Thomas Simmen

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM)
    Thomas Simmen
    Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1798:1465-73. 2010
  2. doi request reprint Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease
    Thomas Simmen
    University of Alberta, Department of Cell Biology, Medical Sciences Building, Room 5 65, Edmonton, Alberta, T6G 2H7 Canada
    Expert Opin Ther Targets 15:741-51. 2011
  3. pmc Palmitoylated TMX and calnexin target to the mitochondria-associated membrane
    Emily M Lynes
    Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    EMBO J 31:457-70. 2012
  4. pmc Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties
    Michael Bui
    Department of Cell Biology, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 285:31590-602. 2010
  5. doi request reprint Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling
    Emily M Lynes
    Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada
    J Cell Sci 126:3893-903. 2013
  6. doi request reprint Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM)
    Arun Raturi
    Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1833:213-24. 2013
  7. doi request reprint Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER
    Emily M Lynes
    Department of Cell Biology, University of Alberta, Alberta, Canada
    Biochim Biophys Acta 1813:1893-905. 2011
  8. doi request reprint Rab proteins of the endoplasmic reticulum: functions and interactors
    Carolina Ortiz Sandoval
    Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
    Biochem Soc Trans 40:1426-32. 2012
  9. doi request reprint Mechanisms of cytosolic targeting of matrix metalloproteinase-2
    Mohammad A M Ali
    Department of Pharmacology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Cell Physiol 227:3397-404. 2012
  10. pmc Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM)
    Susanna Y Gilady
    Department of Cell Biology, University of Alberta, Edmonton, AB T6G2H7, Canada
    Cell Stress Chaperones 15:619-29. 2010

Collaborators

  • Luc G Berthiaume
  • Gerardo Z Lederkremer
  • Richard Schulz
  • Stefan Strack
  • Thomas F Mueller
  • Valerie A Luyckx
  • Emily M Lynes
  • Matthew D Benson
  • Michael Bui
  • Arun Raturi
  • Carolina Ortiz Sandoval
  • Susanna Y Gilady
  • Nathan Myhill
  • Megan C Yap
  • Mohammad A M Ali
  • Aleksandra Janowicz
  • Robert E Campbell
  • Marina Shenkman
  • Jiahui Wu
  • Xiaohu Fan
  • Arulmozhi D Kandasamy
  • Lori J West
  • Bryan D Crawford
  • Lars Ellgaard
  • Ava K Chow
  • Bobbie Schneider
  • Neal M Alto
  • Ross E B Fitzsimmons
  • Kevin Gesson
  • Jean E Vance
  • Russell Watts
  • John D Scott
  • Timothy J Cooper
  • Gary Thomas
  • Hao Fei
  • Jalal A Nanji
  • Anastassia D Blagoveshchenskaya
  • Katia Carmine Simmen

Detail Information

Publications12

  1. pmc Oxidative protein folding in the endoplasmic reticulum: tight links to the mitochondria-associated membrane (MAM)
    Thomas Simmen
    Faculty of Medicine and Dentistry, School of Molecular and Systems Medicine, Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1798:1465-73. 2010
    ....
  2. doi request reprint Hax-1: a regulator of calcium signaling and apoptosis progression with multiple roles in human disease
    Thomas Simmen
    University of Alberta, Department of Cell Biology, Medical Sciences Building, Room 5 65, Edmonton, Alberta, T6G 2H7 Canada
    Expert Opin Ther Targets 15:741-51. 2011
    ..Recent findings have demonstrated that the localization to the ER allows Hax-1 to modulate calcium signaling via interactions with polycystin-2 and sarco(endo)plasmic reticulum calcium transport ATPase 2 (SERCA2)...
  3. pmc Palmitoylated TMX and calnexin target to the mitochondria-associated membrane
    Emily M Lynes
    Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    EMBO J 31:457-70. 2012
    ..Since ER-localized heme oxygenase-1, but not cytosolic GRP75 require palmitoylation to reside on the MAM, our findings identify palmitoylation as key for MAM enrichment of ER membrane proteins...
  4. pmc Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties
    Michael Bui
    Department of Cell Biology, School of Molecular and Systems Medicine, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 285:31590-602. 2010
    ..Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of Rab32 determine the speed of apoptosis onset...
  5. doi request reprint Palmitoylation is the switch that assigns calnexin to quality control or ER Ca2+ signaling
    Emily M Lynes
    Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada
    J Cell Sci 126:3893-903. 2013
    ..Our results have therefore identified the switch that assigns calnexin either to Ca(2+) signaling or to protein chaperoning. ..
  6. doi request reprint Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM)
    Arun Raturi
    Department of Cell Biology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1833:213-24. 2013
    ..This article is part of a Special Issue entitled: Mitochondrial dynamics and physiology...
  7. doi request reprint Urban planning of the endoplasmic reticulum (ER): how diverse mechanisms segregate the many functions of the ER
    Emily M Lynes
    Department of Cell Biology, University of Alberta, Alberta, Canada
    Biochim Biophys Acta 1813:1893-905. 2011
    ..The crucial roles of ER domain formation for cell physiology are highlighted with the specific targeting of the tumor metastasis regulator gp78 to ERAD-mediating membranes or of the promyelocytic leukemia protein to the MAM...
  8. doi request reprint Rab proteins of the endoplasmic reticulum: functions and interactors
    Carolina Ortiz Sandoval
    Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
    Biochem Soc Trans 40:1426-32. 2012
    ..In so doing, these Rabs regulate not only ER contacts with other organelles such as mitochondria, but also the formation of autophagosomes...
  9. doi request reprint Mechanisms of cytosolic targeting of matrix metalloproteinase-2
    Mohammad A M Ali
    Department of Pharmacology, Cardiovascular Research Centre, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada
    J Cell Physiol 227:3397-404. 2012
    ..Our results also suggest approaches to specifically investigate the overlooked intracellular biology of MMP-2...
  10. pmc Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM)
    Susanna Y Gilady
    Department of Cell Biology, University of Alberta, Edmonton, AB T6G2H7, Canada
    Cell Stress Chaperones 15:619-29. 2010
    ..In addition, the correct localization of Ero1alpha to the MAM also requires normoxic conditions, but not ongoing oxidative phosphorylation...
  11. pmc The subcellular distribution of calnexin is mediated by PACS-2
    Nathan Myhill
    Department of Cell Biology, University of Alberta, Edmonton, Alberta, T6G2H7, Canada
    Mol Biol Cell 19:2777-88. 2008
    ..Therefore, our results suggest that the phosphorylation state of the calnexin cytosolic domain and its interaction with PACS-2 sort this chaperone between domains of the ER and the plasma membrane...
  12. doi request reprint Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth
    Valerie A Luyckx
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Renal Physiol 297:F1697-705. 2009
    ..03). Low-birth-weight rats exhibit accelerated senescence in kidneys and hearts after rapid catch-up growth, a likely important link between early growth and subsequent hypertension, renal, and cardiovascular disease...