Jeremy M Sivak

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation
    Adrian Nahirnyj
    Department of Vision Sciences, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e83049. 2013
  2. pmc Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization
    Jeremy M Sivak
    Department of Vision Sciences, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 286:44965-75. 2011
  3. doi request reprint The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease
    Jeremy M Sivak
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 54:871-80. 2013
  4. doi request reprint PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina
    Xiaoxin Guo
    Department of Vision Sciences, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Pathol 184:1017-29. 2014
  5. pmc Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation
    Darren A Yuen
    Department of Medicine, St Michael s Hospital, Ontario, Canada
    Stem Cells Transl Med 1:921-6. 2012

Collaborators

Detail Information

Publications5

  1. pmc ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation
    Adrian Nahirnyj
    Department of Vision Sciences, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    PLoS ONE 8:e83049. 2013
    ..These data provide a mechanism to link increased oxidative stress to proinflammatory signaling by astrocytes, and establish this assay as a useful model to further dissect factors regulating the reactive switch. ..
  2. pmc Pharmacologic uncoupling of angiogenesis and inflammation during initiation of pathological corneal neovascularization
    Jeremy M Sivak
    Department of Vision Sciences, Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
    J Biol Chem 286:44965-75. 2011
    ..These data indicate that it is possible to pharmacologically uncouple these mechanisms during early injury-driven neovascularization in the cornea and suggest that initial tissue responses are coordinated by repair epithelial cells...
  3. doi request reprint The aging eye: common degenerative mechanisms between the Alzheimer's brain and retinal disease
    Jeremy M Sivak
    Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 54:871-80. 2013
    ..Based on this comparison, past and current efforts to transfer therapeutic strategies between diseases are discussed...
  4. doi request reprint PGC-1α signaling coordinates susceptibility to metabolic and oxidative injury in the inner retina
    Xiaoxin Guo
    Department of Vision Sciences, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada
    Am J Pathol 184:1017-29. 2014
    ..These data implicate PGC-1α signaling as an important regulator of astrocyte reactivity and RGC homeostasis to coordinate pathogenic susceptibility to metabolic and oxidative injury in the inner retina...
  5. pmc Angiogenic dysfunction in bone marrow-derived early outgrowth cells from diabetic animals is attenuated by SIRT1 activation
    Darren A Yuen
    Department of Medicine, St Michael s Hospital, Ontario, Canada
    Stem Cells Transl Med 1:921-6. 2012
    ..These findings suggest a pivotal role for SIRT1 in diabetes-induced EOC dysfunction and that its pharmacologic activation may provide a new strategy for the restoration of EOC-mediated repair mechanisms...