Victoria Mok Siu

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi request reprint Biological relevance of CNV calling methods using familial relatedness including monozygotic twins
    Christina A Castellani
    Department of Biology, The University of Western Ontario, London N6A 5B7, ON, Canada
    BMC Bioinformatics 15:114. 2014
  2. pmc Ontogenetic de novo copy number variations (CNVs) as a source of genetic individuality: studies on two families with MZD twins for schizophrenia
    Sujit Maiti
    Molecular Genetics Unit, Department of Biology, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 6:e17125. 2011
  3. pmc Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice
    Benjamin I Laufer
    Molecular Genetics Unit, Department of Biology, Western University, London, Ontario, N6A 5B7, Canada
    Dis Model Mech 6:977-92. 2013
  4. pmc Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report
    Richard O'reilly
    Department of Psychiatry, University of Western Ontario, St, Joseph s Regional Mental Health Care, 850 Highbury Avenue North, London, ON, N6A 4H1, Canada
    J Med Case Rep 7:134. 2013
  5. ncbi request reprint Search for missing schizophrenia genes will require a new developmental neurogenomic perspective
    H B Kiran Kumar
    Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, London, Ontario, Canada N6A 5B7
    J Genet 92:335-40. 2013
  6. pmc Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure
    Morgan L Kleiber
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7, Canada
    J Neurodev Disord 5:6. 2013
  7. pmc DNA methylation and mRNA expression of SYN III, a candidate gene for schizophrenia
    Brenda C Murphy
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario N6A 5B7, Canada
    BMC Med Genet 9:115. 2008
  8. doi request reprint Copy number variation showers in schizophrenia: an emerging hypothesis
    S M Singh
    University of Western Ontario, London, ON, Canada
    Mol Psychiatry 14:356-8. 2009
  9. doi request reprint (Epi)genomics and neurodevelopment in schizophrenia: monozygotic twins discordant for schizophrenia augment the search for disease-related (epi)genomic alterations
    Shiva M Singh
    Molecular Genetics Laboratories, Department of Biology, and Division of Medical Genetics, The University of Western Ontario, London, ON N6A5B7, Canada
    Genome 52:8-19. 2009
  10. ncbi request reprint Analysis of behavior using genetical genomics in mice as a model: from alcohol preferences to gene expression differences
    Shiva M Singh
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, ON N6A 5B7, Canada
    Genome 50:877-97. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Biological relevance of CNV calling methods using familial relatedness including monozygotic twins
    Christina A Castellani
    Department of Biology, The University of Western Ontario, London N6A 5B7, ON, Canada
    BMC Bioinformatics 15:114. 2014
    ..It has, therefore, become necessary to develop experimental protocols to test the reliability of CNV calling methods from microarray data so that researchers can properly discriminate biologically relevant data from noise...
  2. pmc Ontogenetic de novo copy number variations (CNVs) as a source of genetic individuality: studies on two families with MZD twins for schizophrenia
    Sujit Maiti
    Molecular Genetics Unit, Department of Biology, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 6:e17125. 2011
    ..The results argue for enduring genome-wide changes during cellular transmission, often ignored in most genetic analyses...
  3. pmc Long-lasting alterations to DNA methylation and ncRNAs could underlie the effects of fetal alcohol exposure in mice
    Benjamin I Laufer
    Molecular Genetics Unit, Department of Biology, Western University, London, Ontario, N6A 5B7, Canada
    Dis Model Mech 6:977-92. 2013
    ..The observed changes could contribute to the initiation and maintenance of the long-lasting effect of alcohol...
  4. pmc Monozygotic twins with early-onset schizophrenia and late-onset bipolar disorder: a case report
    Richard O'reilly
    Department of Psychiatry, University of Western Ontario, St, Joseph s Regional Mental Health Care, 850 Highbury Avenue North, London, ON, N6A 4H1, Canada
    J Med Case Rep 7:134. 2013
    ..Schizophrenia and bipolar disorder are generally considered to be distinct illnesses. One piece of evidence supporting their distinctness is the rarity of schizophrenia and bipolar disorder occurring in monozygotic co‒twins...
  5. ncbi request reprint Search for missing schizophrenia genes will require a new developmental neurogenomic perspective
    H B Kiran Kumar
    Molecular Genetics Unit, Department of Biology and Psychiatry, University of Western Ontario, London, Ontario, Canada N6A 5B7
    J Genet 92:335-40. 2013
    ....
  6. pmc Neurodevelopmental alcohol exposure elicits long-term changes to gene expression that alter distinct molecular pathways dependent on timing of exposure
    Morgan L Kleiber
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7, Canada
    J Neurodev Disord 5:6. 2013
    ..While it is known that alcohol dose and timing play a role in the cognitive and behavioral changes associated with prenatal alcohol exposure, it is unclear what developmental processes are disrupted that may lead to these phenotypes...
  7. pmc DNA methylation and mRNA expression of SYN III, a candidate gene for schizophrenia
    Brenda C Murphy
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario N6A 5B7, Canada
    BMC Med Genet 9:115. 2008
    ..The synapsin III (SYN III) gene on chromosome 22q is a candidate gene for schizophrenia susceptibility due to its chromosome location, neurological function, expression patterns and functional polymorphisms...
  8. doi request reprint Copy number variation showers in schizophrenia: an emerging hypothesis
    S M Singh
    University of Western Ontario, London, ON, Canada
    Mol Psychiatry 14:356-8. 2009
    ..Depending on the timing and the genes involved, this will contribute to the mutational load and disease. The evidence for such a mechanism in schizophrenia is emerging...
  9. doi request reprint (Epi)genomics and neurodevelopment in schizophrenia: monozygotic twins discordant for schizophrenia augment the search for disease-related (epi)genomic alterations
    Shiva M Singh
    Molecular Genetics Laboratories, Department of Biology, and Division of Medical Genetics, The University of Western Ontario, London, ON N6A5B7, Canada
    Genome 52:8-19. 2009
    ..More important, this experimental strategy will be an effective strategy for studies on other complex (behavioural) disorders as well...
  10. ncbi request reprint Analysis of behavior using genetical genomics in mice as a model: from alcohol preferences to gene expression differences
    Shiva M Singh
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, ON N6A 5B7, Canada
    Genome 50:877-97. 2007
    ..The importance of these findings as a novel genetic resource and their use and application in the genetic analysis of complex behavioral phenotypes, susceptibilities, and responses to drugs and chemicals are discussed...
  11. ncbi request reprint Involvement of gene-diet/drug interaction in DNA methylation and its contribution to complex diseases: from cancer to schizophrenia
    S M Singh
    Molecular Genetics Unit, Department of Biology, Division of Medical Genetics, University of Western Ontario, London, Ontario, Canada
    Clin Genet 64:451-60. 2003
    ..A similar mechanism is now recognized in a number of cancers. There is also indirect evidence to suggest that methylation could apply to a number of complex diseases, including schizophrenia...
  12. ncbi request reprint Epigenetic contributors to the discordance of monozygotic twins
    S M Singh
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada
    Clin Genet 62:97-103. 2002
    ..Such an assessment is needed in directing future studies on MZ twins. In particular, we will deal with the origin, development, genetic and epigenetic factors that may have implications in discordance of the MZ twin pairs...
  13. ncbi request reprint Incidental neurodevelopmental episodes in the etiology of schizophrenia: an expanded model involving epigenetics and development
    S M Singh
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, University of Western Ontario, London, Ontario, Canada N6A 5B7, USA
    Clin Genet 65:435-40. 2004
    ..The incidental episodes in neurodevelopment will explain the frequency of schizophrenia in most populations and high discordance of monozygotic twins...
  14. pmc The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction
    Elizabeth P Hayden
    Department of Psychology, University of Western Ontario, London, Ontario, Canada
    Psychiatr Genet 20:304-10. 2010
    ..We sought to replicate and extend these findings using behavioral measures in a nonclinical sample of young children...
  15. pmc The serotonin transporter promoter polymorphism and childhood positive and negative emotionality
    Elizabeth P Hayden
    Department of Psychology, University of Western Ontario, Westminster Hall, London, Ontario, Canada
    Emotion 10:696-702. 2010
    ..Inconsistent links between NE and this gene in previous research may stem from the failure to consider other temperament traits that moderate associations...
  16. ncbi request reprint Role of potassium channel gene Kcnj10 in ethanol preference in C57bl/6J and DBA/2J mice
    Shicong B Zou
    Molecular Genetics Laboratories, Department of Biology, University of Western Ontario, London, Ontario, Canada
    Alcohol Clin Exp Res 33:394-9. 2009
    ..This Kcnj10 SNP and its expression may serve as valuable markers in predicting the ethanol preference phenotype in mice...
  17. doi request reprint Delineation of the role of nicotinic acetylcholine receptor genes in alcohol preference in mice
    Melissa N Symons
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, ON N6A 5B7, Canada
    Behav Genet 40:660-71. 2010
    ..Further, the Chrnb4 and Chrna5 genes showed expression differences between B6 and D2 mice, which is compatible with their involvement in AP in mice and, potentially, alcohol abuse in humans...
  18. pmc Glucagon-like peptide-1 receptor gene polymorphism (Leu260Phe) is associated with morning cortisol in preschoolers
    Haroon I Sheikh
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, Ontario, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 34:980-3. 2010
    ..008). Our results identify associations between a novel genetic variant of GLP-1R and hypothalamus-pituitary-adrenal (HPA) axis regulation. This polymorphism may have functional significance in stress-related psychiatric disorders...
  19. ncbi request reprint Genetic segregation of brain gene expression identifies retinaldehyde binding protein 1 and syntaxin 12 as potential contributors to ethanol preference in mice
    Julie A Treadwell
    Department of Biology and Division of Medical Genetics, University of Western Ontario, London, Ontario, Canada N6A 5B7
    Behav Genet 34:425-39. 2004
    ....
  20. doi request reprint Divergence of the vertebrate sp1A/ryanodine receptor domain and SOCS box-containing (Spsb) gene family and its expression and regulation within the mouse brain
    Morgan L Kleiber
    Molecular Genetics Laboratories, Department of Biology, University of Western Ontario, London, Ontario, Canada N6A 5B7
    Genomics 93:358-66. 2009
    ..Our results contribute to the growing body of data on the expression and function of Spsb genes, which serve as a model for studies on the origin, divergence and specialization of eukaryotic gene families...
  21. doi request reprint Assessing stress reactivity indexed via salivary cortisol in preschool-aged children
    Katie R Kryski
    Department of Psychology, Westminster Hall, University of Western Ontario, London, ON, Canada
    Psychoneuroendocrinology 36:1127-36. 2011
    ..Results indicate that the task successfully elicited the hypothesized cortisol response in 3-year-old children...
  22. doi request reprint Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice
    Julia Weng
    Department of Biology, University of Western Ontario, London, Ontario, Canada
    Alcohol Clin Exp Res 33:1409-16. 2009
    ....
  23. ncbi request reprint Strain-specific brain metallothionein II (MT-II) gene expression, its ethanol responsiveness, and association with ethanol preference in mice
    Kimberly D Loney
    Molecular Genetics Laboratories, Department of Biology and Division of Medical Genetics, University of Western Ontario, London, Ontario, Canada
    Alcohol Clin Exp Res 27:388-95. 2003
    ..Although their specific function has yet to be discovered, they are known to regulate the metabolism of these metals as well as respond to cellular stress agents, particularly oxidants...
  24. ncbi request reprint Analysis of metallothionein brain gene expression in relation to ethanol preference in mice using cosegregation and gene knockouts
    Kimberly D Loney
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, University of Western Ontario, London, ON, Canada N6A 5B7
    Alcohol Clin Exp Res 30:15-25. 2006
    ..We have previously reported 1 isoform, MT-II, as a possible candidate gene for ethanol (EtOH) preference (EP) determination in mice...
  25. ncbi request reprint Towards unraveling ethanol-specific neuro-metabolomics based on ethanol responsive genes in vivo
    Raihan K Uddin
    Department of Biology and Division of Medical Genetics, The University of Western Ontario, N6A 5B7, London, Ontario, Canada
    Neurochem Res 30:1179-90. 2005
    ..We propose a pathway involving nine interacting ethanol responsive genes, which may determine differential ethanol effects in the brain in vivo...
  26. ncbi request reprint Site-specific cytosine methylation in S-COMT promoter in 31 brain regions with implications for studies involving schizophrenia
    Brenda C Murphy
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada
    Am J Med Genet B Neuropsychiatr Genet 133:37-42. 2005
    ..The unique observation of a completely methylated cytosine 23 in one patient with SZ may have the potential to affect COMT mRNA transcription and gene activity, but remains to be evaluated...
  27. ncbi request reprint Microarray analysis of mouse brain gene expression following acute ethanol treatment
    Julie A Treadwell
    Department of Biology, Division of Medical Genetics, University of Western Ontario, London, Ontario, Canada N6A 5B7
    Neurochem Res 29:357-69. 2004
    ..Such genes have the potential to represent candidate genes in the search to elucidate the molecular pathways mediating ethanol's effects in the brain...
  28. doi request reprint Maternal voluntary drinking in C57BL/6J mice: advancing a model for fetal alcohol spectrum disorders
    Morgan L Kleiber
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, Ontario, Canada
    Behav Brain Res 223:376-87. 2011
    ..Given the range of genetic resources available for inbred mouse strains, the model described here may prove to be a useful tool in evaluating the molecular basis of FASD...
  29. ncbi request reprint Examination of ethanol responsive liver and brain specific gene expression, in the mouse strains with variable ethanol preferences, using cDNA expression arrays
    Brenda C Murphy
    Department of Zoology and Division of Medical Genetics, Molecular Genetics Unit, The University of Western Ontario, London, Ontario, Canada N6A 5B7
    Biochem Genet 40:395-410. 2002
    ..The results demonstrate that comparative expression studies are an efficient approach to discover interacting gene networks that underlie the etiology of complex phenotypes including response to alcohols...
  30. doi request reprint Methylation analysis of the NOTCH4 -25 C/T polymorphism in schizophrenia
    Patrick P McDonald
    Department of Biology, Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada
    Psychiatr Genet 21:5-13. 2011
    ..3) and sequence variants have previously shown association to the disease. It is further implicated from a functional standpoint as it plays a critical role during the neurodevelopmental process...
  31. pmc The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality
    Elizabeth P Hayden
    University of Western Ontario, Department of Psychology, London, Ontario, Canada N6A 3K7
    Psychol Sci 21:1678-85. 2010
    ..Our findings suggest that the BDNF met allele confers increased child sensitivity to both positive and negative familial influences...
  32. ncbi request reprint cis-Regulatory sequences of the genes involved in apoptosis, cell growth, and proliferation may provide a target for some of the effects of acute ethanol exposure
    Raihan K Uddin
    Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada N6A 5B7
    Brain Res 1088:31-44. 2006
    ..NFY has the potential to play a critical role in mediating the expression of a set of ER genes whose interactions contribute to apoptosis, cell survival, and proliferation, which in turn may affect alcohol-related behaviors...
  33. ncbi request reprint Genetics and differential expression of NADH:ubiquinone oxidoreductase B8 subunit in brains of genetic strains of mice differing in voluntary alcohol consumption
    Michelle Harrison
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, 307 Western Science Centre, London, Ontario, Canada
    Biochim Biophys Acta 1579:164-72. 2002
    ....
  34. ncbi request reprint Strategies and applications of DNA level diagnosis in genetic diseases: past experiences and future directions
    S M Singh
    Department of Zoology and Paediatrics, University of Western Ontario, London, Canada
    Biotechnol Annu Rev 2:409-46. 1996
    ....
  35. doi request reprint Situs inversus totalis and a novel ZIC3 mutation in a family with X-linked heterotaxy
    Lisa C A D'Alessandro
    Department of Pediatrics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Congenit Heart Dis 8:E36-40. 2013
    ..The spectrum of features in this family emphasizes the importance of thorough molecular and imaging studies in both sporadic and familial cases of heterotaxy to ensure accurate prenatal diagnosis and recurrence risk counseling...
  36. pmc Breakpoint Associated with a novel 2.3 Mb deletion in the VCFS region of 22q11 and the role of Alu (SINE) in recurring microdeletions
    Raihan K Uddin
    Department of Biology, University of Western Ontario, London, Ontario, N6A 5B7, Canada
    BMC Med Genet 7:18. 2006
    ..Individuals with this 22q11 microdeletion syndrome are at a greatly increased risk to develop schizophrenia...
  37. ncbi request reprint Molecular characterization of a 2.7-kb, 12q13-specific, retroviral-related sequence isolated by RDA from monozygotic twin pairs discordant for schizophrenia
    Paromita Deb-Rinker
    Department of Zoology and Division of Medical Genetics, The University of Western Ontario, London, Canada
    Genome 45:381-90. 2002
    ....
  38. pmc Genotyping the BDNF rs6265 (val66met) polymorphism by one-step amplified refractory mutation system PCR
    Haroon I Sheikh
    Molecular Genetics Unit, Department of Biology, University of Western Ontario, London, Ontario, Canada
    Psychiatr Genet 20:109-12. 2010
    ..This polymorphism has been widely implicated in a host of psychiatric disorders and is a focus of many ongoing psychiatric genetic studies...
  39. doi request reprint Studies on Syntaxin 12 and alcohol preference involving C57BL/6J and DBA/2J strains of mice
    J Weng
    Department of Biology, University of Western Ontario, London, Ontario, Canada
    Behav Genet 39:183-91. 2009
    ..Overall, our findings support a role for Syntaxin 12 as a potential contributor to alcohol preference in mice...
  40. ncbi request reprint CpG methylation accounts for a recurrent mutation (c.1222C>T) in the human PAH gene
    B C Murphy
    Molecular Genetics Unit, Department of Biology and Division of Medical Genetics, The University of Western Ontario, London, Ontario, Canada
    Hum Mutat 27:975. 2006
    ..The finding offers at least one explanation for the high relative frequency of the c.1222C>T (p.R408W) allele in the human population...
  41. ncbi request reprint HLA-D-region genomic DNA restriction fragments in DRw15 (DR2) familial narcolepsy
    S D Ditta
    Department of Zoology, Victoria Hospital, London, Ontario, Canada
    Sleep 15:48-57. 1992
    ..Further, such results argue for genetic heterogeneity in narcolepsy, and the role of DRw15 in the development of the disease could at best be viewed as contributory and not essential...
  42. ncbi request reprint Distinct mRNA-binding proteins interacting with short repeat sequences of the 3' UTR may be involved in the post-transcriptional regulation of the mouse catalase gene, Cas-1
    D L Reimer
    Molecular Genetics Laboratories, Department of Zoology and Division of Medical Genetics, University of Western Ontario, London, Canada
    DNA Cell Biol 15:317-28. 1996
    ....
  43. ncbi request reprint Complete cDNA and 5' genomic sequences and multilevel regulation of the mouse catalase gene
    D L Reimer
    Department of Zoology, University of Western Ontario, London, Canada
    Genomics 21:325-36. 1994
    ..We propose that this housekeeping antioxidant enzyme is under multilevel regulation, and the determinants include both 5' and 3' Cas-1 sequences...
  44. ncbi request reprint Studies with cDNA probes on the in vivo effect of ethanol on expression of the genes of alcohol metabolism
    S L Bond
    Department of Zoology, University of Western Ontario, London, Canada
    Alcohol Alcohol 25:385-94. 1990
    ....