Don D Sin

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients?
    Don D Sin
    The University of British Columbia Respiratory Division, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 13:90-7. 2007
  2. pmc Treatment of mild chronic obstructive pulmonary disease
    Alex Chee
    Department of Medicine, Division of Respirology, The University of British Columbia and Providence Heart and Lung Institute and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 3:563-73. 2008
  3. pmc Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital and the Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    BMC Pulm Med 5:3. 2005
  4. pmc The influence of gender on the effects of aspirin in preventing myocardial infarction
    Todd Yerman
    Department of Medicine Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, British Columbia, Canada
    BMC Med 5:29. 2007
  5. ncbi Effects of nocturnal noninvasive mechanical ventilation on heart rate variability of patients with advanced COPD
    Don D Sin
    Pulmonary Division, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
    Chest 131:156-63. 2007
  6. ncbi Arterial carbon dioxide tension on admission as a marker of in-hospital mortality in community-acquired pneumonia
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    Am J Med 118:145-50. 2005
  7. pmc Recruitment for a provincial asthma study. Participation of network and non-network primary care physicians
    Don D Sin
    Department of Medicine, University of British Columbia, Vancouver
    Can Fam Physician 50:1251-4. 2004
  8. ncbi Effects of increased primary care access on process of care and health outcomes among patients with asthma who frequent emergency departments
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    Am J Med 117:479-83. 2004
  9. ncbi Systemic inflammation and mortality in chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul, s Hospital, Vancouver, Canada
    Can J Physiol Pharmacol 85:141-7. 2007
  10. ncbi Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Curr Pharm Des 10:3547-60. 2004

Detail Information

Publications110 found, 100 shown here

  1. ncbi Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients?
    Don D Sin
    The University of British Columbia Respiratory Division, Vancouver, British Columbia, Canada
    Curr Opin Pulm Med 13:90-7. 2007
    ..Whether these medications prolong survival is uncertain...
  2. pmc Treatment of mild chronic obstructive pulmonary disease
    Alex Chee
    Department of Medicine, Division of Respirology, The University of British Columbia and Providence Heart and Lung Institute and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 3:563-73. 2008
    ..Influenza and pneumococcal vaccination and pulmonary rehabilitation are other therapies that may be considered for select patients with mild disease. In this paper, we summarize the current standard of care for patients with mild COPD...
  3. pmc Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysis
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital and the Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    BMC Pulm Med 5:3. 2005
    ..We sought to determine the effects of inhaled corticosteroids on sputum indices of inflammation in stable COPD...
  4. pmc The influence of gender on the effects of aspirin in preventing myocardial infarction
    Todd Yerman
    Department of Medicine Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, British Columbia, Canada
    BMC Med 5:29. 2007
    ..We conducted a systematic review and meta-analysis to determine whether gender mix might play a role in explaining the large variation of aspirin efficacy across primary and secondary MI prevention trials...
  5. ncbi Effects of nocturnal noninvasive mechanical ventilation on heart rate variability of patients with advanced COPD
    Don D Sin
    Pulmonary Division, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
    Chest 131:156-63. 2007
    ....
  6. ncbi Arterial carbon dioxide tension on admission as a marker of in-hospital mortality in community-acquired pneumonia
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    Am J Med 118:145-50. 2005
    ..We sought to determine the association between arterial carbon dioxide tension (P(a)CO(2)) and in-hospital mortality in patients admitted with pneumonia...
  7. pmc Recruitment for a provincial asthma study. Participation of network and non-network primary care physicians
    Don D Sin
    Department of Medicine, University of British Columbia, Vancouver
    Can Fam Physician 50:1251-4. 2004
  8. ncbi Effects of increased primary care access on process of care and health outcomes among patients with asthma who frequent emergency departments
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
    Am J Med 117:479-83. 2004
    ..This study was conducted to determine the effectiveness of a health professional-based intervention in improving process of care and health outcomes among asthmatic patients discharged from emergency departments...
  9. ncbi Systemic inflammation and mortality in chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul, s Hospital, Vancouver, Canada
    Can J Physiol Pharmacol 85:141-7. 2007
    ..Systemic inflammation may contribute substantially to the overall morbidity and mortality of COPD patients...
  10. ncbi Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Curr Pharm Des 10:3547-60. 2004
    ..This article will present a comprehensive overview of the currently available clinical evidence for the use of combination therapy as well as the potential mechanisms of their actions in COPD...
  11. ncbi Mortality in COPD: Role of comorbidities
    D D Sin
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Eur Respir J 28:1245-57. 2006
    ..e. inflammation), and the tools used to predict chronic obstructive pulmonary disease mortality...
  12. ncbi Pharmacotherapy for mortality reduction in chronic obstructive pulmonary disease
    Don D Sin
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Proc Am Thorac Soc 3:624-9. 2006
    ..This article reviews some of the relevant epidemiologic and pathophysiologic processes that affect mortality in COPD and critically examines the effect of current COPD therapies on mortality...
  13. ncbi Chronic obstructive pulmonary disease: a novel risk factor for cardiovascular disease
    Don D Sin
    Department of Medicine, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
    Can J Physiol Pharmacol 83:8-13. 2005
    ..In this paper, we discuss the epidemiologic evidence linking COPD and cardiovascular events as well as the potential mechanism(s) which may be responsible for this association...
  14. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  15. ncbi Commentary: fuelling the fire--systemic inflammation and development of lung disease in the general community
    Don D Sin
    The James Hogg Icapture Center For Cardiovascular, Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Int J Epidemiol 35:1008-10. 2006
  16. ncbi Emerging drugs for the treatment of chronic obstructive pulmonary disease
    Samir Malhotra
    University of British Columbia and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Respiratory Division, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    Expert Opin Emerg Drugs 11:275-91. 2006
    ..Many of these drugs may enter the COPD market within the next decade. This paper reviews the molecular rationale for these emerging drugs and their potential efficacy in COPD...
  17. ncbi Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality
    Don D Sin
    Department of Medicine, University of British Columbia, Canada
    Proc Am Thorac Soc 2:8-11. 2005
    ..These data indicate that chronic obstructive pulmonary disease is a powerful, independent risk factor for cardiovascular morbidity and mortality...
  18. pmc Can inhaled fluticasone alone or in combination with salmeterol reduce systemic inflammation in chronic obstructive pulmonary disease? Study protocol for a randomized controlled trial [NCT00120978]
    Don D Sin
    Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada
    BMC Pulm Med 6:3. 2006
    ....
  19. pmc Inhaled corticosteroids and mortality in chronic obstructive pulmonary disease
    D D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, and Department of Medicine, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
    Thorax 60:992-7. 2005
    ..Clinical studies suggest that inhaled corticosteroids reduce exacerbations and improve health status in chronic obstructive pulmonary disease (COPD). However, their effect on mortality is unknown...
  20. ncbi Forced expiratory volume in 1 second and physical activity in the general population
    Don D Sin
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Am J Med 117:270-3. 2004
  21. ncbi Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    JAMA 292:367-76. 2004
    ..Over the last 2 decades, many new pharmacological agents have been introduced to reduce the growing morbidity associated with asthma, but the long-term effects of these agents on exacerbations are unclear...
  22. ncbi Corticosteroids and adrenoceptor agonists: the compliments for combination therapy in chronic airways diseases
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, and Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, B C, Canada V6Z 1Y6
    Eur J Pharmacol 533:28-35. 2006
    ..There is a large clinical trial currently underway, which will provide mortality data by the year 2006. On balance, clinical evidence supports the use of combination therapy in moderate to severe asthma and COPD...
  23. doi Surfactant protein D: a lung specific biomarker in COPD?
    Don D Sin
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Ther Adv Respir Dis 2:65-74. 2008
    ..In this paper, we review one promising systemic biomarker that ful"lls some of these criteria, surfactant protein D (SPD)...
  24. doi Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary disease
    Don D Sin
    Respiratory Division, Department of Medicine, University of British Columbia, Canada
    Curr Opin Pulm Med 14:115-21. 2008
    ..Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in patients with chronic obstructive pulmonary disease. The epidemiological and mechanistic evidence linking these disorders, however, is uncertain...
  25. ncbi Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and women
    Don D Sin
    University of British Columbia, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 4:671-4. 2007
    ..This article reviews this and other potential mechanisms that may confer increased susceptibility of COPD to female smokers...
  26. doi Budesonide and the risk of pneumonia: a meta-analysis of individual patient data
    Don D Sin
    Providence Heart and Lung Institute, St Paul s Hospital iCAPTURE Centre, and Department of Medicine Division of Respirology, University of British Columbia, Vancouver, BC, Canada
    Lancet 374:712-9. 2009
    ..We aimed to establish the effects of inhaled budesonide on the risk of pneumonia in such patients...
  27. ncbi The tip of the "ICEBERGS": a National Conference to Combat the Growing Global Epidemic of COPD in women
    Don D Sin
    James Hogg iCAPTURE Center, St Paul s Hospital, Vancouver, BC, V6Z 1Y6 Canada
    Proc Am Thorac Soc 4:669-70. 2007
  28. doi Biomarkers in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Division of Respiratory Medicine, the University of British Columbia and The Providence Heart and Lung Institute, James Hogg iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 6:543-5. 2009
    ..In this article, we discuss the current barriers of biomarker discovery and propose possible criteria and methods for developing novel biomarkers in COPD...
  29. ncbi Spirometric findings among school-aged First Nations children on a reserve: a pilot study
    Don D Sin
    Department of Medicine, University of Alberta, Edmonton
    Can Respir J 11:45-8. 2004
    ..Although hospital utilization for asthma and COPD among First Nations peoples has been increasing, the prevalence of asthma or wheezing is comparable to national averages...
  30. ncbi Combination of ICSs and LABAs should be used in the management of patients with COPD--the pro argument
    Don D Sin
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Medicine, University of British Columbia, Vancouver
    Can Respir J 11:221-3. 2004
  31. pmc Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot study
    Don D Sin
    The University of British Columbia Respiratory Division, Vancouver, BC
    BMC Pulm Med 7:13. 2007
    ..The principal aim of this pilot study was to determine whether circulating surfactant protein D (SPD) or Clara Cell protein-16 (CC16) levels are associated with lung function or health status in patients with severe COPD...
  32. doi Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer
    Don D Sin
    St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Chest 134:582-8. 2008
    ..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers...
  33. doi The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, Canada
    Am J Respir Crit Care Med 177:1207-14. 2008
    ..Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD)...
  34. ncbi Club cell protein 16 and disease progression in chronic obstructive pulmonary disease
    Hye Yun Park
    1 University of British Columbia James Hogg Research Center and the Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 188:1413-9. 2013
    ..Club (Clara) cell protein 16 (CC-16) is a protein that is synthesized predominantly in the lungs and is detectable in serum. Its expression decreases with lung injury and smoking, and is thus a marker of bronchial cell dysfunction...
  35. ncbi Endotoxin-induced cardiovascular dysfunction in mice: effect of simvastatin
    Koichi Suda
    Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 111:1118-24. 2011
    ..SS significantly improved LPS-induced cardiovascular dysfunction possibly by reducing systemic expression of IL-6 and its downstream signaling pathways. These findings may explain how statins improve health outcomes in patients with ALI...
  36. pmc Marijuana and chronic obstructive lung disease: a population-based study
    Wan C Tan
    iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and the University of British Columbia, Vancouver, Canada
    CMAJ 180:814-20. 2009
    ..Our aim was to determine the combined and independent effects of tobacco and marijuana smoking on respiratory symptoms and chronic obstructive pulmonary disease (COPD) in the general population...
  37. ncbi The complex relationship of serum adiponectin to COPD outcomes COPD and adiponectin
    Ho Il Yoon
    University of British Columbia James Hogg Research Center, Vancouver, BC, Canada
    Chest 142:893-99. 2012
    ..Adiponectin is a hormone that has anti inflammatory, antidiabetic, and anti atherogenic activities. We investigated the relationship of serum adiponectin to health outcomes in COPD...
  38. pmc The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD)
    Jee Lee
    The Providence Heart and Lung Institute at St Paul s Hospital, The UBC James Hogg Research Centre and Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 7:e35567. 2012
    ..In conclusion, COPD patients have short leukocyte telomeres, which are in turn associated increased risk of total and cancer mortality. Accelerated aging is of particular relevance to cancer mortality in COPD...
  39. ncbi Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease
    Don D Sin
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 170:760-5. 2004
    ..Inhaled and oral corticosteroids are effective in reducing serum CRP levels in patients with COPD and suggest their potential use for improving cardiovascular outcomes in COPD...
  40. ncbi Contemporary management of chronic obstructive pulmonary disease: scientific review
    Don D Sin
    Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada
    JAMA 290:2301-12. 2003
    ..The care of patients with chronic obstructive pulmonary disease (COPD) has changed radically over the past 2 decades, and novel therapies can not only improve the health status of patients with COPD but also modify its natural course...
  41. ncbi The relationship between birth weight and childhood asthma: a population-based cohort study
    Don D Sin
    Pulmonary Division, The Department of Medicine, University of Alberta, Edmonton, Canada
    Arch Pediatr Adolesc Med 158:60-4. 2004
    ..Because obesity promotes inflammation and imposes mechanical constraints to the airways, a high birth weight may be a risk factor for asthma in childhood. However, to our knowledge, few studies have examined this potential relationship...
  42. doi Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterol
    Koichi Suda
    Division of Respiratory Medicine, University of British Columbia, Providence Heart and Lung Institute, St Paul s Hospital, 1081 Burrard St, Vancouver, British Columbia V6Z 1Y6, Canada
    Am J Respir Cell Mol Biol 45:510-6. 2011
    ..ICS/LABA may reduce acute cardiovascular events related to ALI...
  43. pmc Aging does not enhance experimental cigarette smoke-induced COPD in the mouse
    Steven Zhou
    Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e71410. 2013
    ..We conclude, in this model, animal age does not affect the development of emphysema and small airway remodeling. ..
  44. pmc The relation of serum myeloperoxidase to disease progression and mortality in patients with chronic obstructive pulmonary disease (COPD)
    Hye Yun Park
    UBC James Hogg Research Center and The Institute of Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 8:e61315. 2013
    ....
  45. ncbi Statins reduce ambient particulate matter-induced lung inflammation by promoting the clearance of particulate matter, < 10 μm from lung tissues
    Ryohei Miyata
    UBC James Hogg Research Centre, Institute for Heart Lung Health, St Paul s Hospital, The University of British Columbia, Vancouver, BC
    Chest 143:452-60. 2013
    ..The aim of this study was to determine the effect of statins on PM(10) -induced lung inflammation in vivo...
  46. doi The relationship between lung inflammation and cardiovascular disease
    Stephan van Eeden
    Division of Respiratory Medicine, Department of Medicine, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 186:11-6. 2012
    ....
  47. ncbi The effects of beta-blockers on morbidity and mortality in a population-based cohort of 11,942 elderly patients with heart failure
    Don D Sin
    Department of Pulmonary Medicine DDS, University of Alberta Hospital, Edmonton, Canada
    Am J Med 113:650-6. 2002
    ..However, whether beta-blockers are effective in older patients or those with conditions that would have led to their exclusion from these trials remains unclear...
  48. pmc Effect of gene environment interactions on lung function and cardiovascular disease in COPD
    Tillie Louise Hackett
    University of British Columbia, James Hogg Research Laboratories, St Paul s Hospital, Division of Respirology, Department of Medicine, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 6:277-87. 2011
    ....
  49. ncbi Contemporary management of chronic obstructive pulmonary disease: clinical applications
    S F Paul Man
    Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada
    JAMA 290:2313-6. 2003
    ..Finally, correction of resting arterial hypoxemia with oxygen therapy for more than 15 h/d prolongs survival of COPD patients for those with a resting PaO2 lower than 55 to 60 mm Hg...
  50. ncbi Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulation
    Eiji Tamagawa
    Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, BC, Canada
    Innate Immun 15:251-8. 2009
    ..This murine model facilitates the estimation of cytokine translocation across the lungs and evaluation of compounds to modulate this gradient...
  51. ncbi The determinants of poor respiratory health status in adults living with human immunodeficiency virus infection
    Janice M Leung
    1 UBC James Hogg Research Centre, Vancouver, BC, Canada
    AIDS Patient Care STDS 28:240-7. 2014
    ..Limitations of this analysis include the absence of available echocardiograms, diffusion capacity and lung volume testing, and an all-male cohort due to the demographics of the clinic population...
  52. pmc Bronchodilator responsiveness and reported respiratory symptoms in an adult population
    Wan C Tan
    UBC James Hogg Research Laboratories, Providence Heart Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e58932. 2013
    ..The relationship between patient-reported symptoms and objective measures of lung function is poorly understood...
  53. doi Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortality
    John Hill
    Providence Heart and Lung Institute and The UBC James Hogg Research Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Eur Heart J 32:1918-25. 2011
    ..Surfactant protein-D (SP-D) is a lung-specific protein that is detectable in human plasma. We determined the relationship of circulating SP-D to cardiovascular disease (CVD) and total mortality in subjects with and without CVD...
  54. pmc Progression of airway dysplasia and C-reactive protein in smokers at high risk of lung cancer
    Don D Sin
    Division of Respirology, Department of Medicine, University of British Columbia, Canada V5Z 1L3
    Am J Respir Crit Care Med 173:535-9. 2006
    ..Chronic inflammation has been implicated in the development of airway dysplasia and lung cancer. It is unclear whether circulating biomarkers of inflammation could be used to predict progression of airway dysplasia...
  55. doi Sex-related differences in serum cotinine concentrations in daily cigarette smokers
    Wen Qi Gan
    The Heart and Lung Institute and the James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Nicotine Tob Res 10:1293-300. 2008
    ..These findings indicate that significant sex-related differences exist in serum cotinine levels among smokers, which suggests that self-reports may overestimate cigarette exposure in women compared with men...
  56. doi Statins attenuate the development of atherosclerosis and endothelial dysfunction induced by exposure to urban particulate matter (PM10)
    Ryohei Miyata
    UBC James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Toxicol Appl Pharmacol 272:1-11. 2013
    ..Taken together, statins protect against PM10-induced cardiovascular disease by reducing atherosclerosis and improving endothelial function via their anti-inflammatory properties. ..
  57. pmc What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screening
    Joanna H Zurawska
    Department of Medicine, Division of Respiratory Medicine, University of British Columbia, BC, Canada
    Chest 141:1147-52. 2012
    ..In this article, we offer a possible low-cost strategy to risk-stratify smokers on the basis of spirometry measurements and emphysema scoring by radiologists on CT scans...
  58. pmc The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis
    David A Ngan
    UBC James Hogg Research Centre, Institute for Heart Lung Health at St, Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    BMC Pulm Med 12:3. 2012
    ..The relationship of plasma inflammatory biomarkers to lung function and hospitalization history remains largely unexplored...
  59. pmc The relationship between stage 1 and 2 non-small cell lung cancer and lung function in men and women
    Samir Malhotra
    Respiratory Division, Department of Medicine, University of British Columbia, British Columbia, Canada
    BMC Pulm Med 6:2. 2006
    ..Using a large tissue registry, we sought to determine the relationship between FEV1 and subtypes of NSCLC and determine whether this relationship is modified by gender...
  60. ncbi Management of asthma among community-based primary care physicians
    Ross T Tsuyuki
    University of Alberta, Edmonton
    J Asthma 42:163-7. 2005
    ..Despite significant improvements in asthma treatment and the dissemination of national and international guidelines for asthma management, there are ongoing concerns that suboptimal care is being provided for patients with asthma...
  61. pmc The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease
    Agnes Kliber
    Department of Medicine Respiratory Division, University of British Columbia, 6040 Iona Drive, Vancouver, V6T 2E8, Canada
    Respir Res 11:56. 2010
    ..We performed a comprehensive systematic review and meta-analysis to evaluate the effects of long-acting bronchodilators on total mortality in stable COPD...
  62. doi Particulate matter induces translocation of IL-6 from the lung to the systemic circulation
    Takashi Kido
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
    Am J Respir Cell Mol Biol 44:197-204. 2011
    ..These results support our hypothesis that exposure to PM(10) increases pulmonary inflammatory mediators that translocate to the circulation, contributing to systemic inflammation, with downstream effects such as vascular dysfunction...
  63. doi Vascular risk in chronic obstructive pulmonary disease: role of inflammation and other mediators
    S F Paul Man
    Department of Medicine Division of Respiratory Medicine, University of British Columbia UBC, and the UBC James Hogg Centre for Cardiovascular and Pulmonary Research, Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Can J Cardiol 28:653-61. 2012
    ....
  64. pmc The lung tissue microbiome in chronic obstructive pulmonary disease
    Marc A Sze
    The James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:1073-80. 2012
    ..Based on surface brushings and bronchoalveolar lavage fluid, Hilty and coworkers demonstrated microbiomes in the human lung characteristic of asthma and chronic obstructive pulmonary disease (COPD), which have now been confirmed by others...
  65. doi Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease
    Andrew Churg
    Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 185:34-43. 2012
    ..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation...
  66. pmc Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Respiratory Research, University of British Columbia, Vancouver, BC, Canada
    Respir Res 7:52. 2006
    ....
  67. doi The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory study
    S F Paul Man
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Ther Adv Respir Dis 3:73-80. 2009
    ..Several studies suggest that inhaled and oral corticosteroids repress systemic inflammation in chronic obstructive pulmonary disease (COPD). However, the cytokines that may respond to these medications are unclear...
  68. pmc Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease
    Don D Sin
    UBC James Hogg Research Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Crit Care Med 183:1187-92. 2011
    ..There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum...
  69. doi The airway epithelium: more than just a structural barrier
    Anthony Tam
    The UBC James Hogg Research Centre, Providence Heart and Lung Centre and Department of Medicine, University of British Columbia, UBC, Vancouver, BC, Canada
    Ther Adv Respir Dis 5:255-73. 2011
    ..In this paper, we review the current understanding of the airway epithelial response to injury and its interaction with inflammatory cells, in particular the neutrophil...
  70. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  71. ncbi Can universal access to health care eliminate health inequities between children of poor and nonpoor families?: A case study of childhood asthma in Alberta
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, AB, Canada
    Chest 124:51-6. 2003
    ..We sought to determine whether in a health-care system that provides free access to outpatient and hospital services, the disparities in the rates of emergency visits for asthma would be less apparent across the income gradient...
  72. pmc Airway wall thickness assessed using computed tomography and optical coherence tomography
    Harvey O Coxson
    Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:1201-6. 2008
    ..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less...
  73. ncbi The impact of follow-up physician visits on emergency readmissions for patients with asthma and chronic obstructive pulmonary disease: a population-based study
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Am J Med 112:120-5. 2002
    ..To examine the relation between follow-up office visits after emergency discharge and the risk of emergency readmissions in patients with asthma or chronic obstructive pulmonary disease (COPD)...
  74. ncbi The interactions between cigarette smoking and reduced lung function on systemic inflammation
    Wen Qi Gan
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room No 368A, 1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada
    Chest 127:558-64. 2005
    ..Low-grade systemic inflammation is commonly observed in conditions associated with reduced FEV(1). Active cigarette smoking, which is a leading risk factor for decreased FEV(1), can also independently induce systemic inflammation...
  75. ncbi The costs of implementing the 1999 Canadian Asthma Consensus Guidelines recommendation of asthma education and spirometry for the family physician
    Susan P Corrigan
    University of British Columbia, Vancouver
    Can Respir J 11:349-53. 2004
    ..The cost of implementing these interventions in family physician practices is not known...
  76. ncbi Asthma and COPD among aboriginals in Alberta, Canada
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Chest 121:1841-6. 2002
    ..Although there is a greater prevalence of smoking, poor housing, and overcrowding in aboriginal than nonaboriginal communities, the rates of office and emergency visits for asthma and COPD among aboriginals are not well known...
  77. ncbi Inhaled corticosteroids in the long-term management of patients with chronic obstructive pulmonary disease
    Don D Sin
    The Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Drugs Aging 20:867-80. 2003
    ....
  78. ncbi Effects of corticosteroids on systemic inflammation in chronic obstructive pulmonary disease
    S F Paul Man
    Department of Medicine, University of British Columbia, Canada
    Proc Am Thorac Soc 2:78-82. 2005
    ..We found that withdrawal of inhaled corticosteroids increased serum CRP levels, and that reintroduction of inhaled fluticasone could suppress CRP levels...
  79. ncbi Low-dose inhaled corticosteroid therapy and risk of emergency department visits for asthma
    Don D Sin
    Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    Arch Intern Med 162:1591-5. 2002
    ..While the use of inhaled corticosteroids has been demonstrated to improve asthma symptoms and lung function, it is not clear whether their use after discharge from the ED reduces asthma relapse rates...
  80. ncbi The impact of chronic obstructive pulmonary disease on work loss in the United States
    Don D Sin
    Department of Medicine Pulmonary Division, Institute of Health Economics, 2E4 29 Walter C Mackenzie Centre, University of Alberta, Edmonton, Alberta, T6G 2B7 Canada
    Am J Respir Crit Care Med 165:704-7. 2002
    ..These data suggest that COPD has a considerable adverse impact on work force participation. Based on these data, we estimate that, in 1994, COPD was responsible for work loss of approximately $9.9 billion in the U.S...
  81. pmc Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detection
    John Yee
    Division of Thoracic Surgery, Vancouver General Hospital, The University of British Columbia, Canada
    J Clin Oncol 27:2787-92. 2009
    ..There are no reliable blood biomarkers to detect early lung cancer. We used a novel strategy that allows discovery of differentially present proteins against a complex and variable background...
  82. ncbi Economic evaluation of a community-based pulmonary rehabilitation program for chronic obstructive pulmonary disease
    Kamran Golmohammadi
    Institute of Health Economics, Edmonton, Alberta, Canada
    Lung 182:187-96. 2004
    ..This suggests that pulmonary rehabilitation is cost-effective for patients with relatively high utilization of emergency and hospital-based services...
  83. doi Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysis
    Bradley S Quon
    Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
    Chest 133:756-66. 2008
    ..However, their clinical benefits in various settings are uncertain. We undertook a systematic review and metaanalysis to systematically evaluate the effectiveness of these therapies...
  84. ncbi Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a clinical benefit?
    S F Paul Man
    Department of Medicine, Pulmonary Division, St Paul s Hospital, Vancouver, British Columbia
    Drugs 65:579-91. 2005
    ..On balance, for those with moderate-to-severe COPD and those who experience frequent exacerbations, judicious use of inhaled corticosteroids alone or in combination with long-acting beta2-adrenoceptor agonists appears reasonable...
  85. pmc Acute exacerbation of chronic obstructive pulmonary disease: influence of social factors in determining length of hospital stay and readmission rates
    Alyson W M Wong
    The James iCAPTURE Centre for Cardiovascular and pulmonary Research, Heart and Lung Institute, St Paul s Hospital, Providence Healthcare, University of British Columbia, Vancouver, British Columbia, Canada
    Can Respir J 15:361-4. 2008
    ..Identifying factors that influence the time a patient spends in the hospital and readmission rates will allow for better use of scarce hospital resources...
  86. ncbi Estimation of cancer mortality associated with repetitive computed tomography scanning
    Pim A de Jong
    Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Am J Respir Crit Care Med 173:199-203. 2006
    ..Low-dose radiation from computed tomography (CT) may increase the risk of certain cancers, especially in children...
  87. ncbi Developments in drugs for the treatment of chronic obstructive pulmonary disease
    Tammy Sy Mui
    The Providence Heart and Lung Center, The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital and the Department of Medicine Respiratory Division, The University of British Columbia, Vancouver, BC, Canada
    Expert Rev Clin Immunol 4:365-77. 2008
    ..In this article, we will review the current paradigm of COPD pathogenesis and discuss some promising molecular targets that may be modified in the future to improve health outcomes of patients with COPD...
  88. ncbi Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease
    Stephan F van Eeden
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
    Respiration 75:224-38. 2008
    ..This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects...
  89. ncbi Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease
    Don D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Circulation 107:1514-9. 2003
    ..Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease 2- to 3-fold. The factors responsible for this association remain largely unknown...
  90. ncbi The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trials
    Abdullah Alsaeedi
    Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    Am J Med 113:59-65. 2002
    ..Further research is required to define the long-term effects of these medications and the benefit/risk ratio for patients with COPD...
  91. ncbi The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism
    Sigal Ben-Zaken Cohen
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, and the Department of Medicine, The University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 176:113-20. 2007
    ..In this article, we explore CYP and other related pathways as potential mechanisms and targets of future research and novel discoveries to curb the growing epidemic of COPD and lung cancer in women...
  92. ncbi Therapeutic options for chronic obstructive pulmonary disease: present and future
    D D Sin
    Department of Medicine, Pulmonary Division, St Paul s Hospital, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
    Eur Rev Med Pharmacol Sci 8:247-58. 2004
    ..Drugs such as phosphodiesterase 4 inhibitors, tyrosine kinase blockers and peroxisome proliferator-activated gamma receptor agonists show great promise as disease-modifying agents in COPD...
  93. pmc C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease
    S F P Man
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Thorax 61:849-53. 2006
    ..Although C-reactive protein (CRP) levels are increased in chronic obstructive pulmonary disease (COPD), it is not certain whether they are associated with adverse clinical outcomes...
  94. ncbi Inhaled corticosteroids and survival in chronic obstructive pulmonary disease: does the dose matter?
    D D Sin
    Dept of Medicine, Pulmonary Division, University of Alberta, Edmonton, Canada
    Eur Respir J 21:260-6. 2003
    ..Low- was inferior to medium- or high-dose therapy in protecting against mortality in chronic obstructive pulmonary disease...
  95. ncbi Underuse of inhaled steroid therapy in elderly patients with asthma
    D D Sin
    Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    Chest 119:720-5. 2001
    ....
  96. pmc Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis
    W Q Gan
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
    Thorax 59:574-80. 2004
    ..Systemic inflammation may be involved in the pathogenesis of these disorders. A study was undertaken to determine whether systemic inflammation is present in stable COPD...
  97. pmc Associations of IL6 polymorphisms with lung function decline and COPD
    J Q He
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Thorax 64:698-704. 2009
    ..There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers...
  98. pmc Prediction of the rate of decline in FEV(1) in smokers using quantitative Computed Tomography
    R Yuan
    University of British Columbia James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research and the Providence Heart Lung Institute, St Paul s Hospital, British Columbia, Canada
    Thorax 64:944-9. 2009
    ....
  99. pmc Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysis
    S Wasswa-Kintu
    Department of Medicine Respiratory Division, University of Bristish Columbia and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Thorax 60:570-5. 2005
    ..Moreover, there is little consensus on whether men and women have similar risks for lung cancer for similar decreases in FEV(1)...
  100. pmc Impaired lung function and serum leptin in men and women with normal body weight: a population based study
    D D Sin
    Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
    Thorax 58:695-8. 2003
    ..Whether circulating factors are responsible for this association is unknown. A study was undertaken to determine whether leptin, a hormone that can promote atherothrombosis, is raised in individuals with impaired lung function...
  101. doi Circulating fibronectin to C-reactive protein ratio and mortality: a biomarker in COPD?
    S F P Man
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Eur Respir J 32:1451-7. 2008
    ..While promising, future studies are needed to validate this simple index as a biomarker in COPD...