Immunity, and Inflammation, Liver Unit, Department of Medicine, University of Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 301:G749-61. 2011
    ..Understanding how the liver communicates with the brain in the setting of chronic inflammatory liver diseases will help delineate novel therapeutic targets that can reduce the burden of symptoms in patients with liver disease...
  31. ncbi request reprint Essential role for neutrophil recruitment to the liver in concanavalin A-induced hepatitis
    Claudine S Bonder
    Immunology Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Immunol 172:45-53. 2004
    ..In summary, the present data support the concept that neutrophils play an important and previously unrecognized role in governing Con A-induced CD4+ T cell recruitment to the liver and the subsequent development of hepatitis...
  32. ncbi request reprint Increased sensitivity to the locomotor-activating effects of corticotropin-releasing hormone in cholestatic rats
    Kelly W Burak
    Gastrointestinal Research Group, Liver Unit, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 122:681-8. 2002
    ..Therefore, we hypothesized that reduced central CRH release contributes to fatigue associated with cholestatic liver disease and tested this hypothesis in cholestatic rats...
  33. ncbi request reprint CCR5 in T cell-mediated liver diseases: what's going on?
    Maureen N Ajuebor
    Gastrointestinal Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive Northwest, Calgary, Alberta, Canada
    J Immunol 177:2039-45. 2006
    ..Therefore, in this brief review, we highlight the evidence that supports an important role of CCR5 in the pathophysiology of T cell-mediated liver diseases with specific emphasis on autoimmune and viral liver diseases...
  34. ncbi request reprint TNF-alpha-secreting monocytes are recruited into the brain of cholestatic mice
    Steven M Kerfoot
    Immunology Research Group, Health Sciences Center, University of Calgary, Calgary, Alberta, Canada
    Hepatology 43:154-62. 2006
    ..We hypothesize that enhanced TNF-alpha release within the brain may contribute to the development of cholestasis-associated sickness behaviors, including fatigue...
  35. ncbi request reprint A Canadian multicenter retrospective study evaluating transjugular liver biopsy in patients with congenital bleeding disorders and hepatitis C: is it safe and useful?
    Jennifer L Shin
    Department of Medicine at University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 78:85-93. 2005
    ..We conclude that this procedure can be safely performed on an outpatient basis. The diagnosis of cirrhosis and/or portal hypertension was made in a substantial proportion of individuals (26%), all of whom had asymptomatic liver disease...