N M Sherwood

Summary

Affiliation: University of Victoria
Country: Canada

Publications

  1. ncbi request reprint Developmental role of GnRH and PACAP in a zebrafish model
    Nancy M Sherwood
    Department of Biology, University of Victoria, Victoria, BC, Canada V8W 3N5
    Gen Comp Endocrinol 142:74-80. 2005
  2. ncbi request reprint Knocked down and out: PACAP in development, reproduction and feeding
    Nancy M Sherwood
    Department of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada
    Peptides 28:1680-7. 2007
  3. ncbi request reprint The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
    N M Sherwood
    Department of Biology, University of Victoria, British Columbia, Canada
    Endocr Rev 21:619-70. 2000
  4. ncbi request reprint Developmental expression, alternative splicing and gene copy number for the pituitary adenylate cyclase-activating polypeptide (PACAP) and growth hormone-releasing hormone (GRF) gene in rainbow trout
    S L Krueckl
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2
    Mol Cell Endocrinol 182:99-108. 2001
  5. ncbi request reprint Identity of gonadotropin-releasing hormone in passerine birds: comparison of GnRH in song sparrow (Melospiza melodia) and starling (Sturnus vulgaris) with five vertebrate GnRHs
    N M Sherwood
    Department of Biology, University of Victoria, British Columbia, Canada
    Gen Comp Endocrinol 69:341-51. 1988
  6. ncbi request reprint Regulation and expression of gonadotropin-releasing hormone in salmon embryo and gonad
    K R von Schalburg
    Department of Biology, University of Victoria, BC, Canada
    Mol Cell Endocrinol 157:41-54. 1999
  7. ncbi request reprint Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish
    Sandra L Krueckl
    Department of Biology, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
    J Comp Neurol 455:396-405. 2003
  8. ncbi request reprint Regulation and expression of gonadotropin-releasing hormone gene differs in brain and gonads in rainbow trout
    K R von Schalburg
    Department of Biology, University of Victoria, British Columbia, Canada
    Endocrinology 140:3012-24. 1999
  9. ncbi request reprint Gonadotropin-releasing hormone from brains of reptiles: turtles (Pseudemys scripta) and snakes (Thamnophis sirtalis parietalis)
    N M Sherwood
    Department of Biology, University of Victoria, British Columbia, Canada
    Gen Comp Endocrinol 69:319-27. 1988
  10. ncbi request reprint Early expression of pituitary adenylate cyclase-activating polypeptide and activation of its receptor in chick neuroblasts
    N M Erhardt
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada, V8W 2Y2
    Endocrinology 142:1616-25. 2001

Collaborators

  • Sheng Wu
  • S L Gray
  • George O Mackie
  • Kristian R von Schalburg
  • Javier A Tello
  • Bruce A Adams
  • Kevin J Cummings
  • Nola M Erhardt
  • Erica A Fradinger
  • Jean E Rivier
  • Graeme J Roch
  • Emma R Isaac
  • Aurélie Allais
  • Jonathan D Pendlebury
  • Richard J A Wilson
  • Sandra L Krueckl
  • N M Erhardt
  • S L Krueckl
  • Antonio J Vidal-Puig
  • Antonio C Bianco
  • Hubert Vaudry
  • Delphine Burel
  • Magali Basille
  • Aurélia Ravni
  • Bruno J Gonzalez
  • Terry W Pearson
  • Lee R Haines
  • D W Lescheid
  • Frank R Jirik
  • J E McRory
  • Judit Erchegyi
  • Doley J Hong
  • Carol Warby
  • Wylie Vale
  • Karen O Akinsanya
  • Collan J T Simmons
  • Laurence W Crim
  • David W Lescheid
  • Elaine D Vickers
  • Christine A Kozak
  • J E Rivier
  • E A Fradinger
  • L A Cervini
  • R P Millar
  • E Terasawa
  • H F Urbanski
  • R L Parker
  • C M Warby
  • L A Abler
  • R Kelsall
  • I R Coe

Detail Information

Publications35

  1. ncbi request reprint Developmental role of GnRH and PACAP in a zebrafish model
    Nancy M Sherwood
    Department of Biology, University of Victoria, Victoria, BC, Canada V8W 3N5
    Gen Comp Endocrinol 142:74-80. 2005
    ..In similar studies on GHRH-PACAP, gene knockdown resulted in a smaller brain and eyes, but a normal-appearing heart. The evidence supports a role for the three neuropeptides in early development...
  2. ncbi request reprint Knocked down and out: PACAP in development, reproduction and feeding
    Nancy M Sherwood
    Department of Biology, University of Victoria, Victoria, BC V8W 3N5, Canada
    Peptides 28:1680-7. 2007
    ..The evidence suggests PACAP is important for brain development in zebrafish and is required for normal reproduction, but not for body mass or food intake in mice maintained near thermoneutrality...
  3. ncbi request reprint The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
    N M Sherwood
    Department of Biology, University of Victoria, British Columbia, Canada
    Endocr Rev 21:619-70. 2000
    ..In addition, PACAP regulates metabolism and the cardiovascular, endocrine, and immune systems, although the physiological event(s) that coordinates PACAP responses remains to be identified...
  4. ncbi request reprint Developmental expression, alternative splicing and gene copy number for the pituitary adenylate cyclase-activating polypeptide (PACAP) and growth hormone-releasing hormone (GRF) gene in rainbow trout
    S L Krueckl
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada V8W 2Y2
    Mol Cell Endocrinol 182:99-108. 2001
    ....
  5. ncbi request reprint Identity of gonadotropin-releasing hormone in passerine birds: comparison of GnRH in song sparrow (Melospiza melodia) and starling (Sturnus vulgaris) with five vertebrate GnRHs
    N M Sherwood
    Department of Biology, University of Victoria, British Columbia, Canada
    Gen Comp Endocrinol 69:341-51. 1988
    ..Starlings can be added now to the growing list of submammalian species that express multiple forms of GnRH in their brains...
  6. ncbi request reprint Regulation and expression of gonadotropin-releasing hormone in salmon embryo and gonad
    K R von Schalburg
    Department of Biology, University of Victoria, BC, Canada
    Mol Cell Endocrinol 157:41-54. 1999
    ..We conclude that differential regulation of GnRH occurs in embryos, ovary and testis compared to brain in salmonids and that more than one form of GnRH is expressed in the salmonid gonad...
  7. ncbi request reprint Developmental changes in the expression of growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide in zebrafish
    Sandra L Krueckl
    Department of Biology, University of Victoria, Victoria, British Columbia V8W 3N5, Canada
    J Comp Neurol 455:396-405. 2003
    ..The temporal and spatial expression pattern of the ghrh-pacap1 transcript suggests that these hormones may modulate patterning during development...
  8. ncbi request reprint Regulation and expression of gonadotropin-releasing hormone gene differs in brain and gonads in rainbow trout
    K R von Schalburg
    Department of Biology, University of Victoria, British Columbia, Canada
    Endocrinology 140:3012-24. 1999
    ..The duplicated trout genes provide a model to study a critical gene whose product controls reproduction in all vertebrates...
  9. ncbi request reprint Gonadotropin-releasing hormone from brains of reptiles: turtles (Pseudemys scripta) and snakes (Thamnophis sirtalis parietalis)
    N M Sherwood
    Department of Biology, University of Victoria, British Columbia, Canada
    Gen Comp Endocrinol 69:319-27. 1988
    ..This assertion is based on the present demonstration and work by others showing that chicken I and II GnRH-like peptides are in turtle and alligator, chicken I is in snake, and chicken II is in lizard...
  10. ncbi request reprint Early expression of pituitary adenylate cyclase-activating polypeptide and activation of its receptor in chick neuroblasts
    N M Erhardt
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada, V8W 2Y2
    Endocrinology 142:1616-25. 2001
    ....
  11. ncbi request reprint Neuroendocrinology of protochordates: insights from Ciona genomics
    Nancy M Sherwood
    Department of Biology, University of Victoria, Victoria, B C, Canada V8W 3N5
    Comp Biochem Physiol A Mol Integr Physiol 144:254-71. 2006
    ..Other neuroendocrine components that have been annotated in the genome are a multitude of receptors, which are available for cloning, expression and functional studies...
  12. ncbi request reprint Role of two genes encoding PACAP in early brain development in zebrafish
    Sheng Wu
    Department of Biology, University of Victoria, 3800 Finnerty Road, Victoria, B C V8W 3N5, Canada
    Ann N Y Acad Sci 1070:602-21. 2006
    ..The early expression of transcripts for PACAP and its receptors by 0.5-6 hpf make both PACAP1 and PACAP2 candidates for factors that influence brain development...
  13. ncbi request reprint A role for GnRH in early brain regionalization and eye development in zebrafish
    Sheng Wu
    Department of Biology, University of Victoria, Victoria, BC, Canada
    Mol Cell Endocrinol 257:47-64. 2006
    ..These experiments suggest that GnRH loss-of-function affects early brain and eye formation during development...
  14. ncbi request reprint Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism
    S L Gray
    Department of Biology, University of Victoria, Victoria, British Columbia, V8W 3N5 Canada
    Mol Endocrinol 15:1739-47. 2001
    ..Glycogen in the liver was reduced. These results suggest PACAP is a critical hormonal regulator of lipid and carbohydrate metabolism...
  15. ncbi request reprint A second form of gonadotropin-releasing hormone (GnRH) with characteristics of chicken GnRH-II is present in the primate brain
    D W Lescheid
    Department of Biology, University of Victoria, British Columbia, Canada
    Endocrinology 138:5618-29. 1997
    ..We conclude that the primate brain contains mGnRH and a cGnRH-II-like molecule, although the function of the latter is unknown...
  16. ncbi request reprint Expression and alternative processing of a chicken gene encoding both growth hormone-releasing hormone and pituitary adenylate cyclase-activating polypeptide
    J E McRory
    Department of Biology, University of Victoria, British Columbia, Canada
    DNA Cell Biol 16:95-102. 1997
    ..We showed previously that these two neuropeptides were encoded in the same cDNA in fish, but the present evidence in chicken suggests a gene duplication in stem mammals...
  17. ncbi request reprint A new member of the gonadotropin-releasing hormone family in teleosts: catfish gonadotropin-releasing hormone
    N M Sherwood
    Biology Department, University of Victoria, British Columbia, Canada
    Gen Comp Endocrinol 75:427-36. 1989
    ..The lack of the salmon form of GnRH and the presence of a unique GnRH form constitute another example of the considerable evolutionary variation that has occurred in the catfish family compared with other teleosts...
  18. ncbi request reprint Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish
    Erica A Fradinger
    Department of Biology EAF, JAT, NMS, University of Victoria, P O Box 3020 STN CSC, Victoria, BC, Canada V8W 3N5
    Mol Cell Endocrinol 231:49-63. 2005
    ..Therefore, PACAP and GHRH have widespread, overlapping target sites suggesting a coordinated role for these hormones in evolution...
  19. doi request reprint Newly-identified receptors for peptide histidine-isoleucine and GHRH-like peptide in zebrafish help to elucidate the mammalian secretin superfamily
    Sheng Wu
    Department of Biology, University of Victoria, Victoria BC, Canada
    J Mol Endocrinol 41:343-66. 2008
    ..Our evidence that zebrafish PHI is more potent than human PHM in activating the human VPAC2R (EC(50)=7.4x10(-9) M) supports our suggestion that the VPAC2R and PHIR shared a common ancestral receptor...
  20. ncbi request reprint Inhibition of PACAP activity by a receptor antagonist results in changes in cell cycle and apoptotic proteins in chick neuroblasts
    Nola M Erhardt
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    J Mol Neurosci 27:107-23. 2005
    ..In summary, we have confirmed that withdrawal of PACAP from early chick neuroblasts causes cell cycle exit and apoptosis, and identified proteins involved in proliferation, exit, apoptosis, and possibly differentiation...
  21. ncbi request reprint Phylogeny and ontogeny of gonadotropin-releasing hormone: comparison of guinea pig, rat, and a protochordate
    R Kelsall
    Department of Biology, University of Victoria, British Columbia, Canada
    Gen Comp Endocrinol 78:479-94. 1990
    ..This is the first report using RIA, HPLC, and immunocytochemistry to show that protochordates have GnRH-like material. The results suggest that GnRH may have been present at the transition between the invertebrates and vertebrates...
  22. pmc Feeding and metabolism in mice lacking pituitary adenylate cyclase-activating polypeptide
    Bruce A Adams
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    Endocrinology 149:1571-80. 2008
    ..These results demonstrate that PACAP is not required for the regulation of food intake yet is necessary to maintain normal energy homeostasis, likely playing a role in central cold-sensing mechanisms...
  23. doi request reprint Hormones and receptors in fish: do duplicates matter?
    Graeme J Roch
    Department of Biology, University of Victoria, Victoria, BC, Canada V8W 3N5
    Gen Comp Endocrinol 161:3-12. 2009
    ..We conclude that fish duplicates in the secretin superfamily are a rich, mostly unexplored area for endocrine research...
  24. doi request reprint Amphioxus: beginning of vertebrate and end of invertebrate type GnRH receptor lineage
    Javier A Tello
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada
    Endocrinology 150:2847-56. 2009
    ..This is the first report to suggest that distinct invertebrate and vertebrate GnRHRs are present simultaneously in a basal chordate, amphioxus...
  25. ncbi request reprint Tunicate gonadotropin-releasing hormone (GnRH) peptides selectively activate Ciona intestinalis GnRH receptors and the green monkey type II GnRH receptor
    Javier A Tello
    Department of Biology, University of Victoria, P O Box 3020 STN CSC, Victoria, British Columbia, Canada V8W 3N5
    Endocrinology 146:4061-73. 2005
    ..intestinalis genome were all transcribed into messenger RNA, but only three of the Ciona GnRH receptors were biologically active in our assays. The Ciona GnRH receptors almost exclusively activated the cAMP pathway...
  26. ncbi request reprint Mouse pituitary adenylate cyclase-activating polypeptide (PACAP): gene, expression and novel splicing
    Kevin J Cummings
    Department of Biology, University of Victoria, BC, V8W2Y2, Victoria, Canada
    Mol Cell Endocrinol 192:133-45. 2002
    ..We identify continuous expression of PACAP in the brain and eye and stage-specific expression in the gonads and thymus. The complex splicing of PACAP transcripts may regulate the tissue-and stage-specific expression...
  27. ncbi request reprint Transcription and translation of the salmon gonadotropin-releasing hormone genes in brain and gonads of sexually maturing rainbow trout (Oncorhynchus mykiss)
    Sarah L Gray
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada V8W 3N5
    Biol Reprod 67:1621-7. 2002
    ..These results suggest that either the sGnRH transcripts in the gonads are not translated into protein or, if translated, the protein is rapidly released, resulting in gonadal content below 1 fM per fish...
  28. doi request reprint Disruption of the single copy gonadotropin-releasing hormone receptor in mice by gene trap: severe reduction of reproductive organs and functions in developing and adult mice
    Sheng Wu
    Department of Biology, University of Victoria, 3800 Finnerty Road, Victoria, British Columbia, Canada
    Endocrinology 151:1142-52. 2010
    ..In terms of gonadal morphology, adult gene trap-Gnrhr null mice demonstrate a complete cessation of reproduction and serve as an important model for understanding GnRH/GnRHR physiology...
  29. ncbi request reprint Six novel gonadotropin-releasing hormones are encoded as triplets on each of two genes in the protochordate, Ciona intestinalis
    Bruce A Adams
    Department of Biology, University of Victoria, Victoria, British Columbia, Canada V8W 3N5
    Endocrinology 144:1907-19. 2003
    ..These data provide insight into the structural evolution of the GnRH peptides and their genes and show a functional role for GnRH in tunicate spawning...
  30. ncbi request reprint Pituitary adenylate cyclase-activating polypeptide and growth hormone-releasing hormone-like peptide in sturgeon, whitefish, grayling, flounder and halibut: cDNA sequence, exon skipping and evolution
    Bruce A Adams
    Department of Biology, University of Victoria, BC, Canada
    Regul Pept 109:27-37. 2002
    ..This suggests that exon skipping in GHRH-PACAP transcripts may be an important mechanism for regulating the ratio of PACAP to GHRH peptides...
  31. ncbi request reprint PACAP maintains cell cycling and inhibits apoptosis in chick neuroblasts
    Nola M Erhardt
    Department of Biology, University of Victoria, P O Box 1700, 3800 Finnerty Road, Victoria, BC, Canada V8W 2Y2
    Mol Cell Endocrinol 221:121-34. 2004
    ..We conclude that chick neuroblasts require production of PACAP to inhibit apoptosis and maintain full proliferative activity during early brain development...
  32. ncbi request reprint Temperature-sensitive phenotype in mice lacking pituitary adenylate cyclase-activating polypeptide
    Sarah L Gray
    Department of Biology, University of Victoria, British Columbia, Canada V8W 3N5
    Endocrinology 143:3946-54. 2002
    ..We conclude that under prolonged but mild cold stress, lack of PACAP results in inadequate heat production due to insufficient norepinephrine stimulation of brown adipose tissue...
  33. ncbi request reprint A SIDS-like phenotype is associated with reduced respiratory chemoresponses in PACAP deficient neonatal mice
    Kevin J Cummings
    Faculty of Medicine, Department of Physiology and Biophysics, University of Calgary, Calgary AB, Canada
    Adv Exp Med Biol 551:77-83. 2004
  34. pmc Sudden neonatal death in PACAP-deficient mice is associated with reduced respiratory chemoresponse and susceptibility to apnoea
    Kevin J Cummings
    Respiratory Research Group, Department of Physiology and Biophysics, University of Calgary, 3330 Hospital Dr NW, Calgary, Alberta T2N 4N1, Canada
    J Physiol 555:15-26. 2004
    ....
  35. ncbi request reprint Altered cerebellar development in mice lacking pituitary adenylate cyclase-activating polypeptide
    Aurélie Allais
    European Institute for Peptide Research IFRMP 23, Laboratory of Cellular and Molecular Neuroendocrinology, University of Rouen, 76821 Mont Saint Aignan, France
    Eur J Neurosci 25:2604-18. 2007
    ..These data provide the first evidence of a physiological role for PACAP during cerebellar development...