Lawrence L Spriet

Summary

Affiliation: University of Guelph
Country: Canada

Publications

  1. ncbi request reprint Regulation of substrate use during the marathon
    Lawrence L Spriet
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Sports Med 37:332-6. 2007
  2. ncbi request reprint Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Exerc Sport Sci Rev 30:91-5. 2002
  3. pmc Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 550:325-32. 2003
  4. ncbi request reprint The effects of training in hyperoxia vs. normoxia on skeletal muscle enzyme activities and exercise performance
    Christopher G R Perry
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 102:1022-7. 2007
  5. ncbi request reprint Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses
    Shannon E Pratt
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol 103:1063-9. 2007
  6. ncbi request reprint New insights into the interaction of carbohydrate and fat metabolism during exercise
    Lawrence L Spriet
    Department of Human Health and Nutritional Sciences, University of Guelph, Room 354, ANNU Building, Guelph, ON, N1G 2W1, Canada
    Sports Med 44:87-96. 2014
  7. ncbi request reprint Nutritional strategies to influence adaptations to training
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Sports Sci 22:127-41. 2004
  8. doi request reprint Legal pre-event nutritional supplements to assist energy metabolism
    Lawrence L Spriet
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Essays Biochem 44:27-43. 2008
  9. ncbi request reprint Regulation of skeletal muscle fat oxidation during exercise in humans
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Med Sci Sports Exerc 34:1477-84. 2002
  10. ncbi request reprint Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006

Detail Information

Publications63

  1. ncbi request reprint Regulation of substrate use during the marathon
    Lawrence L Spriet
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Sports Med 37:332-6. 2007
    ..However, they compete at such high running speeds, that CHO oxidation (also highly adapted) may be the exclusive source of energy while racing. Further work with elite athletes is needed to examine this possibility...
  2. ncbi request reprint Regulation of pyruvate dehydrogenase (PDH) activity in human skeletal muscle during exercise
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Exerc Sport Sci Rev 30:91-5. 2002
    ..During exercise, pyruvate dehydrogenase activation in human skeletal muscle is proportional to the relative aerobic power output (percent VO2max) and is regulated by increases in Ca2+, free ADP, and pyruvate concentrations...
  3. pmc Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 550:325-32. 2003
    ..The results also demonstrate that increased ERK 1/2 phosphorylation coincides with elevated HSL activity, indicating that ERK 1/2 may mediate the contraction-induced increase in HSL activity early in exercise...
  4. ncbi request reprint The effects of training in hyperoxia vs. normoxia on skeletal muscle enzyme activities and exercise performance
    Christopher G R Perry
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 102:1022-7. 2007
    ....
  5. ncbi request reprint Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses
    Shannon E Pratt
    Department of Animal and Poultry Science, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol 103:1063-9. 2007
    ....
  6. ncbi request reprint New insights into the interaction of carbohydrate and fat metabolism during exercise
    Lawrence L Spriet
    Department of Human Health and Nutritional Sciences, University of Guelph, Room 354, ANNU Building, Guelph, ON, N1G 2W1, Canada
    Sports Med 44:87-96. 2014
    ..This information has led to the proposal of mechanisms to explain the downregulation of fat metabolism that occurs in the face of increasing carbohydrate availability and when moving from moderate to intense aerobic exercise. ..
  7. ncbi request reprint Nutritional strategies to influence adaptations to training
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Sports Sci 22:127-41. 2004
    ..Research in these areas in the coming years will lead to strategies designed to improve the adaptive response to training...
  8. doi request reprint Legal pre-event nutritional supplements to assist energy metabolism
    Lawrence L Spriet
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Essays Biochem 44:27-43. 2008
    ..However, other studies have reported no benefit and the incidence of negative side effects is high...
  9. ncbi request reprint Regulation of skeletal muscle fat oxidation during exercise in humans
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Med Sci Sports Exerc 34:1477-84. 2002
    ..VO(2max)). Although it is expected that the signals that activate carbohydrate metabolism during exercise (Ca and free ADP, AMP, and P(i)) would also play a role in fat metabolism, this has not been demonstrated to date...
  10. ncbi request reprint Adrenergic regulation of HSL serine phosphorylation and activity in human skeletal muscle during the onset of exercise
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Regul Integr Comp Physiol 291:R1094-9. 2006
    ..This adrenergic stimulation contributes to the increase in HSL activity that occurs in human skeletal muscle in the first minute of exercise at 65% and 90% VO2 peak...
  11. doi request reprint Exercise training increases sarcolemmal and mitochondrial fatty acid transport proteins in human skeletal muscle
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 299:E180-8. 2010
    ..These results suggest that increases in skeletal muscle fatty acid oxidation following training are related in part to changes in fatty acid transport protein content and localization...
  12. doi request reprint High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle
    Christopher G R Perry
    Department of Human Health and Nutritional Sciences, University of Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 33:1112-23. 2008
    ..week-1) is a powerful method to increase whole-body and skeletal muscle capacities to oxidize fat and carbohydrate in previously untrained individuals...
  13. pmc Mitochondrial long chain fatty acid oxidation, fatty acid translocase/CD36 content and carnitine palmitoyltransferase I activity in human skeletal muscle during aerobic exercise
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada
    J Physiol 571:201-10. 2006
    ..We further suggest that decreased CPTI M-CoA sensitivity and increased mitochondrial FAT/CD36 protein are both important for increasing whole body fatty acid oxidation during prolonged exercise...
  14. pmc Fatty acid binding protein facilitates sarcolemmal fatty acid transport but not mitochondrial oxidation in rat and human skeletal muscle
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Canada, N1G 2W1
    J Physiol 582:393-405. 2007
    ....
  15. ncbi request reprint Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, 50 Stone Rd, Guelph, Ontario, Canada N1G2W1
    Am J Physiol Endocrinol Metab 292:E1782-9. 2007
    ..In addition, it appears that mitochondrial FAT/CD36 may be involved in regulating fatty acid oxidation in human skeletal muscle...
  16. doi request reprint Fluid and electrolyte supplementation after prolonged moderate-intensity exercise enhances muscle glycogen resynthesis in Standardbred horses
    Amanda P Waller
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, ON, Canada N1G 2W1
    J Appl Physiol (1985) 106:91-100. 2009
    ..It is speculated that postexercise dehydration may be one key contributor to the slow muscle glycogen replenishment in horses...
  17. doi request reprint PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein
    Graham P Holloway
    Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 294:E1060-9. 2008
    ..Also, it does not appear that alterations in the proteins associated with mitochondrial network formation and degradation can account for the observed decrease in mitochondrial content...
  18. ncbi request reprint Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration
    Trent Stellingwerff
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 290:E380-8. 2006
    ....
  19. ncbi request reprint Effects of hyperoxia on skeletal muscle carbohydrate metabolism during transient and steady-state exercise
    Trent Stellingwerff
    Dept of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 98:250-6. 2005
    ..The mechanism responsible for the decreased muscle glycogenolysis during hyperoxia in the present study is not clear...
  20. ncbi request reprint Increase in skeletal-muscle glycogenolysis and perceived exertion with progressive dehydration during cycling in hydrated men
    Heather M Logan-Sprenger
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Int J Sport Nutr Exerc Metab 23:220-9. 2013
    ..349 ± 27 mmol · kg-1 · dm-1). In conclusion, dehydration of <2% BM elevated physiological parameters and perceived exertion, as well as muscle glycogenolysis, during exercise without affecting whole-body CHO oxidation...
  21. ncbi request reprint Hormone-sensitive lipase activity and fatty acyl-CoA content in human skeletal muscle during prolonged exercise
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol (1985) 95:314-21. 2003
    ..The accumulation of LCFA CoA in the 2nd h of exercise may also have reduced the flux through HSL and accounted for the reduction in IMTG utilization previously observed late in prolonged exercise...
  22. pmc Skeletal muscle fat and carbohydrate metabolism during recovery from glycogen-depleting exercise in humans
    Nicholas E Kimber
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 548:919-27. 2003
    ..Plasma fatty acids, very low density lipoprotein triacylglycerols, as well as intramuscular acetylcarnitine stores are likely to be important fuel sources for aerobic energy, particularly during the first few hours of recovery...
  23. doi request reprint Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals
    Graham P Holloway
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Clin Nutr 89:455S-62S. 2009
    ..These findings imply that obese individuals would benefit from interventions that increase the skeletal muscle mitochondrial content and the potential for oxidizing FAs...
  24. ncbi request reprint Effects of reduced free fatty acid availability on hormone-sensitive lipase activity in human skeletal muscle during aerobic exercise
    Marcus O'Neill
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1
    J Appl Physiol 97:1938-45. 2004
    ..In conclusion, reduced plasma FFA availability accompanied by increased epinephrine concentration did not further activate HSL beyond exercise alone...
  25. ncbi request reprint Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1
    J Appl Physiol (1985) 97:1261-7. 2004
    ..The increased PDK activity was independent of changes in intra-mitochondrial effectors, and PDK-2 and PDK-4 protein content, suggesting that it was caused by a change in the specific activity of the existing kinases...
  26. doi request reprint Oral acetate supplementation after prolonged moderate intensity exercise enhances early muscle glycogen resynthesis in horses
    Amanda P Waller
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G2W1
    Exp Physiol 94:888-98. 2009
    ..It is concluded that oral acetate could be an alternative energy source in the horse...
  27. doi request reprint On-ice sweat rate, voluntary fluid intake, and sodium balance during practice in male junior ice hockey players drinking water or a carbohydrate-electrolyte solution
    Matthew S Palmer
    Department of Human Health and Nutritional Sciences, University of Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 35:328-35. 2010
    ..The CES provided some salt to offset the salt lost in sweat, and carbohydrate, which may help maintain physical and mental performance in the later stages of practice...
  28. doi request reprint Effects of dehydration during cycling on skeletal muscle metabolism in females
    Heather M Logan-Sprenger
    Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada
    Med Sci Sports Exerc 44:1949-57. 2012
    ..This study investigated the effects of progressive dehydration on the time course of changes to whole body substrate oxidation and skeletal muscle metabolism during 120 min of cycling in hydrated females...
  29. pmc Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria
    Carley R Benton
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 586:1755-66. 2008
    ..Moreover, these studies identify for the first time a mechanism by which rosiglitazone stimulates fatty acid oxidation in skeletal muscle, namely the chronic, subcellular relocation of FAT/CD36 to mitochondria...
  30. ncbi request reprint Hyperoxia decreases muscle glycogenolysis, lactate production, and lactate efflux during steady-state exercise
    Trent Stellingwerff
    Dept of Human Health and Nutritional Sciences, Univ of Guelph, Guelph, ON, N1G 2W1, Canada
    Am J Physiol Endocrinol Metab 290:E1180-90. 2006
    ..The tighter metabolic match between pyruvate production and oxidation resulted in a decrease in total lactate production and efflux over 40 min of exercise during hyperoxia...
  31. pmc Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1
    J Physiol 541:969-78. 2002
    ..Although the factor underlying the PDHa decrease was not apparent, reduced pyruvate provision secondary to diminished glycolytic flux is the most likely mechanism...
  32. ncbi request reprint Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet
    Tanya L Pehleman
    Dept of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol 98:100-7. 2005
    ..The rapid increase in PDK activity during the HF/LC diet appeared to account for the reduced potential for oxidative carbohydrate disposal...
  33. pmc Carbohydrate ingestion reduces skeletal muscle acetylcarnitine availability but has no effect on substrate phosphorylation at the onset of exercise in man
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario N1G 2W1, Canada
    J Physiol 544:949-56. 2002
    ..These data suggest that acetylcarnitine availability is unlikely to be the site of metabolic inertia during the transition from rest to steady-state moderate intensity exercise...
  34. pmc Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle
    Yuko Yoshida
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 582:1317-35. 2007
    ..e. an intracellular lactate shuttle) does not occur within the matrix in either IMF or SS mitochondria obtained from red or white rat skeletal muscle, because of the very limited quantity of LDH within mitochondria...
  35. ncbi request reprint The effect of acute taurine ingestion on endurance performance and metabolism in well-trained cyclists
    Jane A Rutherford
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Int J Sport Nutr Exerc Metab 20:322-9. 2010
    ..The acute ingestion of 1.66 g of T before exercise did not enhance TT performance but did result in a small but significant increase in fat oxidation during submaximal cycling in endurance-trained cyclists...
  36. ncbi request reprint Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase
    Trent Stellingwerff
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 284:E589-96. 2003
    ..The increased activation of PDH was not explained by changes in muscle pyruvate or the ATP/ADP ratio but may be related to a decrease in the NADH/NAD(+) ratio or an epinephrine-induced increase in calcium concentration...
  37. ncbi request reprint Two weeks of high-intensity aerobic interval training increases the capacity for fat oxidation during exercise in women
    Jason L Talanian
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Appl Physiol (1985) 102:1439-47. 2007
    ..In summary, seven sessions of HIIT over 2 wk induced marked increases in whole body and skeletal muscle capacity for fatty acid oxidation during exercise in moderately active women...
  38. pmc AMP-activated protein kinase is required for exercise-induced peroxisome proliferator-activated receptor co-activator 1 translocation to subsarcolemmal mitochondria in skeletal muscle
    Brennan K Smith
    Human Health and Nutritional Sciences, University of Guelph, 491 Gordon St, Guelph, ON, N1G 2W1, Canada
    J Physiol 591:1551-61. 2013
    ..These data suggest that exercise causes translocation of PGC-1α preferentially to SS mitochondria in an AMPK-dependent manner...
  39. doi request reprint Estimated fluid and sodium balance and drink preferences in elite male junior players during an ice hockey game
    Heather M Logan-Sprenger
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada
    Appl Physiol Nutr Metab 36:145-52. 2011
    ..Losing 2% BM has been associated with decreases in athletic performance...
  40. pmc Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Physiol 547:301-8. 2003
    ....
  41. ncbi request reprint Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting
    Lawrence L Spriet
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Appl Physiol (1985) 96:2082-7. 2004
    ..The changes in PDK-4 expression and PDH activity did not coincide with increases in the transcriptional activators PPAR-alpha and FKHR...
  42. ncbi request reprint Regulation and role of hormone-sensitive lipase activity in human skeletal muscle
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    Proc Nutr Soc 63:315-22. 2004
    ..For example, it must be remembered that the actual flux (IMTG degradation) through HSL may be allosterically inhibited during prolonged exercise as a result of the accumulation of long-chain fatty acyl-CoA...
  43. pmc Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle
    Christopher G R Perry
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    J Physiol 590:5475-86. 2012
    ..This enhanced regulation of miCK-dependent phosphate shuttling may improve energy homeostasis through more efficient coupling of oxidative phosphorylation to perturbations in cellular energy charge during subsequent bouts of contraction...
  44. doi request reprint Acute endurance exercise increases plasma membrane fatty acid transport proteins in rat and human skeletal muscle
    Nicolette S Bradley
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 302:E183-9. 2012
    ..This study is also the first to demonstrate that endurance cycling induces an increase in plasma membrane FAT/CD36 and FABPpm content in human skeletal muscle, which is predicted to increase fatty acid transport...
  45. ncbi request reprint Skeletal muscle metabolism is unaffected by DCA infusion and hyperoxia after onset of intense aerobic exercise
    Ingrid Savasi
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 283:E108-15. 2002
    ....
  46. ncbi request reprint Effects of microhydrin supplementation on endurance performance and metabolism in well-trained cyclists
    Lee R Glazier
    Dept of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Int J Sport Nutr Exerc Metab 14:560-73. 2004
    ..05). The results indicate that oral Microhydrin supplementation does not enhance cycling time trial performance or alter metabolism during prolonged submaximal exercise in endurance-trained cyclists...
  47. ncbi request reprint Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation
    Veronic Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Am J Physiol Endocrinol Metab 290:E509-15. 2006
    ....
  48. doi request reprint Prolonged moderate-intensity aerobic exercise does not alter apoptotic signaling and DNA fragmentation in human skeletal muscle
    Joe Quadrilatero
    Dept of Kinesiology, Univ of Waterloo, ON, Canada
    Am J Physiol Endocrinol Metab 298:E534-47. 2010
    ..These findings suggest that a single bout of prolonged moderate-intensity aerobic exercise is not sufficient to alter apoptotic signaling in skeletal muscle of healthy humans...
  49. doi request reprint Metabolic regulation of fat use during exercise and in recovery
    Lawrence L Spriet
    Department of Human Health and Nutritional Science, University of Guelph, Guelph, ON, Canada
    Nestle Nutr Inst Workshop Ser 69:39-53; discussion 53-8. 2011
    ..Recent work using molecular and cellular compartmentalization techniques have advanced the knowledge in this area...
  50. ncbi request reprint Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy?
    Matthew J Watt
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    J Appl Physiol (1985) 93:1185-95. 2002
    ..Therefore, it is our contention that the muscle biopsy, isotope tracer, and (1)H-MRS techniques report significant and energetically important oxidation of free fatty acids derived from IMTGs during prolonged moderate exercise...
  51. ncbi request reprint Regulation of CPT I activity in intermyofibrillar and subsarcolemmal mitochondria from human and rat skeletal muscle
    Veronic Bezaire
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Am J Physiol Endocrinol Metab 286:E85-91. 2004
    ..Exercise-induced increases in calcium and adenylate charge metabolites do not appear responsible for upregulating CPT I activity in human or rat skeletal muscle during moderate aerobic exercise...
  52. pmc The Physical Activity Scale for the Elderly (PASE) questionnaire; does it predict physical health?
    Samantha L Logan
    Department of Human Health and Nutrition Sciences, 50 Stone Rd E, ANNU Bldg Rm 205, University of Guelph, Guelph, ON N1G 2W1, Canada
    Int J Environ Res Public Health 10:3967-86. 2013
    ..In conclusion, findings demonstrated that PASE scores cannot be used to predict healthy physical measures, although the relationships between PASE and WC could be used to encourage older adults to become more physically active. ..
  53. doi request reprint The acute effects of fluid intake on urine specific gravity and fluid retention in a mildly dehydrated state
    Heather M Logan-Sprenger
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Strength Cond Res 27:1002-8. 2013
    ..Following this practice will minimize the incidence of starting a practice or competition hypohydrated...
  54. doi request reprint Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men
    Michael A Zulyniak
    Department of Human Health and Nutritional Sciences University of Guelph, Guelph, Ontario, Canada, N1G 2W1
    Metabolism 62:1107-13. 2013
    ..The goal of the present study was to examine the influence of fish oil supplementation on lipid metabolites and the inflammatory status of young healthy men...
  55. ncbi request reprint Increase in skeletal-muscle glycogenolysis and perceived exertion with progressive dehydration during cycling in hydrated men
    Heather M Logan-Sprenger
    Dept of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Int J Sport Nutr Exerc Metab 23:220-9. 2013
    ..349 ± 27 mmol · kg-1 · dm-1). In conclusion, dehydration of <2% BM elevated physiological parameters and perceived exertion, as well as muscle glycogenolysis, during exercise without affecting whole-body CHO oxidation...
  56. doi request reprint Sweat rate, salt loss, and fluid intake during an intense on-ice practice in elite Canadian male junior hockey players
    Matthew S Palmer
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada
    Appl Physiol Nutr Metab 33:263-71. 2008
    ..However, 1/3 of players lost more than 1% body mass despite ready access to fluid and numerous drinking opportunities from the coaches...
  57. ncbi request reprint Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans
    Valerie Eyjolfson
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Med Sci Sports Exerc 36:814-20. 2004
    ..However, in lean rats, CLA causes hyperinsulinemia. Furthermore, experiments in humans also suggest that CLA may worsen insulin sensitivity...
  58. ncbi request reprint Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle
    Rebecca J Tunstall
    School of Health Sciences, Deakin University, Burwood, VIC 3125, Australia
    Biochem Biophys Res Commun 294:301-8. 2002
    ..This suggests a unique role for UCP3 in the regulation of FA homeostasis during fasting as adaptation to 40 h of fasting does not require alterations in the expression of other genes necessary for lipid metabolism...
  59. ncbi request reprint Significant intramyocellular lipid use during prolonged cycling in endurance-trained males as assessed by three different methodologies
    Trent Stellingwerff
    Department of Movement Science, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Endocrinol Metab 292:E1715-23. 2007
    ..In addition, this study shows differences in resting subcellular intramyocellular lipid deposit distribution and in the subsequent net use of these deposits during exercise...
  60. ncbi request reprint Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid
    Matthew J Watt
    School of Medical Sciences, Royal Melbourne Institute of Technology, PO Box 71, Bundoora, Victoria 3083, Australia
    Am J Physiol Endocrinol Metab 285:E412-9. 2003
    ..It is possible that more powerful signals or a higher [Ca2+] may override the lipid-storage effect of the CPA-mediated effects during muscular contractions...
  61. doi request reprint Seven days of oral taurine supplementation does not increase muscle taurine content or alter substrate metabolism during prolonged exercise in humans
    Stuart D R Galloway
    Department of Sports Studies, University of Stirling, Stirling, United Kingdom
    J Appl Physiol (1985) 105:643-51. 2008
    ....
  62. ncbi request reprint Human skeletal muscle creatine transporter mRNA and protein expression in healthy, young males and females
    Robyn M Murphy
    School of Health Sciences, Deakin University, Burwood, Australia
    Mol Cell Biochem 244:151-7. 2003
    ..8 +/- 2.2, females: 125.3 +/- 4.3 mmol.kg(-1) dry mass) were also unaffected (p > 0.05) by gender. These data demonstrate that gender does not influence skeletal muscle TCr content and CreaT gene expression in young human subjects...
  63. ncbi request reprint Reply to letter "Pyruvate metabolism in working human skeletal muscle" by Henderson et al
    Trent Stellingwerff
    Am J Physiol Endocrinol Metab 292:E1238-9. 2007