P H Silverstone

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 17:321-7. 2002
  2. ncbi request reprint Differential effects of chronic lithium and valproate on brain activation in healthy volunteers
    Emily C Bell
    Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 20:415-24. 2005
  3. ncbi request reprint Single- and multiple-dose bioequivalence of two once-daily tramadol formulations using stereospecific analysis of tramadol and its demethylated (M1 and M5) metabolites
    Okponanabofa Eradiri
    Biovail Technologies Ltd, Chantilly, VA 20151, USA
    Curr Med Res Opin 23:1593-604. 2007
  4. pmc Atomoxetine treatment for nicotine withdrawal: a pilot double-blind, placebo-controlled, fixed-dose study in adult smokers
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Ann Gen Psychiatry 11:6. 2012
  5. doi request reprint Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, AB, Canada T6G 2B7
    Int Rev Psychiatry 21:414-23. 2009
  6. ncbi request reprint Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Bipolar Disord 7:1-10. 2005
  7. ncbi request reprint Qualitative review of SNRIs in anxiety
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, 1E1 07 Mackenzie Center, Alberta, Canada
    J Clin Psychiatry 65:19-28. 2004
  8. ncbi request reprint A review of acute treatments for bipolar depression
    Peter H Silverstone
    Departments of Psychiatry and Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    Int Clin Psychopharmacol 19:113-24. 2004
  9. ncbi request reprint Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, 1E1 07 Mackenzie Center, 8440 112 Street, Edmonton AB, Canada
    World J Biol Psychiatry 5:38-44. 2004
  10. ncbi request reprint Defining anxious depression: going beyond comorbidity
    Peter H Silverstone
    Departments of Psychiatry and Neuroscience, 1E1 07 Mackenzie Center, University of Alberta, Edmonton, AB T6G 2B7
    Can J Psychiatry 48:675-80. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Chronic treatment with both lithium and sodium valproate may normalize phosphoinositol cycle activity in bipolar patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 17:321-7. 2002
    ..The objective of the present study was to test the hypothesis that chronic treatment with either lithium or sodium valproate in patients with bipolar mood disorder leads to a normalization in the activity of the PI-cycle...
  2. ncbi request reprint Differential effects of chronic lithium and valproate on brain activation in healthy volunteers
    Emily C Bell
    Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 20:415-24. 2005
    ..However, the fact that these patients are often on medication makes it unclear to what extent these changes reflect treatment effects...
  3. ncbi request reprint Single- and multiple-dose bioequivalence of two once-daily tramadol formulations using stereospecific analysis of tramadol and its demethylated (M1 and M5) metabolites
    Okponanabofa Eradiri
    Biovail Technologies Ltd, Chantilly, VA 20151, USA
    Curr Med Res Opin 23:1593-604. 2007
    ..To assess bioequivalence of two once-daily formulations of tramadol (T) as well as delineate pharmacokinetics of its enantiomers and those of its main metabolites after single- and multiple-dose administration...
  4. pmc Atomoxetine treatment for nicotine withdrawal: a pilot double-blind, placebo-controlled, fixed-dose study in adult smokers
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Ann Gen Psychiatry 11:6. 2012
    ..abstract:..
  5. doi request reprint Lithium and valproate and their possible effects on themyo-inositol second messenger system in healthy volunteers and bipolar patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, AB, Canada T6G 2B7
    Int Rev Psychiatry 21:414-23. 2009
    ..Nonetheless, given the current technical and clinical limitations of the literature to date, this conclusion cannot be considered completely definitive...
  6. ncbi request reprint Bipolar disorder and myo-inositol: a review of the magnetic resonance spectroscopy findings
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Bipolar Disord 7:1-10. 2005
    ..myo-Inositol concentrations can be measured in vivo with magnetic resonance spectroscopy (MRS)...
  7. ncbi request reprint Qualitative review of SNRIs in anxiety
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, 1E1 07 Mackenzie Center, Alberta, Canada
    J Clin Psychiatry 65:19-28. 2004
    ..Future research will be valuable in determining if antidepressants that combine pharmacologic actions on serotonergic and noradrenergic systems have advantages over more selective agents in treating anxiety disorders...
  8. ncbi request reprint A review of acute treatments for bipolar depression
    Peter H Silverstone
    Departments of Psychiatry and Neuroscience, University of Alberta, Edmonton, Alberta, Canada
    Int Clin Psychopharmacol 19:113-24. 2004
    ..Further research is clearly required to examine this approach and compare it with other possible treatment options...
  9. ncbi request reprint Lithium and valproate protect against dextro-amphetamine induced brain choline concentration changes in bipolar disorder patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, 1E1 07 Mackenzie Center, 8440 112 Street, Edmonton AB, Canada
    World J Biol Psychiatry 5:38-44. 2004
    ..In addition, we wanted to determine if valproate would also have any effects upon choline levels...
  10. ncbi request reprint Defining anxious depression: going beyond comorbidity
    Peter H Silverstone
    Departments of Psychiatry and Neuroscience, 1E1 07 Mackenzie Center, University of Alberta, Edmonton, AB T6G 2B7
    Can J Psychiatry 48:675-80. 2003
    ..We therefore wanted to determine more accurately the type of patients best described by the term "anxious depression." We also wanted to review the literature to assess the most appropriate treatment(s) for these patients...
  11. ncbi request reprint Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients
    Peter H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Canada
    Int Clin Psychopharmacol 18:73-9. 2003
    ..These findings suggest that sodium valproate and lithium may not share a common mechanism of action in bipolar disorder involving neurotrophic or neuroprotective effects...
  12. ncbi request reprint Efficacy of venlafaxine extended release in patients with major depressive disorder and comorbid generalized anxiety disorder
    P H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Canada
    J Clin Psychiatry 62:523-9. 2001
    ..placebo-controlled study comparing the efficacy and safety of venlafaxine extended release (XR) and fluoxetine...
  13. ncbi request reprint Dextro-amphetamine increases phosphoinositol cycle activity in volunteers: an MRS study
    Peter H Silverstone
    Department of Psychiatry, University Hospital, University of Alberta, Edmonton, Alberta T6G 2B7, Canada
    Hum Psychopharmacol 17:425-9. 2002
    ..This was an open-label study carried out before and after administration of 20 mg oral dextro-amphetamine. Subjects also rated the subjective effects of dextro-amphetamine administration using visual analog scales (VAS)...
  14. pmc Lithium does not alter the choline/creatine ratio in the temporal lobe of human volunteers as measured by proton magnetic resonance spectroscopy
    P H Silverstone
    Department of Psychiatry, University of Alberta, Hanstock
    J Psychiatry Neurosci 24:222-6. 1999
    ..To study the effect of lithium administration on brain choline/creatine (Cho/Cr) ratios in healthy volunteers...
  15. ncbi request reprint Chronic lithium and sodium valproate both decrease the concentration of myoinositol and increase the concentration of inositol monophosphates in rat brain
    T O'Donnell
    Department of Psychiatry, University of Alberta Hospital, Edmonton AB T6G 2B7, Canada
    Eur Neuropsychopharmacol 13:199-207. 2003
    ..These novel findings suggest that both lithium and sodium valproate may share a common mechanism of action in the treatment of bipolar disorder via actions on the PI cycle...
  16. ncbi request reprint Effects of chronic lithium and sodium valproate on concentrations of brain amino acids
    T O'Donnell
    Department of Psychiatry, University of Alberta Hospital, Edmonton, AB T6G 2B7, Canada
    Eur Neuropsychopharmacol 13:220-7. 2003
    ..These findings indicate that lithium and sodium valproate share common effects on the concentrations of certain amino acid neurotransmitters in whole brain which may be related to their mechanisms of action in bipolar disorder...
  17. ncbi request reprint Lithium does not attenuate the effects of D-amphetamine in healthy volunteers
    P H Silverstone
    Department of Psychiatry, University of Alberta Hospital, Edmonton, Canada
    Psychiatry Res 79:219-26. 1998
    ..It is suggested that whilst D-amphetamine may produce effects similar to mania, its mechanism of action is different from that which occurs in mania, and therefore the usefulness of the amphetamine model of mania is called into question...
  18. ncbi request reprint Unlike lithium, anticonvulsants and antidepressants do not alter rat brain myo-inositol
    Brent M McGrath
    Department of Psychiatry, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Neuroreport 18:1595-8. 2007
    ..This suggests that these agents might work via a mechanism that is not centered on changes in myo-inositol concentration...
  19. ncbi request reprint Valproate attenuates dextroamphetamine-induced subjective changes more than lithium
    Morgan C Willson
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Eur Neuropsychopharmacol 15:633-9. 2005
    ..These results suggest that lithium and valproate do not have the same mechanism of action on dextroamphetamine-induced changes, and this finding may relate to differences in their mechanism of action in mood disorders...
  20. ncbi request reprint Two items on the Hamilton Depression rating scale are effective predictors of remission: comparison of selective serotonin reuptake inhibitors with the combined serotonin/norepinephrine reuptake inhibitor, venlafaxine
    P H Silverstone
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Int Clin Psychopharmacol 17:273-80. 2002
    ..The present results demonstrate that using just two items of the HAM-D17 can be very useful in assessing treatment response, differentiating between treatment groups and predicting remission rates...
  21. doi request reprint Acute dextro-amphetamine administration does not alter brain myo-inositol levels in humans and animals: MRS investigations at 3 and 18.8 T
    Brent M McGrath
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    Neurosci Res 61:351-9. 2008
    ....
  22. ncbi request reprint Lithium and valproate attenuate dextroamphetamine-induced changes in brain activation
    Emily C Bell
    Department of Psychiatry, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 20:87-96. 2005
    ..The current study assessed the effect of 14 days pretreatment with lithium and valproate on these dextroamphetamine-induced changes in regional brain activity in healthy volunteers...
  23. ncbi request reprint Venlafaxine in treatment-resistant major depression: a Canadian multicenter, open-label trial
    C de Montigny
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    J Clin Psychopharmacol 19:401-6. 1999
    ..In conclusion, these results suggest that venlafaxine is effective and well tolerated for the management of patients with treatment-resistant major depression...
  24. ncbi request reprint Relationship of plasma amphetamine levels to physiological, subjective, cognitive and biochemical measures in healthy volunteers
    Sheila J Asghar
    Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 18:291-9. 2003
    ..In conclusion, while dextro-amphetamine administration definitely causes several changes which are seen in mania, there remain some physiological and metabolic differences between these two conditions...
  25. ncbi request reprint Lithium alters regional rat brain myo-inositol at 2 and 4 weeks: an ex-vivo magnetic resonance spectroscopy study at 18.8 T
    Brent M McGrath
    Department of Psychiatry, National High Field Magnetic Resonance Centre, University of Alberta, Edmonton, Alberta, Canada
    Neuroreport 17:1323-6. 2006
    ..Studies suggest brain region-specific alterations in myo-inositol concentrations among bipolar patients. Our findings suggest that lithium-induced reduction of myo-inositol is more global...
  26. ncbi request reprint A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders--focus on magnetic resonance spectroscopy (MRS) studies
    Hyeonjin Kim
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    Hum Psychopharmacol 20:309-26. 2005
    ..More definitive investigation is required before PI-cycle dysfunction can be considered specific to bipolar disorder...
  27. ncbi request reprint The non-antiemetic uses of serotonin 5-HT3 receptor antagonists. Clinical pharmacology and therapeutic applications
    A J Greenshaw
    Department of Psychiatry, University of Alberta, Edmonton, Canada
    Drugs 53:20-39. 1997
    ....
  28. pmc Effects of dextroamphetamine, lithium chloride, sodium valproate and carbamazepine on intraplatelet Ca2+ levels
    Michele L Ulrich
    Department of Psychiatry, Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Alta
    J Psychiatry Neurosci 28:115-25. 2003
    ....
  29. ncbi request reprint A rapid method of determining amphetamine in plasma samples using pentafluorobenzenesulfonyl chloride and electron-capture gas chromatography
    S J Asghar
    Department of Psychiatry, University of Alberta, IE7 44 W Mackenzie Health Sciences Center Edmonton, AB, Canada T6G 2R7
    J Pharmacol Toxicol Methods 46:111-5. 2001
    ....
  30. ncbi request reprint Dextroamphetamine causes a change in regional brain activity in vivo during cognitive tasks: a functional magnetic resonance imaging study of blood oxygen level-dependent response
    Morgan C Willson
    Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Biol Psychiatry 56:284-91. 2004
    ..One method to measure this is to use functional magnetic resonance imaging (fMRI)...
  31. ncbi request reprint Neurobiological findings in bipolar II disorder compared with findings in bipolar I disorder
    Brent M McGrath
    Department of Psychiatry, University of Alberta, Edmonton
    Can J Psychiatry 49:794-801. 2004
    ..To determine whether there are consistent neurobiological differences between patients with bipolar I disorder (BD I) and those with bipolar II disorder (BD II)...