Research Topics
| P H SilverstoneSummaryAffiliation: University of Alberta Country: Canada Publications
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Detail Information
Publications
Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patientsPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Hum Psychopharmacol 17:321-7. 2002..The objective of the present study was to test the hypothesis that chronic treatment with either lithium or sodium valproate in patients with bipolar mood disorder leads to a normalization in the activity of the PI-cycle...- Differential effects of chronic lithium and valproate on brain activation in healthy volunteersEmily C Bell
Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Hum Psychopharmacol 20:415-24. 2005..061 (lithium approached significance); p = 0.050 (valproate)). CONCLUSIONS: These findings suggest that lithium and valproate have independent effects on brain activation that vary in a task and region-dependent manner... - Single- and multiple-dose bioequivalence of two once-daily tramadol formulations using stereospecific analysis of tramadol and its demethylated (M1 and M5) metabolitesOkponanabofa Eradiri
Biovail Technologies Ltd, Chantilly, VA 20151, USA
Curr Med Res Opin 23:1593-604. 2007..To assess bioequivalence of two once-daily formulations of tramadol (T) as well as delineate pharmacokinetics of its enantiomers and those of its main metabolites after single- and multiple-dose administration... 
Atomoxetine treatment for nicotine withdrawal: a pilot double-blind, placebo-controlled, fixed-dose study in adult smokersPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Ann Gen Psychiatry 11:6. 2012..abstract:..
Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patientsPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, AB, Canada T6G 2B7
Int Rev Psychiatry 21:414-23. 2009..Nonetheless, given the current technical and clinical limitations of the literature to date, this conclusion cannot be considered completely definitive...- Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findingsPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Bipolar Disord 7:1-10. 2005..myo-Inositol concentrations can be measured in vivo with magnetic resonance spectroscopy (MRS)... - Qualitative review of SNRIs in anxietyPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, 1E1 07 Mackenzie Center, Alberta, Canada
J Clin Psychiatry 65:19-28. 2004..Future research will be valuable in determining if antidepressants that combine pharmacologic actions on serotonergic and noradrenergic systems have advantages over more selective agents in treating anxiety disorders... - A review of acute treatments for bipolar depressionPeter H Silverstone
Departments of Psychiatry and Neuroscience, University of Alberta, Edmonton, Alberta, Canada
Int Clin Psychopharmacol 19:113-24. 2004..Further research is clearly required to examine this approach and compare it with other possible treatment options... - Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patientsPeter H Silverstone
Department of Psychiatry, University of Alberta, 1E1 07 Mackenzie Center, 8440 112 Street, Edmonton AB, Canada
World J Biol Psychiatry 5:38-44. 2004..In addition, we wanted to determine if valproate would also have any effects upon choline levels... - Defining anxious depression: going beyond comorbidityPeter H Silverstone
Departments of Psychiatry and Neuroscience, 1E1 07 Mackenzie Center, University of Alberta, Edmonton, AB T6G 2B7
Can J Psychiatry 48:675-80. 2003..We therefore wanted to determine more accurately the type of patients best described by the term "anxious depression." We also wanted to review the literature to assess the most appropriate treatment(s) for these patients... - Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patientsPeter H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Canada
Int Clin Psychopharmacol 18:73-9. 2003..These findings suggest that sodium valproate and lithium may not share a common mechanism of action in bipolar disorder involving neurotrophic or neuroprotective effects... - Efficacy of venlafaxine extended release in patients with major depressive disorder and comorbid generalized anxiety disorderP H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Canada
J Clin Psychiatry 62:523-9. 2001..placebo-controlled study comparing the efficacy and safety of venlafaxine extended release (XR) and fluoxetine... - Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: an MRS studyPeter H Silverstone
Department of Psychiatry, University Hospital, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
Hum Psychopharmacol 17:425-9. 2002..This was an open-label study carried out before and after administration of 20 mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS)... - Lithium does not alter the choline/creatine ratio in the temporal lobe of human volunteers as measured by proton magnetic resonance spectroscopyP H Silverstone
Department of Psychiatry, University of Alberta, Hanstock
J Psychiatry Neurosci 24:222-6. 1999..To study the effect of lithium administration on brain choline/creatine (Cho/Cr) ratios in healthy volunteers... - Chronic lithium and sodium valproate both decrease the concentration of myoinositol and increase the concentration of inositol monophosphates in rat brainS Rotzinger
Department of Psychiatry, University of Alberta Hospital, Edmonton AB T6G 2B7, Canada
Eur Neuropsychopharmacol 13:199-207. 2003..These novel findings suggest that both lithium and sodium valproate may share a common mechanism of action in the treatment of bipolar disorder via actions on the PI cycle... - Lithium does not attenuate the effects of D-amphetamine in healthy volunteersP H Silverstone
Department of Psychiatry, University of Alberta Hospital, Edmonton, Canada
Psychiatry Res 79:219-26. 1998..It is suggested that whilst D-amphetamine may produce effects similar to mania, its mechanism of action is different from that which occurs in mania, and therefore the usefulness of the amphetamine model of mania is called into question... - Effects of chronic lithium and sodium valproate on concentrations of brain amino acidsS Rotzinger
Department of Psychiatry, University of Alberta Hospital, Edmonton, AB T6G 2B7, Canada
Eur Neuropsychopharmacol 13:220-7. 2003..These findings indicate that lithium and sodium valproate share common effects on the concentrations of certain amino acid neurotransmitters in whole brain which may be related to their mechanisms of action in bipolar disorder... - Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositolBrent M McGrath
Department of Psychiatry, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
Neuroreport 18:1595-8. 2007..This suggests that these agents might work via a mechanism that is not centered on changes in myo-inositol concentration... - Valproate attenuates dextroamphetamine-induced subjective changes more than lithiumMorgan C Willson
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Eur Neuropsychopharmacol 15:633-9. 2005..These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders... - Two items on the Hamilton Depression rating scale are effective predictors of remission: comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxineP H Silverstone
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Int Clin Psychopharmacol 17:273-80. 2002..The present results demonstrate that using just two items of the HAM-D17 can be very useful in assessing treatment response, differentiating between treatment groups and predicting remission rates... - Acute dextro-amphetamine administration does not alter brain myo-inositol levels in humans and animals: MRS investigations at 3 and 18.8 TBrent M McGrath
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
Neurosci Res 61:351-9. 2008.... - Lithium and valproate attenuate dextroamphetamine-induced changes in brain activationEmily C Bell
Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Hum Psychopharmacol 20:87-96. 2005..This is the first human evidence to suggest that both lithium and valproate may have a similar effect on regional brain activation, conceivably via similar effects on PI-cycle activity... - Venlafaxine in treatment-resistant major depression: a Canadian multicenter, open-label trialC de Montigny
Department of Psychiatry, McGill University, Montreal, Quebec, Canada
J Clin Psychopharmacol 19:401-6. 1999..In conclusion, these results suggest that venlafaxine is effective and well tolerated for the management of patients with treatment-resistant major depression... - Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteersSheila J Asghar
Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
Hum Psychopharmacol 18:291-9. 2003..In conclusion, while dextro-amphetamine administration definitely causes several changes which are seen in mania, there remain some physiological and metabolic differences between these two conditions... - Lithium alters regional rat brain myo-inositol at 2 and 4 weeks: an ex-vivo magnetic resonance spectroscopy study at 18.8 TBrent M McGrath
Department of Psychiatry, National High Field Magnetic Resonance Centre, University of Alberta, Edmonton, Alberta, Canada
Neuroreport 17:1323-6. 2006..Studies suggest brain region-specific alterations in myo-inositol concentrations among bipolar patients. Our findings suggest that lithium-induced reduction of myo-inositol is more global... - A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders--focus on magnetic resonance spectroscopy (MRS) studiesHyeonjin Kim
Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
Hum Psychopharmacol 20:309-26. 2005..More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder... - The non-antiemetic uses of serotonin 5-HT3 receptor antagonists. Clinical pharmacology and therapeutic applicationsA J Greenshaw
Department of Psychiatry, University of Alberta, Edmonton, Canada
Drugs 53:20-39. 1997.... - Effects of dextroamphetamine, lithium chloride, sodium valproate and carbamazepine on intraplatelet Ca2+ levelsMichele L Ulrich
Department of Psychiatry, Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Alta
J Psychiatry Neurosci 28:115-25. 2003.... - A rapid method of determining amphetamine in plasma samples using pentafluorobenzenesulfonyl chloride and electron-capture gas chromatographyS J Asghar
Department of Psychiatry, University of Alberta, IE7 44 W Mackenzie Health Sciences Center Edmonton, AB, Canada T6G 2R7
J Pharmacol Toxicol Methods 46:111-5. 2001.... - Dextroamphetamine causes a change in regional brain activity in vivo during cognitive tasks: a functional magnetic resonance imaging study of blood oxygen level-dependent responseMorgan C Willson
Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
Biol Psychiatry 56:284-91. 2004..These changes might be linked to behavioral changes observed after dextroamphetamine administration and could possibly be mediated by alterations in dopaminergic activation... - Neurobiological findings in bipolar II disorder compared with findings in bipolar I disorderBrent M McGrath
Department of Psychiatry, University of Alberta, Edmonton
Can J Psychiatry 49:794-801. 2004..Given the importance of understanding whether there are neurochemical differences between these groups, further research in this area is clearly needed...