Theodore S Steiner

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc How flagellin and toll-like receptor 5 contribute to enteric infection
    Theodore S Steiner
    Division of Infectious Diseases, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, BC, Canada
    Infect Immun 75:545-52. 2007
  2. doi request reprint The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells
    Sabine M Ivison
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Inflamm Bowel Dis 17:319-33. 2011
  3. ncbi request reprint Protein kinase D1 and D2 are involved in chemokine release induced by toll-like receptors 2, 4, and 5
    Theodore S Steiner
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Rm D452 HP East, VGH, 2733 Heather St, Vancouver, BC, Canada V5Z 3J5
    Cell Immunol 264:135-42. 2010
  4. doi request reprint TLR5 is not required for flagellin-mediated exacerbation of DSS colitis
    Sabine M Ivison
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Inflamm Bowel Dis 16:401-9. 2010
  5. ncbi request reprint Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin
    Sabine M Ivison
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Am J Physiol Gastrointest Liver Physiol 299:G733-41. 2010
  6. ncbi request reprint Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin
    Sabine M Ivison
    Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 178:5735-43. 2007
  7. pmc The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells
    Mohammed A Khan
    Division of Pediatric Gastroenterology, BC Children s Hospital, Vancouver, British Columbia V6H 3V4, Canada
    J Immunol 184:2305-13. 2010
  8. doi request reprint ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation
    Yu Yao
    Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada
    Eur J Immunol 42:3310-21. 2012
  9. pmc Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium
    Mohammed A Khan
    Division of Gastroenterology, BC Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:1410-22. 2008
  10. ncbi request reprint Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada
    Int Immunol 19:345-54. 2007

Collaborators

  • Megan K Levings
  • Artem Cherkasov
  • Eva d'Hennezel
  • Kiran Assi
  • Huifang Li
  • Xiaoxia Li
  • Jian Kang
  • Rosa Bacchetta
  • Yu Yao
  • Isabella T Tai
  • Bruce A Vallance
  • Megan E Himmel
  • Sabine M Ivison
  • Gijs Hardenberg
  • Arnawaz Kifayet
  • Mohammed A Khan
  • Jared Sheridan
  • Sarah E Allan
  • Natasha K Crellin
  • Mohammed A S Khan
  • Ciriaco A Piccirillo
  • Sarah Q Crome
  • Rosa V Garcia
  • Nicholas R Graham
  • Cecily Q Bernales
  • Meghan A Donnelly
  • David M Israel
  • Devendra K Amre
  • David R Mack
  • Katherine G Macdonald
  • Guy Grimard
  • Paul C Orban
  • Matt Mayer
  • Ciriaco Piccirillo
  • Sabine Ivison
  • Bill Salh
  • Matt L Mayer
  • Jingtian T Huang
  • Paige A J Wark
  • Ho Pan Sham
  • Kirk S Bergstrom
  • Ce Wang
  • Jonathan Delano
  • Carrie M Rosenberger
  • Caixia Ma
  • Deanna L Gibson
  • Saeid Bouzari
  • Kirk S B Bergstrom
  • Leila A Shobab
  • Laura Passerini
  • Arnawaz Kaleem
  • Maria G Roncarolo
  • Natalie Ng
  • Chelsea O Tirling
  • Omeed Hadisfar

Detail Information

Publications22

  1. pmc How flagellin and toll-like receptor 5 contribute to enteric infection
    Theodore S Steiner
    Division of Infectious Diseases, Vancouver Coastal Health Research Institute and University of British Columbia, Vancouver, BC, Canada
    Infect Immun 75:545-52. 2007
  2. doi request reprint The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells
    Sabine M Ivison
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Inflamm Bowel Dis 17:319-33. 2011
    ..To better understand the signals that regulate the inflammatory responses of IECs, we investigated whether the danger signal ATP (which is released from injured cells) could alter responses to bacterial products...
  3. ncbi request reprint Protein kinase D1 and D2 are involved in chemokine release induced by toll-like receptors 2, 4, and 5
    Theodore S Steiner
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Rm D452 HP East, VGH, 2733 Heather St, Vancouver, BC, Canada V5Z 3J5
    Cell Immunol 264:135-42. 2010
    ..These kinases likely act downstream of the TLRs themselves to facilitate NF-kappaB activation but not MAP kinase phosphorylation...
  4. doi request reprint TLR5 is not required for flagellin-mediated exacerbation of DSS colitis
    Sabine M Ivison
    Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Inflamm Bowel Dis 16:401-9. 2010
    ..A recent study found that administration of flagellin enemas to mice along with dextran sodium sulfate (DSS) made their colitis worse...
  5. ncbi request reprint Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin
    Sabine M Ivison
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Am J Physiol Gastrointest Liver Physiol 299:G733-41. 2010
    ..This suggests that epithelial cells are capable of sensing the extracellular environment and adjusting their antimicrobial responses accordingly...
  6. ncbi request reprint Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin
    Sabine M Ivison
    Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 178:5735-43. 2007
    ....
  7. pmc The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells
    Mohammed A Khan
    Division of Pediatric Gastroenterology, BC Children s Hospital, Vancouver, British Columbia V6H 3V4, Canada
    J Immunol 184:2305-13. 2010
    ..Our findings show that Sigirr broadly regulates innate responses in differentiated human IECs; therefore, it may modulate epithelial involvement in infectious and inflammatory bowel diseases...
  8. doi request reprint ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation
    Yu Yao
    Department of Medicine, University of British Columbia and Vancouver Coastal Health Research Institute, Vancouver, BC, Canada
    Eur J Immunol 42:3310-21. 2012
    ..These findings indicate that ATP influences the response of IECs to TLR ligands and biases the maturation of DCs to become inflammatory...
  9. pmc Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium
    Mohammed A Khan
    Division of Gastroenterology, BC Children s Hospital, Vancouver, British Columbia, Canada
    Infect Immun 76:1410-22. 2008
    ....
  10. ncbi request reprint Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada
    Int Immunol 19:345-54. 2007
    ..These data indicate that our current understanding of how FOXP3 contributes to immune tolerance in humans needs to be re-evaluated...
  11. ncbi request reprint Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans
    Megan E Himmel
    Department of Surgery, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Immunol 190:2001-8. 2013
    ....
  12. pmc Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers
    Megan E Himmel
    Department of Surgery, University of British Columbia and Child and Family Research Centre, Vancouver, BC, Canada
    Immunology 136:115-22. 2012
    ....
  13. doi request reprint Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice
    Gijs Hardenberg
    Department of Surgery, University of British Columbia and Immunity in Health and Disease, Child and Family Research Institute, British Columbia Children s Hospital, Vancouver, Canada
    Inflamm Bowel Dis 18:85-93. 2012
    ..The aim of this study was to determine the role of TLR5 in CD4(+) T cell subsets versus other cells in induction of disease in a model of T cell-dependent colitis...
  14. doi request reprint Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils
    Megan E Himmel
    Department of Surgery, University of British Columbia, Vancouver, BC, Canada
    Eur J Immunol 41:306-12. 2011
    ....
  15. pmc A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin
    Jared Sheridan
    Division of Infectious Diseases, Vancouver Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e61326. 2013
    ..We aimed to examine potential CD-associated TLR5 variants and assess whether they modified inflammatory responses to bacterial flagellins...
  16. doi request reprint Environmental influences on T regulatory cells in inflammatory bowel disease
    Gijs Hardenberg
    Department of Surgery, University of British Columbia and Immunity in Health and Disease, Child and Family Research Institute, British Columbia Children s Hospital, Vancouver, BC, Canada
    Semin Immunol 23:130-8. 2011
    ..We will also discuss how these environmental signals can be manipulated therapeutically in order to improve the function of regulatory T cells and ultimately restore mucosal homeostasis in patients with IBD...
  17. pmc The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
    Megan E Himmel
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, Canada
    Immunology 125:145-53. 2008
    ..In addition, we discuss evidence that direct signaling via TLRs to T cells can affect IBD and that T-cell-dependent responses to bacterial proteins, such as flagellin, are central to the aetiology of this disease...
  18. ncbi request reprint A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin
    Sabine M Ivison
    Division of Infectious Diseases, University of British Columbia Vancouver Coastal Health Research Institute, Canada
    Biochem Biophys Res Commun 352:936-41. 2007
    ..Together, these results suggest that phosphorylation of Y798 in TLR5 is required for signalling, but not for TLR5 dimerization...
  19. pmc Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation
    Mohammed A S Khan
    Division of Infectious Diseases, University of British Columbia, Vancouver Hospital and Health Sciences Centre, 2733 Heather Street, Vancouver, BC V5Z 3J5 Canada
    Immunology 112:651-60. 2004
    ....
  20. ncbi request reprint Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells
    Natasha K Crellin
    Department of Surgery, University of British Columbia and Immunity and Infection Centre, Vancouver, BC
    J Immunol 175:8051-9. 2005
    ..These observations suggest that, in addition to their APC-mediated indirect effects, TLR ligands have the capacity to directly regulate T cell responses and modulate the suppressive activity of Treg cells...
  21. ncbi request reprint Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5
    Meghan A Donnelly
    Division of Geographic and International Medicine, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Biol Chem 277:40456-61. 2002
    ..These results highlight the complexity of the interaction between bacterial flagellin and its eukaryotic recognition partners and provide the basis for further studies to characterize the innate immune response to flagellin...