David G Simmons

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint Chorioallantoic morphogenesis and formation of the placental villous tree
    James C Cross
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Ann N Y Acad Sci 995:84-93. 2003
  2. pmc Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus
    David G Simmons
    Department of Comparative Biology and Experimental Medicine, The University of Calgary, Calgary, Canada
    BMC Genomics 9:352. 2008
  3. doi request reprint Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development
    Erica D Watson
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 240:2505-19. 2011
  4. pmc Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
    David G Simmons
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Development 135:2083-91. 2008
  5. doi request reprint The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer
    Dong Hu
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada Center for Stem Cell Application and Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Electronic address
    Dev Biol 382:470-81. 2013
  6. ncbi request reprint Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development
    Erica D Watson
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 241:C1. 2012
  7. ncbi request reprint Branching morphogenesis during development of placental villi
    James C Cross
    Department of Biochemistry and Molecular Biology, University of Calgary, HSC Room 2279, 3330 Hospital Drive NW, Calgary AB, Canada T2N 4N1
    Differentiation 74:393-401. 2006
  8. ncbi request reprint Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta
    David G Simmons
    Department of Biochemistry and Molecular Biology, University of Calgary, Faculty of Medicine, Calgary, Alberta, and Department of Human Genetics, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Dev Biol 304:567-78. 2007
  9. ncbi request reprint Determinants of trophoblast lineage and cell subtype specification in the mouse placenta
    David G Simmons
    Department of Biochemistry and Molecular Biology, University of Calgary, HSC Room 2279, 3330 Hospital Drive N W, Calgary, AB, Canada T2N 4N1
    Dev Biol 284:12-24. 2005
  10. ncbi request reprint PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human
    Shu Hong Zhao
    Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA
    Genomics 84:114-25. 2004

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Chorioallantoic morphogenesis and formation of the placental villous tree
    James C Cross
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Ann N Y Acad Sci 995:84-93. 2003
    ..The restricted expression and/or action of the signaling components indicate that a series of intercellular interactions regulate chorioallantoic development...
  2. pmc Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus
    David G Simmons
    Department of Comparative Biology and Experimental Medicine, The University of Calgary, Calgary, Canada
    BMC Genomics 9:352. 2008
    ..To understand the regulation and potential functions of these genes, we conducted a detailed temporal and spatial expression study in the placenta between embryonic days 7.5 and E18.5 in three genetic strains...
  3. doi request reprint Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development
    Erica D Watson
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 240:2505-19. 2011
    ..Lastly, we show that Mrj(-/-) chorions at embryonic day 8.5 have expanded Rhox4b expression domains and do not form normal layers of gene expression suggesting that chorion patterning requires Mrj...
  4. pmc Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth
    David G Simmons
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada
    Development 135:2083-91. 2008
    ..These data indicate that the three differentiated trophoblast cell types in the labyrinth arise from distinct and autonomous precursors in the chorion that are patterned before morphogenesis begins...
  5. doi request reprint The basic helix-loop-helix transcription factor Hand1 regulates mouse development as a homodimer
    Dong Hu
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, AB, Canada Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada Center for Stem Cell Application and Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Electronic address
    Dev Biol 382:470-81. 2013
    ....
  6. ncbi request reprint Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development
    Erica D Watson
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 241:C1. 2012
    ..Immunofluorescence staining of actin (red), keratin 18 (green) and DNA (blue) in Mrj(-/-) trophoblast stem cells cultured in the absence of growth factors. From Watson et al., Developmental Dynamics 240:2505-2519, 2011...
  7. ncbi request reprint Branching morphogenesis during development of placental villi
    James C Cross
    Department of Biochemistry and Molecular Biology, University of Calgary, HSC Room 2279, 3330 Hospital Drive NW, Calgary AB, Canada T2N 4N1
    Differentiation 74:393-401. 2006
    ....
  8. ncbi request reprint Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta
    David G Simmons
    Department of Biochemistry and Molecular Biology, University of Calgary, Faculty of Medicine, Calgary, Alberta, and Department of Human Genetics, Montreal Children s Hospital Research Institute, Montreal, Quebec, Canada
    Dev Biol 304:567-78. 2007
    ..Furthermore, cell lineage tracing studies indicated unique origins for different TGC subtypes, in contrast with previous suggestions that secondary TGCs all arise from Tpbpa+ ectoplacental cone precursors...
  9. ncbi request reprint Determinants of trophoblast lineage and cell subtype specification in the mouse placenta
    David G Simmons
    Department of Biochemistry and Molecular Biology, University of Calgary, HSC Room 2279, 3330 Hospital Drive N W, Calgary, AB, Canada T2N 4N1
    Dev Biol 284:12-24. 2005
    ..Here, we review recent insights into the molecular pathways regulating trophoblast lineage segregation, stem cell maintenance, and subtype differentiation...
  10. ncbi request reprint PLET1 (C11orf34), a highly expressed and processed novel gene in pig and mouse placenta, is transcribed but poorly spliced in human
    Shu Hong Zhao
    Department of Animal Science, Iowa State University, 2255 Kildee Hall, Ames, IA 50011, USA
    Genomics 84:114-25. 2004
    ..Our data correct GenomeScan annotation of this region of the human genome and describe functional gene discovery in mammals not recognized in human EST projects...
  11. ncbi request reprint Rat endometrial Vdup1 expression: changes related to sensitization for the decidual cell reaction and hormonal control
    David G Simmons
    Physiology and Pharmacology, and Obstetrics and Gynaecology, University of Western Ontario, London, Ontario, Canada, N6A 5C1
    Reproduction 127:475-82. 2004
    ..Together, these results suggest a novel mechanism by which suppression of the decidual response in the nonreceptive endometrium may occur...
  12. ncbi request reprint Sp1/Sp3 compound heterozygous mice are not viable: impaired erythropoiesis and severe placental defects
    Imme Krüger
    Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Marburg, Germany
    Dev Dyn 236:2235-44. 2007
    ..Our findings demonstrate that a threshold of Sp1 and Sp3 activity is required for normal embryonic development, suggesting that Sp1 and Sp3 act cooperatively to regulate downstream targets...