A Shuaib

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. pmc The preventing recurrent vascular events and neurological worsening through intensive organized case-management (PREVENTION) trial protocol [clinicaltrials.gov identifier: NCT00931788]
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta Hospital, 8440 112 Street, Edmonton, Canada
    Implement Sci 5:27. 2010
  2. pmc Delayed minocycline but not delayed mild hypothermia protects against embolic stroke
    Chen Xu Wang
    Stroke Research Laboratory, Department of Medicine, University of Alberta, Canada
    BMC Neurol 2:2. 2002
  3. ncbi request reprint Effects of nonpeptide V(1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model
    Ashfaq Shuaib
    Stroke Research Laboratory, Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Stroke 33:3033-7. 2002
  4. ncbi request reprint Neuroprotection in acute ischemic stroke: are we there yet?
    Ashfaq Shuaib
    Stroke Research Laboratory, University of Alberta, Edmonton, Canada
    Int J Stroke 1:100-1. 2006
  5. ncbi request reprint The past and future of neuroprotection in cerebral ischaemic stroke
    Ashfaq Shuaib
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alta, Canada
    Eur Neurol 59:4-14. 2008
  6. doi request reprint Introduction of portable computed tomography scanners, in the treatment of acute stroke patients via telemedicine in remote communities
    A Shuaib
    Department of Medicine Neurology and the Stroke Program, University of Alberta, Edmonton, AB, T6G 2B7, Canada
    Int J Stroke 5:62-6. 2010
  7. doi request reprint Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial
    Ashfaq Shuaib
    Stroke Program, University of Alberta, Canada
    Stroke 42:1680-90. 2011
  8. doi request reprint Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
    Ashfaq Shuaib
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Lancet Neurol 10:909-21. 2011
  9. ncbi request reprint Usefulness of postischemic thrombolysis with or without neuroprotection in a focal embolic model of cerebral ischemia
    Y Yang
    Department of Medicine Neurology, University of Alberta, Edmonton, Canada
    J Neurosurg 92:841-7. 2000
  10. ncbi request reprint An improved version of embolic model of brain ischemic injury in the rat
    C X Wang
    The Department of Medicine, Division of Neurology, 533 HMRC, Neurology Laboratory, University of Alberta, AB T6G 2S2, Edmonton, Canada
    J Neurosci Methods 109:147-51. 2001

Detail Information

Publications78

  1. pmc The preventing recurrent vascular events and neurological worsening through intensive organized case-management (PREVENTION) trial protocol [clinicaltrials.gov identifier: NCT00931788]
    Finlay A McAlister
    Division of General Internal Medicine, University of Alberta Hospital, 8440 112 Street, Edmonton, Canada
    Implement Sci 5:27. 2010
    ..If our intervention improves the provision of secondary prevention therapies in these patients, the clinical (and financial) implications will be enormous...
  2. pmc Delayed minocycline but not delayed mild hypothermia protects against embolic stroke
    Chen Xu Wang
    Stroke Research Laboratory, Department of Medicine, University of Alberta, Canada
    BMC Neurol 2:2. 2002
    ..In the present study, effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia on focal embolic cerebral ischemia have been examined...
  3. ncbi request reprint Effects of nonpeptide V(1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model
    Ashfaq Shuaib
    Stroke Research Laboratory, Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Stroke 33:3033-7. 2002
    ..We tested the neuroprotective effects of a new potent nonpeptide vasopressin receptor V(1) antagonist, SR-49059, in a focal embolic stroke model in rats...
  4. ncbi request reprint Neuroprotection in acute ischemic stroke: are we there yet?
    Ashfaq Shuaib
    Stroke Research Laboratory, University of Alberta, Edmonton, Canada
    Int J Stroke 1:100-1. 2006
  5. ncbi request reprint The past and future of neuroprotection in cerebral ischaemic stroke
    Ashfaq Shuaib
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alta, Canada
    Eur Neurol 59:4-14. 2008
    ..There is hope that such careful strategies may guide continued progress in neuroprotective drug development...
  6. doi request reprint Introduction of portable computed tomography scanners, in the treatment of acute stroke patients via telemedicine in remote communities
    A Shuaib
    Department of Medicine Neurology and the Stroke Program, University of Alberta, Edmonton, AB, T6G 2B7, Canada
    Int J Stroke 5:62-6. 2010
    ..This is a luxury not widely available, especially in remote sites. Recently, Neurologica introduced a portable computed tomography scanner that can be operated after minimal training...
  7. doi request reprint Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial
    Ashfaq Shuaib
    Stroke Program, University of Alberta, Canada
    Stroke 42:1680-90. 2011
    ..Fewer than 5% of patients with acute ischemic stroke are currently treated, and there is need for additional treatment options. A novel catheter treatment (NeuroFlo) that increases cerebral blood flow was tested to 14 hours...
  8. doi request reprint Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target
    Ashfaq Shuaib
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Lancet Neurol 10:909-21. 2011
    ..Several interventions that might augment collateral blood flow are being investigated...
  9. ncbi request reprint Usefulness of postischemic thrombolysis with or without neuroprotection in a focal embolic model of cerebral ischemia
    Y Yang
    Department of Medicine Neurology, University of Alberta, Edmonton, Canada
    J Neurosurg 92:841-7. 2000
    ....
  10. ncbi request reprint An improved version of embolic model of brain ischemic injury in the rat
    C X Wang
    The Department of Medicine, Division of Neurology, 533 HMRC, Neurology Laboratory, University of Alberta, AB T6G 2S2, Edmonton, Canada
    J Neurosci Methods 109:147-51. 2001
    ..The model shows a close similarity to thromboembolic stroke in human, and it provides a useful tool to investigate mechanisms and test thrombolytic agents in ischemic brain injury...
  11. ncbi request reprint A focal embolic model of cerebral ischemia in rats: introduction and evaluation
    C X Wang
    Department of Medicine, 533 HMRC, Neurology Laboratory, Division of Neurology, University of Alberta Hospital, T6G 2B2, Edmonton, Canada
    Brain Res Brain Res Protoc 7:115-20. 2001
    ..The model is relevant to thromboembolic ischemia in patients, and may offer a useful tool to investigate mechanisms underlying ischemic brain injury. It may also be used to test thrombolytic agents in ischemic brain injury...
  12. ncbi request reprint Different dynamic patterns of extracellular glutamate release in rat hippocampus after permanent or 30-min transient cerebral ischemia and histological correlation
    Y Yang
    Department of Medicine, University of Alberta, Edmonton, Canada
    Neuropathology 21:181-7. 2001
    ....
  13. ncbi request reprint Patency of cerebral microvessels after focal embolic stroke in the rat
    C X Wang
    Department of Neurology, University of Alberta, Edmonton, Alberta, Canada
    J Cereb Blood Flow Metab 21:413-21. 2001
    ..These results may in part explain the resistance of the striatum to neuroprotective strategies used for the treatment of focal cerebral ischemia...
  14. ncbi request reprint Angiographic evaluation of middle cerebral artery reperfusion caused by platelet glycoprotein IIb/IIIa receptor complex antagonist murine 7E3 F(ab')2 in a model of focal cerebral ischemia in rats
    Y Yang
    Division of Neurology, University of Alberta Hospital, Edmonton, Canada
    J Neurosurg 94:582-8. 2001
    ..Neuronal lesions were significantly reduced when the treatment was delayed up to 3 hours...
  15. doi request reprint Effect of hyperthermia on prognosis after acute ischemic stroke
    Monica Saini
    Division of Neurology, Department of Medicine, University of Alberta, AB, Canada
    Stroke 40:3051-9. 2009
    ..Clinical studies evaluating the effect of temperature on poststroke outcome have, however, been limited by small sample sizes. We sought to evaluate the effect of temperature and timing of hyperthermia on outcome after ischemic stroke...
  16. ncbi request reprint Return of stuttering after stroke
    M S Mouradian
    Department of Medicine, Walter Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada
    Brain Lang 73:120-3. 2000
    ..This case supports the theory that acquired brain lesions may cause a return of stuttering, possibly by interfering with the compensatory mechanism(s) that once had relieved the developmental stuttering...
  17. ncbi request reprint Reliability of carotid doppler performed in a dedicated stroke prevention clinic
    N Dean
    Division of Neurology, The Al Owen and Family Stroke Prevention Clinic, University of Alberta, Edmonton, Alberta, Canada
    Can J Neurol Sci 32:327-31. 2005
    ..Recent reports suggest that the DUS may be inaccurate in over 28% of patients. We sought to evaluate the accuracy of DUS, when performed in a dedicated stroke prevention clinic (SPC)...
  18. ncbi request reprint Response of non-migrainous headaches to chlorpromazine
    C L Barclay
    Department of Clinical Neurosciences, Foothills Hospital, Calgary, Alberta, Canada
    Headache 30:85-7. 1990
    ..It is only by doing so that we may avoid missing more serious and life-threatening conditions such as those with which our patients presented...
  19. pmc Intravenous rt-PA for acute stroke: comparing its effectiveness in younger and older patients
    M S Mouradian
    Department of Medicine, Division of Neurology, University of Alberta, 2E3 13 Walter C Mackenzie Health Sciences Centre, Edmonton, Alberta, Canada T6G 2B7
    J Neurol Neurosurg Psychiatry 76:1234-7. 2005
    ....
  20. ncbi request reprint Stroke prophylaxis in nonvalvular atrial fibrillation
    T J Bungard
    EPICORE Centre, Division of Cardiology, Cardiology, University of Alberta, Edmonton, Alberta, Canada
    Curr Opin Neurol 14:59-65. 2001
    ..Narrowing this gap between research evidence and clinical practice may be accomplished by identifying those patients who are eligible for prophylaxis, and then maintaining them at an adequate level of anticoagulation...
  21. ncbi request reprint Randomized controlled trial of modafinil for the treatment of fatigue in postpolio patients
    K Ming Chan
    Division of Physical Medicine and Rehabilitation, 513 Heritage Medical Research Centre, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    Muscle Nerve 33:138-41. 2006
    ..Scores for most of the other tests did not change during the study. Therefore, we conclude that modafinil was not effective in alleviating the symptoms of fatigue in postpolio patients...
  22. ncbi request reprint Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial
    Kennedy R Lees
    Acute Stroke Unit and Cerebrovascular Clinic, University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, 44 Church St, Glasgow, Scotland G11 6NT
    Stroke 37:2970-8. 2006
    ..NXY-059 is a free radical-trapping neuroprotectant demonstrated to reduce disability from ischemic stroke. We conducted analyses on additional end points and sensitivity analyses to confirm our findings...
  23. ncbi request reprint Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study
    Gregory W Albers
    Department of Neurology and Neurological Sciences and the Stanford Stroke Center, Stanford University Medical Center, Stanford, CA 94304, USA
    Ann Neurol 60:508-17. 2006
    ..To determine whether prespecified baseline magnetic resonance imaging (MRI) profiles can identify stroke patients who have a robust clinical response after early reperfusion when treated 3 to 6 hours after symptom onset...
  24. ncbi request reprint Therapeutic strategies for the treatment of stroke
    A Richard Green
    Global Discovery CNS and Pain Control, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK
    Drug Discov Today 11:681-93. 2006
    ..There are a variety of new neuroprotective compounds in the early stages of investigation and some could prove clinically effective, provided appropriate preclinical development guidelines are observed...
  25. ncbi request reprint Foville's syndrome masquerading as Wernicke's encephalopathy
    Nizam Ahmed
    University of Alberta Hospital, Edmonton, Alberta, Canada
    N Z Med J 119:U1928. 2006
  26. ncbi request reprint NXY-059 for acute ischemic stroke
    Kennedy R Lees
    Acute Stroke Unit and Cerebrovascular Clinic, University Department of Medicine and Therapeutics, Gardiner Institute, Western Infirmary, Glasgow, United Kingdom
    N Engl J Med 354:588-600. 2006
    ..NXY-059 is a free-radical-trapping agent that is neuroprotective in animal models of stroke. We tested whether it would reduce disability in humans after acute ischemic stroke...
  27. ncbi request reprint Role of MC-1 alone and in combination with tissue plasminogen activator in focal ischemic brain injury in rats
    Chen Xu Wang
    Stroke Research Laboratory, University of Alberta, Edmonton, Canada
    J Neurosurg 103:165-9. 2005
    ..In the present project, the authors have studied whether MC-1, an analog of PLP, alone or in combination with the thrombolytic agent tissue plasminogen activator (tPA), can protect the brains of rats injured by ischemia...
  28. ncbi request reprint Clinical deterioration after intravenous recombinant tissue plasminogen activator treatment: a multicenter transcranial Doppler study
    Maher Saqqur
    University of Alberta, Department of Medicine, Division of Neurology, 2 E3 Walter Mckenzie Center, 8440 112 Ave, Edmonton, Alberta T6G 2B7, Canada
    Stroke 38:69-74. 2007
    ..We evaluated the ability of flow findings on transcranial Doppler to predict CD and outcomes on modified Rankin Scale...
  29. ncbi request reprint Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Edmonton, Alberta, Canada
    Stroke 38:948-54. 2007
    ..Angiographic studies with intraarterial thrombolysis suggest more proximal occlusions carry greater thrombus burden and benefit less from local therapy...
  30. doi request reprint Reduction of ischemic brain injury in rats with normothermic and hyperthermic conditions
    Alireza P Shabanzadeh
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Neurosurg 109:522-9. 2008
    ..In this study they further examined whether treatment with simvastatin can reduce ischemic brain injury in a hyperthermic condition...
  31. doi request reprint Treatment with melagatran alone or in combination with thrombolytic therapy reduced ischemic brain injury
    Chen Xu Wang
    Stroke Research Laboratory, Department of Medicine, University of Alberta, Edmonton, Canada
    Exp Neurol 213:171-5. 2008
    ..Finally, the combination with melagatran and tPA appears safe and superior to each treatment offered alone...
  32. doi request reprint NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials
    Hans Christoph Diener
    Department of Neurology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Stroke 39:1751-8. 2008
    ..SAINT I and II were randomized, placebo-controlled, double-blind trials to investigate the efficacy of NXY-059 in patients with AIS...
  33. ncbi request reprint Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial
    Patrick D Lyden
    UCSD Stroke Center, San Diego, CA 92103, USA
    Stroke 38:2262-9. 2007
    ..To facilitate prompt administration of treatment, potentially before neuroimaging, we investigated the safety of NXY-059 in patients with intracerebral hemorrhage (ICH)...
  34. ncbi request reprint Critical role of microvasculature basal lamina in ischemic brain injury
    Chen Xu Wang
    Stroke Research Laboratory, University of Alberta, Edmonton, Canada
    Prog Neurobiol 83:140-8. 2007
    ..The present article reviews microvascular changes during ischemic brain injury, with emphasis on basal lamina damage...
  35. ncbi request reprint NXY-059 for the treatment of acute ischemic stroke
    Ashfaq Shuaib
    Division of Neurology, University of Alberta, Edmonton, Canada
    N Engl J Med 357:562-71. 2007
    ..We sought confirmation of efficacy in a second, larger trial...
  36. ncbi request reprint Neuroprotective effects of free radical scavengers in stroke
    Chen X Wang
    Stroke Research Laboratory, University of Alberta, Edmonton, Alberta, Canada
    Drugs Aging 24:537-46. 2007
    ....
  37. ncbi request reprint Combination treatment with dipyridamole, aspirin, and tPA in an embolic model of stroke in rats
    Samer Aldandashi
    Stroke Research Laboratory, University of Alberta, 533 HMRC, Edmonton, Alberta, Canada T6G 2S2
    Exp Neurol 205:563-8. 2007
    ..Dipyridamole with tPA also significantly reduced infarct volume as compared to tPA alone. Our data suggests that higher doses of antithrombotic therapy with dipyridamole offer best neuroprotection...
  38. ncbi request reprint Cervical electromyogram profile differences between patients of neck pain and control
    Shrawan Kumar
    Department of Physical Therapy, University of Alberta, Edmonton, Alberta, Canada
    Spine (Phila Pa 1976) 32:E246-53. 2007
    ..A comparative analysis of electromyogram (EMG) signals of patients of cervical pain and normal controls...
  39. ncbi request reprint Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke
    Alireza P Shabanzadeh
    Stroke Research Laboratory, 533 HMRC, University of Alberta, Edmonton, Canada ABT6G 2S2
    Brain Res 1042:1-5. 2005
    ..01). These studies thus suggest that simvastatin is a protective agent in ischemic brain injury and this protective effect may be partially due to its action in the improvement of microvascular reperfusion...
  40. ncbi request reprint Derivation of transcranial Doppler criteria for rescue intra-arterial thrombolysis: multicenter experience from the Interventional Management of Stroke study
    Maher Saqqur
    Department of Medicine Neurology, University of Alberta, Alberta, Canada
    Stroke 36:865-8. 2005
    ..We examined clinical utility and prognostic value of TCD flow findings in patients enrolled in an intravenous/intra-arterial rtPA pilot trial (Interventional Management of Stroke [IMS] study)...
  41. ncbi request reprint Matrix metalloproteinase activation and blood-brain barrier breakdown following thrombolysis
    Melissa A Kelly
    Center for Neuroscience, University of Alberta, Edmonton, AB, Canada
    Exp Neurol 200:38-49. 2006
    ..Our study is the first to demonstrate the temporal profile of MMP activation following thrombolysis with tPA in a model of thrombotic focal cerebral ischemia...
  42. ncbi request reprint Cervical arterial dissection: time for a therapeutic trial?
    Vadim Beletsky
    University of Western Ontario, London, Ontario, Canada
    Stroke 34:2856-60. 2003
    ..The goal of this study was to assess the natural history of the disorder and to decide on the feasibility of a therapeutic trial...
  43. ncbi request reprint Effects of minocycline alone and in combination with mild hypothermia in embolic stroke
    Chen Xu Wang
    Stroke Research Laboratory, 533 HMRC, University of Alberta, T6G 2S2, Edmonton, Canada
    Brain Res 963:327-9. 2003
    ..These results suggest that minocycline is beneficial in focal ischemic brain injury, and the lack of the enhanced neuroprotection may be due to the brief exposure to hypothermia...
  44. pmc Atrial myxoma as a cause of stroke: case report and discussion
    Fintan O'Rourke
    Stroke Prevention Clinic, University of Alberta Hospital, Edmonton, AB
    CMAJ 169:1049-51. 2003
    ..The clinical presentation of cardiac myxoma is discussed, along with appropriate investigations and treatment, which may prevent such sequelae...
  45. ncbi request reprint Improved detection of microbubble signals using power M-mode Doppler
    Maher Saqqur
    Department of Medicine Neurology, University of Calgary, Calgary, Alberta, Canada
    Stroke 35:e14-7. 2004
    ..We developed criteria for emboli detection using PMD. Then, we performed a blinded comparison of transcranial PMD with single-gate spectral TCD in TCD bubble study patients...
  46. ncbi request reprint Effect of zinc in ischemic brain injury in an embolic model of stroke in rats
    Alireza P Shabanzadeh
    Stroke Research Laboratory, University of Alberta, Edmonton, Canada
    Neurosci Lett 356:69-71. 2004
    ..These results thus support the hypothesis that administration of zinc i.p. worsens the outcome of ischemic brain injury in the embolic model of stroke in rats...
  47. ncbi request reprint Failure of delayed and prolonged hypothermia to favorably affect hemorrhagic stroke in rats
    Crystal MacLellan
    Department of Psychology, P217 Biological Sciences Building, University of Alberta, Alberta, T6G 2E9, Edmonton, Canada
    Brain Res 958:192-200. 2002
    ..This indicates that skilled reaching is more severely disrupted than spontaneous paw usage or walking after a striatal hemorrhage...
  48. ncbi request reprint A new reproducible focal cerebral ischemia model by introduction of polyvinylsiloxane into the middle cerebral artery: a comparison study
    Yi Yang
    Department of Medicine, Division of Neurology, 2E3 13 Walter Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    J Neurosci Methods 118:199-206. 2002
    ..Our data suggests that permanent focal cerebral ischemia with high reproducibility and low mortality can be achieved by introducing PVS into the right MCA...
  49. ncbi request reprint Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model
    Yi Yang
    Department of Medicine and Therapeutics, University of Glasgow, Glasgow, England
    AJNR Am J Neuroradiol 23:1229-36. 2002
    ..The current study was designed to study the relationship between stenotic degree and TCD-detectable turbulent flow and its differentiation from cerebral emboli...
  50. ncbi request reprint Can rt-PA be administered to the wrong patient? Two patients with somatoform disorder
    Mikael S Mouradian
    Division of Neurology, Department of Medicine, Queens University, Kingston, Ontario, Canada
    Can J Neurol Sci 31:99-101. 2004
    ..Diagnosis of the somatoform disorder is often delayed, and thrombolytics in these patients for their stroke-like presentation subjects them to risk for hemorrhage...
  51. ncbi request reprint Antiischemic effects of topiramate in a transient global forebrain ischemia model: a neurochemical, histological, and behavioral evaluation
    S H Khan
    Stroke Research Unit, University of Saskatchewan, Saskatoon, SK, Canada
    Neurochem Res 28:1235-9. 2003
    ..The difference in effect, which may be due to the difference in species or the type of ischemia, points to the need for caution when extrapolating animal data from this drug to humans...
  52. ncbi request reprint Pyridoxine as a template for the design of antiplatelet agents
    Wenlian Zhang
    Canam Bioresearch Inc, 6 1200 Waverley Street, Winnipeg, MB, Canada R3T 0P4
    Bioorg Med Chem Lett 14:4747-50. 2004
    ..The present study describes the synthesis of several of these derivatives along with the antiplatelet and antiischemic activity of derivative 16...
  53. ncbi request reprint Reduced brain infarct volume and improved neurological outcome by inhibition of the NR2B subunit of NMDA receptors by using CP101,606-27 alone and in combination with rt-PA in a thromboembolic stroke model in rats
    Yi Yang
    Acute Stroke Program, Neurology Division, University of Alberta Hospital, Edmonton, Alberta, Canada
    J Neurosurg 98:397-403. 2003
    ..In current experiments, the authors investigated its neuroprotective effect alone and in combination with recombinant tissue plasminogen activator (rt-PA) in thromboembolic focal cerebral ischemia in rats...
  54. ncbi request reprint Hyperthermia masks the neuroprotective effects of tissue plaminogen activator
    Raza Noor
    Stroke Research Laboratory, Department of Medicine, University of Alberta, Edmonton, AB, Canada
    Stroke 36:665-9. 2005
    ..In the present study, we examined the effects of hyperthermia on the efficacy of thrombolytic therapy in this stroke model...
  55. ncbi request reprint Glycoprotein IIb/IIIa antagonist, murine 7E3 F(ab') 2, and tissue plasminogen activator in focal ischemia: evaluation of efficacy and risk of hemorrhage with combination therapy
    Ashfaq Shuaib
    Acute Stroke Program, Neurology Division, University of Alberta Hospital, Edmonton, Alberta, Canada
    J Cereb Blood Flow Metab 22:215-22. 2002
    ....
  56. ncbi request reprint Acetylsalicylic acid reduces perfusion deficit in ischemic injured brain in rats
    Ghias Uddin
    Stroke Research Laboratory, 533 HRMC, University of Alberta, Edmonton ABT6G 2S2, Canada
    Neuroreport 14:1753-5. 2003
    ..These findings thus support that ASA is useful agent in treatment and prevention of stroke, and show that its mechanism of action is likely through the reopening of cerebral microvessels...
  57. ncbi request reprint Transient ischaemic attacks: unstable, treatable, neglected
    Naeem Dean
    Royal Alexandra Hospital, Edmonton, AB, Canada
    Lancet 370:1398-400. 2007
  58. doi request reprint Research into neuroprotection must continue ... But with a different approach
    Muhammad S Hussain
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Canada
    Stroke 39:521-2. 2008
  59. ncbi request reprint Applicability, validity, and reliability of the Piper Fatigue Scale in postpolio patients
    Fay J Strohschein
    Centre for Neuroscience, University of Alberta, Edmonton, Canada
    Am J Phys Med Rehabil 82:122-9. 2003
    ..To identify a scale that is potentially applicable for measuring the fatigue in postpolio patients and to evaluate its validity and reliability in this population...
  60. ncbi request reprint Spinal cord transient ischemic attacks: a possible role for abciximab
    Muhammad S Hussain
    Division of Neurology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Neurology 64:761-2. 2005
  61. ncbi request reprint Neuroprotective effect of tiagabine in transient forebrain global ischemia: an in vivo microdialysis, behavioral, and histological study
    Saeeda Iqbal
    Department of Neurology, Royal University Hospital, Saskatoon, Saskatchewan, Canada S7N 0X8
    Brain Res 946:162-70. 2002
    ..Histology showed no neuroprotection in this group (P>0.05). These results show that tiagabine offers a significant neuroprotection in global ischemia in gerbils when given 30 min before ischemia but not when given 3 h after ischemia...
  62. ncbi request reprint How well are hypertension, hyperlipidemia, diabetes, and smoking managed after a stroke or transient ischemic attack?
    Mikael S Mouradian
    Division of Neurology, University of Alberta, Edmonton, Alberta, Canada
    Stroke 33:1656-9. 2002
    ..The effect of consultations generated at SPCs on the adequacy of the management of these risk factors for stroke has not been well described, and few studies have long-term follow-up...
  63. ncbi request reprint Trimetazidine as a potential neuroprotectant in transient global ischemia in gerbils: a behavioral and histological study
    Saeeda Iqbal
    Department of Neurology, Royal University Hospital, Saskatoon, Sasketchewan, Canada S7N 0W8
    Brain Res 928:1-7. 2002
    ..We conclude that TMZ shows signs of promise as a neuroprotective agent, and further studies should look at pre-treatment with different doses and different times...
  64. ncbi request reprint Endothelial progenitor cells and cerebrovascular diseases
    Bertrand Lapergue
    Stroke Research Unit, Division of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Alberta, Canada
    Prog Neurobiol 83:349-62. 2007
    ..In this review, we discuss the present level of knowledge about the characteristics of EPCs, their possible therapeutic role in CVD and how they could alter clinical practice in the future...
  65. ncbi request reprint The relative importance of barriers to the prescription of warfarin for nonvalvular atrial fibrillation
    Tammy J Bungard
    Division of Cardiology, University of Alberta, Edmonton
    Can J Cardiol 19:280-4. 2003
    ..The purpose of this study was to assess the relative importance of various barriers that may influence the prescription of warfarin in patients with nonvalvular atrial fibrillation...
  66. ncbi request reprint NMDA/NR2B selective antagonists in the treatment of ischemic brain injury
    Chen Xu Wang
    Stroke Research Laboratory, Department of Medicine, University of Alberta, Edmonton, Canada
    Curr Drug Targets CNS Neurol Disord 4:143-51. 2005
    ..The present review describes the role of glutamate in ischemic brain injury with an emphasis on the NR2B containing NMDA receptors...
  67. ncbi request reprint Endothelial progenitor cells during cerebrovascular disease
    Usman Ghani
    Stroke Research, Division of Neurology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    Stroke 36:151-3. 2005
    ..There are no reports of EPCs with cerebrovascular disease. We present our experience with EPCs in patients with cerebrovascular disease...
  68. pmc Current and future concepts in stroke prevention
    Fintan O'Rourke
    Stroke Prevention Clinic, University of Alberta Hospital, Mackenzie Health Sciences Centre
    CMAJ 170:1123-33. 2004
    ..Specifically, we review the evidence for antiplatelet agents, anticoagulants, antihypertensive medications, lipid-lowering agents and carotid endarterectomy for stroke prevention...
  69. ncbi request reprint The relationship between diffusion anisotropy and time of onset after stroke
    Yusuf A Bhagat
    Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada
    J Cereb Blood Flow Metab 26:1442-50. 2006
    ..Similar anisotropy changes were noted in subcortical WM regions in the gyri...
  70. ncbi request reprint Agreement between patient and proxy assessments of health-related quality of life after stroke using the EQ-5D and Health Utilities Index
    A Simon Pickard
    College of Pharmacy, University of Illinois at Chicago, 60612, USA
    Stroke 35:607-12. 2004
    ..The purpose of this study was to examine patient-proxy agreement on the domains and summary scores of the EQ-5D and Health Utilities Index Mark 3 (HUI3) after stroke...
  71. ncbi request reprint Clot fragments formed from original thrombus obstruct downstream arteries in the ischemic injured brain
    Chen Xu Wang
    Stroke Research Laboratory, University of Alberta, Edmonton, Alberta, Canada
    Microcirculation 13:229-36. 2006
    ..However, the mechanism for the perfusion deficits is not fully understood. The authors examined whether distal movement of fragments formed from the original thrombus contributes to the perfusion deficits...
  72. pmc Use of MRI in the identification and treatment of early ischemic stroke lesions
    Fintan O'Rourke
    Stroke Prevention Clinic, Division of Neurology, University of Alberta Hospital, Edmonton, Alberta, Canada
    CMAJ 170:335-6. 2004
  73. ncbi request reprint Thrombolysis for acute ischemic stroke in India: overcoming the challenges
    Muhammad S Hussain
    Division of Neurology, Department of Medicine, University of Alberta, Canada
    Neurol India 55:9-10. 2007
  74. ncbi request reprint Effects of hyperthermia on infarct volume in focal embolic model of cerebral ischemia in rats
    Raza Noor
    Department of Neurology, University of Alberta Hospital, Edmonton, Alta 6G 2S2, Canada
    Neurosci Lett 349:130-2. 2003
    ..In addition, hyperthermia also significantly increased mortality. Our data thus show that hyperthermia exacerbates neuronal injury in the focal embolic model of cerebral ischemia in rats...
  75. ncbi request reprint The role of taurine in cerebral ischemia: studies in transient forebrain ischemia and embolic focal ischemia in rodents
    Ashfaq Shuaib
    Department of Medicine, University of Alberta, Edmonton, Canada
    Adv Exp Med Biol 526:421-31. 2003
    ..Further studies are necessary to better understand the potential for taurine as a neuroprotective agent in cerebral ischemia...
  76. ncbi request reprint Randomized, double-blind, placebo-controlled, international trial of the oral IIb/IIIa antagonist lotrafiban in coronary and cerebrovascular disease
    Eric J Topol
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Circulation 108:399-406. 2003
    ....
  77. ncbi request reprint Progress in clinical neurosciences: The 'antiplatelet' agents and the role of the endothelium
    Farrah J Mateen
    College of Medicine, University of Saskatchewan FJM, Saskatoon, Canada
    Can J Neurol Sci 34:270-9. 2007
    ..The role of each of the above medications is explored in relation to vasodilation, inflammation, oxidation, platelet-leukocyte interactions, and thrombogenic tendency via platelet-vessel wall interactions...
  78. doi request reprint Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial
    Wade S Smith
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0114, USA
    Stroke 39:1205-12. 2008
    ..Enhancements in embolectomy device design may improve recanalization rates...