Eric C K Siu

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Non-nicotinic therapies for smoking cessation
    Eric C K Siu
    Center for Addiction and Mental Health and Department of Pharmacology, University of Toronto, Toronto, Canada
    Annu Rev Pharmacol Toxicol 47:541-64. 2007
  2. ncbi request reprint Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice
    Eric C K Siu
    The Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Mol Pharmacol 71:826-34. 2007
  3. ncbi request reprint Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice
    Eric C K Siu
    Department of Pharmacology, University of Toronto, 1 King s College Circle, Room 4326, Toronto, Ontario, Canada
    J Pharmacol Exp Ther 324:992-9. 2008
  4. ncbi request reprint Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5
    Eric C K Siu
    Centre for Addiction and Mental Health and Department of Pharmacology, University of Toronto, Toronto, Canada
    Psychopharmacology (Berl) 184:401-8. 2006
  5. doi request reprint Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats
    Megan J Shram
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, T700, Toronto, ON, Canada M5S 2S1
    Psychopharmacology (Berl) 198:181-90. 2008

Detail Information

Publications5

  1. ncbi request reprint Non-nicotinic therapies for smoking cessation
    Eric C K Siu
    Center for Addiction and Mental Health and Department of Pharmacology, University of Toronto, Toronto, Canada
    Annu Rev Pharmacol Toxicol 47:541-64. 2007
    ..In conclusion, promising new therapeutic products are emerging and they will provide smokers additional options to assist in achieving smoking cessation...
  2. ncbi request reprint Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice
    Eric C K Siu
    The Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada
    Mol Pharmacol 71:826-34. 2007
    ..Genetic differences in Cyp2a5 potentially contributed to similar nicotine but different cotinine metabolism, which may confound the interpretation of nicotine pharmacological studies and studies using cotinine as a biomarker...
  3. ncbi request reprint Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice
    Eric C K Siu
    Department of Pharmacology, University of Toronto, 1 King s College Circle, Room 4326, Toronto, Ontario, Canada
    J Pharmacol Exp Ther 324:992-9. 2008
    ..Our findings suggest that an additional potential mechanism of selegiline in smoking cessation is through inhibition of nicotine metabolism...
  4. ncbi request reprint Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5
    Eric C K Siu
    Centre for Addiction and Mental Health and Department of Pharmacology, University of Toronto, Toronto, Canada
    Psychopharmacology (Berl) 184:401-8. 2006
    ..Different mouse strains self-administer different amounts of oral nicotine and quantitative trait loci analyses in mice suggested that Cyp2a5 may be involved in differential nicotine consumption behaviors...
  5. doi request reprint Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats
    Megan J Shram
    Department of Neuroscience, Centre for Addiction and Mental Health, 33 Russell Street, T700, Toronto, ON, Canada M5S 2S1
    Psychopharmacology (Berl) 198:181-90. 2008
    ..Although adolescents may exhibit a greater susceptibility to nicotine addiction, relatively little is known about the influence of the aversive effects of nicotine withdrawal in maintaining smoking behavior...