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Genomes and Genes | Don D SinSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Do chronic inhaled steroids alone or in combination with a bronchodilator prolong life in chronic obstructive pulmonary disease patients?Don D Sin
The University of British Columbia Respiratory Division, Vancouver, British Columbia, Canada
Curr Opin Pulm Med 13:90-7. 2007..Whether these medications prolong survival is uncertain...
Effects of inhaled corticosteroids on sputum cell counts in stable chronic obstructive pulmonary disease: a systematic review and a meta-analysisWen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital and the Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
BMC Pulm Med 5:3. 2005..We sought to determine the effects of inhaled corticosteroids on sputum indices of inflammation in stable COPD...- The influence of gender on the effects of aspirin in preventing myocardial infarctionTodd Yerman
Department of Medicine Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, British Columbia, Canada
BMC Med 5:29. 2007..We conducted a systematic review and meta-analysis to determine whether gender mix might play a role in explaining the large variation of aspirin efficacy across primary and secondary MI prevention trials... 
Budesonide and the risk of pneumonia: a meta-analysis of individual patient dataDon D Sin
Providence Heart and Lung Institute, St Paul s Hospital iCAPTURE Centre, and Department of Medicine Division of Respirology, University of British Columbia, Vancouver, BC, Canada
Lancet 374:712-9. 2009..We aimed to establish the effects of inhaled budesonide on the risk of pneumonia in such patients...- Arterial carbon dioxide tension on admission as a marker of in-hospital mortality in community-acquired pneumoniaDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
Am J Med 118:145-50. 2005..We sought to determine the association between arterial carbon dioxide tension (P(a)CO(2)) and in-hospital mortality in patients admitted with pneumonia... - Combination therapy of inhaled corticosteroids and long-acting beta2-adrenergics in management of patients with chronic obstructive pulmonary diseaseDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Curr Pharm Des 10:3547-60. 2004..This article will present a comprehensive overview of the currently available clinical evidence for the use of combination therapy as well as the potential mechanisms of their actions in COPD... - Surfactant protein D: a lung specific biomarker in COPD?Don D Sin
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Ther Adv Respir Dis 2:65-74. 2008..In this paper, we review one promising systemic biomarker that ful"lls some of these criteria, surfactant protein D (SPD)... - Effects of increased primary care access on process of care and health outcomes among patients with asthma who frequent emergency departmentsDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, Canada
Am J Med 117:479-83. 2004..This study was conducted to determine the effectiveness of a health professional-based intervention in improving process of care and health outcomes among asthmatic patients discharged from emergency departments... - Pharmacotherapy for mortality reduction in chronic obstructive pulmonary diseaseDon D Sin
The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
Proc Am Thorac Soc 3:624-9. 2006..This article reviews some of the relevant epidemiologic and pathophysiologic processes that affect mortality in COPD and critically examines the effect of current COPD therapies on mortality... - Forced expiratory volume in 1 second and physical activity in the general populationDon D Sin
Department of Medicine, University of British Columbia, Vancouver, Canada
Am J Med 117:270-3. 2004 - The tip of the "ICEBERGS": a National Conference to Combat the Growing Global Epidemic of COPD in womenDon D Sin
James Hogg iCAPTURE Center, St. Paul's Hospital, Vancouver, BC, V6Z 1Y6 Canada
Proc Am Thorac Soc 4:669-70. 2007 - Corticosteroids and adrenoceptor agonists: the compliments for combination therapy in chronic airways diseasesDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard Street, and Department of Medicine Pulmonary Division, University of British Columbia, Vancouver, B C, Canada V6Z 1Y6
Eur J Pharmacol 533:28-35. 2006..There is a large clinical trial currently underway, which will provide mortality data by the year 2006. On balance, clinical evidence supports the use of combination therapy in moderate to severe asthma and COPD... - Commentary: fuelling the fire--systemic inflammation and development of lung disease in the general communityDon D Sin
The James Hogg Icapture Center For Cardiovascular, Pulmonary Research, St Paul's Hospital, Vancouver, BC, Canada
Int J Epidemiol 35:1008-10. 2006 - Chronic obstructive pulmonary disease: a novel risk factor for cardiovascular diseaseDon D Sin
Department of Medicine, University of British Columbia, St Paul s Hospital, Vancouver, BC, Canada
Can J Physiol Pharmacol 83:8-13. 2005..In this paper, we discuss the epidemiologic evidence linking COPD and cardiovascular events as well as the potential mechanism(s) which may be responsible for this association... - The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literatureDon D Sin
Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
Chest 127:1952-9. 2005..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking... - Emerging drugs for the treatment of chronic obstructive pulmonary diseaseSamir Malhotra
University of British Columbia and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Department of Medicine Respiratory Division, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
Expert Opin Emerg Drugs 11:275-91. 2006..Many of these drugs may enter the COPD market within the next decade. This paper reviews the molecular rationale for these emerging drugs and their potential efficacy in COPD... - Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortalityDon D Sin
Department of Medicine, University of British Columbia, Canada
Proc Am Thorac Soc 2:8-11. 2005..These data indicate that chronic obstructive pulmonary disease is a powerful, independent risk factor for cardiovascular morbidity and mortality... - Can inhaled fluticasone alone or in combination with salmeterol reduce systemic inflammation in chronic obstructive pulmonary disease? Study protocol for a randomized controlled trial [NCT00120978]Don D Sin
Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, Canada
BMC Pulm Med 6:3. 2006.... - Inhaled corticosteroids and mortality in chronic obstructive pulmonary diseaseD D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, and Department of Medicine, University of British Columbia, Vancouver, BC, Canada, V6Z 1Y6
Thorax 60:992-7. 2005..Clinical studies suggest that inhaled corticosteroids reduce exacerbations and improve health status in chronic obstructive pulmonary disease (COPD). However, their effect on mortality is unknown... - Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysisDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
JAMA 292:367-76. 2004..Over the last 2 decades, many new pharmacological agents have been introduced to reduce the growing morbidity associated with asthma, but the long-term effects of these agents on exacerbations are unclear... - Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and womenDon D Sin
University of British Columbia, Vancouver, British Columbia, Canada
Proc Am Thorac Soc 4:671-4. 2007..This article reviews this and other potential mechanisms that may confer increased susceptibility of COPD to female smokers... - Systemic inflammation and mortality in chronic obstructive pulmonary diseaseDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul, s Hospital, Vancouver, Canada
Can J Physiol Pharmacol 85:141-7. 2007..Systemic inflammation may contribute substantially to the overall morbidity and mortality of COPD patients... - Impact of cancers and cardiovascular diseases in chronic obstructive pulmonary diseaseDon D Sin
Respiratory Division, Department of Medicine, University of British Columbia, Canada
Curr Opin Pulm Med 14:115-21. 2008..Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in patients with chronic obstructive pulmonary disease. The epidemiological and mechanistic evidence linking these disorders, however, is uncertain... - Circulating surfactant protein D as a potential lung-specific biomarker of health outcomes in COPD: a pilot studyDon D Sin
The University of British Columbia Respiratory Division, Vancouver, BC
BMC Pulm Med 7:13. 2007..The principal aim of this pilot study was to determine whether circulating surfactant protein D (SPD) or Clara Cell protein-16 (CC16) levels are associated with lung function or health status in patients with severe COPD... - Mortality in COPD: Role of comorbiditiesD D Sin
The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Eur Respir J 28:1245-57. 2006..e. inflammation), and the tools used to predict chronic obstructive pulmonary disease mortality... - Effects of nocturnal noninvasive mechanical ventilation on heart rate variability of patients with advanced COPDDon D Sin
Pulmonary Division, Department of Medicine, The University of British Columbia, Vancouver, BC, Canada
Chest 131:156-63. 2007.... - Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancerDon D Sin
St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Chest 134:582-8. 2008..Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers... - Biomarkers in chronic obstructive pulmonary diseaseDon D Sin
Department of Medicine, Division of Respiratory Medicine, the University of British Columbia and The Providence Heart and Lung Institute, James Hogg iCAPTURE Center, St Paul s Hospital, Vancouver, British Columbia, Canada
Proc Am Thorac Soc 6:543-5. 2009..In this article, we discuss the current barriers of biomarker discovery and propose possible criteria and methods for developing novel biomarkers in COPD... - Spirometric findings among school-aged First Nations children on a reserve: a pilot studyDon D Sin
Department of Medicine, University of Alberta, Edmonton
Can Respir J 11:45-8. 2004..Although hospital utilization for asthma and COPD among First Nations peoples has been increasing, the prevalence of asthma or wheezing is comparable to national averages... - Combination of ICSs and LABAs should be used in the management of patients with COPD--the pro argumentDon D Sin
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Department of Medicine, University of British Columbia, Vancouver
Can Respir J 11:221-3. 2004 - Recruitment for a provincial asthma study. Participation of network and non-network primary care physiciansDon D Sin
Department of Medicine, University of British Columbia, Vancouver
Can Fam Physician 50:1251-4. 2004 - The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary diseaseDon D Sin
Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, Canada
Am J Respir Crit Care Med 177:1207-14. 2008..Small studies have suggested that inhaled corticosteroids can suppress systemic inflammation in chronic obstructive pulmonary disease (COPD)... - Endotoxin-induced cardiovascular dysfunction in mice: effect of simvastatinKoichi Suda
Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, British Columbia, Canada
J Appl Physiol 111:1118-24. 2011..SS significantly improved LPS-induced cardiovascular dysfunction possibly by reducing systemic expression of IL-6 and its downstream signaling pathways. These findings may explain how statins improve health outcomes in patients with ALI... - Marijuana and chronic obstructive lung disease: a population-based studyWan C Tan
iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and the University of British Columbia, Vancouver, Canada
CMAJ 180:814-20. 2009..Our aim was to determine the combined and independent effects of tobacco and marijuana smoking on respiratory symptoms and chronic obstructive pulmonary disease (COPD) in the general population... - The relationship between telomere length and mortality in chronic obstructive pulmonary disease (COPD)Jee Lee
The Providence Heart and Lung Institute at St Paul s Hospital, The UBC James Hogg Research Centre and Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada
PLoS ONE 7:e35567. 2012..In conclusion, COPD patients have short leukocyte telomeres, which are in turn associated increased risk of total and cancer mortality. Accelerated aging is of particular relevance to cancer mortality in COPD... - Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary diseaseDon D Sin
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Am J Respir Crit Care Med 170:760-5. 2004..Inhaled and oral corticosteroids are effective in reducing serum CRP levels in patients with COPD and suggest their potential use for improving cardiovascular outcomes in COPD... - The relationship between birth weight and childhood asthma: a population-based cohort studyDon D Sin
Pulmonary Division, The Department of Medicine, University of Alberta, Edmonton, Canada
Arch Pediatr Adolesc Med 158:60-4. 2004..Because obesity promotes inflammation and imposes mechanical constraints to the airways, a high birth weight may be a risk factor for asthma in childhood. However, to our knowledge, few studies have examined this potential relationship... - Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterolKoichi Suda
Division of Respiratory Medicine, University of British Columbia, Providence Heart and Lung Institute, St Paul s Hospital, 1081 Burrard St, Vancouver, British Columbia V6Z 1Y6, Canada
Am J Respir Cell Mol Biol 45:510-6. 2011..ICS/LABA may reduce acute cardiovascular events related to ALI... - Treatment of mild chronic obstructive pulmonary diseaseAlex Chee
Department of Medicine, Division of Respirology, The University of British Columbia and Providence Heart and Lung Institute and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 3:563-73. 2008..Influenza and pneumococcal vaccination and pulmonary rehabilitation are other therapies that may be considered for select patients with mild disease. In this paper, we summarize the current standard of care for patients with mild COPD... - The relationship between lung inflammation and cardiovascular diseaseStephan van Eeden
Division of Respiratory Medicine, Department of Medicine, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Am J Respir Crit Care Med 186:11-6. 2012.... - Contemporary management of chronic obstructive pulmonary disease: clinical applicationsS F Paul Man
Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada
JAMA 290:2313-6. 2003..Finally, correction of resting arterial hypoxemia with oxygen therapy for more than 15 h/d prolongs survival of COPD patients for those with a resting PaO2 lower than 55 to 60 mm Hg... - The effects of beta-blockers on morbidity and mortality in a population-based cohort of 11,942 elderly patients with heart failureDon D Sin
Department of Pulmonary Medicine (DDS, University of Alberta Hospital, Edmonton, Canada
Am J Med 113:650-6. 2002..There is a need for a randomized trial comparing different doses of beta-blockers in heart failure... - Effect of gene environment interactions on lung function and cardiovascular disease in COPDTillie Louise Hackett
University of British Columbia, James Hogg Research Laboratories, St Paul s Hospital, Division of Respirology, Department of Medicine, Vancouver, BC, Canada
Int J Chron Obstruct Pulmon Dis 6:277-87. 2011.... - Endotoxin-induced translocation of interleukin-6 from lungs to the systemic circulationEiji Tamagawa
Division of Respiratory Medicine, The University of British Columbia, the Providence Heart and Lung Institute and The James Hogg iCapture Center for Cardiovascular and Pulmonary Research St Paul s Hospital, Vancouver, BC, Canada
Innate Immun 15:251-8. 2009..This murine model facilitates the estimation of cytokine translocation across the lungs and evaluation of compounds to modulate this gradient... - Sex-related differences in serum cotinine concentrations in daily cigarette smokersWen Qi Gan
The Heart and Lung Institute and the James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research at St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Nicotine Tob Res 10:1293-300. 2008..These findings indicate that significant sex-related differences exist in serum cotinine levels among smokers, which suggests that self-reports may overestimate cigarette exposure in women compared with men... - Progression of airway dysplasia and C-reactive protein in smokers at high risk of lung cancerDon D Sin
Division of Respirology, Department of Medicine, University of British Columbia, Canada V5Z 1L3
Am J Respir Crit Care Med 173:535-9. 2006.... - Circulating surfactant protein-D and the risk of cardiovascular morbidity and mortalityJohn Hill
Providence Heart and Lung Institute and The UBC James Hogg Research Center, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Eur Heart J 32:1918-25. 2011..Surfactant protein-D (SP-D) is a lung-specific protein that is detectable in human plasma. We determined the relationship of circulating SP-D to cardiovascular disease (CVD) and total mortality in subjects with and without CVD... - The complex relationship of serum adiponectin to COPD outcomes COPD and adiponectinHo Il Yoon
University of British Columbia James Hogg Research Center, Vancouver, BC, Canada
Chest 142:893-99. 2012..Adiponectin is a hormone that has anti inflammatory, antidiabetic, and anti atherogenic activities. We investigated the relationship of serum adiponectin to health outcomes in COPD... - What to do when a smoker's CT scan is "normal"?: Implications for lung cancer screeningJoanna H Zurawska
Department of Medicine, Division of Respiratory Medicine, University of British Columbia, BC, Canada
Chest 141:1147-52. 2012..In this article, we offer a possible low-cost strategy to risk-stratify smokers on the basis of spirometry measurements and emphysema scoring by radiologists on CT scans... - The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosisDavid A Ngan
UBC James Hogg Research Centre, Institute for Heart Lung Health at St, Paul s Hospital and Department of Medicine, University of British Columbia, Vancouver, BC, Canada
BMC Pulm Med 12:3. 2012..The relationship of plasma inflammatory biomarkers to lung function and hospitalization history remains largely unexplored... - The relationship between stage 1 and 2 non-small cell lung cancer and lung function in men and womenSamir Malhotra
Respiratory Division, Department of Medicine, University of British Columbia, British Columbia, Canada
BMC Pulm Med 6:2. 2006..Using a large tissue registry, we sought to determine the relationship between FEV1 and subtypes of NSCLC and determine whether this relationship is modified by gender... - The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary diseaseAgnes Kliber
Department of Medicine Respiratory Division, University of British Columbia, 6040 Iona Drive, Vancouver, V6T 2E8, Canada
Respir Res 11:56. 2010..We performed a comprehensive systematic review and meta-analysis to evaluate the effects of long-acting bronchodilators on total mortality in stable COPD... - Management of asthma among community-based primary care physiciansRoss T Tsuyuki
University of Alberta, Edmonton
J Asthma 42:163-7. 2005..CONCLUSIONS: Our study indicates a gap in the provision of asthma education, written action plans, and spirometric testing for patients diagnosed with asthma among primary care physicians... - Particulate matter induces translocation of IL-6 from the lung to the systemic circulationTakashi Kido
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
Am J Respir Cell Mol Biol 44:197-204. 2011..These results support our hypothesis that exposure to PM(10) increases pulmonary inflammatory mediators that translocate to the circulation, contributing to systemic inflammation, with downstream effects such as vascular dysfunction... - Vascular risk in chronic obstructive pulmonary disease: role of inflammation and other mediatorsS F Paul Man
Department of Medicine Division of Respiratory Medicine, University of British Columbia UBC, and the UBC James Hogg Centre for Cardiovascular and Pulmonary Research, Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, BC, Canada
Can J Cardiol 28:653-61. 2012.... - The lung tissue microbiome in chronic obstructive pulmonary diseaseMarc A Sze
The James Hogg Research Centre, Providence Heart Lung Institute at St Paul s Hospital, Departments of Medicine and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 185:1073-80. 2012..Based on surface brushings and bronchoalveolar lavage fluid, Hilty and coworkers demonstrated microbiomes in the human lung characteristic of asthma and chronic obstructive pulmonary disease (COPD), which have now been confirmed by others... - Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary diseaseAndrew Churg
Department of Pathology and UBC James Hogg Research Centre, Institute for Heart and Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Crit Care Med 185:34-43. 2012..Myeloperoxidase (MPO), a neutrophil and macrophage product, is important in bacterial killing, but also drives inflammatory reactions and tissue oxidation... - Female smokers beyond the perimenopausal period are at increased risk of chronic obstructive pulmonary disease: a systematic review and meta-analysisWen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Respiratory Research, University of British Columbia, Vancouver, BC, Canada
Respir Res 7:52. 2006.... - The airway epithelium: more than just a structural barrierAnthony Tam
The UBC James Hogg Research Centre, Providence Heart and Lung Centre and Department of Medicine, University of British Columbia, UBC, Vancouver, BC, Canada
Ther Adv Respir Dis 5:255-73. 2011..In this paper, we review the current understanding of the airway epithelial response to injury and its interaction with inflammatory cells, in particular the neutrophil... - The effects of inhaled and oral corticosteroids on serum inflammatory biomarkers in COPD: an exploratory studyS F Paul Man
Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Ther Adv Respir Dis 3:73-80. 2009..Several studies suggest that inhaled and oral corticosteroids repress systemic inflammation in chronic obstructive pulmonary disease (COPD). However, the cytokines that may respond to these medications are unclear... - Airway wall thickness assessed using computed tomography and optical coherence tomographyHarvey O Coxson
Department of Radiology, Vancouver General Hospital, 855 West 12th Avenue, Room 3350 JPN, Vancouver, BC, Canada
Am J Respir Crit Care Med 177:1201-6. 2008..Optical coherence tomography (OCT) is a promising new micron-scale resolution imaging technique that can image small airways 2 mm in diameter or less... - The impact of follow-up physician visits on emergency readmissions for patients with asthma and chronic obstructive pulmonary disease: a population-based studyDon D Sin
Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
Am J Med 112:120-5. 2002.... - The interactions between cigarette smoking and reduced lung function on systemic inflammationWen Qi Gan
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Room No. 368A, 1081 Burrard St, Vancouver, BC, V6Z 1Y6 Canada
Chest 127:558-64. 2005.... - Contemporary management of chronic obstructive pulmonary disease: scientific reviewDon D Sin
Division of Pulmonary Medicine, University of Alberta, Edmonton, Canada
JAMA 290:2301-12. 2003..The care of patients with chronic obstructive pulmonary disease (COPD) has changed radically over the past 2 decades, and novel therapies can not only improve the health status of patients with COPD but also modify its natural course... - Can universal access to health care eliminate health inequities between children of poor and nonpoor families?: A case study of childhood asthma in AlbertaDon D Sin
Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, AB, Canada
Chest 124:51-6. 2003..We sought to determine whether in a health-care system that provides free access to outpatient and hospital services, the disparities in the rates of emergency visits for asthma would be less apparent across the income gradient... - Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary diseaseDon D Sin
UBC James Hogg Research Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
Am J Respir Crit Care Med 183:1187-92. 2011..There are no accepted blood-based biomarkers in chronic obstructive pulmonary disease (COPD). Pulmonary and activation-regulated chemokine (PARC/CCL-18) is a lung-predominant inflammatory protein that is found in serum... - Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathologyJames C Hogg
University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Am J Respir Crit Care Med 176:454-9. 2007..COPD is associated with reduced life expectancy... - The costs of implementing the 1999 Canadian Asthma Consensus Guidelines recommendation of asthma education and spirometry for the family physicianSusan P Corrigan
University of British Columbia, Vancouver
Can Respir J 11:349-53. 2004..In light of the evidence of the effectiveness of these interventions, health insurance plans should consider adding these services to fee schedules... - The impact of chronic obstructive pulmonary disease on work loss in the United StatesDon D Sin
Department of Medicine Pulmonary Division, Institute of Health Economics, 2E4 29 Walter C Mackenzie Centre, University of Alberta, Edmonton, Alberta, T6G 2B7 Canada
Am J Respir Crit Care Med 165:704-7. 2002..These data suggest that COPD has a considerable adverse impact on work force participation. Based on these data, we estimate that, in 1994, COPD was responsible for work loss of approximately $9.9 billion in the U.S... - Effects of corticosteroids on systemic inflammation in chronic obstructive pulmonary diseaseS F Paul Man
Department of Medicine, University of British Columbia, Canada
Proc Am Thorac Soc 2:78-82. 2005..We found that withdrawal of inhaled corticosteroids increased serum CRP levels, and that reintroduction of inhaled fluticasone could suppress CRP levels... - Asthma and COPD among aboriginals in Alberta, CanadaDon D Sin
Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
Chest 121:1841-6. 2002..Although there is a greater prevalence of smoking, poor housing, and overcrowding in aboriginal than nonaboriginal communities, the rates of office and emergency visits for asthma and COPD among aboriginals are not well known... - Inhaled corticosteroids in the long-term management of patients with chronic obstructive pulmonary diseaseDon D Sin
The Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
Drugs Aging 20:867-80. 2003.... - Low-dose inhaled corticosteroid therapy and risk of emergency department visits for asthmaDon D Sin
Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
Arch Intern Med 162:1591-5. 2002..While the use of inhaled corticosteroids has been demonstrated to improve asthma symptoms and lung function, it is not clear whether their use after discharge from the ED reduces asthma relapse rates... - Connective tissue-activating peptide III: a novel blood biomarker for early lung cancer detectionJohn Yee
Division of Thoracic Surgery, Vancouver General Hospital, The University of British Columbia, Canada
J Clin Oncol 27:2787-92. 2009..There are no reliable blood biomarkers to detect early lung cancer. We used a novel strategy that allows discovery of differentially present proteins against a complex and variable background... - Inhaled corticosteroids in chronic obstructive pulmonary disease: is there a clinical benefit?S F Paul Man
Department of Medicine, Pulmonary Division, St Paul s Hospital, Vancouver, British Columbia
Drugs 65:579-91. 2005..On balance, for those with moderate-to-severe COPD and those who experience frequent exacerbations, judicious use of inhaled corticosteroids alone or in combination with long-acting beta2-adrenoceptor agonists appears reasonable... - Economic evaluation of a community-based pulmonary rehabilitation program for chronic obstructive pulmonary diseaseKamran Golmohammadi
Institute of Health Economics, Edmonton, Alberta, Canada
Lung 182:187-96. 2004..This suggests that pulmonary rehabilitation is cost-effective for patients with relatively high utilization of emergency and hospital-based services... - Acute exacerbation of chronic obstructive pulmonary disease: influence of social factors in determining length of hospital stay and readmission ratesAlyson W M Wong
The James iCAPTURE Centre for Cardiovascular and pulmonary Research, Heart and Lung Institute, St Paul s Hospital, Providence Healthcare, University of British Columbia, Vancouver, British Columbia, Canada
Can Respir J 15:361-4. 2008..Identifying factors that influence the time a patient spends in the hospital and readmission rates will allow for better use of scarce hospital resources... - Contemporary management of acute exacerbations of COPD: a systematic review and metaanalysisBradley S Quon
Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC, Canada
Chest 133:756-66. 2008..However, their clinical benefits in various settings are uncertain. We undertook a systematic review and metaanalysis to systematically evaluate the effectiveness of these therapies... - Developments in drugs for the treatment of chronic obstructive pulmonary diseaseTammy Sy Mui
The Providence Heart and Lung Center, The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital and the Department of Medicine Respiratory Division, The University of British Columbia, Vancouver, BC, Canada
Expert Rev Clin Immunol 4:365-77. 2008..In this article, we will review the current paradigm of COPD pathogenesis and discuss some promising molecular targets that may be modified in the future to improve health outcomes of patients with COPD... - Estimation of cancer mortality associated with repetitive computed tomography scanningPim A de Jong
Department of Pediatric Pulmonology and Allergology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
Am J Respir Crit Care Med 173:199-203. 2006..Low-dose radiation from computed tomography (CT) may increase the risk of certain cancers, especially in children... - Chronic obstructive pulmonary disease: a chronic systemic inflammatory diseaseStephan F van Eeden
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St Paul s Hospital, Vancouver, B C, Canada
Respiration 75:224-38. 2008..This review describes the nature of the systemic inflammatory response in COPD and the clinical manifestations associated with the systemic response, with a focus on the potential mechanisms for these adverse health effects... - Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary diseaseDon D Sin
Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
Circulation 107:1514-9. 2003..Chronic obstructive pulmonary disease (COPD) increases the risk of cardiovascular disease 2- to 3-fold. The factors responsible for this association remain largely unknown... - The effects of inhaled corticosteroids in chronic obstructive pulmonary disease: a systematic review of randomized placebo-controlled trialsAbdullah Alsaeedi
Division of Pulmonary Medicine, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
Am J Med 113:59-65. 2002..Further research is required to define the long-term effects of these medications and the benefit/risk ratio for patients with COPD... - The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolismSigal Ben Zaken Cohen
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, and the Department of Medicine, The University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
Am J Respir Crit Care Med 176:113-20. 2007..In this article, we explore CYP and other related pathways as potential mechanisms and targets of future research and novel discoveries to curb the growing epidemic of COPD and lung cancer in women... - Therapeutic options for chronic obstructive pulmonary disease: present and futureD D Sin
Department of Medicine, Pulmonary Division, St Paul's Hospital, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
Eur Rev Med Pharmacol Sci 8:247-58. 2004..Drugs such as phosphodiesterase 4 inhibitors, tyrosine kinase blockers and peroxisome proliferator-activated gamma receptor agonists show great promise as disease-modifying agents in COPD... - Inhaled corticosteroids and survival in chronic obstructive pulmonary disease: does the dose matter?D D Sin
Dept of Medicine, Pulmonary Division, University of Alberta, Edmonton, Canada
Eur Respir J 21:260-6. 2003..Low- was inferior to medium- or high-dose therapy in protecting against mortality in chronic obstructive pulmonary disease... - C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary diseaseS F P Man
James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Thorax 61:849-53. 2006.... - Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysisW Q Gan
The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul's Hospital, Room 368A, 1081 Burrard Street, Vancouver, British Columbia, Canada V6A 1Y6
Thorax 59:574-80. 2004..29 to 0.89)). CONCLUSIONS: Reduced lung function is associated with increased levels of systemic inflammatory markers which may have important pathophysiological and therapeutic implications for subjects with stable COPD... - Underuse of inhaled steroid therapy in elderly patients with asthmaD D Sin
Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
Chest 119:720-5. 2001.... - Prediction of the rate of decline in FEV(1) in smokers using quantitative Computed TomographyR Yuan
University of British Columbia James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research and the Providence Heart Lung Institute, St Paul s Hospital, British Columbia, Canada
Thorax 64:944-9. 2009.... - Associations of IL6 polymorphisms with lung function decline and COPDJ Q He
UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
Thorax 64:698-704. 2009..There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region of IL6. It was hypothesised that IL6 SNPs influence susceptibility for impaired lung function and COPD in smokers... - Impaired lung function and serum leptin in men and women with normal body weight: a population based studyD D Sin
Department of Medicine, Pulmonary Division, University of Alberta, Edmonton, Alberta, Canada
Thorax 58:695-8. 2003..Whether circulating factors are responsible for this association is unknown. A study was undertaken to determine whether leptin, a hormone that can promote atherothrombosis, is raised in individuals with impaired lung function... - Circulating fibronectin to C-reactive protein ratio and mortality: a biomarker in COPD?S F P Man
The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
Eur Respir J 32:1451-7. 2008..While promising, future studies are needed to validate this simple index as a biomarker in COPD... - Relationship between reduced forced expiratory volume in one second and the risk of lung cancer: a systematic review and meta-analysisS Wasswa-Kintu
Department of Medicine(Respiratory Division, University of Bristish Columbia and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul's Hospital, Room #368A, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Thorax 60:570-5. 2005..05 to 1.62) and 2.64 fold in women (95% CI 1.30 to 5.31). CONCLUSION: Reduced FEV1 is strongly associated with lung cancer. Even a relatively modest reduction in FEV1 is a significant predictor of lung cancer, especially among women... - Is systemic inflammation responsible for pulmonary hypertension in COPD?Don D Sin
Chest 130:310-2. 2006 - Breaking down the "Great Wall" of COPD care in ChinaDon D Sin
Am J Respir Crit Care Med 176:732-3. 2007 - Interleukin-6: a red herring or a real catch in COPD?Don D Sin
Chest 133:4-6. 2008 - A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placeboJoan B Soriano
Head, Program of Epidemiology and Clinical Research, Fundació Caubet CIMERA Illes Balears, International Centre for Advanced Respiratory Medicine, Recinte Hospital Joan March, Bunyola, Mallorca, Spain
Chest 131:682-9. 2007..There is controversy about whether therapy with inhaled corticosteroids (ICSs) modifies the natural history of COPD, characterized by an accelerated decline in FEV(1)... - Asthma control and management in the community: indices in 1997 compared with indices in 2002Robert L Cowie
Calgary COPD and Asthma Program, Canada
Can Fam Physician 52:750-1. 2006..To determine whether there was any change in indices of asthma control in population-based samples of patients with asthma between 1997 and 2002... - Development and validation of a prognostic index for health outcomes in chronic obstructive pulmonary diseaseAndrew Briggs
Section of Public Health and Health Policy, University of Glasgow, 1 Lilybank Gardens, Glasgow G12 8RZ, Scotland
Arch Intern Med 168:71-9. 2008..The severity of the condition has typically been characterized by a single physiological measurement: forced expiratory volume in 1 second, which has been shown to be prognostic for mortality... - Impact of cardioselective beta-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosisYvette R B M van Gestel
Department of Anesthesiology, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Respir Crit Care Med 178:695-700. 2008..There is a general reluctance to prescribe beta-blockers in patients with chronic obstructive pulmonary disease (COPD) because they may worsen symptoms...