F E Simons

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. ncbi request reprint Mosquito allergy: recombinant mosquito salivary antigens for new diagnostic tests
    F E Simons
    Department of Pediatrics and Child Health, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Int Arch Allergy Immunol 124:403-5. 2001
  2. ncbi request reprint Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast
    F E Simons
    Health Sciences Clinical Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Ann Allergy Asthma Immunol 86:44-50. 2001
  3. ncbi request reprint Can epinephrine inhalations be substituted for epinephrine injection in children at risk for systemic anaphylaxis?
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatrics 106:1040-4. 2000
  4. pmc Income-based drug benefit policy: impact on receipt of inhaled corticosteroid prescriptions by Manitoba children with asthma
    A L Kozyrskyj
    Department of Community Health Sciences, Manitoba Centre for Health Policy and Evaluation, Faculty of Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 165:897-902. 2001
  5. ncbi request reprint Expression, purification, characterization and clinical relevance of rAed a 1--a 68-kDa recombinant mosquito Aedes aegypti salivary allergen
    Z Peng
    Department of Pediatrics and Child Health, and Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:1445-52. 2001
  6. ncbi request reprint The comparative pharmacokinetics of H1-receptor antagonists
    F E Simons
    University of Manitoba, Winnipeg, Canada
    Ann Allergy 59:20-4. 1987
  7. ncbi request reprint Production and characterization of monoclonal antibodies to two new mosquito Aedes aegypti salivary proteins
    Z Peng
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Canada
    Insect Biochem Mol Biol 29:909-14. 1999
  8. ncbi request reprint Epinephrine absorption in adults: intramuscular versus subcutaneous injection
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 108:871-3. 2001
  9. ncbi request reprint CpG oligodeoxynucleotide vaccination suppresses IgE induction but may fail to down-regulate ongoing IgE responses in mice
    Z Peng
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, and Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:3-11. 2001
  10. ncbi request reprint The clinical pharmacology of brompheniramine in children
    F E Simons
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 103:223-6. 1999

Detail Information

Publications20

  1. ncbi request reprint Mosquito allergy: recombinant mosquito salivary antigens for new diagnostic tests
    F E Simons
    Department of Pediatrics and Child Health, Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada
    Int Arch Allergy Immunol 124:403-5. 2001
    ..aegypti bite test reactions. None of 15 A. aegypti bite test-negative subjects had a positive skin test to any of the recombinant antigens. Recombinant mosquito salivary antigens will facilitate the diagnosis of mosquito allergy...
  2. ncbi request reprint Suppression of the early and late cutaneous allergic responses using fexofenadine and montelukast
    F E Simons
    Health Sciences Clinical Research Centre, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Ann Allergy Asthma Immunol 86:44-50. 2001
    ..The relative contribution of histamine and the cysteinyl leukotrienes to the early and late cutaneous allergic responses (ECAR and LCAR) can be studied using antagonists of these mediators...
  3. ncbi request reprint Can epinephrine inhalations be substituted for epinephrine injection in children at risk for systemic anaphylaxis?
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatrics 106:1040-4. 2000
    ..For out-of-hospital treatment of anaphylaxis, inhalation of epinephrine from a pressurized metered-dose inhaler is sometimes recommended as a noninvasive, user-friendly alternative to an epinephrine injection...
  4. pmc Income-based drug benefit policy: impact on receipt of inhaled corticosteroid prescriptions by Manitoba children with asthma
    A L Kozyrskyj
    Department of Community Health Sciences, Manitoba Centre for Health Policy and Evaluation, Faculty of Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 165:897-902. 2001
    ....
  5. ncbi request reprint Expression, purification, characterization and clinical relevance of rAed a 1--a 68-kDa recombinant mosquito Aedes aegypti salivary allergen
    Z Peng
    Department of Pediatrics and Child Health, and Department of Immunology, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:1445-52. 2001
    ....
  6. ncbi request reprint The comparative pharmacokinetics of H1-receptor antagonists
    F E Simons
    University of Manitoba, Winnipeg, Canada
    Ann Allergy 59:20-4. 1987
    ..There is no evidence for the introduction of metabolism of H1-receptor antagonists, even after months of treatment...
  7. ncbi request reprint Production and characterization of monoclonal antibodies to two new mosquito Aedes aegypti salivary proteins
    Z Peng
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Canada
    Insect Biochem Mol Biol 29:909-14. 1999
    ..These mAbs provide a means to purify proteins, to isolate new genes from the salivary gland cDNA library, and to standardise mosquito extracts, facilitating studies of disease transmission by mosquitoes and of mosquito allergy...
  8. ncbi request reprint Epinephrine absorption in adults: intramuscular versus subcutaneous injection
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 108:871-3. 2001
    ..We recommend intramuscular injection of epinephrine into the thigh as the preferred route and site of injection of this life-saving medication in the initial treatment of anaphylaxis...
  9. ncbi request reprint CpG oligodeoxynucleotide vaccination suppresses IgE induction but may fail to down-regulate ongoing IgE responses in mice
    Z Peng
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, and Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba R3E 3P5, Canada
    Int Immunol 13:3-11. 2001
    ..Strikingly, a transient skin delayed-type hypersensitivity reaction occurred in CpG ODN-treated mice. These observations provide a new insight into the potential therapeutic application of CpG ODN to allergic disorders...
  10. ncbi request reprint The clinical pharmacology of brompheniramine in children
    F E Simons
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 103:223-6. 1999
    ..Brompheniramine has been widely used in the treatment of allergic rhinitis and other disorders during the past 4 decades. There are no published studies of its clinical pharmacology in children...
  11. ncbi request reprint Skin concentrations of H1-receptor antagonists
    F E Simons
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 107:526-30. 2001
    ..CONCLUSION: In disorders in which the presence and the effects of H1-receptor antagonists in the skin are clinically relevant, our results support the use of fexofenadine and indicate the need to re-examine the role of diphenhydramine...
  12. doi request reprint The role of antihistamines in the new millennium
    F E Simons
    Children s Hospital, Winnipeg, Manitoba, Canada R3A 1S1
    Postgrad Med 106:7-11. 1999
    ..This review explores the pharmacologic properties of these agents, their roles in treating allergic disorders, their safety, and the avenues of future inquiry that might further define their therapeutic possibilities...
  13. ncbi request reprint Inhaled glucocorticoids in children: A favourable therapeutic index
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada
    Can Respir J 6:175-8. 1999
    ..Inhaled glucocorticoids have a favourable risk to benefit ratio in this population...
  14. ncbi request reprint Montelukast added to budesonide in children with persistent asthma: a randomized, double-blind, crossover study
    F E Simons
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
    J Pediatr 138:694-8. 2001
    ..CONCLUSIONS: Montelukast, 5 mg, added to budesonide improved asthma control significantly, indicated by a small additive effect on lung function and a clinically relevant decrease in asthma exacerbation days...
  15. ncbi request reprint Epinephrine dispensing for the out-of-hospital treatment of anaphylaxis in infants and children: a population-based study
    F E Simons
    Department of Pediatrics and Child Health, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Ann Allergy Asthma Immunol 86:622-6. 2001
    ..Epinephrine is life-saving in the treatment of anaphylaxis. A limited number of fixed-dose epinephrine formulations are available for out-of-hospital treatment of this disorder...
  16. ncbi request reprint Experimental approaches to analysis of immune dysregulation in human allergic disease
    K T HayGlass
    Department of Immunology, University of Manitoba, 730 William Avenue, R3E 0W3, Winnipeg MB, Canada
    Immunopharmacology 48:283-90. 2000
    ....
  17. ncbi request reprint Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: is the ampule/syringe/needle method practical?
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Faculty of Pharmacy, University of Manitoba, Winnipeg, Canada
    J Allergy Clin Immunol 108:1040-4. 2001
    ..Little information is available about administration of an accurate epinephrine dose to infants experiencing anaphylaxis outside the hospital setting...
  18. ncbi request reprint Clinical pharmacology of new histamine H1 receptor antagonists
    F E Simons
    Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Clin Pharmacokinet 36:329-52. 1999
    ..The studies cited in this review provide the scientific foundation for using the new H1 antagonists with optimal effectiveness and safety...
  19. ncbi request reprint Socioeconomic status, drug insurance benefits, and new prescriptions for inhaled corticosteroids in schoolchildren with asthma
    A L Kozyrskyj
    Department of Community Health Sciences, Manitoba Centre for Health Policy and Evaluation, Faculty of Medicine, University of Manitoba, S101 750 Bannatyne Ave, Winnipeg, Manitoba R3E 0W3, Canada
    Arch Pediatr Adolesc Med 155:1219-24. 2001
    ..Low-income children with asthma are less likely to receive inhaled corticosteroid prescriptions that can prevent asthma morbidity...
  20. ncbi request reprint Prevention of acute urticaria in young children with atopic dermatitis
    F E Simons
    Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada, R3A 1R9
    J Allergy Clin Immunol 107:703-6. 2001
    ..CONCLUSION: Acute urticaria is common in toddlers with atopic dermatitis and can be prevented with cetirizine in this high-risk population...