J Sodek

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC
    Jaro Sodek
    CIHR Group in Matrix Dynamics, 234 FitzGerald Building, Faculty of Dentistry, University of Toronto, Toronto M5S 3E2, Canada
    Connect Tissue Res 43:308-19. 2002
  2. ncbi request reprint Osteopontin
    J Sodek
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, ON, Canada
    Crit Rev Oral Biol Med 11:279-303. 2000
  3. ncbi request reprint Analysis of intracellular osteopontin as a marker of osteoblastic cell differentiation and mesenchymal cell migration
    R Zohar
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Eur J Oral Sci 106:401-7. 1998
  4. ncbi request reprint Characteristics of vitamin D3 receptor (VDR) binding to the vitamin D response element (VDRE) in rat bone sialoprotein gene promoter
    J J Li
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Eur J Oral Sci 106:408-17. 1998
  5. ncbi request reprint Influence of osteogenic protein-1 (OP-1;BMP-7) and transforming growth factor-beta 1 on bone formation in vitro
    S Cheifetz
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ont, Canada
    Connect Tissue Res 35:71-8. 1996
  6. ncbi request reprint Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis
    S Gangbar
    Department of Periodontics, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Periodontal Res 25:257-67. 1990
  7. ncbi request reprint Mechanism of cyclosporin-induced inhibition of intracellular collagen degradation
    P D Arora
    Canadian Institutes of Health Research Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 276:14100-9. 2001
  8. ncbi request reprint Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts
    K Suzuki
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Canada
    J Bone Miner Res 17:1486-97. 2002
  9. ncbi request reprint An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements
    Tamotsu Kiyoshima
    CIHR Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Room 239 FitzGerald Building, 150 College Street, Toronto, Ontario M5S 3E2, Canada
    Gene 299:205-17. 2002
  10. ncbi request reprint Mineral-binding proteoglycans of fetal porcine calvarial bone
    H A Goldberg
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Biol Chem 263:12092-101. 1988

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC
    Jaro Sodek
    CIHR Group in Matrix Dynamics, 234 FitzGerald Building, Faculty of Dentistry, University of Toronto, Toronto M5S 3E2, Canada
    Connect Tissue Res 43:308-19. 2002
    ..The identification of OPN and SPARC inside specialized cells introduces a novel concept in cellular regulation by matricellular proteins...
  2. ncbi request reprint Osteopontin
    J Sodek
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, ON, Canada
    Crit Rev Oral Biol Med 11:279-303. 2000
    ..In this review, we discuss the structural features of OPN that relate to its function in the formation, remodeling, and maintenance of bones and teeth...
  3. ncbi request reprint Analysis of intracellular osteopontin as a marker of osteoblastic cell differentiation and mesenchymal cell migration
    R Zohar
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Eur J Oral Sci 106:401-7. 1998
    ..These studies show that OPN is expressed early in mesenchymal cell differentiation and is related to cell migration as well as osteogenesis...
  4. ncbi request reprint Characteristics of vitamin D3 receptor (VDR) binding to the vitamin D response element (VDRE) in rat bone sialoprotein gene promoter
    J J Li
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Eur J Oral Sci 106:408-17. 1998
    ..These studies demonstrate that subtle differences in the nucleotide sequence of VDREs affect VDR binding, which mediates the vitamin D3 response...
  5. ncbi request reprint Influence of osteogenic protein-1 (OP-1;BMP-7) and transforming growth factor-beta 1 on bone formation in vitro
    S Cheifetz
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ont, Canada
    Connect Tissue Res 35:71-8. 1996
    ..Thus OP-1 has selective effects on bone matrix protein expression that are dependent on the differentiated state of the cells...
  6. ncbi request reprint Identification of polymorphonuclear leukocyte collagenase and gelatinase activities in mouthrinse samples: correlation with periodontal disease activity in adult and juvenile periodontitis
    S Gangbar
    Department of Periodontics, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Periodontal Res 25:257-67. 1990
    ..The results of these studies indicate that measurement of active collagenase and gelatinase in mouthrinse samples is potentially useful in the diagnosis and assessment of periodontal disease activity...
  7. ncbi request reprint Mechanism of cyclosporin-induced inhibition of intracellular collagen degradation
    P D Arora
    Canadian Institutes of Health Research Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 276:14100-9. 2001
    ..Collectively, these data indicate that CsA inhibits collagen phagocytosis by blocking calcium release from ER stores and may perturb functional interactions between the ER and mitochondria that regulate calcium stores...
  8. ncbi request reprint Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts
    K Suzuki
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Canada
    J Bone Miner Res 17:1486-97. 2002
    ..These studies have identified an intracellular form of OPN, colocalizing with CD44 in cell processes, that appears to function in the formation and activity of osteoclasts...
  9. ncbi request reprint An L1 element disrupts human bone sialoprotein promoter: lack of tissue-specific regulation by distalless5 (Dlx5) and runt homeodomain protein2 (Runx2)/core binding factor a1 (Cbfa1) elements
    Tamotsu Kiyoshima
    CIHR Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Room 239 FitzGerald Building, 150 College Street, Toronto, Ontario M5S 3E2, Canada
    Gene 299:205-17. 2002
    ..These studies have characterized the upstream promoter of the human BSP gene, which is interrupted by a unique high-frequency DNA insert that suppresses BSP gene transcription...
  10. ncbi request reprint Mineral-binding proteoglycans of fetal porcine calvarial bone
    H A Goldberg
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Biol Chem 263:12092-101. 1988
    ....
  11. pmc Full length cDNA sequence of porcine secreted phosphoprotein-I (SPP-I, osteopontin)
    J L Wrana
    MRC Group in Periodontal Physiology, University of Toronto, Canada
    Nucleic Acids Res 17:10119. 1989
  12. pmc The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization
    W K Suh
    Advanced Medical Discovery Institute, Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 101:12969-73. 2004
    ..In addition, our findings identified B7-H3 as another molecule that has a dual role in the bone-immune interface...
  13. ncbi request reprint Temporal and spatial expression of a novel zinc finger transcription factor, AJ18, in developing murine skeletal tissues
    Andrew Jheon
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Histochem Cytochem 50:973-82. 2002
    ..Therefore, the expression of AJ18 is consistent with its perceived role as a transcriptional factor that regulates developmental processes downstream of BMP-7...
  14. ncbi request reprint Characterization of fetal porcine bone sialoproteins, secreted phosphoprotein I (SPPI, osteopontin), bone sialoprotein, and a 23-kDa glycoprotein. Demonstration that the 23-kDa glycoprotein is derived from the carboxyl terminus of SPPI
    Q Zhang
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Biol Chem 265:7583-9. 1990
    ..The rapid generation of the 23-kDa glycoprotein and its presence in different bone tissues at different developmental stages indicate that the fragmentation of SPPI is important in bone formation and remodeling...
  15. pmc Characterization of porcine osteonectin extracted from foetal calvariae
    C Domenicucci
    Medical Research Council Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Biochem J 253:139-51. 1988
    ..The chemical and binding properties of porcine osteonectin are closely similar to the recently described 'culture shock', SPARC and BM-40 proteins, indicating that these are homologous proteins...
  16. ncbi request reprint A novel model system for characterization of phagosomal maturation, acidification, and intracellular collagen degradation in fibroblasts
    P D Arora
    Medical Research Council Group in Periodontal Physiology, The Faculty of Dentistry, and the Faculty of Medicine, Division of Respirology, University of Toronto, Toronto M5S 3E8, Ontario, Canada
    J Biol Chem 275:35432-41. 2000
    ..These studies demonstrate that the cellular machinery required for intracellular collagen degradation in fibroblasts closely resembles the vacuolar system in macrophages...
  17. ncbi request reprint MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures
    M Komaki
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, ON M5S 3E2, Canada
    J Cell Sci 117:1457-68. 2004
    ....
  18. ncbi request reprint Osteopontin and mucosal protection
    J Sodek
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, ON, Canada
    J Dent Res 85:404-15. 2006
    ....
  19. ncbi request reprint Synthesis and processing of bone sialoproteins during de novo bone formation in vitro
    X L Zhu
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, ON
    Biochem Cell Biol 79:737-46. 2001
    ..Moreover, the additional phosphorylation of BSP and OPN catalyzed by ectokinase activity does not appear to alter the distribution of these sialoproteins...
  20. pmc Evidence for polymorphonuclear leukocyte collagenase and 92-kilodalton gelatinase in gingival crevicular fluid
    C M Overall
    Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    Infect Immun 59:4687-92. 1991
    ....
  21. ncbi request reprint Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence
    R H Kim
    Department of Biochemistry, University of Toronto, Ontario, Canada
    Matrix Biol 14:31-40. 1994
    ..These studies have defined the structure of the human BSP gene and have identified novel transcriptional elements in the promoter that may be involved in the developmentally regulated, tissue specific expression of this gene...
  22. ncbi request reprint Recruitment of nuclear factor Y to the inverted CCAAT element (ICE) by c-Jun and E1A stimulates basal transcription of the bone sialoprotein gene in osteosarcoma cells
    Ming Su
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, ON
    J Biol Chem 280:38365-75. 2005
    ....
  23. ncbi request reprint Collagen phagocytosis by fibroblasts is regulated by decorin
    Vinay M Bhide
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Ontario
    J Biol Chem 280:23103-13. 2005
    ..Thus a novel collagen binding domain in decorin acts cooperatively with leucine-rich repeat 4 to mask the alpha2beta1 integrin-binding site on collagen, an important sequence for the phagocytosis of collagen fibrils...
  24. ncbi request reprint Characterization of the 5'-flanking region of the rat AJ18 gene
    Andrew H Jheon
    Department of Biochemistry, University of Toronto, Room 239 FitzGerald Building, 150 College Street, Toronto, Ont M5S 3E2, Canada
    Gene 310:203-13. 2003
    ..8/17 compared to the fibroblast-like C3H10T1/2. Notably, this is the first gene promoter from the large KRAB/C(2)H(2) zinc finger family of proteins to be identified and characterized...
  25. ncbi request reprint Increased cell death in osteopontin-deficient cardiac fibroblasts occurs by a caspase-3-independent pathway
    Ron Zohar
    Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, 124 Edward Street, Rm 464A, Toronto, Ontario M5G 1G6, Canada
    Am J Physiol Heart Circ Physiol 287:H1730-9. 2004
    ..We suggest that the increased expression of OPN in the myocardium after reperfusion may promote fibrosis by protecting cardiac fibroblasts from cell death...
  26. ncbi request reprint Stereochemical analysis of the functional significance of the conserved inverted CCAAT and TATA elements in the rat bone sialoprotein gene promoter
    Ming Su
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, 234 FitzGerald Building, 150 College Street, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 281:9882-90. 2006
    ..Thus, the precise location and orientation of the CCAAT element is necessary for optimizing basal transcription of the bone sialoprotein gene...
  27. pmc Bone sialoprotein does not interact with pro-gelatinase A (MMP-2) or mediate MMP-2 activation
    Queena Hwang
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Canada
    BMC Cancer 9:121. 2009
    ..This model is particularly relevant to cancer cell metastasis to bone since BSP, bound to the alphavbeta3 integrin through its arginine-glycine-aspartic acid motif, could recruit MMP-2 to the cell surface...
  28. ncbi request reprint Phagocytosis of collagen by fibroblasts and invasive cancer cells is mediated by MT1-MMP
    H Lee
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, Room 234, Fitzgerald Building, University of Toronto, 150 College Street, Toronto, ON, Canada M5S 3E2
    Biochem Soc Trans 35:704-6. 2007
    ..Collectively, these studies demonstrate a pivotal role for catalytically active MT1-MMP in preparing collagen fibrils for phagocytic degradation by normal and transformed cells...
  29. ncbi request reprint Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration
    R Zohar
    MRC Group in Periodontal Physiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Cell Physiol 184:118-30. 2000
    ..These studies indicate that OPN exists as an integral component of a hyaluronan-CD44-ERM attachment complex that is involved in the migration of embryonic fibroblasts, activated macrophages, and metastatic cells...
  30. ncbi request reprint Characterization of a novel KRAB/C2H2 zinc finger transcription factor involved in bone development
    A H Jheon
    CIHR Group in Periodontal Physiology and the Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 276:18282-9. 2001
    ..These studies, therefore, have identified a novel zinc finger transcription factor in bone that can modulate Runx2 activity and osteogenic differentiation...
  31. ncbi request reprint Is SPARC an evolutionarily conserved collagen chaperone?
    N Martinek
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada M5S 3G5
    J Dent Res 86:296-305. 2007
    ..Hence, SPARC may also play a role in regulating post-endoplasmic reticulum events that promote collagen fibrillogenesis...
  32. ncbi request reprint Osteopontin expression is required for myofibroblast differentiation
    Yair Lenga
    Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario M5G 1G6, Canada
    Circ Res 102:319-27. 2008
    ..These studies demonstrate that OPN is required for the differentiation and activity of myofibroblasts formed in response to the profibrotic cytokine transforming growth factor-beta1...
  33. pmc Role of osteopontin in neutrophil function
    Adeline Koh
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, Department of Biochemistry, University of Toronto, Toronto, Ont, Canada
    Immunology 122:466-75. 2007
    ..These studies demonstrate that, while exogenous OPN may be important for the recruitment and migration of neutrophils, expression of OPN by neutrophils is not required for their destructive capabilities...
  34. ncbi request reprint Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death
    Andre Paes Batista Da Silva
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada
    J Cell Physiol 208:629-39. 2006
    ..Collectively, these studies demonstrate that OPN is required for mucosal protection in acute inflammatory colitis...
  35. ncbi request reprint Methylglyoxal inhibits the binding step of collagen phagocytosis
    Sandra A C Chong
    Canadian Institutes of Health Research Group in Matrix Dynamics, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    J Biol Chem 282:8510-20. 2007
    ..Thus, MGO modifications of Arg residues in collagen could be a key factor in the impaired degradation of collagen that promotes fibrosis in chronic infections, such as periodontitis...
  36. ncbi request reprint Differential binding to dorsal and ventral cell surfaces of fibroblasts: effect on collagen phagocytosis
    Pamela D Arora
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3EZ, Canada
    Exp Cell Res 286:366-80. 2003
    ..Thus integrin ligation by actin filaments regulates the mobility of collagen receptors which in turn mediates the enhanced binding of collagen beads on spreading surfaces...
  37. ncbi request reprint Analysis of human bone sialoprotein in normal and pathological tissues using a monoclonal antibody (BSP 1.2 mab)
    Gabrielle Cogan
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Ontario, Canada
    Connect Tissue Res 45:60-71. 2004
    ..These studies, therefore, have identified a unique epitope in human BSP recognized by a monoclonal antibody, BSP 1.2 mab, which can be used for the unequivocal identification of BSP in normal and pathological human tissues...
  38. ncbi request reprint Characterization of the promoter region of the porcine opn (osteopontin, secreted phosphoprotein 1) gene. Identification of positive and negative regulatory elements and a 'silent' second promoter
    Q Zhang
    MRC Group in Periodontal Physiology, University of Toronto, Canada
    Eur J Biochem 207:649-59. 1992
    ..Setoguchi, M., Yoshida, S., Higuchi, Y., Akizuki, S. & Yamamoto, S. (1990) J. Biol. Chem. 265, 14432-14438).(ABSTRACT TRUNCATED AT 400 WORDS)..
  39. pmc A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis
    Hyejin Lee
    Canadian Institutes of Health Research Group in Matrix Dynamics, Faculty of Dentistry, and Department of Biochemistry, Faculty of Medicine, University of Toronto, Toronto, Ontario M5S 3E2, Canada
    Mol Biol Cell 17:4812-26. 2006
    ..In contrast to MT1-MMP, the gelatinolytic activity of MMP-2 was not required for collagen phagocytosis. These studies demonstrate a pivotal role of catalytically active MT1-MMP in preparing collagen fibrils for phagocytic degradation...
  40. ncbi request reprint Evolutionary conservation and association of SPARC with the basal lamina in Drosophila
    Nathalie Martinek
    Department of Zoology, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    Dev Genes Evol 212:124-33. 2002
    ....
  41. ncbi request reprint Thrombin mediated migration of osteogenic cells
    Jeffrey M Karp
    Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Toronto, Ontario, Canada
    Bone 37:337-48. 2005
    ..The cell migration/bone nodule assay described here is the first assay that can be specifically used to examine the effects of factors on the migration of osteoprogenitor cells, particularly those derived from primary populations...
  42. ncbi request reprint Polarization and directed migration of murine neutrophils is dependent on cell surface expression of CD44
    Per Alstergren
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Canada M5S 3E2
    Cell Immunol 231:146-57. 2004
    ..Thus, both polarization and directed migration of neutrophils are dependent on the expression of CD44 and its interaction with hyaluronan, which could modulate neutrophil migration into inflamed tissues...
  43. ncbi request reprint Emdogain regulation of cellular differentiation in wounded rat periodontium
    Laura Chano
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Canada
    J Periodontal Res 38:164-74. 2003
    ..Therefore the effect of Emdogain on wound healing in the periodontium may be independent of differentiation in the cell populations examined in this model...
  44. ncbi request reprint Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin
    Baoqian Zhu
    CIHR Group in Matrix Dynamics, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Cell Physiol 198:155-67. 2004
    ....
  45. doi request reprint Osteopontin attenuation of dextran sulfate sodium-induced colitis in mice
    Andre Paes Batista Da Silva
    CIHR Group in Matrix Dynamics, University of Toronto, Toronto, ON, Canada
    Lab Invest 89:1169-81. 2009
    ..This study shows that administration of a physiological concentration of milk OPN in drinking water ameliorates the destructive host response in DSS-induced acute colitis...
  46. ncbi request reprint Delineation of the hydroxyapatite-nucleating domains of bone sialoprotein
    Coralee E Tye
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Biochemistry, School of Dentistry, University of Western Ontario, London, Canada
    J Biol Chem 278:7949-55. 2003
    ..These results demonstrate that a sequence of at least eight contiguous glutamic acid residues is required for the nucleation of HA by BSP and that this nucleating "site" is not alpha-helical in conformation...
  47. ncbi request reprint Prostaglandin E2 stimulates bone sialoprotein (BSP) expression through cAMP and fibroblast growth factor 2 response elements in the proximal promoter of the rat BSP gene
    Hiroshi Samoto
    Periodontology, Endodontics, Pharmacology, Physiology, and Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Chiba, 271 8587, Japan
    J Biol Chem 278:28659-67. 2003
    ..These studies show that PGE2 induces BSP transcription in UMR 106 cells through juxtaposed CRE and FRE elements in the proximal promoter of the BSP gene...
  48. ncbi request reprint Identification of FGF2-response element in the rat bone sialoprotein gene promoter
    Emi Shimizu-Sasaki
    Department of Endodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    Connect Tissue Res 44:103-8. 2003
    ..Thus, we have identified a novel FRE within the proximal promoter of the BSP gene that mediates both constitutive and FGF2-induced BSP transcription...
  49. ncbi request reprint Fibroblast growth factor 2 and cyclic AMP synergistically regulate bone sialoprotein gene expression
    Emi Shimizu
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba 271 8587, Japan
    Bone 39:42-52. 2006
    ....
  50. ncbi request reprint Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway
    Wen Chin Huang
    Molecular Urology and Therapeutics Program, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 65:2303-13. 2005
    ....
  51. ncbi request reprint Insulin-like growth factor-I increases bone sialoprotein (BSP) expression through fibroblast growth factor-2 response element and homeodomain protein-binding site in the proximal promoter of the BSP gene
    Youhei Nakayama
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, Japan
    J Cell Physiol 208:326-35. 2006
    ..These studies demonstrate that IGF-I stimulates BSP transcription by targeting the FRE and HOX elements in the proximal promoter of BSP gene...
  52. ncbi request reprint An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter
    Ling Li
    Division of Oral Biology, Tufts School of Dental Medicine, Boston, Massachusetts 02111, USA
    J Bone Miner Res 20:1403-13. 2005
    ..The model was validated by showing suppressed BSP expression and delayed bone and tooth formation after infection with a virus expressing a mutated Cbfa1/Runx2 gene...
  53. ncbi request reprint TNF-alpha suppresses bone sialoprotein (BSP) expression in ROS17/2.8 cells
    Hiroshi Samoto
    Department of Orthodontics, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    J Cell Biochem 87:313-23. 2002
    ....
  54. pmc Osteoclast responses to lipopolysaccharide, parathyroid hormone and bisphosphonates in neonatal murine calvaria analyzed by laser scanning confocal microscopy
    Keiko Suzuki
    Department of Pharmacology, School of Dentistry, Showa University, Shinagawa, Tokyo, Japan
    J Histochem Cytochem 53:1525-37. 2005
    ....