A S Slutsky

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study
    Jan Willem Kuiper
    From the Department of Paediatric Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Anesthesiol 11:26. 2011
  2. pmc Protective ventilation of patients with acute respiratory distress syndrome
    Claudia C dos Santos
    Interdepartmental Division of Critical Care Medicine, and Department of Medicine, University of Toronto, Toronto, Canada
    Crit Care 8:145-7. 2004
  3. pmc Bench-to-bedside review: Biotrauma and modulation of the innate immune response
    Claudia C dos Santos
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care 9:280-6. 2005
  4. pmc Assisted spontaneous breathing during early acute lung injury
    Lukas Brander
    Interdepartmental Division of Critical Care, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care 10:102. 2006
  5. pmc Year in review in Critical Care, 2003 and 2004: respirology and critical care
    Lukas Brander
    Interdepartmental Division of Critical Care, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care 9:517-22. 2005
  6. pmc Year in review 2005: Critical Care--respirology: mechanical ventilation, infection, monitoring, and education
    Jack J Haitsma
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Crit Care 10:217. 2006
  7. pmc Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation
    Martin C J Kneyber
    Department of Pediatric Intensive Care, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Crit Care 13:R87. 2009
  8. pmc Monitoring and oversight in critical care research
    James V Lavery
    Centre for Global Health Research and Inner City Health Research Unit, St Michael s Hospital, Department of Public Health Sciences and Joint Centre for Bioethics, University of Toronto, Toronto, Canada
    Crit Care 8:403-5. 2004
  9. ncbi request reprint Data safety and monitoring boards
    Arthur S Slutsky
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    N Engl J Med 350:1143-7. 2004
  10. pmc Hot new therapy for sepsis and the acute respiratory distress syndrome
    Arthur S Slutsky
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 110:737-9. 2002

Research Grants

  1. From Bench to Bedside to Curbside
    Arthur Slutsky; Fiscal Year: 2007

Detail Information

Publications90

  1. pmc High tidal volume mechanical ventilation-induced lung injury in rats is greater after acid instillation than after sepsis-induced acute lung injury, but does not increase systemic inflammation: an experimental study
    Jan Willem Kuiper
    From the Department of Paediatric Intensive Care, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Anesthesiol 11:26. 2011
    ..abstract:..
  2. pmc Protective ventilation of patients with acute respiratory distress syndrome
    Claudia C dos Santos
    Interdepartmental Division of Critical Care Medicine, and Department of Medicine, University of Toronto, Toronto, Canada
    Crit Care 8:145-7. 2004
    ..Special emphasis is placed on the theory of biotrauma, which attempts to explain how multi-organ failure may develop in patients who ultimately succumb to this syndrome...
  3. pmc Bench-to-bedside review: Biotrauma and modulation of the innate immune response
    Claudia C dos Santos
    Department of Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care 9:280-6. 2005
    ..In this paper, we explore the pertinent evidence implicating biotrauma caused by cyclic MV and its effect on innate immune responses...
  4. pmc Assisted spontaneous breathing during early acute lung injury
    Lukas Brander
    Interdepartmental Division of Critical Care, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care 10:102. 2006
    ..Combined with previous data demonstrating improved cardiorespiratory variables, airway pressure release ventilation with spontaneous breathing may turn out to be a less injurious ventilatory strategy...
  5. pmc Year in review in Critical Care, 2003 and 2004: respirology and critical care
    Lukas Brander
    Interdepartmental Division of Critical Care, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, Toronto, Ontario, Canada
    Crit Care 9:517-22. 2005
    ....
  6. pmc Year in review 2005: Critical Care--respirology: mechanical ventilation, infection, monitoring, and education
    Jack J Haitsma
    Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada
    Crit Care 10:217. 2006
    ....
  7. pmc Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation
    Martin C J Kneyber
    Department of Pediatric Intensive Care, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Crit Care 13:R87. 2009
    ..We hypothesized that mechanical ventilation (MV) augmented sepsis-induced myocardial CML deposition and inflammation...
  8. pmc Monitoring and oversight in critical care research
    James V Lavery
    Centre for Global Health Research and Inner City Health Research Unit, St Michael s Hospital, Department of Public Health Sciences and Joint Centre for Bioethics, University of Toronto, Toronto, Canada
    Crit Care 8:403-5. 2004
    ..The appropriate role of critical care researchers and research administrators is to provide leadership to move toward a greater recognition of the importance of monitoring and oversight for ethical and high quality clinical research...
  9. ncbi request reprint Data safety and monitoring boards
    Arthur S Slutsky
    Department of Medicine, St Michael s Hospital, Toronto, Canada
    N Engl J Med 350:1143-7. 2004
  10. pmc Hot new therapy for sepsis and the acute respiratory distress syndrome
    Arthur S Slutsky
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
    J Clin Invest 110:737-9. 2002
  11. pmc Mechanical ventilation: lessons from the ARDSNet trial
    A S Slutsky
    St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Respir Res 1:73-7. 2000
    ..The implications of this study with respect to clinical practice, further ARDS studies and clinical research in the critical care setting are discussed...
  12. ncbi request reprint Genetics of asthma: a primer
    A S Slutsky
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Canada
    Can Respir J 5:4A-8A. 1998
    ....
  13. ncbi request reprint William John Sibbald: in memoriam
    Arthur S Slutsky
    Interdepartmental Division of Critical Care Medicine, University of Toronto, St Michael s Hospital, Ont, Toronto, Canada
    Intensive Care Med 32:1945-6. 2006
  14. doi request reprint Plasma-derived human antithrombin attenuates ventilator-induced coagulopathy but not inflammation in a Streptococcus pneumoniae pneumonia model in rats
    H Aslami
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, ON, Canada
    J Thromb Haemost 10:399-410. 2012
    ....
  15. ncbi request reprint Effect of adrenoreceptors on endotoxin-induced cytokines and lipid peroxidation in lung explants
    H Zhang
    Division of Respiratory Medicine, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Toronto, Ontario, Canad
    Am J Respir Crit Care Med 160:1703-10. 1999
    ....
  16. ncbi request reprint Exhaled nitric oxide and bronchial reactivity during and after inhaled beclomethasone in mild asthma
    P E Silkoff
    Division of Respiratory Medicine, Faculty of Medicine, The University of Toronto, Canada
    J Asthma 35:473-9. 1998
    ..3+/-46.1 at 1 week after withdrawal. ENO did not correlate with PC20 or FEV1. The changes in ENO and PC20 were inversely correlated (r2 = 0.325). ENO may be an index of airway inflammation and therapeutic response in bronchial asthma...
  17. ncbi request reprint Pressure-time curve predicts minimally injurious ventilatory strategy in an isolated rat lung model
    V M Ranieri
    Division of Respiratory Medicine, Samuel Lunenfeld Research Institute, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 93:1320-8. 2000
    ..We tested the hypothesis that the pressure-time (P-t) curve during constant flow ventilation can be used to set a noninjurious ventilatory strategy...
  18. ncbi request reprint Changes in cross-sectional airway areas induced by methacholine, histamine, and LTC4 in asthmatic subjects
    N A Molfino
    Department of Medicine, University of Toronto, Ontario, Canada
    Am Rev Respir Dis 146:577-80. 1992
    ..05; ANOVA). These results may be explained by distinct pharmacologic properties of the agents used and may have relevance in the understanding of the pathophysiology of asthma...
  19. ncbi request reprint Defining the asthma phenotype for the purpose of genetic analysis
    S Kesten
    University of Toronto, Canada
    J Asthma 34:483-91. 1997
    ....
  20. ncbi request reprint Direct and indirect bacterial killing functions of neutrophil defensins in lung explants
    G A Porro
    Respiratory Division, Department of Anaesthesia, St. Michael's Hospital, Toronto M5B 1W8, Canada
    Am J Physiol Lung Cell Mol Physiol 281:L1240-7. 2001
    ..We conclude that defensins exert a significant antimicrobial effect under physiological conditions and that this effect is enhanced in the presence of lung tissue by a mechanism that involves the production of reactive oxygen species...
  21. ncbi request reprint An evaluation of flow-volume curves as a screening test for obstructive sleep apnea
    I Katz
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Chest 98:337-40. 1990
    ..We conclude that because of low sensitivity, flow-volume loops are not a useful screening test for the diagnosis of OSA in snoring patients...
  22. doi request reprint Ventilator-induced coagulopathy in experimental Streptococcus pneumoniae pneumonia
    J J Haitsma
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Keenan Research Center, Li Ka Shing Knowledge Institute, St Michael s Hospital, 30 Bond Street, Queen Wing 4 042, Toronto, ON, M5B 1W8 Canada
    Eur Respir J 32:1599-606. 2008
    ..Mechanical ventilation causing ventilator-induced lung injury increases pulmonary coagulopathy in an animal model of Streptococcus pneumoniae pneumonia and results in systemic coagulopathy...
  23. ncbi request reprint Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines
    R A Veldhuizen
    Dept of Medicine, University of Western Ontario, Toronto, Canada
    Eur Respir J 17:488-94. 2001
    ..It was also concluded that in this model, the lung injury is, in part, mediated by the surfactant system and the release of inflammatory mediators...
  24. ncbi request reprint Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion
    H Zhang
    Departments of Anaesthesia and Critical Care Medicine, St Michael s Hospital, Toronto M5B 1W8, Ontario M5G 2C4, Canada
    Am J Physiol Lung Cell Mol Physiol 280:L947-54. 2001
    ....
  25. ncbi request reprint Safety and efficacy of a sustained inflation for alveolar recruitment in adults with respiratory failure
    S E Lapinsky
    Department of Medicine, Mount Sinai Hospital, Ontario, Canada
    Intensive Care Med 25:1297-301. 1999
    ..To assess the safety and efficacy of a sustained inflation, used as a lung volume recruitment maneuver in ventilated patients with hypoxemic respiratory failure...
  26. ncbi request reprint Relative hysteresis of the airways and lung parenchyma in normal subjects
    I Katz
    Department of Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    J Appl Physiol (1985) 65:2390-4. 1988
    ....
  27. ncbi request reprint Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
    V M Ranieri
    Istituto di Anestesiologia e Rianimazione, Universita di Bari, Ospedale Policlinico, Italy
    JAMA 282:54-61. 1999
    ....
  28. ncbi request reprint Alterations of nitric oxide synthase expression and activity during rat lung transplantation
    M Liu
    Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto M5G 2C4, Canada
    Am J Physiol Lung Cell Mol Physiol 278:L1071-81. 2000
    ..We conclude that ischemic lung preservation and reperfusion result in altered NOS gene and protein expression with inhibited NOS activity, which may contribute to the injury of lung transplants...
  29. doi request reprint Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury
    S C Ko
    The Keenan Research Centre in the Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, ON, Canada
    Acta Anaesthesiol Scand 52:514-21. 2008
    ..Different levels of positive end-expiratory pressure (PEEP) with and without a recruitment maneuver (RM) may have a significant impact on ventilator-induced lung injury but this issue has not been well addressed...
  30. ncbi request reprint DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch
    C C dos Santos
    Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada
    Physiol Genomics 19:331-42. 2004
    ..Results from this study indicate that AECs can tailor their response to different stimuli or/and combination of stimuli and subsequently play an important role in acute inflammatory responses in the lung...
  31. pmc The pulmonary physician in critical care * 7: ventilator induced lung injury
    T Whitehead
    Department of Critical Care, St Michael s Hospital, Interdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada
    Thorax 57:635-42. 2002
  32. ncbi request reprint Agreement between alternative classifications of acute respiratory distress syndrome
    M O Meade
    Department of Medicine, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 163:490-3. 2001
    ..These discordant classifications had no prognostic importance...
  33. ncbi request reprint Lung recruitment during small tidal volume ventilation allows minimal positive end-expiratory pressure without augmenting lung injury
    P C Rimensberger
    Department of Critical Care, The Hospital for Sick Children, University of Toronto, Ontario, Canada
    Crit Care Med 27:1940-5. 1999
    ....
  34. ncbi request reprint Overview of high-frequency ventilation modes, clinical rationale, and gas transport mechanisms
    C C dos Santos
    Department of Critical Care Medicine, University of Toronto, Ontario, Canada
    Respir Care Clin N Am 7:549-75. 2001
    ..It is hoped that the results of these studies will identify the future role for HFV in the clinical setting...
  35. ncbi request reprint Pharmacotherapy of acute respiratory distress syndrome
    C C dos Santos
    Department of Critical Care Medicine, St Michael s Hospital, Toronto, Ontario, Canada
    Expert Opin Pharmacother 3:875-88. 2002
    ..In addition, the pathophysiological basis for their putative modes of action, the current state of the literature and the potential for future clinical development will be discussed...
  36. ncbi request reprint Dose-response relationship and reproducibility of the fall in exhaled nitric oxide after inhaled beclomethasone dipropionate therapy in asthma patients
    P E Silkoff
    Toronto Hospital, Toronto, Ontario, Canada
    Chest 119:1322-8. 2001
    ..We determined the dose response and the reproducibility of the FENO fall following inhaled beclomethasone dipropionate (iBDP) therapy in nonsteroid-treated asthmatic patients...
  37. ncbi request reprint The contribution of biophysical lung injury to the development of biotrauma
    Claudia C dos Santos
    Department of Medicine, St Michael s Hospital, Toronto, Ontario M5B 1W8, Canada
    Annu Rev Physiol 68:585-618. 2006
    ..In this review we explore the biotrauma hypothesis, the causal relationship between biophysical injury and organ failure, and its implications for the future therapy and management of critically ill patients...
  38. doi request reprint Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial
    Maureen O Meade
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 299:637-45. 2008
    ..Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality...
  39. ncbi request reprint Development of a clinical definition for acute respiratory distress syndrome using the Delphi technique
    Niall D Ferguson
    Interdepartmental Division of Critical Care, University of Toronto, ON, Canada
    J Crit Care 20:147-54. 2005
    ..The objective of this study is to describe the implementation of formal consensus techniques in the development of a clinical definition for acute respiratory distress syndrome...
  40. ncbi request reprint Angiotensin-converting enzyme 2 protects from severe acute lung failure
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna A 1030, Austria
    Nature 436:112-6. 2005
    ..Our data identify a critical function for ACE2 in acute lung injury, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year...
  41. ncbi request reprint Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumonia--a review
    Marcus J Schultz
    Department of Intensive Care Medicine, University of Amsterdam, Netherlands, and the Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, ON, Canada
    Crit Care Med 34:871-7. 2006
    ..To review the involvement of coagulation and fibrinolysis in the pathogenesis of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), pulmonary infection, and ventilator-induced lung injury (VILI)...
  42. ncbi request reprint Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..Moreover, deletion of ncf1, which controls ROS production, improves the severity of H5N1-mediated ALI. Our data identify oxidative stress and innate immunity as key lung injury pathways that control the severity of ALI...
  43. ncbi request reprint Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats
    Ettore Crimi
    Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Am J Respir Crit Care Med 174:178-86. 2006
    ..Hypothesis: HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury...
  44. doi request reprint Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates ventilator-induced lung injury
    Rosanna Vaschetto
    The Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 108:261-8. 2008
    ..Therefore, the authors hypothesized that the pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase by PJ-34 would attenuate ventilator-induced lung injury...
  45. ncbi request reprint Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome
    Jesus Villar
    Multidisciplinary Organ Dysfunction Evaluation Research Network MODERN, Research Unit, Hospital Universitario Dr Negrin, Barranco de la Ballena, Las Palmas de Gran Canaria, Canary Islands, Spain
    Intensive Care Med 34:488-95. 2008
    ..We hypothesized that the I/D polymorphism also confers susceptibility to sepsis and is a predisposing factor for morbidity and mortality of patients with severe sepsis...
  46. ncbi request reprint Non-invasive neurally adjusted ventilatory assist in rabbits with acute lung injury
    Jennifer Beck
    Sunnybrook Health Sciences Centre, Department of Newborn and Developmental Paediatrics, 76 Grenville, 4th floor Paediatrics, M5S 1B6, Toronto, Ontario, Canada
    Intensive Care Med 34:316-23. 2008
    ..The aim of this study was to evaluate whether NAVA can deliver assist in synchrony and proportionally to EAdi after extubation, with a leaky non-invasive interface...
  47. ncbi request reprint A primer on data safety monitoring boards: mission, methods, and controversies
    Lisa K Hicks
    Department of Medicine, Division of Oncology Hematology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada
    Intensive Care Med 33:1815-8. 2007
  48. ncbi request reprint Understanding high-frequency oscillation: lessons from the animal kingdom
    Niall D Ferguson
    Intensive Care Med 33:1316-8. 2007
  49. ncbi request reprint What tidal volumes should be used in patients without acute lung injury?
    Marcus J Schultz
    Department of Intensive Care Medicine and Laboratory of Experimental Intensive Care and Anesthesiology, University of Amsterdam, and Interdepartmental Division of Critical Care, St Michael s Hospital, Toronto, Ontario, Canada
    Anesthesiology 106:1226-31. 2007
    ..Prospective studies should be performed to evaluate optimal ventilator management strategies for patients without ALI...
  50. ncbi request reprint Improved synchrony and respiratory unloading by neurally adjusted ventilatory assist (NAVA) in lung-injured rabbits
    Jennifer Beck
    Sunnybrook Health Sciences Centre, Department of Pediatrics, University of Toronto, Women s College Hospital, Toronto, Ontario, Canada M5S 1B6
    Pediatr Res 61:289-94. 2007
    ..05) due to the increased wasted efforts. We conclude that synchrony with the ventilator is an important determinant for diaphragm unloading...
  51. ncbi request reprint Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome
    Pier Paolo Terragni
    Universita di Torino, Dipartimento di Anestesiologia e Rianimazione, Ospedale S Giovanni Battista Molinette, Corso Dogliotti 14, 10126 Turin, Italy
    Am J Respir Crit Care Med 175:160-6. 2007
    ..Computed tomography demonstrated a small, normally aerated compartment on the top of poorly aerated and nonaerated compartments that may be hyperinflated by tidal inflation...
  52. ncbi request reprint Role of oxidative stress in experimental sepsis and multisystem organ dysfunction
    Ettore Crimi
    Department of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, Novara, Italy
    Free Radic Res 40:665-72. 2006
    ..Based on this experimental evidence, we could improve the rationale of supplementation of antioxidants alone or in combination with standard therapies aimed to reduce oxidative stress as novel adjunct treatment in critical care...
  53. ncbi request reprint Influence of neurally adjusted ventilatory assist and positive end-expiratory pressure on breathing pattern in rabbits with acute lung injury
    Jean Christophe Allo
    Service d Acceuil et de Traitement des Urgences, Hopital Cochin, Paris, France
    Crit Care Med 34:2997-3004. 2006
    ..To evaluate the influence of neurally adjusted ventilatory assist (NAVA) and positive end-expiratory pressure (PEEP) on the control of breathing in rabbits with acute lung injury...
  54. ncbi request reprint Ventilator-induced lung injury: from barotrauma to biotrauma
    Arthur S Slutsky
    Interdepartmental Division of Critcal Care Medicine, University of Toronto, Ontario, Canada
    Respir Care 50:646-59. 2005
  55. ncbi request reprint Pathogenesis of ventilator-induced lung injury: trials and tribulations
    Lorraine N Tremblay
    Am J Physiol Lung Cell Mol Physiol 288:L596-8. 2005
  56. ncbi request reprint High-frequency oscillatory ventilation and ventilator-induced lung injury
    Yumiko Imai
    Institute of Molecular Biotechnology, Austrian Academy of Science, Vienna, Austria
    Crit Care Med 33:S129-34. 2005
    ....
  57. ncbi request reprint Critically ill patients with severe acute respiratory syndrome
    Robert A Fowler
    Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario
    JAMA 290:367-73. 2003
    ..Severe acute respiratory syndrome (SARS) is a newly recognized infectious disease capable of causing severe respiratory failure...
  58. ncbi request reprint The ICU outreach team
    Damon C Scales
    Adult Critical Care Program, and the Interdepartmental Division of Critical Care Medicine, University of Toronto, Ontario, Canada
    J Crit Care 18:95-106. 2003
  59. ncbi request reprint Effects of albumin and Ringer's lactate on production of lung cytokines and hydrogen peroxide after resuscitated hemorrhage and endotoxemia in rats
    Haibo Zhang
    Department of Anaesthesia, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, Canada
    Crit Care Med 31:1515-22. 2003
    ..We tested the hypothesis that the types of fluids used during early resuscitation have an important effect on the evolution of lung injury...
  60. ncbi request reprint Mechanical ventilation may increase susceptibility to the development of bacteremia
    Chang Yi Lin
    Department of Medicine, Mackay Memorial Hospital, Taiwan
    Crit Care Med 31:1429-34. 2003
    ..We examined the hypothesis that mechanical ventilation with a potentially injurious strategy would predispose animals to the detrimental effects of subsequent instillation of bacteria...
  61. ncbi request reprint Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome
    Yumiko Imai
    Department of Critical Care, St Michael s Hospital, University of Toronto, Toronto, Ontario
    JAMA 289:2104-12. 2003
    ..Recent clinical trials have demonstrated a decrease in multiple organ dysfunction syndrome (MODS) and mortality in patients with acute respiratory distress syndrome (ARDS) treated with a protective ventilatory strategy...
  62. ncbi request reprint Conventional mechanical ventilation is associated with bronchoalveolar lavage-induced activation of polymorphonuclear leukocytes: a possible mechanism to explain the systemic consequences of ventilator-induced lung injury in patients with ARDS
    Haibo Zhang
    Department of Anaesthesia and Critical Care Program, Interdepartmental Division of Critical Care Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesthesiology 97:1426-33. 2002
    ....
  63. ncbi request reprint Genetics of critical illness: methodological issues
    Arthur S Slutsky
    Crit Care Med 30:2382-3. 2002
  64. ncbi request reprint Injurious ventilation induces widespread pulmonary epithelial expression of tumor necrosis factor-alpha and interleukin-6 messenger RNA
    Lorraine N Tremblay
    Department of Critical Care, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Crit Care Med 30:1693-700. 2002
    ..We examined the hypothesis that injurious strategies of mechanical ventilation alter the expression and distribution within the lung of tumor necrosis factor-alpha and interleukin-6 that are both duration and ventilation strategy dependent...
  65. ncbi request reprint Ventilation with negative airway pressure induces a cytokine response in isolated mouse lung
    Kuo Chen Cheng
    Departments of Anaesthesia and Critical Care Medicine, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada
    Anesth Analg 94:1577-82, table of contents. 2002
    ..Atelectatic lung during repeated collapse and reopening of lung units accentuates the lung cytokine response that may contribute to lung injury even during relatively low VT mechanical ventilation...
  66. pmc From bench to bedside: bacterial growth and cytokines
    Claudia C dos Santos
    University of Toronto, Ontario, Canada
    Crit Care 6:4-6. 2002
  67. ncbi request reprint Ventilator-induced lung injury, cytokines, PEEP, and mortality: implications for practice and for clinical trials
    Arthur S Slutsky
    Intensive Care Med 29:1218-21. 2003
  68. pmc Weapons of mass salvation: Canada's role in improving the health of the global poor
    Prabhat Jha
    Department of Public Health Sciences, University of Toronto, Toronto, Ont
    CMAJ 170:66-7. 2004
  69. ncbi request reprint Effect of mechanical ventilation on cytokine response to intratracheal lipopolysaccharide
    Thomas C Whitehead
    Departments of Anesthesia and Critical Care Medicine, St Michael s Hospital, University of Toronto, Canada
    Anesthesiology 101:52-8. 2004
    ..The authors tested the hypothesis that intratracheal lipopolysaccharide amplifies the cytokine response to mechanical ventilation...
  70. ncbi request reprint Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses
    Frans B Plötz
    Department of Pediatric Intensive Care, VU Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Intensive Care Med 30:1865-72. 2004
    ..To review how biotrauma leads to the development of multiple system organ failure (MSOF)...
  71. ncbi request reprint Clinical issues and research in respiratory failure from severe acute respiratory syndrome
    Mitchell M Levy
    Department of Medicine, Brown University Rhode Island Hospital, Providence, USA
    Am J Respir Crit Care Med 171:518-26. 2005
    ..The group recommended preparation for studies, including protocols, ethical considerations, Web-based registries, and data entry systems...
  72. ncbi request reprint Mechanical ventilation and acute renal failure
    Jan Willem Kuiper
    Department of Pediatric Intensive Care, VU Medical Center, Amsterdam, The Netherlands
    Crit Care Med 33:1408-15. 2005
    ..To review the current literature on possible mechanisms by which mechanical ventilation may initiate or aggravate acute renal failure...
  73. ncbi request reprint Biotrauma hypothesis of ventilator-induced lung injury
    Stefan Uhlig
    Am J Respir Crit Care Med 169:314-5; author reply 315. 2004
  74. ncbi request reprint Effects of cyclic opening and closing at low- and high-volume ventilation on bronchoalveolar lavage cytokines
    Eric K Chu
    Department of Medicine and Critical Care Medicine, St Michael s Hospital, University of Toronto, Ontario, Canada
    Crit Care Med 32:168-74. 2004
    ..To examine the mechanisms of ventilator-induced lung injury at low and high lung volumes...
  75. ncbi request reprint Mechanical ventilation alters the immune response in children without lung pathology
    Frans B Plötz
    Pediatric Intensive Care Unit, University Medical Center Utrecht, The Netherlands
    Intensive Care Med 28:486-92. 2002
    ..This study was undertaken to examine the hypothesis that mechanical ventilation in association with anesthesia would alter the cytokine profile in infants without preexisting lung pathology...
  76. ncbi request reprint Effects of recruiting maneuvers in patients with acute respiratory distress syndrome ventilated with protective ventilatory strategy
    Salvatore Grasso
    Servizio di Anestesiologia e Rianimazione, Ospedale Di Venere, Bari, Italy
    Anesthesiology 96:795-802. 2002
    ..This study examined the hypothesis that the effectiveness of a recruiting maneuver to improve oxygenation in patients with ARDS would be influenced by the elastic properties of the lung and chest wall...
  77. ncbi request reprint Lung stress and strain in acute respiratory distress syndrome: good ideas for clinical management?
    Roy G Brower
    Am J Respir Crit Care Med 178:323-4. 2008
  78. ncbi request reprint Airway pressure-time curve profile (stress index) detects tidal recruitment/hyperinflation in experimental acute lung injury
    Salvatore Grasso
    Servizio di Anestesia e Rianimazione, Ospedale Di Venere, Bari, Italy
    Crit Care Med 32:1018-27. 2004
    ..To evaluate whether the shape of the airway pressure-time (Paw-t) curve during constant flow inflation corresponds to radiologic evidence of tidal recruitment or tidal hyperinflation in an experimental model of acute lung injury...
  79. ncbi request reprint What lessons can we learn from NOS knockout mice in acute pulmonary disease?
    Jeremy A Scott
    Crit Care Med 30:2143-5. 2002
  80. ncbi request reprint Intercellular adhesion molecule-1 mediates cellular cross-talk between parenchymal and immune cells after lipopolysaccharide neutralization
    Jin Hwa Lee
    Departments of Anaesthesia and Critical Care Medicine, Division of Respiratory Medicine, University of Toronto, St Michael s Hospital, 30 Bond Street, Toronto, Ontario, Canada M5B 1W8
    J Immunol 172:608-16. 2004
    ..This may provide an explanation for the failure of anti-LPS therapies in sepsis trials...
  81. ncbi request reprint Effect of ventilator-induced lung injury on the development of reperfusion injury in a rat lung transplant model
    Marc de Perrot
    Thoracic Surgery Research Laboratory, Toronto General Hospital, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 124:1137-44. 2002
    ..This study was undertaken to examine the effect of 2 ventilatory strategies on the development of ischemia-reperfusion injury after lung transplantation...
  82. ncbi request reprint Ventilator-induced lung injury: from the bench to the bedside
    Lorraine N Tremblay
    Department of Surgery, Sunnybrook and Women s Health Sciences Center, Toronto, Ont, Canada
    Intensive Care Med 32:24-33. 2006
  83. ncbi request reprint Future research directions in acute lung injury: summary of a National Heart, Lung, and Blood Institute working group
    Michael A Matthay
    Division of Lung Diseases, National Heart, Lung, and Blood Institute NIH, Bethesda, MD, USA
    Am J Respir Crit Care Med 167:1027-35. 2003
    ..Cellular and molecular methods combined with animal and clinical studies should lead to further progress in the detection and treatment of this complex disease...
  84. ncbi request reprint Identification of severe acute respiratory syndrome in Canada
    Susan M Poutanen
    Toronto Medical Laboratories and Mount Sinai Hospital Department of Microbiology, Toronto, Canada
    N Engl J Med 348:1995-2005. 2003
    ..This report summarizes the initial epidemiologic findings, clinical description, and diagnostic findings that followed the identification of SARS in Canada...
  85. ncbi request reprint Inflammation and the acute respiratory distress syndrome
    Ettore Crimi
    Division of Respiratory Medicine, Department of Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Ont, Canada
    Best Pract Res Clin Anaesthesiol 18:477-92. 2004
    ..This chapter will review the current state of the literature on the pathogenesis of ARDS and ventilatory and pharmacotherapy approaches to its management...
  86. ncbi request reprint Five percent albumin for adult burn shock resuscitation: lack of effect on daily multiple organ dysfunction score
    Andrew B Cooper
    Department of Critical Care Medicine, Sunnybrook and Women s College Health Science Center, North York, Ontario, Canada
    Transfusion 46:80-9. 2006
    ..The effect of 5 percent human albumin on multiple organ dysfunction was investigated during the first 14 days of treatment to determine whether albumin resuscitation might benefit adult burn patients...
  87. ncbi request reprint The role of oxidative stress in adult critical care
    Ettore Crimi
    Department of Anesthesiology and Critical Care Medicine, University of Eastern Piedmont, 28100 Novara, Italy
    Free Radic Biol Med 40:398-406. 2006
    ..Newer large multicenter trials with antioxidant supplementation should be performed, considering administration at an early stage of illness and a wider population of critically ill patients...
  88. ncbi request reprint Modulation of bacterial growth by tumor necrosis factor-alpha in vitro and in vivo
    Jin Hwa Lee
    Department of Anaesthesia, St Michael s Hospital, Toronto, ON, M5B 1W8 Canada
    Am J Respir Crit Care Med 168:1462-70. 2003
    ..coli growth in vitro and in vivo. However, in vivo, this effect becomes only apparent in neutropenic animals. The relevance of these findings for immune compromised patients remains to be investigated...
  89. ncbi request reprint Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome
    Angela M Cheung
    Department of Medicine, University Health Network, Toronto, ON, Canada
    Am J Respir Crit Care Med 174:538-44. 2006
    ..Little is known about the long-term outcomes and costs of survivors of acute respiratory distress syndrome (ARDS)...
  90. ncbi request reprint PEEP or no PEEP--lung recruitment may be the solution
    Arthur S Slutsky
    N Engl J Med 354:1839-41. 2006

Research Grants2

  1. From Bench to Bedside to Curbside
    Arthur Slutsky; Fiscal Year: 2007
    ..4) To develop a program, which will train the next generation of investigators in research skills related to resuscitation medicine. ..