David Sigalet

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint Long term cardiopulmonary effects of closed repair of pectus excavatum
    David L Sigalet
    Alberta Children s Hospital, University of Calgary, 2888 Shaganappi Trail NW, Calgary, Canada
    Pediatr Surg Int 23:493-7. 2007
  2. ncbi request reprint Combined immunosuppression with cyclosporine, rapamycin, and mycophenolate mofetil controls rejection with minimal nutritional impact in experimental small intestinal transplantation
    D L Sigalet
    GI Research Group, University of Calgary and Alberta Children s Hospital, Calgary, Alberta, Canada
    Transplant Proc 34:1121-3. 2002
  3. doi request reprint Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs
    David L Sigalet
    Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Dept of Surgery, Faculty of Medicine, University of Calgary, Calgary, AB, Canada Electronic address
    Regul Pept 188:70-80. 2014
  4. doi request reprint Nutritional support of infants with intestinal failure: something more than fishy is going on here!
    David Sigalet
    Department of Surgery, Alberta Children s Hospital, University of Calgary, 2888 Shaganappi Trail NW, Calgary, AB, T3B 6A8, Canada
    Pediatr Surg Int 29:975-81. 2013
  5. pmc Glucagon-like peptide 2 induces vasoactive intestinal polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-γ signaling
    Elaine de Heuvel
    Gastrointestinal Research Group, Snyder Institute for Chronic Diseases
    Am J Physiol Endocrinol Metab 303:E994-1005. 2012
  6. doi request reprint Nonruminant Nutrition Symposium: The role of glucagon-like peptide-2 in controlling intestinal function in human infants: regulator or bystander?
    D L Sigalet
    Alberta Children s Hospital, University of Calgary, Calgary, Alberta, Canada T3B 6A8
    J Anim Sci 90:1224-32. 2012
  7. ncbi request reprint A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome
    David L Sigalet
    GI Research Group, University of Calgary, Calgary, Alberta, Canada TZT SC7
    J Pediatr Surg 40:763-8. 2005
  8. doi request reprint Improved outcomes in paediatric intestinal failure with aggressive prevention of liver disease
    D Sigalet
    Alberta Children s Hospital University of Calgary, Pediatric General Surgery, Calgary, Canada
    Eur J Pediatr Surg 19:348-53. 2009
  9. ncbi request reprint Glucagon-like peptide-2 induces a specific pattern of adaptation in remnant jejunum
    D L Sigalet
    University of Calgary, Gastrointestinal Research Group, Calgary, Alberta, Canada
    Dig Dis Sci 51:1557-66. 2006
  10. ncbi request reprint Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2
    David L Sigalet
    Gastrointestinal Research Group, Institute of Infection, Immunity, and Inflammation, Faculty of Medicine, University of Calgary, Health Science Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G211-21. 2007

Detail Information

Publications44

  1. ncbi request reprint Long term cardiopulmonary effects of closed repair of pectus excavatum
    David L Sigalet
    Alberta Children s Hospital, University of Calgary, 2888 Shaganappi Trail NW, Calgary, Canada
    Pediatr Surg Int 23:493-7. 2007
    ....
  2. ncbi request reprint Combined immunosuppression with cyclosporine, rapamycin, and mycophenolate mofetil controls rejection with minimal nutritional impact in experimental small intestinal transplantation
    D L Sigalet
    GI Research Group, University of Calgary and Alberta Children s Hospital, Calgary, Alberta, Canada
    Transplant Proc 34:1121-3. 2002
  3. doi request reprint Effects of chronic glucagon-like peptide-2 therapy during weaning in neonatal pigs
    David L Sigalet
    Gastrointestinal Research Group, Snyder Institute of Infection, Immunity and Inflammation, Dept of Surgery, Faculty of Medicine, University of Calgary, Calgary, AB, Canada Electronic address
    Regul Pept 188:70-80. 2014
    ..We studied the effects of GLP-2 in the neonatal pig to determine the potential effects of exogenous administration...
  4. doi request reprint Nutritional support of infants with intestinal failure: something more than fishy is going on here!
    David Sigalet
    Department of Surgery, Alberta Children s Hospital, University of Calgary, 2888 Shaganappi Trail NW, Calgary, AB, T3B 6A8, Canada
    Pediatr Surg Int 29:975-81. 2013
    ..This review will highlight recent advances in the care of infants with Intestinal Failure, focusing on the benefits of a multi-disciplinary team and the types of nutrition used...
  5. pmc Glucagon-like peptide 2 induces vasoactive intestinal polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-γ signaling
    Elaine de Heuvel
    Gastrointestinal Research Group, Snyder Institute for Chronic Diseases
    Am J Physiol Endocrinol Metab 303:E994-1005. 2012
    ..We conclude that GLP-2 acts on enteric neurons and glial cells in culture via a PI3Kγ/Akt pathway, stimulating neuronal differentiation via mTOR and ERK pathways, and expression of receptors and ligands for the IGF-I and ErbB pathways...
  6. doi request reprint Nonruminant Nutrition Symposium: The role of glucagon-like peptide-2 in controlling intestinal function in human infants: regulator or bystander?
    D L Sigalet
    Alberta Children s Hospital, University of Calgary, Calgary, Alberta, Canada T3B 6A8
    J Anim Sci 90:1224-32. 2012
    ..We will review the functioning of this system in the developing human infant and the role of GLP-2 in the regulation of adaptation, with the general implications for nutrient absorption in animals and humans...
  7. ncbi request reprint A pilot study of the use of epidermal growth factor in pediatric short bowel syndrome
    David L Sigalet
    GI Research Group, University of Calgary, Calgary, Alberta, Canada TZT SC7
    J Pediatr Surg 40:763-8. 2005
    ..This study examined the effects of enterally administered epidermal growth factor (EGF) on nutrient absorption and tolerance of enteral feeds in pediatric patients with short bowel syndrome (SBS)...
  8. doi request reprint Improved outcomes in paediatric intestinal failure with aggressive prevention of liver disease
    D Sigalet
    Alberta Children s Hospital University of Calgary, Pediatric General Surgery, Calgary, Canada
    Eur J Pediatr Surg 19:348-53. 2009
    ..We report our results from 2006-2009, and compare them to the outcomes of our previous cohort of patients (1998-2006)...
  9. ncbi request reprint Glucagon-like peptide-2 induces a specific pattern of adaptation in remnant jejunum
    D L Sigalet
    University of Calgary, Gastrointestinal Research Group, Calgary, Alberta, Canada
    Dig Dis Sci 51:1557-66. 2006
    ..Nonetheless, remnant jejunum is responsive to GLP-2 in the absence of enteral nutrition. Further studies are warranted to establish the mechanisms of action and therapeutic potential of GLP-2 in modulating nutrient absorptive capacity...
  10. ncbi request reprint Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2
    David L Sigalet
    Gastrointestinal Research Group, Institute of Infection, Immunity, and Inflammation, Faculty of Medicine, University of Calgary, Health Science Centre, 3330 Hospital Drive NW, Calgary, Alberta, Canada
    Am J Physiol Gastrointest Liver Physiol 293:G211-21. 2007
    ..They support further studies to examine the role of neural signaling in the regulation of intestinal inflammation...
  11. ncbi request reprint GLP-2 levels in infants with intestinal dysfunction
    David L Sigalet
    Division of Pediatrics, General Surgery, Alberta Children s Hospital, Calgary, AB, T2T 5C7, Canada
    Pediatr Res 56:371-6. 2004
    ..Further studies are suggested to examine the ontogeny of the GLP-2 axis and the possible therapeutic role of GLP-2 supplementation...
  12. ncbi request reprint 3-0 methylglucose uptake as a marker of nutrient absorption and bowel length in pediatric patients
    David L Sigalet
    Department of Surgery, Alberta Children s Hospital, 1820 Richmond Road SW, Calgary, AB T2T 5C7, Canada
    JPEN J Parenter Enteral Nutr 28:158-62. 2004
    ..This study examines the correlation of 3-0 MG absorption with nutrient absorption, bowel length, and the tolerance of enteral feeds in pediatric patients...
  13. doi request reprint The effects of glucagon-like peptide 2 on enteric neurons in intestinal inflammation
    D L Sigalet
    Department of Surgery, Faculty of Medicine, Snyder Institute of Infection, Immunity and Inflammation, Alberta Children s Hospital, University of Calgary, Calgary, AB, Canada
    Neurogastroenterol Motil 22:1318-e350. 2010
    ..This study examined the effects of GLP-2 treatment on the submucosal plexus of rat colon in the trinitrobenzene sulfonic acid (TNBS) model of colitis...
  14. ncbi request reprint ALX-0600 (NPS Allelix Corp)
    D L Sigalet
    University of Calgary, Pediatric General Surgeon, Department of Surgery, Canada
    Curr Opin Investig Drugs 2:505-9. 2001
    ..In August 1998, the USPTO issued a notice of allowance to Allelix for its basic patent containing claims covering the composition and medical uses of ALX-0600 and related GI drug candidate compounds [2946571...
  15. doi request reprint Elements of successful intestinal rehabilitation
    David Sigalet
    Division of Pediatric General Surgery, Alberta Children s Hospital, University of Calgary, Calgary, Canada
    J Pediatr Surg 46:150-6. 2011
    ..The optimal therapy for intestinal failure (IF) is unknown. The results of a systematic, protocol-driven management strategy by a multidisciplinary team are described...
  16. ncbi request reprint Nutritional effects of surgical and medical treatment for short bowel syndrome
    D L Sigalet
    Department of Surgery, Alberta Children s Hospital, University of Calgary, Canada
    JPEN J Parenter Enteral Nutr 25:330-6. 2001
    ....
  17. doi request reprint The assessment, and glucagon-like peptide-2 modulation, of intestinal absorption and function
    David L Sigalet
    Alberta Children s Hospital Intestinal Rehabilitation Program, Alberta Children s Hospital and University of Calgary, Calgary, Alberta, Canada
    Semin Pediatr Surg 19:44-9. 2010
    ..Investigational methods, such as nutrient balance studies, plasma citrulline levels, and the absorption of inert sugars (3-0 methyl glucose, mannitol, and lactulose) are discussed with the evidence to support their use...
  18. doi request reprint Pancreatic islet transplantation into the bone marrow of the rat
    Anastasio Salazar-Bañuelos
    Department of Surgery, Division of Transplantation, University of Calgary, Calgary, Alberta, Canada T2N2T9
    Am J Surg 195:674-8; discussion 678. 2008
    ..We asked whether pancreatic islets could be engrafted in the bone marrow, an easily accessible and widely distributed transplant site that may lack the limitations seen in the liver...
  19. doi request reprint Medical management of motility disorders in patients with intestinal failure: a focus on necrotizing enterocolitis, gastroschisis, and intestinal atresia
    Bryan J Dicken
    Division of Pediatric Surgery, Stollery Children s Hospital, University of Alberta Hospital, Edmonton, Alberta, Canada
    J Pediatr Surg 46:1618-30. 2011
    ..Therapy may be classified into medical (prokinetic and antidiarrheal agents) and surgical to deal with the overdistended poorly motile bowel...
  20. ncbi request reprint Gut hormones, and short bowel syndrome: the enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation
    G R Martin
    Department of Gastrointestinal Sciences, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    World J Gastroenterol 12:4117-29. 2006
    ....
  21. ncbi request reprint Epidermal growth factor improves nutritional outcome in a rat model of short bowel syndrome
    J Sham
    Calgary, Alberta
    J Pediatr Surg 37:765-9. 2002
    ..This study investigates the effect of epidermal growth factor (EGF) on nutrient absorption in a rat model of short bowel syndrome (SBS)...
  22. ncbi request reprint Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome
    G R Martin
    University of Calgary, Gastrointestinal Research Group, Health Sciences Bldg, Rm 1746, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
    Am J Physiol Gastrointest Liver Physiol 288:G431-8. 2005
    ..These findings suggest that GLP-2 is important in initiating and maintaining the small intestinal adaptive response to resection...
  23. doi request reprint Temporal expression of cytokines in rat cutaneous, fascial, and intestinal wounds: a comparative study
    Ahmad Zubaidi
    Department of Surgery, Division of Colorectal Surgery, University of Calgary, Calgary, AB, Canada
    Dig Dis Sci 55:1581-8. 2010
    ....
  24. ncbi request reprint In vivo measurement of intestinal absorption using 3-0 methylglucose in short bowel syndrome
    E Debru
    Department of Surgery, University of Calgary, Alberta Children's Hospital, Calgary, Alberta, Canada
    J Pediatr Surg 36:745-9. 2001
    ..Further studies to validate these methods in human patients with short bowel syndrome are suggested...
  25. doi request reprint Intestinal muscularis propria increases in thickness with corrected gestational age and is focally attenuated in patients with isolated intestinal perforations
    Sarah Lai
    Division of Pediatic Surgery, Alberta Children s Hospital, University of Calgary, Calgary, Alberta, Canada
    J Pediatr Surg 49:114-9. 2014
    ..However, developmental events leading to IIP are not well understood. This study examines the relationship between corrected gestational age (CGA) and intestinal muscle development in controls and patients with IIP...
  26. doi request reprint Pectus carinatum treatment in Canada: current practices
    Sherif Emil
    Division of Pediatric General Surgery, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Pediatr Surg 47:862-6. 2012
    ..Multiple treatment options currently exist for the correction of pectus carinatum (PC). We performed a survey of Canadian pediatric surgeons to define current practices...
  27. doi request reprint Neonatal acute appendicitis: a proposed algorithm for timely diagnosis
    Kevin L Schwartz
    Department of Paediatrics, Alberta Children s Hospital, University of Calgary, Alberta, Canada T3B6A8
    J Pediatr Surg 46:2060-4. 2011
    ..Neonatal appendicitis (NA) is a rare disease with a high mortality. The diagnosis has never been reported preoperatively and is notoriously difficult to make...
  28. ncbi request reprint Clinical impact of optical imaging with 3-D reconstruction of torso topography in common anterior chest wall anomalies
    Philippe Poncet
    Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, AB, Canada T2N 1N4
    J Pediatr Surg 42:898-903. 2007
    ..The purpose of this study is to describe an optical imaging technique that provides accurate cross-sectional images of the chest, and to compare these with standard CT-derived images of chest wall abnormalities...
  29. doi request reprint Intussusception associated with a Meckel's diverticulum and a duplication cyst
    Kris Milbrandt
    Department of Pediatric Surgery, Alberta Children s Hospital, Calgary, Alberta, Canada T3B 6A8
    J Pediatr Surg 43:e21-3. 2008
    ..Although both Meckel's diverticulum and duplication cysts have both been reported numerous times in the past as a source of a lead point, we report, to our knowledge, the only case of both found in a child requiring operative reduction...
  30. doi request reprint A multiinstitutional review of central venous line complications: retained intravascular fragments
    Kris Milbrandt
    Division of Paediatric General Surgery, Alberta Children s Hospital, University of Calgary, Calgary, Alberta, Canada
    J Pediatr Surg 44:972-6. 2009
    ..We report on a series of 6 patients from 2 tertiary pediatric hospitals that had intravascular segments of long-term central venous lines that could not be removed and so were left in situ...
  31. ncbi request reprint Laparoscopic resection of extra-adrenal pheochromocytoma--case report and review of the literature in pediatric patients
    Dragan Kravarusic
    Department of Pediatric Surgery, Alberta Children s Hospital, University of Calgary, Calgary, Canada T3B 6A8
    J Pediatr Surg 42:1780-4. 2007
    ..Proper patient preparation and monitoring are critical for success...
  32. ncbi request reprint The bone marrow as a potential receptor site for pancreatic islet grafts
    Anastasio Salazar-Bañuelos
    Department of Surgery, Division of Transplantation, University of Calgary, Calgary Canada
    Arch Med Res 39:139-41. 2008
    ..Bone marrow offers an easily accessible extrahepatic receptor site. Therefore, we attempted to explore the survival of pancreatic islets transplanted into the bone marrow of rats...
  33. ncbi request reprint Short bowel syndrome in infants and children: an overview
    D L Sigalet
    The Alberta Children's Hospital, Calgary, Alberta, Canada
    Semin Pediatr Surg 10:49-55. 2001
    ..This chapter presents an overview of the current status of care and outcome in this difficult population; these topics are further expanded in subsequent chapters...
  34. doi request reprint Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study
    Marli A Robertson
    Department of Pediatrics, University of Calgary, Calgary, AB, Canada
    J Autism Dev Disord 38:1066-71. 2008
    ..Our study did not detect differences in these measures of gastrointestinal function in a group of children with autism...
  35. ncbi request reprint 3-0 methylglucose absorption in vivo correlates with nutrient absorption and intestinal surface area in experimental short bowel syndrome
    Gary R Martin
    Gastrointestinal Research Group, University of Calgary, AB, Canada
    JPEN J Parenter Enteral Nutr 27:65-70. 2003
    ..This study examined the use of quantifying 3-0 methylglucose (3-0 MG) absorption as a marker of intestinal surface area and active nutrient transport capability...
  36. ncbi request reprint Cardiopulmonary effects of closed repair of pectus excavatum
    David L Sigalet
    Division of Pediatric Surgery, Department of Surgery, Alberta Children s Hospital, Calgary, Alberta, Canada
    J Pediatr Surg 38:380-5; discussion 380-5. 2003
    ..This study examined the early postoperative effects of closed repair of pectus on pulmonary function, exercise tolerance, and cardiac function...
  37. ncbi request reprint Alpha1-adrenoceptors down-regulate ClC-2 chloride channels in epithelial cells from the acutely denervated jejunum
    Carolyn J Baglole
    Gastrointestinal Research Group, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
    Eur J Pharmacol 565:202-6. 2007
    ..These data suggest that inhibition of chloride secretion following alpha1-adrenoceptor activation in the acutely denervated small intestine may be through ClC-2 down-regulation...
  38. ncbi request reprint Acute abdominal pain in children
    Alexander K C Leung
    University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    Am Fam Physician 67:2321-6. 2003
    ..Selected imaging studies also might be helpful. Surgical consultation is necessary if a surgical cause is suspected or the cause is not obvious after a thorough evaluation...
  39. ncbi request reprint Glucagon-like peptide-2 induces intestinal adaptation in parenterally fed rats with short bowel syndrome
    Gary R Martin
    University of Calgary, Gastrointestinal Research Group, Calgary, Alberta, Canada, T2T 5C7
    Am J Physiol Gastrointest Liver Physiol 286:G964-72. 2004
    ..Further studies are warranted to establish the mechanisms of action and therapeutic potential of GLP-2...
  40. doi request reprint Functional ontogeny of the proglucagon-derived peptide axis in the premature human neonate
    Harish Amin
    Department of Neonatology, Foothills Hospital, Calgary, Alberta, Canada
    Pediatrics 121:e180-6. 2008
    ..The "hindgut" hormones glucagon-like peptides 1 and 2 have been shown to play an important role in the regulation of nutrient assimilation, intestinal growth, and function...
  41. ncbi request reprint Midterm evaluation of cardiopulmonary effects of closed repair for pectus excavatum
    Osama A Bawazir
    Department of Surgery, Pediatric General Surgery, Alberta Children s Hospital, Calgary, AB, Canada T2T 5C7
    J Pediatr Surg 40:863-7. 2005
    ..This report details the effects over time of closed repair of pectus excavatum on pulmonary function, cardiac function, exercise tolerance, and the patient's perception of appearance and subjective ability to exercise...
  42. pmc Acute denervation alters the epithelial response to adrenoceptor activation through an increase in alpha1-adrenoceptor expression on villus enterocytes
    Carolyn J Baglole
    Gastrointestinal Research Group, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 147:101-8. 2006
    ..The increase in adrenoceptors may reflect a compensatory mechanism to combat the increased secretory state of the bowel due to the loss of the sympathetic innervation and tonic control over intestinal secretion...
  43. ncbi request reprint The effects of systemic hypoxia on colon anastomotic healing: an animal model
    Jo Anne P Attard
    GI Research Group, Department of Surgery, University of Calgary, Calgary, Alberta, Canada
    Dis Colon Rectum 48:1460-70. 2005
    ....
  44. pmc Enteral nutrition and mucosal immunity: implications for feeding strategies in surgery and trauma
    David L Sigalet
    Department of Surgery, University of Calgary, Calgary, Alta
    Can J Surg 47:109-16. 2004
    ....