Y Shimoni

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint Gender differences in ANG II levels and action on multiple K+ current modulation pathways in diabetic rats
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 287:H311-9. 2004
  2. pmc Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice
    Yakhin Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, 3330 Hospital Dr N W, Calgary AB, Canada T2N 4N1
    J Physiol 555:345-54. 2004
  3. pmc Dexamethasone and cardiac potassium currents in the diabetic rat
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, 3330 Hospital Dr N W, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 146:280-7. 2005
  4. pmc Sex differences in the modulation of K+ currents in diabetic rat cardiac myocytes
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Alberta, Canada T2N 4N1
    J Physiol 550:401-12. 2003
  5. ncbi request reprint Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 284:H1168-81. 2003
  6. ncbi request reprint Differential autocrine modulation of atrial and ventricular potassium currents and of oxidative stress in diabetic rats
    Yakhin Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 290:H1879-88. 2006
  7. ncbi request reprint Type 1 diabetes leads to cytoskeleton changes that are reflected in insulin action on rat cardiac K(+) currents
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary Health Sciences Centre, 3330 Hospital Dr NW, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Endocrinol Metab 281:E575-85. 2001
  8. pmc Aldosterone and the autocrine modulation of potassium currents and oxidative stress in the diabetic rat heart
    Y Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 154:675-87. 2008
  9. ncbi request reprint Insulin resistance and the modulation of rat cardiac K(+) currents
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 279:H639-49. 2000
  10. pmc Protein kinase C regulation of K+ currents in rat ventricular myocytes and its modification by hormonal status
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Physiol 520:439-49. 1999

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Gender differences in ANG II levels and action on multiple K+ current modulation pathways in diabetic rats
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 287:H311-9. 2004
    ..A contribution of non-ANG II-dependent activation of PKC is suggested. These results describe some of the mechanisms that may underlie gender-specific differences in the development of cardiac disease and arrhythmias...
  2. pmc Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice
    Yakhin Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, 3330 Hospital Dr N W, Calgary AB, Canada T2N 4N1
    J Physiol 555:345-54. 2004
    ..Insulin is not involved in these gender differences, since the absence of insulin action in CIRKO mice diminishes K(+) currents in cells from both males and females...
  3. pmc Dexamethasone and cardiac potassium currents in the diabetic rat
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, 3330 Hospital Dr N W, Calgary, Alberta, Canada T2N 4N1
    Br J Pharmacol 146:280-7. 2005
    ..In conclusion, type I diabetes is associated with gender-specific changes in sensitivity of K+ currents to glucocorticoids, linked to alterations in tyrosine-phosphorylated proteins...
  4. pmc Sex differences in the modulation of K+ currents in diabetic rat cardiac myocytes
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Alberta, Canada T2N 4N1
    J Physiol 550:401-12. 2003
    ..Oestradiol plays a key role in reducing this modulation. These results may underlie some of the sex differences associated with development of cardiac arrhythmias...
  5. ncbi request reprint Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin
    Yakhin Shimoni
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 284:H1168-81. 2003
    ....
  6. ncbi request reprint Differential autocrine modulation of atrial and ventricular potassium currents and of oxidative stress in diabetic rats
    Yakhin Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 290:H1879-88. 2006
    ..The evidence suggests that this is largely due to inhibition of RAS activation and/or action by ANP in A cells. These results may underlie chamber-specific arrhythmogenic mechanisms...
  7. ncbi request reprint Type 1 diabetes leads to cytoskeleton changes that are reflected in insulin action on rat cardiac K(+) currents
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary Health Sciences Centre, 3330 Hospital Dr NW, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Endocrinol Metab 281:E575-85. 2001
    ..These results suggest an impairment of cytoskeleton function and structure under insulin-deficient conditions, which may have implications for cardiac function...
  8. pmc Aldosterone and the autocrine modulation of potassium currents and oxidative stress in the diabetic rat heart
    Y Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, Calgary, Alberta, Canada
    Br J Pharmacol 154:675-87. 2008
    ..Aldosterone plays a major role in cardiac pathology. This study was designed to investigate the role of cardiac aldosterone in modulating K(+) currents and oxidative stress in the streptozotocin-induced diabetic rat heart...
  9. ncbi request reprint Insulin resistance and the modulation of rat cardiac K(+) currents
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 279:H639-49. 2000
    ..Vanadate compounds, which mimic the effects of insulin on metabolism, also mimic the augmenting effects of insulin on a cardiac K(+) current in a manner suggesting synthesis of new channels...
  10. pmc Protein kinase C regulation of K+ currents in rat ventricular myocytes and its modification by hormonal status
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Physiol 520:439-49. 1999
    ..This presumably reflects a (partial) reversal of a chronic translocation and a shift in the balance between PKC and its anchoring proteins...
  11. doi request reprint Sex-dependent impairment of cardiac action potential conduction in type 1 diabetic rats
    Yakhin Shimoni
    Department of Physiology and Biophysics, University of Calgary, Health Sciences Centre, 3330 Hospital Dr N W, Calgary, AB Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 296:H1442-50. 2009
    ..This difference is (partly) mediated by sex differences in activation of the cardiac renin-angiotensin system...
  12. pmc Modulation of potassium currents by angiotensin and oxidative stress in cardiac cells from the diabetic rat
    Y Shimoni
    Department of Physiology and Biophysics, Health Sciences Centre, University of Calgary, 3330 Hospital Dr N W, Calgary, Alberta, Canada T2N 4N1
    J Physiol 567:177-90. 2005
    ..When ANG II levels are lower, as in diabetic females or following ACE inhibition in males, oxidative stress is reduced, with blunted alterations in K+ currents...
  13. pmc Type I and II models of diabetes produce different modifications of K+ currents in rat heart: role of insulin
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary, Alberta, Canada
    J Physiol 507:485-96. 1998
    ..Insulin action on I(t) may therefore involve changes in transcription or expression of channel proteins, rather than changes in cellular metabolism...
  14. pmc Insulin stimulation of rat ventricular K+ currents depends on the integrity of the cytoskeleton
    Y Shimoni
    Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    J Physiol 514:735-45. 1999
    ..The possibility that newly formed channels translocate to the plasma membrane in a process dependent on different elements of the cytoskeleton is discussed...
  15. pmc Inhibition of the formation or action of angiotensin II reverses attenuated K+ currents in type 1 and type 2 diabetes
    Y Shimoni
    Department of Physiology and Biophysics, Cardiovascular Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Physiol 537:83-92. 2001
    ..This may underlie the proven benefits of ATII receptor blockade or ACE inhibition in diabetes, by providing protection against cardiac arrhythmias...
  16. pmc Transmural differences in rat ventricular protein kinase C epsilon correlate with its functional regulation of a transient cardiac K+ current
    K S Thorneloe
    Department of Biochemistry and Molecular Biology, Canadian Institute of Health Research Group in Regulation of Vascular Contractility, Calgary, Alberta, Canada
    J Physiol 533:145-54. 2001
    ..These differences are absent in diabetic and hypothyroid conditions...
  17. pmc Propagation of the cardiac impulse in the diabetic rat heart: reduced conduction reserve
    A Nygren
    Department of Electrical and Computer Engineering, University of Calgary, Alberta, Canada
    J Physiol 580:543-60. 2007
    ..In conclusion, conduction reserve is smaller in the diabetic heart, priming it for impaired conduction upon further challenges. This can desynchronize contraction and contribute to arrhythmogenesis...
  18. ncbi request reprint Treatment of type 2 diabetic db/db mice with a novel PPARgamma agonist improves cardiac metabolism but not contractile function
    Andrew N Carley
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Am J Physiol Endocrinol Metab 286:E449-55. 2004
    ..Metabolic changes in COOH-treated db/db hearts are most likely indirect, secondary to changes in supply of exogenous substrates in vivo and insulin sensitization...
  19. ncbi request reprint Decrease in density of INa is in the common final pathway to heart block in murine hearts overexpressing calcineurin
    J Guo
    Dept of Cardiac Sciences, University of Calgary, AB, Canada T2N 4N1
    Am J Physiol Heart Circ Physiol 291:H2669-79. 2006
    ..We conclude that decrease in sodium channel activity is in the common final pathway to asystole in CN mice...
  20. pmc Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts
    Bailong Xiao
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Biochem J 396:7-16. 2006
    ..Our results also suggest that phosphorylation of RyR2 at Ser-2030 may be an important event associated with altered Ca2+ handling and cardiac arrhythmia that is commonly observed in heart failure upon beta-adrenergic stimulation...
  21. doi request reprint Simulations of reduced conduction reserve in the diabetic rat heart: response to uncoupling and reduced excitability
    Haisam A Ghaly
    Department of Electrical and Computer Engineering, University of Calgary, 2500 University Dr NW, Calgary, AB T2N 1N4, Canada
    Ann Biomed Eng 38:1415-25. 2010
    ....
  22. pmc Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+
    Huihui Kong
    Cardiovascular Research Group, Department of Physiology and Biophysics, and Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    Biophys J 92:2757-70. 2007
    ....
  23. pmc K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association
    Donald J Hunt
    Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Biochem J 404:431-8. 2007
    ..Our results also suggest that suppression of spontaneous Ca2+ release and the activity of RyR2 contributes, at least in part, to the anti-arrhythmic properties of K201...