Arno G Siraki

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis
    Arno G Siraki
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chem Res Toxicol 23:880-7. 2010
  2. doi request reprint The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 91:228-35. 2013
  3. doi request reprint Scavenging of free-radical metabolites of aniline xenobiotics and drugs by amino Acid derivatives: toxicological implications of radical-transfer reactions
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Chem Res Toxicol 26:1872-83. 2013
  4. doi request reprint Post-trapping derivatization of radical-derived EPR-silent adducts: application to free radical detection by HPLC/UV in chemical, biochemical, and biological systems and comparison with EPR spectroscopy
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Anal Chem 84:6739-46. 2012
  5. doi request reprint 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites
    Pratik Arvadia
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Arch Biochem Biophys 515:120-6. 2011
  6. doi request reprint The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical
    Naif Aljuhani
    a University of Alberta, Faculty of Pharmacy and Pharmaceutical Sciences, Edmonton, AB T6G 2E1, Canada
    Can J Physiol Pharmacol 91:783-90. 2013
  7. doi request reprint Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites
    Malyaj Narwaley
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Chem Res Toxicol 24:1031-9. 2011
  8. doi request reprint Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism
    Mohamed A M El Gendy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Ethnopharmacol 144:416-24. 2012

Collaborators

Detail Information

Publications8

  1. pmc Investigating the mechanisms of aromatic amine-induced protein free radical formation by quantitative structure-activity relationships: implications for drug-induced agranulocytosis
    Arno G Siraki
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Chem Res Toxicol 23:880-7. 2010
    ..Interestingly, we found that only those aniline derivatives that produced a phenyl radical also formed MPO*. We propose that the phenyl radical is the reactive free radical metabolite responsible for generating the MPO*...
  2. doi request reprint The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, Katz Group Centre for Pharmacy and Health Research, University of Alberta, Edmonton, AB, Canada
    Can J Physiol Pharmacol 91:228-35. 2013
    ..In conclusion, di- and poly-amines are capable of enhancing the formation of aromatic-amine-derived free radicals, a fact that is expected to have toxicological consequences...
  3. doi request reprint Scavenging of free-radical metabolites of aniline xenobiotics and drugs by amino Acid derivatives: toxicological implications of radical-transfer reactions
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Chem Res Toxicol 26:1872-83. 2013
    ..These findings may have significant implications for the biological fate of arylamine xenobiotic and drug free-radical metabolites. ..
  4. doi request reprint Post-trapping derivatization of radical-derived EPR-silent adducts: application to free radical detection by HPLC/UV in chemical, biochemical, and biological systems and comparison with EPR spectroscopy
    Karim Michail
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
    Anal Chem 84:6739-46. 2012
    ..We believe the proposed methodology could represent a valuable tool to probe free radical metabolites in vivo using DMPO, the least toxic spin trap...
  5. doi request reprint 4-Aminobenzoic acid hydrazide inhibition of microperoxidase-11: catalytic inhibition by reactive metabolites
    Pratik Arvadia
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Arch Biochem Biophys 515:120-6. 2011
    ..We conclude that the 4-ABAH free radical metabolites which were bound to MP-11 were involved in the catalytic inhibition and were scavenged by DMPO...
  6. doi request reprint The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical
    Naif Aljuhani
    a University of Alberta, Faculty of Pharmacy and Pharmaceutical Sciences, Edmonton, AB T6G 2E1, Canada
    Can J Physiol Pharmacol 91:783-90. 2013
    ..These findings demonstrate the importance of NaHCO3 in menadione redox cycling and cytotoxicity. ..
  7. doi request reprint Drug-induced protein free radical formation is attenuated by unsaturated fatty acids by scavenging drug-derived phenyl radical metabolites
    Malyaj Narwaley
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Chem Res Toxicol 24:1031-9. 2011
    ....
  8. doi request reprint Induction of quinone oxidoreductase 1 enzyme by Rhazya stricta through Nrf2-dependent mechanism
    Mohamed A M El Gendy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    J Ethnopharmacol 144:416-24. 2012
    ..Rhazya stricta has been used traditionally to treat several diseases including tumors; however, the underlying mechanism is still not fully elucidated...