Robert Sutherland

Summary

Affiliation: University of Lethbridge
Country: Canada

Publications

  1. pmc Suppression of neurotoxic lesion-induced seizure activity: evidence for a permanent role for the hippocampus in contextual memory
    Fraser T Sparks
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    PLoS ONE 6:e27426. 2011
  2. ncbi request reprint Rodent spatial navigation: at the crossroads of cognition and movement
    Robert J Sutherland
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Neurosci Biobehav Rev 28:687-97. 2004
  3. pmc Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    Neuropsychologia 48:2357-69. 2010
  4. ncbi request reprint Spatial memory: a Rosetta stone for rat and human hippocampal discourse: Theoretical comment on Goodrich-Hunsaker and Hopkins (2010)
    Robert J Sutherland
    Department of Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, AB Canada, T1K 3M4
    Behav Neurosci 124:434-6. 2010
  5. ncbi request reprint The hippocampus makes a significant contribution to experience-dependent neocortical plasticity
    Rob Sutherland
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 214:121-4. 2010
  6. ncbi request reprint Seahorse wins all races: hippocampus participates in both linear and non-linear visual discrimination learning
    Ira Driscoll
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Alta
    Behav Brain Res 164:29-35. 2005
  7. ncbi request reprint Absence of systems consolidation of fear memories after dorsal, ventral, or complete hippocampal damage
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 18:710-8. 2008
  8. doi request reprint Alternative conceptions of memory consolidation and the role of the hippocampus at the systems level in rodents
    R J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Curr Opin Neurobiol 21:446-51. 2011
  9. ncbi request reprint Growth points in research on memory and hippocampus
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Alberta
    Can J Exp Psychol 60:166-74. 2006
  10. ncbi request reprint Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine
    Simon C Spanswick
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 17:137-46. 2007

Research Grants

  1. ARNDS--CORTICAL PLASTICITY AND LEARNING
    Robert Sutherland; Fiscal Year: 2001
  2. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2003
  3. ARNDS--CORTICAL PLASTICITY AND LEARNING
    Robert Sutherland; Fiscal Year: 1999
  4. ARNDS--CORTICAL PLASTICITY AND LEARNING
    Robert Sutherland; Fiscal Year: 2000
  5. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2002
  6. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2004
  7. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2005
  8. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2006

Detail Information

Publications45

  1. pmc Suppression of neurotoxic lesion-induced seizure activity: evidence for a permanent role for the hippocampus in contextual memory
    Fraser T Sparks
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    PLoS ONE 6:e27426. 2011
    ..Moreover, the memory deficit observed at both time points offers additional evidence supporting the proposition that the HPC has a continuing role in maintaining contextual memories...
  2. ncbi request reprint Rodent spatial navigation: at the crossroads of cognition and movement
    Robert J Sutherland
    Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alta, Canada T1K 3M4
    Neurosci Biobehav Rev 28:687-97. 2004
    ..A variety of extant behavioral and neurophysiological data that support the basic utility of this conceptual framework are discussed...
  3. pmc Hippocampus and retrograde amnesia in the rat model: a modest proposal for the situation of systems consolidation
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, Alberta, Canada
    Neuropsychologia 48:2357-69. 2010
    ....
  4. ncbi request reprint Spatial memory: a Rosetta stone for rat and human hippocampal discourse: Theoretical comment on Goodrich-Hunsaker and Hopkins (2010)
    Robert J Sutherland
    Department of Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, AB Canada, T1K 3M4
    Behav Neurosci 124:434-6. 2010
    ..2005)...
  5. ncbi request reprint The hippocampus makes a significant contribution to experience-dependent neocortical plasticity
    Rob Sutherland
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Behav Brain Res 214:121-4. 2010
    ..The apical fields failed to show an effect of experience in either hemisphere. The hippocampus plays a crucial role in neocortical experience-dependent plasticity...
  6. ncbi request reprint Seahorse wins all races: hippocampus participates in both linear and non-linear visual discrimination learning
    Ira Driscoll
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Alta
    Behav Brain Res 164:29-35. 2005
    ....
  7. ncbi request reprint Absence of systems consolidation of fear memories after dorsal, ventral, or complete hippocampal damage
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 18:710-8. 2008
    ..These findings support the idea that the hippocampal formation plays an essential and possibly permanent role in fear memories...
  8. doi request reprint Alternative conceptions of memory consolidation and the role of the hippocampus at the systems level in rodents
    R J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Curr Opin Neurobiol 21:446-51. 2011
    ..Many detailed memories always depend on the hippocampus; the others may be established and maintained independently...
  9. ncbi request reprint Growth points in research on memory and hippocampus
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Alberta
    Can J Exp Psychol 60:166-74. 2006
    ..Finally, we outline a project to understand and manipulate adult hippocampal neurogenesis in order to repair damaged hippocampal circuitry to recover lost cognitive functions...
  10. ncbi request reprint Adrenalectomy-induced granule cell degeneration in the hippocampus causes spatial memory deficits that are not reversed by chronic treatment with corticosterone or fluoxetine
    Simon C Spanswick
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Hippocampus 17:137-46. 2007
    ....
  11. ncbi request reprint Interleukin-1beta induces anorexia but not spatial learning and memory deficits in the rat
    Lisa M Thomson
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alta, Canada T1K 3M4
    Behav Brain Res 170:302-7. 2006
    ....
  12. pmc Retrograde amnesia for visual memories after hippocampal damage in rats
    Jonathan Epp
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
    Learn Mem 15:214-21. 2008
    ..Thus, the hippocampus plays an essential role in long-term memories supporting simple picture discriminations...
  13. ncbi request reprint Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation
    Lisa M Thomson
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Dr, Lethbridge, Alta, Canada T1K 3M4
    Brain Res Bull 67:24-9. 2005
    ....
  14. ncbi request reprint Attention modulates responses to motion reversals in human visual cortex
    Matthew S Tata
    The University of Lethbridge, Lethbridge, Alberta, Canada
    Neuroreport 18:1361-5. 2007
    ..This effect was localized to extrastriate visual cortex and may be due to reflexive effects of attention orienting triggered by unattended peripheral motion...
  15. ncbi request reprint Evidence for episodic memory in a pavlovian conditioning procedure in rats
    Robert J Sutherland
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, Alberta, Canada
    Hippocampus 17:1149-52. 2007
    ..Thus, rats automatically form an integrated time-place memory that can be flexibly updated by future events, essential characteristics of episodic memory...
  16. doi request reprint A novel method for reliable nuclear antibody detection in tissue with high levels of pathology-induced autofluorescence
    Simon C Spanswick
    The Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada
    J Neurosci Methods 185:45-9. 2009
    ..Further co-localization of nuclear markers such as Ki67 or BrdU/NeuN with DAPI or Hoechst should serve to help discriminate between intended and spurious fluorescent signal...
  17. ncbi request reprint Stress and corticosterone enhance cognitive recovery from hippocampal stroke in rats
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Neurosci Lett 462:248-52. 2009
    ..The findings support the view that elevated levels of corticosterone may exert neuroprotective effects in the hippocampus following stroke...
  18. doi request reprint Characterization of spatial performance in male and female Long-Evans rats by means of the Morris water task and the ziggurat task
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, T1K 3M4, Canada
    Brain Res Bull 81:164-72. 2010
    ..Our findings suggest that males and females may employ different learning strategies in the MWT and ZT and that the latter task provides a more favourable task for assessing sex differences in rats...
  19. pmc Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats
    Simon C Spanswick
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge AB T1K 3M4, Canada
    Learn Mem 17:241-5. 2010
    ..These findings add to a body of evidence that the hippocampus is necessary when contextual information is important. We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se...
  20. doi request reprint Stress after hippocampal stroke enhances spatial performance in rats
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Physiol Behav 102:389-99. 2011
    ..No between-group structural difference was observed related to stress. These findings confirm that corticosterone-related experiences may be key factors influencing cognitive performance after HPC focal ischemic stroke...
  21. doi request reprint Chronic stress prior to hippocampal stroke enhances post-stroke spatial deficits in the ziggurat task
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada
    Neurobiol Learn Mem 95:335-45. 2011
    ....
  22. doi request reprint Rats with hippocampal lesion show impaired learning and memory in the ziggurat task: a new task to evaluate spatial behavior
    Jamshid Faraji
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Behav Brain Res 189:17-31. 2008
    ..The findings demonstrate that the ZT is a sensitive and efficient dry task for measuring hippocampus-dependent spatial performance in rats requiring little training and not associated with some of the disadvantages of water tasks...
  23. ncbi request reprint Virtual navigation in humans: the impact of age, sex, and hormones on place learning
    Ira Driscoll
    Department of Psychology and Neuroscience, Canadian Centre for Behavioural Neuroscience, The University of Lethbridge, 4401 University Drive Lethbridge, Alberta, Canada T1H 6P4
    Horm Behav 47:326-35. 2005
    ..Our findings indicate that the persistence of male spatial advantage may be related to circulating testosterone, but not cortisol levels, and independent of generalized age-related cognitive decline...
  24. doi request reprint Expression of a conditioned place preference or spatial navigation task following muscimol-induced inactivations of the amygdala or dorsal hippocampus: A double dissociation in the retrograde direction
    Robert J McDonald
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, AB, Canada
    Brain Res Bull 83:29-37. 2010
    ..Taken together, the results showed a functional dissociation between the, effects of amygdala or hippocampal dysfunction on the expression of these different classes of tasks...
  25. ncbi request reprint Functional organization of adult motor cortex is dependent upon continued protein synthesis
    Jeffrey A Kleim
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta T1K 3M4, Canada
    Neuron 40:167-76. 2003
    ..We propose that the circuitry of adult motor cortex is perpetually labile and requires continued protein synthesis in order to maintain its functional organization...
  26. ncbi request reprint The aging hippocampus: cognitive, biochemical and structural findings
    Ira Driscoll
    Department of Psychology, The University of New Mexico, Albuquerque, New Mexico 87131, USA
    Cereb Cortex 13:1344-51. 2003
    ....
  27. ncbi request reprint Damage to the hippocampal formation does not disrupt representational flexibility as measured by a novelty transfer test
    Ira Driscoll
    Canadian Centre for Behavioural Neuroscience, Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Behav Neurosci 118:1427-32. 2004
    ..Eichenbaum, 1992). They are consistent with the view that simple associative processes guide choice behavior in animals with hippocampal damage that are confronted with novel combinations...
  28. ncbi request reprint The aging hippocampus: navigating between rat and human experiments
    Ira Driscoll
    Canadian Centre for Behavioural Neuroscience, Department of Psychology and Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada
    Rev Neurosci 16:87-121. 2005
    ..In addition, studies of the aging hippocampus may have a side-effect in leading to a better understanding of the mechanisms that underlie learning and memory in general...
  29. ncbi request reprint Differential neurogenesis in the adult rat dentate gyrus: an identifiable zone that consistently lacks neurogenesis
    Neal R Melvin
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Eur J Neurosci 25:1023-9. 2007
    ..We propose that this region may provide a valuable model system to discern the factors that regulate the process of neurogenesis...
  30. ncbi request reprint Complete or partial hippocampal damage produces equivalent retrograde amnesia for remote contextual fear memories
    Hugo Lehmann
    Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, The University of Lethbridge, 4401 University Drive, Lethbridge, Alberta, Canada T1K 3M4
    Eur J Neurosci 25:1278-86. 2007
    ..These findings support the idea that the hippocampal formation has an essential and long-lasting, possibly permanent, role in memory for contexts...
  31. ncbi request reprint Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring
    Jan Tamminga
    Department of Biological Sciences, University of Lethbridge, Alberta, Canada
    Cell Cycle 7:1238-45. 2008
    ....
  32. ncbi request reprint Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus
    Ira Driscoll
    Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, Alta, Canada
    Neurobiol Aging 29:1847-58. 2008
    ..Overall, our pattern of results suggest that the aged hippocampus is more vulnerable to the same insult that has little or no effect on the young hippocampus...
  33. ncbi request reprint Humans with hippocampus damage display severe spatial memory impairments in a virtual Morris water task
    Robert S Astur
    Department of Diagnostic Radiology, Yale University, P O Box 208042, 330 Cedar Street, New Haven, CT 06520 8042, USA
    Behav Brain Res 132:77-84. 2002
    ..Hence, it is apparent across species and irrespective of which hemisphere is damaged that the human HPC is critical for spatial/relational memory...
  34. ncbi request reprint Differential involvement of amygdala and hippocampus in responding to novel objects and contexts
    Sandra N Moses
    Department of Psychology, University of Toronto, Ont, Toronto, Canada
    Brain Res Bull 58:517-27. 2002
    ..To the extent that we tap implicit and explicit knowledge using this paradigm, we suggest that in the rat, the amygdala and hippocampal systems are necessary for at least some types of explicit knowledge...
  35. ncbi request reprint Dose-dependent effects of prenatal ethanol exposure on synaptic plasticity and learning in mature offspring
    Daniel D Savage
    Department of Neurosciences, University of New Mexico, Albuquerque 87131 5223, USA
    Alcohol Clin Exp Res 26:1752-8. 2002
    ..In the present study, we examined the question of whether lower maternal blood ethanol concentrations (BECs) could produce functional deficits in offspring...
  36. ncbi request reprint Children with Fetal Alcohol Syndrome are impaired at place learning but not cued-navigation in a virtual Morris water task
    Derek A Hamilton
    Department of Psychology, The University of New Mexico, Albuquerque, NM 87131, USA
    Behav Brain Res 143:85-94. 2003
    ..This pattern of impaired place learning and spared cued-navigation is similar to that reported in rats exposed to ethanol during periods of prenatal or early postnatal brain growth, as well as in animals with hippocampal damage...
  37. pmc Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology
    Julian R Keith
    Department of Psychology, University of North Carolina at Wilmington, North Carolina 28403 5612, USA
    Behav Pharmacol 18:521-31. 2007
    ....
  38. doi request reprint The relative influence of place and direction in the Morris water task
    Derek A Hamilton
    Department of Psychology, University of New Mexico, Albuquerque 87131, USA
    J Exp Psychol Anim Behav Process 34:31-53. 2008
    ..A modest preference for navigation to the precise spatial location of the platform was observed when the pool wall was virtually eliminated as a source of control by filling it to the top with water (Experiment 6)...
  39. pmc Is it systems or cellular consolidation? Time will tell. An alternative interpretation of the Morris group's recent science paper
    Jerry W Rudy
    Department of Psychology, University of Colorado, CB345, Boulder, CO 80309 0345, USA
    Neurobiol Learn Mem 89:366-9. 2008
  40. ncbi request reprint Human place learning in a virtual Morris water task: some important constraints on the flexibility of place navigation
    Derek A Hamilton
    Department of Psychology, Logan Hall, The University of New Mexico, Albuquerque, NM 87131, USA
    Behav Brain Res 129:159-70. 2002
    ..Oxford, UK: Clarendon Press, 1978). Additionally, the transfer data reported here closely match the data obtained by Sutherland et al. with rats suggesting some generality in the principles involved in place learning...
  41. pmc Navigating from hippocampus to parietal cortex
    Jonathan R Whitlock
    Kavli Institute for Systems Neuroscience, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Proc Natl Acad Sci U S A 105:14755-62. 2008
    ..How this is done remains an enigma. We propose that the posterior parietal cortex is critical for this transformation...
  42. ncbi request reprint Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester
    Brian M Bennett
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada
    Neuropsychopharmacology 32:505-13. 2007
    ..This approach may be superior to that of current drugs that attempt only to salvage the residual function of damaged cholinergic neurons...
  43. pmc Hippocampal evoked potentials in novel environments: a behavioral clamping method
    Ying Wu
    Department of Psychology, University of New Mexico, Albuquerque, NM, USA
    Behav Brain Res 172:63-71. 2006
    ..Prior induction of hippocampal LTP occludes the change induced by exploration. This change is not likely to be due to a reduction of GABAergic inhibition induced by novelty...
  44. ncbi request reprint How do room and apparatus cues control navigation in the Morris water task? Evidence for distinct contributions to a movement vector
    Derek A Hamilton
    Department of PsychologyUniversity of New Mexico, Albuquerque, NM, USA
    J Exp Psychol Anim Behav Process 33:100-14. 2007
    ..The authors propose that navigation in the water task involves a movement vector in which the distal cues and apparatus provide direction and distance information, respectively...
  45. ncbi request reprint A role for olfaction in object recognition by normal and hippocampal-damaged rats
    Robert S Astur
    Department of Diagnostic Radiology, Yale University, New Haven, Connecticut 06520, USA
    Neurobiol Learn Mem 78:186-91. 2002
    ..There was no difference in performance between the rats with hippocampus damage and the sham rats, and this is consistent with the literature on similar tasks...

Research Grants8

  1. ARNDS--CORTICAL PLASTICITY AND LEARNING
    Robert Sutherland; Fiscal Year: 2001
    ..Such information can show the way to preventing life-long cognitive and behavioral handicaps. ..
  2. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2003
    ..The results bear upon fundamental aspects of hippocampal dependent, long-term memory consolidation theories and will delineate a more precise role for the hippocampus formation in long-term memory. ..
  3. ARNDS--CORTICAL PLASTICITY AND LEARNING
    Robert Sutherland; Fiscal Year: 1999
    ..Such information can show the way to preventing life-long cognitive and behavioral handicaps. ..
  4. ARNDS--CORTICAL PLASTICITY AND LEARNING
    Robert Sutherland; Fiscal Year: 2000
    ..Such information can show the way to preventing life-long cognitive and behavioral handicaps. ..
  5. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2002
    ..The results bear upon fundamental aspects of hippocampal dependent, long-term memory consolidation theories and will delineate a more precise role for the hippocampus formation in long-term memory. ..
  6. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2004
    ..The results bear upon fundamental aspects of hippocampal dependent, long-term memory consolidation theories and will delineate a more precise role for the hippocampus formation in long-term memory. ..
  7. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2005
    ..The results bear upon fundamental aspects of hippocampal dependent, long-term memory consolidation theories and will delineate a more precise role for the hippocampus formation in long-term memory. ..
  8. Retrograde amnesia after hippocampal damage
    Robert Sutherland; Fiscal Year: 2006
    ..The results bear upon fundamental aspects of hippocampal dependent, long-term memory consolidation theories and will delineate a more precise role for the hippocampus formation in long-term memory. ..